New and renewed perspectives on embryonic stem cell pluripotency

Frontiers in Bioscience

Volumn 12, Issue 9, 2007, Pages 3321-3332

  Hoffman, Jackson A ^a   Merrill, Bradley J ^a  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

Author keywords

Gastrulation; Lineage commitment; Pluripotency; Review; Stem cells; Tcf3

Indexed keywords

MAMMALIA;

ANIMAL; CELL LINEAGE; CYTOLOGY; HUMAN; MOUSE; PLURIPOTENT STEM CELL; REVIEW;

ANIMALS; CELL LINEAGE; HUMANS; MICE; PLURIPOTENT STEM CELLS;

EID: 34347247280     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/2315     Document Type: Review

References (102)

1. Little, C. C.: Colour inheritance in cats, with special reference to colours, black, yellow, and tortoiseshell. Journal of Genetics 8, 279-290 (1919)
2. Grahn, R. A., B. M. Lemesch, L. V. Millon, T. Matise, Q. R. Rogers, J. G. Morris, N. Fretwell, S. J. Bailey, R. M. Batt, and L. A. Lyons: Localizing the X-linked orange colour phenotype using feline resource families. Anim Genet 36, 67-70 (2005) (Pubitemid 40252776)
3. Lyon, M. F.: Sex chromatin and gene action in the mammalian X-chromosome. Am J Hum Genet 14, 135-148 (1962)
4. Ralston, A. and J. Rossant: Genetic regulation of stem cell origins in the mouse embryo. Clin Genet 68, 106-112 (2005) (Pubitemid 40990621)
5. Yamanaka, Y., A. Ralston, R. O. Stephenson, and J. Rossant: Cell and molecular regulation of the mouse blastocyst. Dev Dyn 235, 2301-2314 (2006) (Pubitemid 44325248)
6. Nagy, A., Gertsenstein, M., Vintersten, K., Behringer, R., Manipulating the Mouse Embryo: A laboratory Manual. Third ed. 2003, Cold Spring Harbor: Cold Spring Harbor Laboratory Press.
7. Stevens, L. C. and C. C. Little: Spontaneous Testicular Teratomas in an Inbred Strain of Mice. Proc Natl Acad Sci U S A 40, 1080-1087 (1954)
8. Stevens, L. C.: Studies on transplantable testicular teratomas of strain 129 mice. J Natl Cancer Inst 20, 1257-1275 (1958)
9. Stevens, L. C.: The biology of teratomas. Adv Morphog 6, 1-31 (1967)
10. Stevens, L. C.: Embryology of testicular teratomas in strain 129 mice. J Natl Cancer Inst 23, 1249-1295 (1959)
11. Stevens, L. C.: The development of transplantable teratocarcinomas from intratesticular grafts of pre-and postimplantation mouse embryos. Dev Biol 21, 364-382 (1970)
12. Stevens, L. C.: Embryonic potency of embryoid bodies derived from a transplantable testicular teratoma of the mouse. Dev Biol 2, 285-297 (1960)
13. Mintz, B. and K. Illmensee: Normal genetically mosaic mice produced from malignant teratocarcinoma cells. Proc Natl Acad Sci U S A 72, 3585-3589 (1975)
14. Brinster, R. L.: The effect of cells transferred into the mouse blastocyst on subsequent development. J Exp Med 140, 1049-1056 (1974)
15. Brinster, R. L.: Participation of teratocarcinoma cells in mouse embryo development. Cancer Res 36, 3412-3414 (1976)
16. Ford, C. E., E. P. Evans, and R. L. Gardner: Marker chromosome analysis of two mouse chimaeras. J Embryol Exp Morphol 33, 447-457 (1975)
17. Gardner, R. L. and J. Rossant: Investigation of the fate of 4-5 day post-coitum mouse inner cell mass cells by blastocyst injection. J Embryol Exp Morphol 52, 141-152 (1979) (Pubitemid 9250107)
18. Tam, P. P. and R. R. Behringer: Mouse gastrulation: the formation of a mammalian body plan. Mech Dev 68, 3-25 (1997) (Pubitemid 28011051)
19. Tam, P. P. and S. X. Zhou: The allocation of epiblast cells to ectodermal and germ-line lineages is influenced by the position of the cells in the gastrulating mouse embryo. Dev Biol 178, 124-132 (1996) (Pubitemid 26297245)
