Guanidine hydrochloride exerts dual effects on the tryptophan synthase α2β2 complex as a cation activator and as a modulator of the active site conformation

Biochemistry

Volumn 38, Issue 24, 1999, Pages 7881-7890

  Fan, Ying Xin ^a   McPhie, Peter ^a   Miles, Edith Wilson ^a  

^a NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 CHLOROALANINE; CATION; GUANIDINE; PYRIDOXAL 5 PHOSPHATE; SERINE; SODIUM CHLORIDE; TRYPTOPHAN SYNTHASE; UREA;

ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; ENZYME ACTIVE SITE; EQUILIBRIUM CONSTANT; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL;

BINDING SITES; CATIONS, MONOVALENT; CHROMATOGRAPHY, GEL; CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GUANIDINE; MACROMOLECULAR SUBSTANCES; MODELS, CHEMICAL; PROTEIN CONFORMATION; SERINE; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY; TRYPTOPHAN SYNTHASE; UREA;

EID: 0033564596     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi990307e     Document Type: Article

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