Mechanisms of cardiac potassium channel trafficking

Journal of Physiology

Volumn 582, Issue 1, 2007, Pages 17-26

  Steele, David F ^a   Eldstrom, Jodene ^a   Fedida, David ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ION CHANNEL; MEMBRANE ASSOCIATED GUANYLATE CYCLASE KINASE; POTASSIUM CHANNEL; CAVEOLIN 3; HEAT SHOCK COGNATE PROTEIN 70; HEAT SHOCK PROTEIN 70; HEAT SHOCK PROTEIN 90; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; KV CHANNEL INTERACTING PROTEIN; POTASSIUM CHANNEL HERG; POTASSIUM CHANNEL KCNK3; POTASSIUM CHANNEL KCNQ1; POTASSIUM CHANNEL KIR2.2; POTASSIUM CHANNEL KV1.1; POTASSIUM CHANNEL KV1.3; POTASSIUM CHANNEL KV1.4; POTASSIUM CHANNEL KV1.5; POTASSIUM CHANNEL KV4.2; PROTEIN CASK; SNARE PROTEIN; SYNAPSE ASSOCIATED PROTEIN 97; SYNAPTOSOMAL ASSOCIATED PROTEIN 25; SYNTAXIN 1A; UNCLASSIFIED DRUG;

CELL MEMBRANE TRANSPORT; CELLULAR DISTRIBUTION; CYTOSKELETON; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; GOLGI COMPLEX; HEART; HEART MUSCLE CELL; INTERNALIZATION; INTRACELLULAR TRANSPORT; KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; QUALITY CONTROL; REGULATORY MECHANISM; REVIEW; SARCOLEMMA; AMINO TERMINAL SEQUENCE; CARBOXY TERMINAL SEQUENCE; CELL MIGRATION; CONFOCAL MICROSCOPY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; HUMAN; IMMUNOCYTOCHEMISTRY; MICROTUBULE; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING;

ANIMALS; CYTOSKELETAL PROTEINS; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; GOLGI APPARATUS; GUANYLATE KINASE; HUMANS; MODELS, MOLECULAR; MOLECULAR CHAPERONES; MYOCARDIUM; POTASSIUM CHANNELS; PROTEIN CONFORMATION; PROTEIN TRANSPORT; SARCOLEMMA;

EID: 34347236923     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2007.130245     Document Type: Review

References (128)