20. Tam, P. P., M. Parameswaran, S. J. Kinder, and R. P. Weinberger: The allocation of epiblast cells to the embryonic heart and other mesodermal lineages: the role of ingression and tissue movement during gastrulation. Development 124, 1631-1642 (1997) (Pubitemid 27248331)
21. Beddington, R. S.: An autoradiographic analysis of tissue potency in different regions of the embryonic ectoderm during gastrulation in the mouse. J Embryol Exp Morphol 69, 265-285 (1982) (Pubitemid 12086433)
22. Lawson, K. A., J. J. Meneses, and R. A. Pedersen: Clonal analysis of epiblast fate during germ layer formation in the mouse embryo. Development 113, 891-911 (1991) (Pubitemid 21900328)
23. Lawson, K. A., J. J. Meneses, and R. A. Pedersen: Cell fate and cell lineage in the endoderm of the presomite mouse embryo, studied with an intracellular tracer. Dev Biol 115, 325-339 (1986) (Pubitemid 16073361)
24. Lawson, K. A. and R. A. Pedersen: Cell fate, morphogenetic movement and population kinetics of embryonic endoderm at the time of germ layer formation in the mouse. Development 101, 627-652 (1987) (Pubitemid 17163347)
25. Martin, G. R.: Isolation of a pluripotent cell line from early mouse embryos cultured in medium conditioned by teratocarcinoma stem cells. Proc Natl Acad Sci U S A 78, 7634-7638 (1981) (Pubitemid 12186197)
26. Evans, M. J. and M. H. Kaufman: Establishment in culture of pluripotential cells from mouse embryos. Nature 292, 154-156 (1981) (Pubitemid 11050741)
27. Bradley, A., M. Evans, M. H. Kaufman, and E. Robertson: Formation of germ-line chimaeras from embryo-derived teratocarcinoma cell lines. Nature 309, 255-256 (1984) (Pubitemid 14139934)
28. Papaioannou, V. E., M. W. McBurney, R. L. Gardner, and M. J. Evans: Fate of teratocarcinoma cells injected into early mouse embryos. Nature 258, 70-73 (1975)
29. Nichols, J., E. P. Evans, and A. G. Smith: Establishment of germ-line-competent embryonic stem (ES) cells using differentiation inhibiting activity. Development 110, 1341-1348 (1990) (Pubitemid 120009502)
30. Williams, R. L., D. J. Hilton, S. Pease, T. A. Willson, C. L. Stewart, D. P. Gearing, E. F. Wagner, D. Metcalf, N. A. Nicola, and N. M. Gough: Myeloid leukaemia inhibitory factor maintains the developmental potential of embryonic stem cells. Nature 336, 684-687 (1988) (Pubitemid 19007951)
31. Niwa, H., T. Burdon, I. Chambers, and A. Smith: Selfrenewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev 12, 2048-2060 (1998) (Pubitemid 28323878)
32. Anneren, C., C. A. Cowan, and D. A. Melton: The Src family of tyrosine kinases is important for embryonic stem cell self-renewal. J Biol Chem 279, 31590-31598 (2004) (Pubitemid 39037828)
33. Matsuda, T., T. Nakamura, K. Nakao, T. Arai, M. Katsuki, T. Heike, and T. Yokota: STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. Embo J 18, 4261-4269 (1999) (Pubitemid 29364128)
34. Suzuki, A., A. Raya, Y. Kawakami, M. Morita, T. Matsui, K. Nakashima, F. H. Gage, C. Rodriguez-Esteban, and J. C. Izpisua Belmonte: Nanog binds to Smad1 and blocks bone morphogenetic protein-induced differentiation of embryonic stem cells. Proc Natl Acad Sci U S A 103, 10294-10299 (2006) (Pubitemid 44051160)
35. Li, M., M. Sendtner, and A. Smith: Essential function of LIF receptor in motor neurons. Nature 378, 724-727 (1995) (Pubitemid 26001944)
36. Takeda, K., K. Noguchi, W. Shi, T. Tanaka, M. Matsumoto, N. Yoshida, T. Kishimoto, and S. Akira: Targeted disruption of the mouse Stat3 gene leads to early embryonic lethality. Proc Natl Acad Sci U S A 94, 3801-3804 (1997) (Pubitemid 27180453)
