Role of extracellular signal-regulated kinase pathway in RRR-α-tocopheryl succinate-induced differentiation of human MDA-MB-435 breast cancer cells

Molecular Carcinogenesis

Volumn 33, Issue 4, 2002, Pages 228-236

  You, Huihong ^a   Yu, Weiping ^a   Munoz Medellin, Debbie ^b   Brown, Powel H ^b   Sanders, Bob G ^a   Kline, Kimberly ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

C jun; Cellular differentiation; Human breast cancer cells; P21 Waf1 Cip1; Vitamin E succinate

Indexed keywords

ALPHA TOCOPHEROL SUCCINATE; CYTOKERATIN 18; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P21; STRESS ACTIVATED PROTEIN KINASE; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; BREAST CANCER; CANCER CELL CULTURE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; KNOCKOUT GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

BREAST NEOPLASMS; CELL DIFFERENTIATION; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DOXYCYCLINE; FEMALE; GENES, JUN; HUMANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KERATINS; MAP KINASE KINASE 1; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; OLIGODEOXYRIBONUCLEOTIDES, ANTISENSE; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-JUN; RECOMBINANT PROTEINS; TRANSFECTION; TUMOR CELLS, CULTURED; VITAMIN E;

EID: 0036216407     PISSN: 08991987     EISSN: None     Source Type: Journal    
DOI: 10.1002/mc.10040     Document Type: Article

References (63)

