-
1
-
-
0037032835
-
The protein kinase complement of the human genome
-
Manning G, Whyte DB, Martinez R, Hunter T, Sudarsanam S. The protein kinase complement of the human genome. Science. 2002;298:1912-1934.
-
(2002)
Science
, vol.298
, pp. 1912-1934
-
-
Manning, G.1
Whyte, D.B.2
Martinez, R.3
Hunter, T.4
Sudarsanam, S.5
-
2
-
-
0020609330
-
Stem cells in normal and leukemic hemopoiesis (Henry Stratton Lecture, 1982)
-
McCulloch EA. Stem cells in normal and leukemic hemopoiesis (Henry Stratton Lecture, 1982). Blood. 1983;62:1-13.
-
(1983)
Blood
, vol.62
, pp. 1-13
-
-
McCulloch, E.A.1
-
3
-
-
27244452986
-
Genetics of myeloid malignancies: Pathogenetic and clinical implications
-
Frohling S, Scholl C, Gilliland DG, Levine RL. Genetics of myeloid malignancies: pathogenetic and clinical implications. J Clin Oncol. 2005;23:6285-6295.
-
(2005)
J Clin Oncol
, vol.23
, pp. 6285-6295
-
-
Frohling, S.1
Scholl, C.2
Gilliland, D.G.3
Levine, R.L.4
-
4
-
-
0031803213
-
Differential constitutive activation between STAT-related proteins and MAP kinase in primary acute myelogenous leukaemia
-
Hayakawa F, Towatari M, Iida H, et al. Differential constitutive activation between STAT-related proteins and MAP kinase in primary acute myelogenous leukaemia. Br J Haematol. 1998;101:521-528.
-
(1998)
Br J Haematol
, vol.101
, pp. 521-528
-
-
Hayakawa, F.1
Towatari, M.2
Iida, H.3
-
5
-
-
0035203382
-
Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts
-
Birkenkamp KU, Geugien M, Lemmink HH, Kruijer W, Vellenga E. Regulation of constitutive STAT5 phosphorylation in acute myeloid leukemia blasts. Leukemia. 2001;15:1923-1931.
-
(2001)
Leukemia
, vol.15
, pp. 1923-1931
-
-
Birkenkamp, K.U.1
Geugien, M.2
Lemmink, H.H.3
Kruijer, W.4
Vellenga, E.5
-
6
-
-
33745717815
-
Phosphoproteomic analysis of AML cell lines identifies leukemic oncogenes
-
Walters DK, Goss VL, Stoffregen EP, et al. Phosphoproteomic analysis of AML cell lines identifies leukemic oncogenes. Leuk Res. 2006;30:1097-1104.
-
(2006)
Leuk Res
, vol.30
, pp. 1097-1104
-
-
Walters, D.K.1
Goss, V.L.2
Stoffregen, E.P.3
-
7
-
-
21144458164
-
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells
-
Rush J, Moritz A, Lee KA, et al. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. Nat Biotechnol. 2005;23:94-101.
-
(2005)
Nat Biotechnol
, vol.23
, pp. 94-101
-
-
Rush, J.1
Moritz, A.2
Lee, K.A.3
-
8
-
-
0032530972
-
Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes
-
Schwaller J, Frantsve J, Aster J, et al. Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes. EMBO J. 1998;17:5321-5333.
-
(1998)
EMBO J
, vol.17
, pp. 5321-5333
-
-
Schwaller, J.1
Frantsve, J.2
Aster, J.3
-
9
-
-
0345359585
-
An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients
-
O'Farrell AM, Foran JM, Fiedler W, et al. An innovative phase I clinical study demonstrates inhibition of FLT3 phosphorylation by SU11248 in acute myeloid leukemia patients. Clin Cancer Res. 2003;9:5465-5476.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 5465-5476
-
-
O'Farrell, A.M.1
Foran, J.M.2
Fiedler, W.3
-
10
-
-
26944447953
-
Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia
-
Goemans BF, Zwaan CM, Miller M, et al. Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia. Leukemia. 2005;19:1536-1542.