37. Dani, C., I. Chambers, S. Johnstone, M. Robertson, B. Ebrahimi, M. Saito, T. Taga, M. Li, T. Burdon, J. Nichols, and A. Smith: Paracrine induction of stem cell renewal by LIF-deficient cells: a new ES cell regulatory pathway. Dev Biol 203, 149-162 (1998) (Pubitemid 28506670)
38. Ying, Q. L., J. Nichols, I. Chambers, and A. Smith: BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell 115, 281-292 (2003) (Pubitemid 37487702)
39. Willert, K. and K. A. Jones: Wnt signaling: is the party in the nucleus? Genes Dev 20, 1394-1404 (2006) (Pubitemid 43830647)
40. Sato, N., L. Meijer, L. Skaltsounis, P. Greengard, and A. H. Brivanlou: Maintenance of pluripotency in human and mouse embryonic stem cells through activation of Wnt signaling by a pharmacological GSK-3-specific inhibitor. Nat Med 10, 55-63 (2004) (Pubitemid 38524699)
41. Kielman, M. F., M. Rindapaa, C. Gaspar, N. van Poppel, C. Breukel, S. van Leeuwen, M. M. Taketo, S. Roberts, R. Smits, and R. Fodde: Apc modulates embryonic stem-cell differentiation by controlling the dosage of beta-catenin signaling. Nat Genet 32, 594-605 (2002) (Pubitemid 35435171)
42. Aubert, J., H. Dunstan, I. Chambers, and A. Smith: Functional gene screening in embryonic stem cells implicates Wnt antagonism in neural differentiation. Nat Biotechnol 20, 1240-1245 (2002) (Pubitemid 35462489)
43. Ogawa, K., R. Nishinakamura, Y. Iwamatsu, D. Shimosato, and H. Niwa: Synergistic action of Wnt and LIF in maintaining pluripotency of mouse ES cells. Biochem Biophys Res Commun 343, 159-166 (2006)
44. Singla, D. K., D. J. Schneider, M. M. LeWinter, and B. E. Sobel: wnt3a but not wnt11 supports self-renewal of embryonic stem cells. Biochem Biophys Res Commun 345, 789-795 (2006) (Pubitemid 43777001)
45. Hao, J., T. G. Li, X. Qi, D. F. Zhao, and G. Q. Zhao: WNT/beta-catenin pathway up-regulates Stat3 and converges on LIF to prevent differentiation of mouse embryonic stem cells. Dev Biol 290, 81-91 (2006) (Pubitemid 43083605)
46. Dravid, G., Z. Ye, H. Hammond, G. Chen, A. Pyle, P. Donovan, X. Yu, and L. Cheng: Defining the Role of Wnt/{beta}-Catenin Signaling in the Survival, Proliferation and Self-Renewal of Human Embryonic Stem Cells. Stem Cells (2005)
47. Otero, J. J., W. Fu, L. Kan, A. E. Cuadra, and J. A. Kessler: Beta-catenin signaling is required for neural differentiation of embryonic stem cells. Development 131, 3545-3557 (2004) (Pubitemid 39199366)
48. Huelsken, J., R. Vogel, V. Brinkmann, B. Erdmann, C. Birchmeier, and W. Birchmeier: Requirement for beta-catenin in anterior-posterior axis formation in mice. J Cell Biol 148, 567-578 (2000)
49. Palmieri, S. L., W. Peter, H. Hess, and H. R. Scholer: Oct-4 transcription factor is differentially expressed in the mouse embryo during establishment of the first two extraembryonic cell lineages involved in implantation. Dev Biol 166, 259-267 (1994) (Pubitemid 24374763)
50. Nichols, J., B. Zevnik, K. Anastassiadis, H. Niwa, D. Klewe-Nebenius, I. Chambers, H. Scholer, and A. Smith: Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95, 379-391 (1998) (Pubitemid 28507326)
51. Niwa, H., J. Miyazaki, and A. G. Smith: Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nat Genet 24, 372-376 (2000) (Pubitemid 30187435)
52. Mitsui, K., Y. Tokuzawa, H. Itoh, K. Segawa, M. Murakami, K. Takahashi, M. Maruyama, M. Maeda, and S. Yamanaka: The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell 113, 631-642 (2003) (Pubitemid 36694188)
