Frequent gain of chromosome 19 in megakaryoblastic leukemias detected by comparative genomic hybridization

Genes Chromosomes and Cancer

Volumn 32, Issue 3, 2001, Pages 285-293

  Alvarez, Sara ^a   MacGrogan, Donal ^a   Calasanz, M Jose ^b   Nimer, Stephen D ^a   Jhanwar, Suresh C ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY OF NAVARRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ACUTE MEGAKARYOCYTIC LEUKEMIA; ADULT; AGED; ARTICLE; CELL LINE; CHILD; CHROMOSOME 19; CHROMOSOME ABERRATION; CHROMOSOME BANDING PATTERN; CHROMOSOME DELETION 13; CHROMOSOME LOSS; CHROMOSOME PAINTING; CHROMOSOME TRANSLOCATION; CLINICAL ARTICLE; COMPARATIVE GENOMIC HYBRIDIZATION; CYTOGENETICS; FEMALE; HUMAN; HUMAN CELL; MALE; MEGAKARYOBLAST; PRIORITY JOURNAL;

ADULT; AGED; CHILD, PRESCHOOL; CHROMOSOME ABERRATIONS; CHROMOSOME PAINTING; CHROMOSOMES, HUMAN, PAIR 19; FEMALE; GENE AMPLIFICATION; HUMANS; LEUKEMIA, MEGAKARYOCYTIC, ACUTE; MALE; MIDDLE AGED; NUCLEIC ACID HYBRIDIZATION;

EID: 0034786240     PISSN: 10452257     EISSN: None     Source Type: Journal    
DOI: 10.1002/gcc.1192     Document Type: Article

References (44)

1. M-07e human leukemic factor-dependent cell line provides a rapid and sensitive bioassay for the human cytokines GM-CSF and IL-3
2. Nineteen cases of the t(1;22)(p13;q13) acute megakaryblastic leukaemia of infants/children and a review of 39 cases: Report from a t(1;22) study group
3. Rearrangements of chromosome 3 involving bands 3q21 and 3q26 are associated with normal or elevated platelet counts in acute nonlymphocytic leukemia
4. The molecular pathophysiology of myeloid leukaemias: Ras revisited
5. The t(1;22) (p13;q13) is nonrandom and restricted to infants with acute megakaryoblastic leukemia: A Pediatric Oncology Group study
6. Reproducibility of the morphological diagnostic criteria for acute myeloid leukemia: The GIMEMA group experience
7. AKT2, a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian carcinomas
8. Amplification of AKT2 in human pancreatic cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
9. Characterization of nonrandom chromosomal gains and losses in multiple myeloma by comparative genomic hybridization
10. Thrombopoietin: Expression of its receptor MPL and proliferative effects on leukemic cells
11. Quantitative analysis of comparative genomic hybridization
12. In vitro establishment and characterization of a human megakaryoblastic cell line
13. Acute megakaryoblastic leukemia
14. The DNA sequence of human chromosome 21. The chromosome 21 mapping and sequencing consortium
15. Cytogenetic and fluorescence in situ hybridization analyses of chromosome 19 aberrations in pancreatic carcinomas: Frequent loss of 19p13.3 and gain of 19q13.1-13.2
16. MLL2, the second human homolog of the Drosophila trithorax gene, maps to 19q13.1 and is amplified in solid tumor cell lines
17. Megakaryocytic leukemia; identification utilizing anti-factor VIII immunoperoxidase
18. Establishment and characterization of a novel human immature megakaryoblastic leukemia cell line. M-MOK, dependent on fibroblasts for its viability
19. Trisomy 19 as the sole chromosomal anomaly in hematologic neoplasms
20. Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors
21. Cyclin E, a potential prognostic marker for breast cancer
22. Establishment and characterization of a human leukemic cell line with megakaryocytic features: Dependency on granulocyte-macrophage colonystimulating factor, interleukin 3, or erythropoietin for growth and survival
23. Distinctive demography, biology, and outcome of acute myeloid leukemia and myelodysplastic syndrome in children with Down syndrome: Children's Cancer Group Studies 2861 and 2891
24. Molecular delineation of 13q deletion boundaries in 20 patients with myeloid malignancies
25. The translocation t(1;22)(p13;q13) is a nonrandom marker specifically associated with acute megakaryocytic leukemia in young children
26. Review of the cytogenetic changes in acute megakaryoblastic leukemia: One disease or several?
27. Cytokine-mediated erythroid maturation in mcgakaryoblastic human cell line HU-3
28. Establishment of a novel human megakaryoblastic leukemia cell line. MEG- 01, with positive Philadelphia chromosome
29. Cytogenetic findings in adult acute leukemia and myeloproliferativc disorders with an involvement of megakaryocyte lineage
30. Establishment and characterization of a new Ph1-positive chronic myeloid leukemia cell line MC3 with trilineage phenotype and an altered p53 gene
31. Correlation between chromosomal abnormalities and blast phenotype in the blast crisis of Ph-positive CGL
32. Cytogenetic abnormalities and their prognostic significance in idiopathic myelofibrosis: A study of 106 cases
33. Acute mcgakaryoblastic leukemia in children and adolescents: A retrospective analysis of 24 cases
34. Epidemiologic studies of childhood leukemia: Where do we go from here?
35. Leukemias with megakaryoblastic involvement: Clinical, hematologic, and immunologic characteristics
36. Establishment of a human leukaemic cell line (CMK) with megakaryocytic characteristics from a Down's syndrome patient with acute megakaryoblastic leukaemia
37. Characteristics of a cell line established from a case of acute megakaryoblastic leukemia
38. Quantitative expression of thrombopoictin receptor on leukaemia cells from patients with acute myeloid leukaemia and acute lymphoblastic leukaemia
39. Acute megakaryoblastic leukemia: Establishment of a new cell line (MKPL- 1) in vitro and in vivo
40. Acute megakaryocytic leukemia: The Eastern Cooperative Oncology Group experience
41. Establishment of a human mcgakaryoblastic cell line (T-33) from chronic myelogenous leukemia in megakaryoblastic crisis
42. Amplification of 19q13.1-q13.2 sequences in ovarian cancer. G-band, FISH, and molecular studies