-
(2005)
Leukemia
, vol.19
, pp. 1536-1542
-
-
Goemans, B.F.1
Zwaan, C.M.2
Miller, M.3
-
11
-
-
33745713168
-
Activating alleles of JAK3 in acute megakaryoblastic leukemia
-
Walters DK, Mercher T, Gu TL, et al. Activating alleles of JAK3 in acute megakaryoblastic leukemia. Cancer Cell. 2006;10:65-75.
-
(2006)
Cancer Cell
, vol.10
, pp. 65-75
-
-
Walters, D.K.1
Mercher, T.2
Gu, T.L.3
-
12
-
-
0026633624
-
Acute megakaryoblastic leukemia: Establishment of a new cell line (MKPL-1) in vitro and in vivo
-
Takeuchi S, Sugito S, Uemura Y, et al. Acute megakaryoblastic leukemia: establishment of a new cell line (MKPL-1) in vitro and in vivo. Leukemia. 1992;6:588-594.
-
(1992)
Leukemia
, vol.6
, pp. 588-594
-
-
Takeuchi, S.1
Sugito, S.2
Uemura, Y.3
-
13
-
-
17044403497
-
Macrophage colony-stimulating factor receptor c-fms is a novel target of imatinib
-
Dewar AL, Cambareri AC, Zannettino AC, et al. Macrophage colony-stimulating factor receptor c-fms is a novel target of imatinib. Blood. 2005;105:3127-3132.
-
(2005)
Blood
, vol.105
, pp. 3127-3132
-
-
Dewar, A.L.1
Cambareri, A.C.2
Zannettino, A.C.3
-
14
-
-
30044449181
-
FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance
-
Taylor JR, Brownlow N, Domin J, Dibb NJ. FMS receptor for M-CSF (CSF-1) is sensitive to the kinase inhibitor imatinib and mutation of Asp-802 to Val confers resistance. Oncogene. 2006;25:147-151.
-
(2006)
Oncogene
, vol.25
, pp. 147-151
-
-
Taylor, J.R.1
Brownlow, N.2
Domin, J.3
Dibb, N.J.4
-
15
-
-
0033594481
-
DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC
-
Drabkin HA, West JD, Hotfilder M, et al. DEF-3(g16/NY-LU-12), an RNA binding protein from the 3p21.3 homozygous deletion region in SCLC. Oncogene. 1999;18:2589-2597.
-
(1999)
Oncogene
, vol.18
, pp. 2589-2597
-
-
Drabkin, H.A.1
West, J.D.2
Hotfilder, M.3
-
16
-
-
0033050855
-
A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3
-
Timmer T, Terpstra P, van den Berg A, et al. A comparison of genomic structures and expression patterns of two closely related flanking genes in a critical lung cancer region at 3p21.3. Eur J Hum Genet. 1999;7:478-486.
-
(1999)
Eur J Hum Genet
, vol.7
, pp. 478-486
-
-
Timmer, T.1
Terpstra, P.2
van den Berg, A.3
-
17
-
-
2642712493
-
Human lung cancer antigens recognized by autologous antibodies: Definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3
-
Gure AO, Altorki NK, Stockert E, Scanlan MJ, Old LJ, Chen YT. Human lung cancer antigens recognized by autologous antibodies: definition of a novel cDNA derived from the tumor suppressor gene locus on chromosome 3p21.3. Cancer Res. 1998;58:1034-1041.
-
(1998)
Cancer Res
, vol.58
, pp. 1034-1041
-
-
Gure, A.O.1
Altorki, N.K.2
Stockert, E.3
Scanlan, M.J.4
Old, L.J.5
Chen, Y.T.6
-
18
-
-
0034786240
-
Frequent gain of chromosome 19 in megakaryoblastic leukemias detected by comparative genomic hybridization
-
Alvarez S, MacGrogan D, Calasanz MJ, Nimer SD, Jhanwar SC. Frequent gain of chromosome 19 in megakaryoblastic leukemias detected by comparative genomic hybridization. Genes Chromosomes Cancer. 2001;32:285-293.