1. Vitamin E and cancer prevention: Recent advances and future potentials
2. Clinical development plan: Vitamin E
3. Vitamin E Mechanisms of action as tumor cell growth inhibitors
4. Vitamin E succinate promotes breast cancer tumor dormancy
5. Growth inhibition of MCF-7 and MCF-10A human breast cells by α- tocopheryl hemisuccinate, cholesteryl hemisuccinate and their ether analogs
6. Induction of cancer cell apoptosis by α-tocopheryl succinate: Molecular pathways and structural requirements
7. Vitamin E succinate: Mechanisms of action as tumor cell growth inhibitor
8. Vitamin E: Mechanisms of action as tumor cell growth inhibitors
9. Selective cancer cell killing by α-tocopheryl succinate
10. Effects of tocopherol (vitamin E) acid succinate on morphological alterations and growth inhibition in melanoma cells in culture
11. Growth-inhibitory effects of vitamin E succinate on retrovirus-transformed tumor cells in vitro
12. Decreased expressions of c-myc and H-ras oncogenes in vitamin E succinate induced morphologically differentiated murine B-16 melanoma cells in culture
13. Effect of vitamin E succinate and a cAMP-stimulating agent on the expression of c-myc and N-myc and H-ras in murine neuroblastoma cells
14. RRR-α-tocopheryl succinate modulation of human promyelocytic leukemia (HL-60) cell proliferation and differentiation
15. The selective cytotoxic effect of carotenoids and α-tocopherol on human cancer cell lines in vitro
16. RRR- α-tocopheryl succinate inhibits proliferation and enhances secretion of transforming growth factor-β (TGF-β) by human breast cancer cells
17. RRR-α-tocopheryl succinate inhibits DNA synthesis and enhances the production and secretion of biologically active transforming growth factor-β by avian retrovirus-transformed lymphoid cells
18. RRR-α-tocopheryl succinate inhibits the proliferation of human prostatic tumor cells with defective cell cycle/differentiation pathways
19. Growth inhibition and apoptosis of RL human B lymphoma cells by vitamin E succinate and retinoic acid: Role for transforming growth factor β
20. RRR-α- tocopheryl succinate enhances TGF-β 1, -β 2, and -β 3 and TGF-β R-II expression by human MDA-MB-435 breast cancer cells
21. RRR-α-tocopheryl succinate induces apoptosis in avian retrovirus-transformed lymphoid cells
22. Evidence for role of transforming growth factor-β in RRR-α-tocopheryl succinate-induced apoptosis of human MDA-MB-435 breast cancer cells
23. Vitamin E succinate induces Fast-mediated apoptosis in estrogen receptor-negative human breast cancer cells
24. Involvement of activator protein-1 (AP-1) in induction of apoptosis by vitamin E succinate in human breast cancer cells
25. RRR-α-tocopheryl succinate induction of prolonged activation of c-jun amino-terminal kinase and c-jun during induction of apoptosis in human MDA-MB-435 breast cancer cells
26. Production of inducible nitric oxide is required for monocytic differentiation of U937 cells induced by vitamin E-succinate
27. Vitamin E succinate (VES) induces Fas sensitivity in human breast cancer cells: Role for Mr 43,000 Fas in VES-triggered apoptosis
28. Lipoprotein- associated α-tocopheryl-succinate inhibits cell growth and induced apoptosis in human MCF-7 and HBL-100 breast cancer cells
29. RRR-α-tocopheryl succinate induces MDA-MB-435 and MCF-7 human breast cancer cells to undergo differentiation
30. Activation of extracellular signal-regulated kinase and c-Jun-NH2-terminal kinase but not p38 mitogen-activated protein kinases is required for RRR-α-tocopheryl succinate-induced apoptosis of human breast cancer cells Cancer Res
31. Tumorigenicity and metastasis of human breast carcinoma cell lines in nude mice
32. Suppression of oncogene induced transformation by a deletion mutant of c-jun
33. AP-1 blockade inhibits the growth of normal and malignant breast cells
34. Constitutive mutant and putative regulatory serine phosphorylation site of mammalian MAP kinase kinase (MEK1)
35. Functional expression and growth factor activation of an epitope-tagged p44-mitogen activated protein kinase, p44mapk
36. mapk are required for fibroblast proliferation
37. MAP kinase pathways
38. Signal transduction by the c-Jun N-terminal kinase
39. Mitogen-activated protein kinase cascades as regulators of stress responses
40. Requirement of JNK for stress-induced activation of the cytochrome c-mediated death pathway
41. Making the connection: Coupling of stress- activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses
42. The MAP kinase cascade is essential for diverse signal transduction pathways
43. Regulation of transcription by MAP kinase cascades
44. ATF-2 contains a phosphorylation-dependent transcriptional activation domain
45. Coupling of the RASMAPK pathway to gene activation by RSK2, a growth factor-regulated CREB kinase
46. Phosphorylation of c-Jun mediated by MAP kinase
47. Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation
48. The beta-PDGF receptor induces neuronal differentiation of PC12 cells
49. Co-regulation of the mitogen-activated protein kinase, extracellular signal-regulated kinase 1, and the 90-kDa ribosomal S6 kinase in PC12 cells: Distinct effects of the neurotrophic factor, nerve growth factor, and the mitogenic factor, epidermal growth factor
50. Adult human mesenchymal stem cell differentiation to the osteogenic or adipogenic lineage is regulated by mitogen-activated protein kinase
51. Prolonged activation of the mitogen-activated protein kinase pathway is required for macrophage-like differentiation of a human myeloid leukemic cell line
52. Regulation of heregulinβ1-induced differentiation in a human breast carcinoma cell line by the extracellular-regulated kinase (ERK) pathway
53. Oncostatin M-induced growth inhibition and morphological changes of MDA-MB-231 breast cancer cells are abolished by blocking the MEK/ERK signaling pathway
54. Terminal differentiation of human breast cancer through PPARγ
55. Diverse functions of JNK signaling and c-Jun in stress response and apoptosis
56. AP-1 in cell proliferation and survival
57. Induction of p21 (WAF-1/CIP1) during differentiation
58. Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD
59. Minireview p21-negative regulator of the cell cycle
60. Regulation of p21 WAF1/CP1 expression through mitogen-activated protein kinase signaling pathway
61. MAPK-dependent expression of p21 WAF and p27 kip1 in PMA-induced differentiation of HL60 cells
62. Cip1/Waf1 gene in chrondrocytes