Roles of PPAR delta in lipid absorption and metabolism: A new target for the treatment of type 2 diabetes

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1740, Issue 2, 2005, Pages 313-317

  Luquet, Serge ^a   Gaudel, Celine ^a   Holst, Dorte ^a   Lopez Soriano, Joaquin ^a   Jehl Pietri, Chantal ^a   Fredenrich, Alexandre ^a   Grimaldi, Paul A ^a  

^a CENTRE DE BIOCHIMIE   (France)

Author keywords

Fatty acid; Metabolic syndrome; Obesity; PPAR; Type 2 diabetes

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; [2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; CELL NUCLEUS RECEPTOR; FATTY ACID DERIVATIVE; FIBRIC ACID DERIVATIVE; GW 0742; INSULIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PHENOXYACETIC ACID DERIVATIVE; POLYUNSATURATED FATTY ACID; PROSTACYCLIN; PROSTAGLANDIN DERIVATIVE; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ADIPOSE TISSUE CELL; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL TYPE; CONFERENCE PAPER; DRUG TARGETING; EXERCISE; FATTY ACID OXIDATION; FATTY ACID TRANSPORT; GENE EXPRESSION; HUMAN; INFLAMMATION; LIPID ABSORPTION; LIPID METABOLISM; LIPOPROTEIN METABOLISM; LIPOPROTEIN SYNTHESIS; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SENSITIZATION; SKELETAL MUSCLE;

ADIPOSE TISSUE; ANIMALS; CARRIER PROTEINS; DIABETES MELLITUS, TYPE 2; FATTY ACID-BINDING PROTEINS; FATTY ACIDS; HUMANS; LIPID METABOLISM; METABOLIC SYNDROME X; MULTIENZYME COMPLEXES; MUSCLE, SKELETAL; PPAR DELTA;

ANIMALIA;

EID: 20444424173     PISSN: 09254439     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbadis.2004.11.011     Document Type: Conference Paper

References (29)