-
(2001)
Genes Chromosomes Cancer
, vol.32
, pp. 285-293
-
-
Alvarez, S.1
MacGrogan, D.2
Calasanz, M.J.3
Nimer, S.D.4
Jhanwar, S.C.5
-
19
-
-
0037100420
-
Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): A study of the Groupe Francais de Cytogenetique Hematologique (GFCH)
-
Dastugue N, Lafage-Pochitaloff M, Pages MP, et al. Cytogenetic profile of childhood and adult megakaryoblastic leukemia (M7): a study of the Groupe Francais de Cytogenetique Hematologique (GFCH). Blood. 2002;100:618-626.
-
(2002)
Blood
, vol.100
, pp. 618-626
-
-
Dastugue, N.1
Lafage-Pochitaloff, M.2
Pages, M.P.3
-
20
-
-
33750627651
-
JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model
-
Mercher T, Wernig G, Moore SA, et al. JAK2T875N is a novel activating mutation that results in myeloproliferative disease with features of megakaryoblastic leukemia in a murine bone marrow transplantation model. Blood. 2006;108:2770-2779.
-
(2006)
Blood
, vol.108
, pp. 2770-2779
-
-
Mercher, T.1
Wernig, G.2
Moore, S.A.3
-
21
-
-
33845501610
-
Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia
-
Gu TL, Goss VL, Reeves C, et al. Phosphotyrosine profiling identifies the KG-1 cell line as a model for the study of FGFR1 fusions in acute myeloid leukemia. Blood. 2006;108:4202-4204.
-
(2006)
Blood
, vol.108
, pp. 4202-4204
-
-
Gu, T.L.1
Goss, V.L.2
Reeves, C.3
-
22
-
-
0035902180
-
Oncogenic kinase signalling
-
Blume-Jensen P, Hunter T. Oncogenic kinase signalling. Nature. 2001;411:355-365.
-
(2001)
Nature
, vol.411
, pp. 355-365
-
-
Blume-Jensen, P.1
Hunter, T.2
-
24
-
-
0034941166
-
Fusion of two novel genes, RBM15 and MKL1, in the t(1; 22)(p13;q13) of acute megakaryoblastic leukemia
-
Ma Z, Morris SW, Valentine V, et al. Fusion of two novel genes, RBM15 and MKL1, in the t(1; 22)(p13;q13) of acute megakaryoblastic leukemia. Nat Genet. 2001;28:220-221.
-
(2001)
Nat Genet
, vol.28
, pp. 220-221
-
-
Ma, Z.1
Morris, S.W.2
Valentine, V.3
-
25
-
-
14344280044
-
Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia
-
Mercher T, Coniat MB, Monni R, et al. Involvement of a human gene related to the Drosophila spen gene in the recurrent t(1;22) translocation of acute megakaryocytic leukemia. Proc Natl Acad Sci U S A. 2001;98:5776-5779.
-
(2001)
Proc Natl Acad Sci U S A
, vol.98
, pp. 5776-5779
-
-
Mercher, T.1
Coniat, M.B.2
Monni, R.3
-
26
-
-
0025190309
-
FMS mutations in myelodysplastic, leukemic, and normal subjects
-
Ridge SA, Worwood M, Oscier D, Jacobs A, Padua RA. FMS mutations in myelodysplastic, leukemic, and normal subjects. Proc Natl Acad Sci U S A. 1990;87:1377-1380.