1. + channels in mouse ventricular myocytes. Circ Res 96, 451-458.
2. Akhavan A, Atanasiu R, Noguchi T, Han W, Holder N & Shrier A (2005). Identification of the cyclic-nucleotide-binding domain as a conserved determinant of ion-channel cell-surface localization. J Cell Sci 118, 2803-2812.
3. An WF, Bowlby MR, Bett M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS & Rhodes KJ (2000). Modulation of A-type potassium channels by a family of calcium sensors. Nature 403, 553-556.
4. Anderson CL, Delisle BP, Anson BD, Kilby JA, Will ML, Tester DJ, Gong QM, Zhou ZF, Ackerman MJ & January CT (2006). Most LQT2 mutations reduce Kv11.1 (hERG) current by a class 2 (trafficking-deficient) mechanism. Circulation 113, 365-373.
5. Aoe T, Lee AJ, van Donselaar E, Peters PJ & Hsu VW (1998). Modulation of intracellular transport by transported proteins: Insight from regulation of COPI-mediated transport. Proc Natl Acad Sci U S A 95, 1624-1629.
6. Asher G, Reuven N & Shaul Y (2006). 20S proteasomes and protein degradation 'by default'. Bioessays 28, 844-849.
7. Bahring R, Dannenberg J, Peters HC, Leicher T, Pongs O & Isbrandt D (2001). Conserved Kv4 N-terminal domain critical for effects of Kv channel-interacting protein 2.2 on channel expression and gating. J Biol Chem 276, 23888-23894.
8. + channels. Circ Res 77, 361-369.
9. Cabrera M, Muniz M, Hidalgo J, Vega L, Martin ME & Velasco A (2003). The retrieval function of the KDEL receptor requires PKA phosphorylation of its C-terminus. Mol Biol Cell 14, 4114-4125.
10. Calaghan SC, Le Guennec JY & White E (2004). Cytoskeletal modulation of electrical and mechanical activity in cardiac myocytes. Prog Biophys Mol Biol 84, 29-59.
11. Carnegie GK & Scott JD (2003). A-kinase anchoring proteins and neuronal signaling mechanisms. Genes Dev 17, 1557-1568.
12. Cereijido M, Contreras RG, Shoshani L & Garcia-Villegas MR (2003). Membrane targeting. Prog Biophys Mol Biol 81, 81-115.
13. Chang XB, Cui LY, Hou YX, Jensen TJ, Aleksandrov AA, Mengos A & Riordan JR (1999). Removal of multiple arginine-framed trafficking signals overcomes misprocessing of Delta F508 CFTR present in most patients with cystic fibrosis. Mol Cell 4, 137-142.
14. + channel by ceramide: Evidence for ubiquitin-mediated lysosomal degradation. J Cell Sci 118, 5325-5334.
15. Choi WS, Khurana A, Mathur R, Viswanathan V, Steele DF & Fedida D (2005). Kv1.5 surface expression is modulated by retrograde trafficking of newly endocytosed channels by the dynein motor. Circ Res 97, 363-371.
16. Chu PJ, Rivera JF & Arnold DB (2006). A role for Kif17 in transport of Kv4.2. J Biol Chem 281, 365-373.
17. + accumulation. J Physiol 537, 979-992.
18. + channels: Potential role of Hsc70. J Neurosci Res 67, 745-752.
19. Conti LR, Radeke CM & Vandenberg CA (2002). Membrane targeting of ATP-sensitive potassium channel - Effects of glycosylation on surface expression. J Biol Chem 277, 25416-25422.
20. Cordes JS, Sun ZQ, Lloyd DB, Bradley JA, Opsahl AC, Tengowski MW, Chen X & Zhou J (2005). Pentamidine reduces hERG expression to prolong the QT interval. Br J Pharmacol 145, 15-23.
21. Cosson P & Letourneur F (1994). Coatomer interaction with di-lysine endoplasmic-reticulum retention motifs. Science 263, 1629-1631.
22. Cukovic D, Lu GWK, Wible B, Steele DF & Fedida D (2001). A discrete amino terminal domain of Kv1.5 and Kv1.4 potassium channels interacts with the spectrin repeats of α-actinin-2. FEBS Letts 498, 87-92.
23. Dhani SU, Mohammad-Panah R, Ahmed N, Ackerley C, Ramjeesingh M & Bear CE (2003). Evidence for a functional interaction between the ClC-2 chloride channel and the retrograde motor dynein complex. J Biol Chem 278, 16262-16270.
24. Eldstrom J, Choi WS, Steele DF & Fedida D (2003). SAP97 increases Kv1.5 currents through an indirect N-terminal mechanism. FEBS Letts 547, 205-211.
25. Eldstrom J, Van Wagoner DR, Moore ED & Fedida D (2006). Localization of Kv1.5 channels in rat and canine myocyte sarcolemma. FEBS Letts 580, 6039-6046.
26. Ficker E, Dennis AT, Wang L & Brown AM (2003). Role of the cytosolic chaperones Hsp70 and Hsp90 in maturation of the cardiac potassium channel HERG. Circ Res 92, e87-100.
27. Ficker E, Obejero-Paz CA, Zhao S & Brown AM (2002). The binding site for channel blockers that rescue misprocessed human long QT syndrome type 2 ether-a-gogo-related gene (HERG) mutations. J Biol Chem 277, 4989-4998.
28. + channel with syntaxin 1A: Functional impact on channel gating. J Neurosci 21, 1964-1974.