53. Chambers, I., D. Colby, M. Robertson, J. Nichols, S. Lee, S. Tweedie, and A. Smith: Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113, 643-655 (2003) (Pubitemid 36694189)
54. Hatano, S. Y., M. Tada, H. Kimura, S. Yamaguchi, T. Kono, T. Nakano, H. Suemori, N. Nakatsuji, and T. Tada: Pluripotential competence of cells associated with Nanog activity. Mech Dev 122, 67-79 (2005) (Pubitemid 39593746)
55. Hough, S. R., I. Clements, P. J. Welch, and K. A. Wiederholt: Differentiation of mouse embryonic stem cells following RNAi-mediated silencing of OCT4 and Nanog. Stem Cells (2006)
56. Ivanova, N., R. Dobrin, R. Lu, I. Kotenko, J. Levorse, C. DeCoste, X. Schafer, Y. Lun, and I. R. Lemischka: Dissecting self-renewal in stem cells with RNA interference. Nature 442, 533-538 (2006) (Pubitemid 44167907)
57. Yuan, H., N. Corbi, C. Basilico, and L. Dailey: Developmental-specific activity of the FGF-4 enhancer requires the synergistic action of Sox2 and Oct-3. Genes Dev 9, 2635-2645 (1995)
58. Botquin, V., H. Hess, G. Fuhrmann, C. Anastassiadis, M. K. Gross, G. Vriend, and H. R. Scholer: New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Genes Dev 12, 2073-2090 (1998) (Pubitemid 28323880)
59. Avilion, A. A., S. K. Nicolis, L. H. Pevny, L. Perez, N. Vivian, and R. Lovell-Badge: Multipotent cell lineages in early mouse development depend on SOX2 function. Genes Dev 17, 126-140 (2003) (Pubitemid 36062514)
60. Loh, Y. H., Q. Wu, J. L. Chew, V. B. Vega, W. Zhang, X. Chen, G. Bourque, J. George, B. Leong, J. Liu, K. Y. Wong, K. W. Sung, C. W. Lee, X. D. Zhao, K. P. Chiu, L. Lipovich, V. A. Kuznetsov, P. Robson, L. W. Stanton, C. L. Wei, Y. Ruan, B. Lim, and H. H. Ng: The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells. Nat Genet (2006)
61. Chew, J. L., Y. H. Loh, W. Zhang, X. Chen, W. L. Tam, L. S. Yeap, P. Li, Y. S. Ang, B. Lim, P. Robson, and H. H. Ng: Reciprocal transcriptional regulation of Pou5f1 and Sox2 via the Oct4/Sox2 complex in embryonic stem cells. Mol Cell Biol 25, 6031-6046 (2005) (Pubitemid 40946556)
62. Kuroda, T., M. Tada, H. Kubota, H. Kimura, S. Y. Hatano, H. Suemori, N. Nakatsuji, and T. Tada: Octamer and Sox Elements Are Required for Transcriptional cis Regulation of Nanog Gene Expression. Mol Cell Biol 25, 2475-2485 (2005) (Pubitemid 40354640)
63. Okumura-Nakanishi, S., M. Saito, H. Niwa, and F. Ishikawa: Oct-3/4 and Sox2 regulate Oct-3/4 gene in embryonic stem cells. J Biol Chem 280, 5307-5317 (2005) (Pubitemid 40280004)
64. Rodda, D. J., J. L. Chew, L. H. Lim, Y. H. Loh, B. Wang, H. H. Ng, and P. Robson: Transcriptional regulation of nanog by OCT4 and SOX2. J Biol Chem 280, 24731-24737 (2005) (Pubitemid 40934562)
65. Boyer, L. A., T. I. Lee, M. F. Cole, S. E. Johnstone, S. S. Levine, J. P. Zucker, M. G. Guenther, R. M. Kumar, H. L. Murray, R. G. Jenner, D. K. Gifford, D. A. Melton, R. Jaenisch, and R. A. Young: Core transcriptional regulatory circuitry in human embryonic stem cells. Cell 122, 947-956 (2005) (Pubitemid 41345211)
66. Wang, J., S. Rao, J. Chu, X. Shen, D. N. Levasseur, T. W. Theunissen, and S. H. Orkin: A protein interaction network for pluripotency of embryonic stem cells. Nature 444, 364-368 (2006) (Pubitemid 44764111)
67. Boyer, L. A., K. Plath, J. Zeitlinger, T. Brambrink, L. A. Medeiros, T. I. Lee, S. S. Levine, M. Wernig, A. Tajonar, M. K. Ray, G. W. Bell, A. P. Otte, M. Vidal, D. K. Gifford, R. A. Young, and R. Jaenisch: Polycomb complexes repress developmental regulators in murine embryonic stem cells. Nature 441, 349-353 (2006) (Pubitemid 44050199)