-
(1990)
Proc Natl Acad Sci U S A
, vol.87
, pp. 1377-1380
-
-
Ridge, S.A.1
Worwood, M.2
Oscier, D.3
Jacobs, A.4
Padua, R.A.5
-
27
-
-
0025276780
-
Mutation of the human FMS gene (M-CSF receptor) in myelodysplastic syndromes and acute myeloid leukemia
-
Tobal K, Pagliuca A, Bhatt B, Bailey N, Layton DM, Mufti GJ. Mutation of the human FMS gene (M-CSF receptor) in myelodysplastic syndromes and acute myeloid leukemia. Leukemia. 1990;4:486-489.
-
(1990)
Leukemia
, vol.4
, pp. 486-489
-
-
Tobal, K.1
Pagliuca, A.2
Bhatt, B.3
Bailey, N.4
Layton, D.M.5
Mufti, G.J.6
-
28
-
-
0027275594
-
c-fms point mutations in acute myeloid leukemia: Fact or fiction?
-
Springall F, O'Mara S, Shounan Y, Todd A, Ford D, Iland H. c-fms point mutations in acute myeloid leukemia: fact or fiction? Leukemia. 1993;7:978-985.
-
(1993)
Leukemia
, vol.7
, pp. 978-985
-
-
Springall, F.1
O'Mara, S.2
Shounan, Y.3
Todd, A.4
Ford, D.5
Iland, H.6
-
29
-
-
0023887668
-
Expression of the macrophage colony-stimulating factor and c-fms genes in human acute myeloblastic leukemia cells
-
Rambaldi A, Wakamiya N, Vellenga E, et al. Expression of the macrophage colony-stimulating factor and c-fms genes in human acute myeloblastic leukemia cells. J Clin Invest. 1988;81:1030-1035.
-
(1988)
J Clin Invest
, vol.81
, pp. 1030-1035
-
-
Rambaldi, A.1
Wakamiya, N.2
Vellenga, E.3
-
30
-
-
0024589705
-
Monoclonal antibodies to the human CSF-1 receptor (c-fms proto-oncogene product) detect epitopes on normal mononuclear phagocytes and on human myeloid leukemic blast cells
-
Ashmun RA, Look AT, Roberts WM, et al. Monoclonal antibodies to the human CSF-1 receptor (c-fms proto-oncogene product) detect epitopes on normal mononuclear phagocytes and on human myeloid leukemic blast cells. Blood. 1989;73:827-837.
-
(1989)
Blood
, vol.73
, pp. 827-837
-
-
Ashmun, R.A.1
Look, A.T.2
Roberts, W.M.3
-
31
-
-
0019847979
-
Distribution of cells bearing receptors for a colony-stimulating factor (CSF-1) in murine tissues
-
Byrne PV, Guilbert LJ, Stanley ER. Distribution of cells bearing receptors for a colony-stimulating factor (CSF-1) in murine tissues. J Cell Biol. 1981;91:848-853.
-
(1981)
J Cell Biol
, vol.91
, pp. 848-853
-
-
Byrne, P.V.1
Guilbert, L.J.2
Stanley, E.R.3
-
32
-
-
0032524350
-
Autoregulatory mechanisms in protein-tyrosine kinases
-
Hubbard SR, Mohammadi M, Schlessinger J. Autoregulatory mechanisms in protein-tyrosine kinases. J Biol Chem. 1998;273:11987-11990.
-
(1998)
J Biol Chem
, vol.273
, pp. 11987-11990
-
-
Hubbard, S.R.1
Mohammadi, M.2
Schlessinger, J.3
-
33
-
-
0028040875
-
The POZ domain: A conserved protein-protein interaction motif
-
Bardwell VJ, Treisman R. The POZ domain: a conserved protein-protein interaction motif. Genes Dev. 1994;8:1664-1677.
-
(1994)
Genes Dev
, vol.8
, pp. 1664-1677
-
-
Bardwell, V.J.1
Treisman, R.2
-
34
-
-
0344987881
-
A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
-
Cools J, DeAngelo DJ, Gotlib J, et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med. 2003;348:1201-1214.