1. W.C. Knowler, E. Barret-Connos, S.E. Fowler, R.F. Hamman, J.M. Lachin, E.A. Walkers, and D.M. Nathan Reduction of the incidence of type 2 diabetes with lifestyle intervention or metformin N. Eng. J. Med. 346 2001 393 403
2. O. Barbier, J.P. Torra, Y. Duguay, C. Blanquart, J.C. Fruchart, C. Glineur, and B. Staels Pleiotropic actions of peroxisome proliferator-activated receptors in lipid metabolism and atherosclerosis Arterioscler. Thromb. Vasc. Biol. 22 2002 716 726
3. E.D. Rosen, C.J. Walkey, P. Puigserver, and B.M. Spiegelman Transcriptional regulation of adipogenesis Genes Dev. 14 2000 1293 1307
4. T. Kadowaki, K. Hara, T. Yamauchi, Y. Terauchi, K. Tobe, and R. Nagai Molecular mechanism of insulin resistance and obesity Exp. Biol. Med. 228 2003 1111 1117
5. T.M. Larsen, S. Toubro, and A. Astrup PPARgamma agonists in the treatment of type II diabetes: is increased fatness commensurate with long-term efficacy Int. J. Obes. Relat. Metab. Disord. 27 2003 147 161
6. J. Tordjman, G. Chauvet, J. Quette, E.G. Beale, C. Forest, and B. Antoine Thiazolidinediones block fatty acid release by inducing glyceroneogenesis in fat cells J. Biol. Chem. 278 2003 18785 18790
7. H.P. Guan, Y. Li, M.V. Jensen, C.B. Newgard, C.M. Steppan, and M.A. Lazar A futile cycle activated in adipocytes by antidiabetic agents Nat. Med. 9 2003 811 812
8. O. Braissant, F. Foufelle, C. Scotto, M. Dauca, and W. Wahli Differential expression of PPARs: tissue distribution of PPAR-alpha, -beta and -gamma in the adult rat Endocrinology 137 1996 354 366
9. E.Z. Amri, F. Bonino, G. Ailhaud, N.A. Abumrad, and P.A. Grimaldi Cloning of a protein that mediates transcriptional effects of fatty acids in preadipocytes. Homology to peroxisome proliferator-activated receptors J. Biol. Chem. 270 1995 2367 2371
10. R. Hertz, I. Berman, D. Keppler, and J. Bar-Tana Activation of gene transcription by prostacyclin analogues is mediated by the peroxisome- proliferator-activated receptor (PPAR) Eur. J. Biochem. 235 1996 242 247
11. M.L. Sznaidman, C.D. Haffner, P.R. Maloney, A. Fivush, E. Chao, D. Goreham, M.L. Sierra, C. LeGrumelec, H.E. Xu, V.G. Montana, M.H. Lambert, T.M. Willson, W.R. Oliver, and D.D. Sternbach Novel selective small molecules agonists for peroxisome proliferator-activated receptor δ (PPARδ)-synthesis and biological activity Bioorg. Med. Chem. Lett. 13 2003 1517 1521
12. J.M. Peters, S.S. Lee, W. Li, J.M. Ward, O. Gavrilova, C. Everett, M.L. Reitman, L.D. Hudson, and F.J. Gonzalez Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta (delta) Mol. Cell. Biol. 20 2000 5119 5128
13. C. Jehl-Pietri, C. Bastie, I. Gillot, S. Luquet, and P.A. Grimaldi Peroxisome-proliferator-activated receptor delta mediates the effects of long-chain fatty acids on post-confluent cell proliferation Biochem. J. 350 2000 93 98
14. C. Bastie, D. Holst, D. Gaillard, C. Jehl-Pietri, and P.A. Grimaldi Expression of peroxisome proliferator-activated receptor PPARdelta promotes induction of PPARgamma and adipocyte differentiation in 3T3C2 fibroblasts J. Biol. Chem. 274 1999 21920 21925
15. C. Bastie, S. Luquet, D. Holst, C. Jehl-Pietri, and P.A. Grimaldi Alterations of peroxisome proliferator-activated receptor delta activity affect fatty acid-controlled adipose differentiation J. Biol. Chem. 275 2000 38768 38773
16. L. Michalik, B. Desvergne, and W. Wahli Peroxisome proliferator-activated receptor β/δ: emerging roles for a previously neglected third family member Curr. Opin. Lipidol. 14 2003 129 135
17. H. Poirier, I. Niot, M.C. Monnot, O. Braissan, C. Meunier-Durmort, P. Costet, T. Pineau, W. Wahli, T.M. Willson, and P. Besnard Differential involvement of peroxisome-proliferator-activated receptors alpha and delta in fibrate and fatty-acid-mediated inductions of the gene encoding liver fatty-acid-binding protein in the liver and the small intestine Biochem. J. 355 2001 481 488
18. T.C. He, T.A. Chan, B. Vogelstein, and K.W. Kinzler PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs Cell 99 1999 335 345
19. B.H. Park, B. Vogelstein, and K.W. Kinzler Genetic disruption of PPARdelta decreases the tumorigenicity of human colon cancer cells Proc. Natl. Acad. Sci. U. S. A. 98 2001 2598 2603
20. P.S. Harman, C.J. Nicol, H.E. Marin, J.M. Ward, F.J. Gonzalez, and J.M. Peters Peroxisome proliferator-activated receptor-delta attenuates colon carcinogenesis Nat. Med. 10 2004 481 483
21. W.R. Oliver, J.L. Shenk, M.R. Snaith, C.S. Russell, K.D. Plunket, N.L. Bodkin, M.C. Lewis, D.A. Winegar, M.L. Sznaidman, M.H. Lambert, H.E. Xu, D.D. Sternbach, S.A. Kliewer, B.C. Hansen, and T.M. Wilson A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport Proc. Natl. Acad. Sci. U. S. A. 98 2001 5306 5311
22. T. Tanaka, J. Yamamoto, S. Iwasaki, H. Asaba, H. Hamura, Y. Ikeda, M. Watanabe, K. Magoori, R.X. Ioka, K. Tachibana, Y. Watanabe, Y. Uchiyama, K. Sumi, H. Iguchi, S. Ito, T. Doi, T. Hamakubo, M. Naito, J. Auwerx, M. Yanagisawa, T. Kodama, and J. Sakai Activation of peroxisome proliferator-activated receptor δ induces fatty acid β-oxidation in skeletal muscle and attenuates metabolic syndrome Proc. Natl. Acad. Sci. U. S. A. 100 2003 15924 15929
23. Y.X. Wang, C.H. Lee, S. Tiep, R.T. Yu, J. Ham, H. Kang, and R.M. Evans Peroxisome proliferator-activated receptor δ activates fat metabolism to prevent obesity Cell 113 2003 159 170
24. D.M. Muoio, P.S. MacLean, D.B. Lang, S. Li, J.A. Houmand, J.M. Way, D.A. Winegar, J.C. Corton, G.L. Dohm, and W.E. Kraus Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) α knockout mice. Evidence for compensatory regulation by PPARα J. Biol. Chem. 277 2002 26089 26097
25. D. Holst, S. Luquet, V. Nogueira, K. Kristiansen, X. Leverve, and P.A. Grimaldi Nutritional regulation and role of peroxisome proliferator-activated receptor α in fatty acid catabolism in skeletal muscle Biochim. Biophys. Acta 1633 2003 43 50
26. U. Dressel, T.L. Allen, J.B. Pippal, P.R. Rohde, P. Lau, and G.E. Muscat The peroxisome proliferator-activated receptor β/δ agonist, GW501516, regulates the expression of genes involved in lipid catabolism and energy uncoupling in skeletal muscle cells Mol. Endocrinol. 17 2003 2477 2493
27. S. Luquet, J. Lopez-Soriano, D. Holst, A. Fredenrich, J. Melki, M. Rassoulzadegan, and P.A. Grimaldi Peroxisome proliferator-activated receptor δ controls muscle development and oxidative capability FASEB J. 17 2003 2299 2301
28. D.L.M. Allen, B.C. Harrison, A. Maass, M.L. Bell, W.C. Byrnes, and L.A. Leinwand Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse J. Appl. Physiol. 90 2001 1900 1908
29. G.E. McCall, W.C. Byrnes, A. Dickinson, P.M. Pattany, and S.J. Fleck Muscle fiber hypertrophy, hyperplasia and capillary density in college men after resistance training J. Appl. Physiol. 81 1996 2004 2012