68. Chickarmane, V., C. Troein, U. A. Nuber, H. M. Sauro, and C. Peterson: Transcriptional Dynamics of the Embryonic Stem Cell Switch. PLoS Comput Biol 2, (2006)
69. Brannon, M., M. Gomperts, L. Sumoy, R. T. Moon, and D. Kimelman: A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus. Genes Dev 11, 2359-2370 (1997) (Pubitemid 27408533)
70. Merrill, B. J., U. Gat, R. DasGupta, and E. Fuchs: Tcf3 and Lef1 regulate lineage differentiation of multipotent stem cells in skin. Genes Dev 15, 1688-1705 (2001) (Pubitemid 32702590)
71. Merrill, B. J., H. A. Pasolli, L. Polak, M. Rendl, M. J. Garcia-Garcia, K. V. Anderson, and E. Fuchs: Tcf3: a transcriptional regulator of axis induction in the early embryo. Development 131, 263-274 (2004) (Pubitemid 38181367)
72. Nguyen, H., M. Rendl, and E. Fuchs: Tcf3 governs stem cell features and represses cell fate determination in skin. Cell 127, 171-183 (2006) (Pubitemid 44466637)
73. Tumbar, T., G. Guasch, V. Greco, C. Blanpain, W. E. Lowry, M. Rendl, and E. Fuchs: Defining the epithelial stem cell niche in skin. Science 303, 359-363 (2004) (Pubitemid 38095773)
74. Ivanova, N. B., J. T. Dimos, C. Schaniel, J. A. Hackney, K. A. Moore, and I. R. Lemischka: A stem cell molecular signature. Science 298, 601-604 (2002)
75. Pereira, L., F. Yi, and B. J. Merrill: Repression of nanog gene transcription by tcf3 limits embryonic stem cell selfrenewal. Mol Cell Biol 26, 7479-7491 (2006) (Pubitemid 44547699)
76. Stead, E., J. White, R. Faast, S. Conn, S. Goldstone, J. Rathjen, U. Dhingra, P. Rathjen, D. Walker, and S. Dalton: Pluripotent cell division cycles are driven by ectopic Cdk2, cyclin A/E and E2F activities. Oncogene 21, 8320-8333 (2002) (Pubitemid 35477872)
77. Burdon, T., A. Smith, and P. Savatier: Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol 12, 432-438 (2002) (Pubitemid 35239952)
78. Fujii-Yamamoto, H., J. M. Kim, K. Arai, and H. Masai: Cell cycle and developmental regulations of replication factors in mouse embryonic stem cells. J Biol Chem 280, 12976-12987 (2005)
79. Faast, R., J. White, P. Cartwright, L. Crocker, B. Sarcevic, and S. Dalton: Cdk6-cyclin D3 activity in murine ES cells is resistant to inhibition by p16 (INK4a). Oncogene 23, 491-502 (2004) (Pubitemid 38175004)
80. Sage, J., G. J. Mulligan, L. D. Attardi, A. Miller, S. Chen, B. Williams, E. Theodorou, and T. Jacks: Targeted disruption of the three Rb-related genes leads to loss of G (1) control and immortalization. Genes Dev 14, 3037-3050 (2000)
81. Savatier, P., H. Lapillonne, L. A. van Grunsven, B. B. Rudkin, and J. Samarut: Withdrawal of differentiation inhibitory activity/leukemia inhibitory factor up-regulates D-type cyclins and cyclin-dependent kinase inhibitors in mouse embryonic stem cells. Oncogene 12, 309-322 (1996) (Pubitemid 26042568)
82. Schwaiger, M. and D. Schubeler: A question of timing: emerging links between transcription and replication. Curr Opin Genet Dev 16, 177-183 (2006) (Pubitemid 43376065)
83. Schubeler, D., D. Scalzo, C. Kooperberg, B. van Steensel, J. Delrow, and M. Groudine: Genome-wide DNA replication profile for Drosophila melanogaster: a link between transcription and replication timing. Nat Genet 32, 438-442 (2002) (Pubitemid 35266122)
84. Azuara, V., P. Perry, S. Sauer, M. Spivakov, H. F. Jorgensen, R. M. John, M. Gouti, M. Casanova, G. Warnes, M. Merkenschlager, and A. G. Fisher: Chromatin signatures of pluripotent cell lines. Nat Cell Biol 8, 532-538 (2006)
85. Santos-Rosa, H., R. Schneider, B. E. Bernstein, N. Karabetsou, A. Morillon, C. Weise, S. L. Schreiber, J. Mellor, and T. Kouzarides: Methylation of histone H3 K4 mediates association of the Isw1p ATPase with chromatin. Mol Cell 12, 1325-1332 (2003) (Pubitemid 37487939)