-
(2003)
N Engl J Med
, vol.348
, pp. 1201-1214
-
-
Cools, J.1
DeAngelo, D.J.2
Gotlib, J.3
-
35
-
-
33744484267
-
Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent
-
Stover EH, Chen J, Folens C, et al. Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent. Proc Natl Acad Sci U S A. 2006;103:8078-8083.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 8078-8083
-
-
Stover, E.H.1
Chen, J.2
Folens, C.3
-
36
-
-
33746169020
-
FLT3 is fused to ETV6 in a myeloproliferative disorder with hypereosinophilia and a t(12;13)(p13;q12) translocation
-
Vu HA, Xinh PT, Masuda M, et al. FLT3 is fused to ETV6 in a myeloproliferative disorder with hypereosinophilia and a t(12;13)(p13;q12) translocation. Leukemia. 2006;20:1414-1421.
-
(2006)
Leukemia
, vol.20
, pp. 1414-1421
-
-
Vu, H.A.1
Xinh, P.T.2
Masuda, M.3
-
37
-
-
33746437130
-
MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia
-
Pikman Y, Lee BH, Mercher T, et al. MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia. PLoS Med. 2006;3:e270.
-
(2006)
PLoS Med
, vol.3
-
-
Pikman, Y.1
Lee, B.H.2
Mercher, T.3
-
38
-
-
33744490974
-
Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model
-
Wernig G, Mercher T, Okabe R, Levine RL, Lee BH, Gilliland DG. Expression of Jak2V617F causes a polycythemia vera-like disease with associated myelofibrosis in a murine bone marrow transplant model. Blood. 2006;107:4274-4281.
-
(2006)
Blood
, vol.107
, pp. 4274-4281
-
-
Wernig, G.1
Mercher, T.2
Okabe, R.3
Levine, R.L.4
Lee, B.H.5
Gilliland, D.G.6
-
39
-
-
0028243483
-
Phosphorylation of the erythroid transcription factor GATA-1
-
Crossley M, Orkin SH. Phosphorylation of the erythroid transcription factor GATA-1. J Biol Chem. 1994;269:16589-16596.
-
(1994)
J Biol Chem
, vol.269
, pp. 16589-16596
-
-
Crossley, M.1
Orkin, S.H.2
-
40
-
-
33746532476
-
Acetylation and MAPK phosphorylation cooperate to regulate the degradation of active GATA-1
-
Hernandez-Hernandez A, Ray P, Litos G, et al. Acetylation and MAPK phosphorylation cooperate to regulate the degradation of active GATA-1. EMBO J. 2006;25:3264-3274.
-
(2006)
EMBO J
, vol.25
, pp. 3264-3274
-
-
Hernandez-Hernandez, A.1
Ray, P.2
Litos, G.3
-
41
-
-
31544481433
-
Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway
-
Zhao W, Kitidis C, Fleming MD, Lodish HF, Ghaffari S. Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway. Blood. 2006;107:907-915.
-
(2006)
Blood
, vol.107
, pp. 907-915
-
-
Zhao, W.1
Kitidis, C.2
Fleming, M.D.3
Lodish, H.F.4
Ghaffari, S.5
-
42
-
-
27644436741
-
Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580
-
Conway JG, McDonald B, Parham J, et al. Inhibition of colony-stimulating-factor-1 signaling in vivo with the orally bioavailable cFMS kinase inhibitor GW2580. Proc Natl Acad Sci U S A. 2005;102:16078-16083.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 16078-16083
-
-
Conway, J.G.1
McDonald, B.2
Parham, J.3
-
43
-
-
0036357121
-
Expression of CSF-1 and its receptor CSF-1R in nonhematopoietic neoplasms
-
Kascinski B. Expression of CSF-1 and its receptor CSF-1R in nonhematopoietic neoplasms. Cancer Treat Res. 2002;107:285-292.
-
(2002)
Cancer Treat Res
, vol.107
, pp. 285-292
-
-
Kascinski, B.1
|