29. Folco EJ, Liu GX & Koren G (2004). Caveolin-3 and SAP97 form a scaffolding protein complex that regulates the voltage-gated potassium channel Kv1.5. Am J Physiol Heart Circ Physiol 287, H681-H690.
30. Furutani M, Trudeau MC, Hagiwara N, Seki A, Gong Q, Zhou Z, Imamura S-I, Nagashima H, Kasanuki H, Takao A, Momma K, January CT, Robertson GA & Matsuoka R (1999). Novel mechanism associated with an inherited cardiac arrhythmia. Defective protein trafficking by the mutant HERG (G601S) potassium channel. Circulation 99, 2290-2294.
31. + channel Kv1.5. J Biol Chem 278, 47046-47052.
32. Godreau D, Vranckx R, Maguy A, Rucker-Martin C, Goyenvalle C, Abdelshafy S, Tessier S, Couétil J-P & Hatem SN (2002). Expression, regulation and role of the MAGUK protein SAP-97 in human atrial myocardium. Cardiovasc Res 56, 433-442.
33. Gong QM, Anderson CL, January CT & Zhou ZF (2002). Role of glycosylation in cell surface expression and stability of HERG potassium channels. Am J Physiol Heart Circ Physiol 283, H77-H84.
34. Gong QM, Jones MA & Zhou ZF (2006). Mechanisms of pharmacological rescue of trafficking-defective hERG mutant channels in human long QT syndrome. J Biol Chem 281, 4069-4074.
35. Gong QM, Keeney DR, Molinari M & Zhou ZF (2005). Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway. J Biol Chem 280, 19419-19425.
36. Gu F, Crump CM & Thomas G (2001). Trans-Golgi network sorting. Cell Mol Life Sci 58, 1067-1084.
37. Gurkan C, Stagg SM, LaPointe P & Balch WE (2006). The COPII cage: unifying principles of vesicle coat assembly. Nat Rev Mol Cell Biol 7, 727-738.
38. Hanada T, Lin LH, Tibaldi EV, Reinherz EL & Chishti AH (2000). GAKIN, a novel kinesin-like protein associates with the human homologue of the Drosophila discs large tumor suppressor in T lymphocytes. J Biol Chem 275, 28774-28784.
39. Hanlon MR & Wallace BA (2002). Structure and function of voltage-dependent ion channel regulatory β subunits. Biochemistry 41, 2886-2894.
40. Harter C & Wieland FT (1998). A single binding site for dilysine retrieval motifs and p23 within the gamma subunit of coatomer. Proc Natl Acad Sci U S A 95, 11649-11654.
41. + channels mediated by KChlP1 is via a novel post-ER vesicular pathway. J Cell Biol 171, 459-469.
42. Hattan D, Nesti E, Cachero TG & Morielli AD (2002). Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin. J Biol Chem 277, 38596-38606.
43. Hong WJ (2005). SNARES and traffic. Biochim Biophys Acta Mol Cell Res 1744, 120-144.
44. Imamura F, Maeda S, Doi T & Fujiyoshi Y (2002). Ligand binding of the second PDZ domain regulates clustering of PSD-95 with the Kv1.4 potassium channel. J Biol Chem 277, 3640-3646.
45. Jahn R & Scheller RH (2006). SNAREs - engines for membrane fusion. Nat Rev Mol Cell Biol 7, 631-643.
46. Jeng RL & Welch MD (2001). Cytoskeleton: Actin and endocytosis - no longer the weakest link. Curr Biol 11, R691-R694.
47. Ji JZ, Tsuk S, Salapatek AMF, Huang XH, Chikvashvili D, Pasyk EA, Kang YH, Sheu L, Tsushima R, Diamant N, Trimble WS, Lotan I & Gaisano HY (2002). The 25-kDa synaptosome-associated protein (SNAP-25) binds and inhibits delayed rectifier potassium channels in secretory cells. J Biol Chem 277, 20195-20204.
48. + channel, in rat myocytes. Am J Physiol Heart Circ Physiol 283, H181-H185.
49. Karcher RL, Deacon SW & Gelfand VI (2002). Motor-cargo interactions: the key to transport specificity. Trends Cell Biol 12, 21-27.
50. Kato M, Ogura K, Miaki J, Sasaki N, Taniguchi S, Igawa O, Yoshida A, Hoshikawa Y, Murata M, Nanba E, Kurata Y, Kawata Y, Ninomiya H, Morisaki T, Kitakaze M & Isatome I (2005). Evidence for proteasomal degradation of Kv1.5 channel protein. Biochem Biophys Res Commun 337, 343-348.
51. Khanna R, Myers MP, LainéM & Papazian DM (2001). Glycosylation increases potassium channel stability and surface expression in mammalian cells. J Biol Chem 276, 34028-34034.
52. + channels by interaction with a family of membrane-associated guanylate kinases. Nature 378, 85-88.
53. + channel T1 recognition domain. J Biol Chem 278, 4305-4313.
54. Kosolapov A, Tu L, Wang J & Deutsch C (2004). Structure acquisition of the T1 domain of Kv1.3 during biogenesis. Neuron 44, 295-307.
55. Kucera JP, Rohr S & Rudy Y (2002). Localization of sodium channels in intercalated disks modulates cardiac conduction. Circ Res 91, 1176-1182.
56. Kuge O, Dascher C, Orci L, Rowe T, Amherdt M, Plutner H, Ravazzola M, Tanigawa G, Rothman JE & Balch WE (1994). Sar1 promotes vesicle budding from the endoplasmic-reticulum but not golgi compartments. J Cell Biol 125, 51-65.