86. Santos-Rosa, H., R. Schneider, A. J. Bannister, J. Sherriff, B. E. Bernstein, N. C. Emre, S. L. Schreiber, J. Mellor, and T. Kouzarides: Active genes are tri-methylated at K4 of histone H3. Nature 419, 407-411 (2002)
87. Cao, R., L. Wang, H. Wang, L. Xia, H. Erdjument-Bromage, P. Tempst, R. S. Jones, and Y. Zhang: Role of histone H3 lysine 27 methylation in Polycomb-group silencing. Science 298, 1039-1043 (2002) (Pubitemid 35247314)
88. Kirmizis, A., S. M. Bartley, A. Kuzmichev, R. Margueron, D. Reinberg, R. Green, and P. J. Farnham: Silencing of human polycomb target genes is associated with methylation of histone H3 Lys 27. Genes Dev 18, 1592-1605 (2004) (Pubitemid 38868910)
89. Sparmann, A. and M. van Lohuizen: Polycomb silencers control cell fate, development and cancer. Nat Rev Cancer 6, 846-856 (2006) (Pubitemid 44629896)
90. Kim, S. Y., S. W. Paylor, T. Magnuson, and A. Schumacher: Juxtaposed Polycomb complexes co-regulate vertebral identity. Development (2006)
91. Meshorer, E., D. Yellajoshula, E. George, P. J. Scambler, D. T. Brown, and T. Misteli: Hyperdynamic plasticity of chromatin proteins in pluripotent embryonic stem cells. Dev Cell 10, 105-116 (2006) (Pubitemid 43025681)
92. Bernstein, B. E., T. S. Mikkelsen, X. Xie, M. Kamal, D. J. Huebert, J. Cuff, B. Fry, A. Meissner, M. Wernig, K. Plath, R. Jaenisch, A. Wagschal, R. Feil, S. L. Schreiber, and E. S. Lander: A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Cell 125, 315-326 (2006)
93. Montgomery, N. D., D. Yee, A. Chen, S. Kalantry, S. J. Chamberlain, A. P. Otte, and T. Magnuson: The murine polycomb group protein Eed is required for global histone H3 lysine-27 methylation. Curr Biol 15, 942-947 (2005) (Pubitemid 40772064)
94. O'Carroll, D., S. Erhardt, M. Pagani, S. C. Barton, M. A. Surani, and T. Jenuwein: The polycomb-group gene Ezh2 is required for early mouse development. Mol Cell Biol 21, 4330-4336 (2001) (Pubitemid 32565314)
95. Meshorer, E. and T. Misteli: Chromatin in pluripotent embryonic stem cells and differentiation. Nat Rev Mol Cell Biol 7, 540-546 (2006) (Pubitemid 44036459)
96. Szutorisz, H. and N. Dillon: The epigenetic basis for embryonic stem cell pluripotency. Bioessays 27, 1286-1293 (2005) (Pubitemid 43076172)
97. Scholer, H. R., G. R. Dressler, R. Balling, H. Rohdewohld, and P. Gruss: Oct-4: a germline-specific transcription factor mapping to the mouse t-complex. Embo J 9, 2185-2195 (1990)
98. Snow, M. H. L.: Gastrulation in the mouse: growth and regionalization of the epiblast. J Embryol Exp Morphol 42, 293-303 (1977) (Pubitemid 8243310)
99. White, J. and S. Dalton: Cell Cycle Control of Embryonic Stem Cells. Stem Cell Reviews 1, 131-138 (2005) (Pubitemid 43074197)
100. Berthet, C., K. D. Klarmann, M. B. Hilton, H. C. Suh, J. R. Keller, H. Kiyokawa, and P. Kaldis: Combined loss of Cdk2 and Cdk4 results in embryonic lethality and Rb hypophosphorylation. Dev Cell 10, 563-573 (2006)
101. Murphy, M., M. G. Stinnakre, C. Senamaud-Beaufort, N. J. Winston, C. Sweeney, M. Kubelka, M. Carrington, C. Brechot, and J. Sobczak-Thepot: Delayed early embryonic lethality following disruption of the murine cyclin A2 gene. Nat Genet 15, 83-86 (1997) (Pubitemid 27014955)
102. O'Neill, L. P., M. D. VerMilyea, and B. M. Turner: Epigenetic characterization of the early embryo with a chromatin immunoprecipitation protocol applicable to small cell populations. Nat Genet 38, 835-841 (2006) (Pubitemid 43980607)