57. Kupershmidt S, Yang T, Chanthaphaychith S, Wang Z, Towbin JA & Roden DM (2002). Defective human ether-a-go-go-related gene trafficking linked to an endoplasmic reticulum retention signal in the C terminus. J Biol Chem 277, 27442-27448.
58. Kuryshev YA, Ficker E, Wang L, Hawryluk P, Dennis AT, Wible BA, Brown AM, Kang JS, Chen XL, Sawamura K, Reynolds W & Rampe D (2005). Pentamidine-induced long QT syndrome and block of hERG trafficking. J Pharmacol Exp Ther 312, 316-323.
59. + channels. Am J Physiol Cell Physiol 278, C931-C941.
60. Lai HC & Jan LY (2006). The distribution and targeting of neuronal voltage-gated ion channels. Nat Rev Neurosci 7, 548-562.
61. Lee MCS, Miller EA, Goldberg J, Orci L & Schekman R (2004). Bi-directional protein transport between the ER and Golgi. Ann Rev Cell Dev Biol 20, 87-123.
62. Leonoudakis D, Conti LR, Radeke CM, McGuire LMM & Vandenberg CA (2004). A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels. J Biol Chem 279, 19051-19063.
63. Leung YM, Kang YH, Gao XD, Xia FZ, Xie HL, Sheu L, Tsuk S, Lotan I, Tsushima RG & Gaisano HY (2003). Syntaxin 1A binds to the cytoplasmic C terminus of Kv2.1 to regulate channel gating and trafficking. J Biol Chem 278, 17532-17538.
64. Li D, Takimoto K & Levitan ES (2000). Surface expression of Kv1 channels is governed by a C-terminal motif. J Biol Chem 275, 11597-11602.
65. Lin DH, Sterling H, Wang ZJ, Babilonia E, Yang BF, Dong K, Hebert SC, Giebisch G & Wang WH (2005). ROMK1 channel activity is regulated by monobuquitination. Proc Natl Acad Sci U S A 102, 4306-4311.
66. Lister I, Roberts R, Schmitz S, Walker M, Trinick J, Veigel C, Buss F & Kendrick-Jones J (2004). Myosin VI: A multifunctional motor. Biochem Soc Trans 32, 685-688.
67. Lu JL & Deutsch C (2005). Secondary structure formation of a transmembrane segment in Kv channels. Biochemistry 44, 8230-8243.
68. Ma D & Jan LY (2002). ER transport signals and trafficking of potassium channels and receptors. Curr Opin Neurobiol 12, 287-292.
69. Ma D, Zerangue N, Lin YF & Collins A, Yu M, Jan YN & Jan LY (2001). Role of ER export signals in controlling surface potassium channel numbers. Science 291, 316-319.
70. McClure SJ & Robinson PJ (1996). Dynamin, endocytosis and intracellular signalling. Mol Membr Biol 13, 189-215.
71. + channels in neuroendocrine islet β-cells through an interaction with the channel N terminus. Mol Endocrinol 16, 2452-2461.
72. Maier SK, Westenbroek RE, Schenkman KA, Feigl EO, Scheuer T & Catterall WA (2002). An unexpected role for brain-type sodium channels in coupling of cell surface depolarization to contraction in the heart. Proc Natl Acad Sci U S A 99, 4073-4078.
73. Manganas LN & Trimmer JS (2004). Calnexin regulates mammalian Kv1 channel trafficking. Biochem Biophys Res Commun 322, 577-584.
74. Margeta-Mitrovic M, Jan YN & Jan LY (2000). A trafficking checkpoint controls GABA B receptor heterodimerization. Neuron 27, 97-106.
75. Martens JR, Navarro-Polanco R, Coppock EA, Nishiyama A, Parshley L, Grobaski T & Tamkun MM (2000). Differential targeting of Shaker-like potassium channels to lipid rafts. J Biol Chem 275, 7443-7446.
76. + channels to distinct lipid raft populations. Targeting of Kv1.5 to caveolae. J Biol Chem 276, 8409-8414.
77. Maruoka ND, Steele DF, Au BPY, Dan P, Zhang X, Moore EDW & Fedida D (2000). α-Actinin-2 couples to cardiac Kv1.5 channels, regulating current density and channel localization in HEK cells. FEBS Letts 473, 188-194.
78. Mason HS, Latten MJ, Godoy LD, Horowitz B & Kenyon JL (2002). Modulation of Kv1.5 currents by protein kinase A, tyrosine kinase, and protein tyrosine phosphatase requires an intact cytoskeleton. Mol Pharmacol 61, 285-293.
79. Mathur R, Choi WS, Eldstrom J, Wang Z, Kim J, Steele DF & Fedida D (2006). A specific N-terminal residue in Kv1.5 is required for upregulation of the channel by SAP97. Biochem Biophys Res Commun 342, 1-8.
80. + channel protein in explanted cardiac tissue. J Clin Invest 96, 282-292.
81. Mellman I & Warren G (2000). The road taken: Past and future foundations of membrane traffic. Cell 100, 99-112.
82. + channel by syntaxin 1A requires the physical interaction of Gβγ with the channel. J Biol Chem 277, 34909-34917.
83. Mogelsvang S & Howell KE (2006). Global approaches to study Golgi function. Curr Opin Cell Biol 18, 438-443.
84. Murata M, Buckett PD, Zhou J, Brunner M, Folco E & Koren G (2001). SAP97 interacts with Kv1.5 in heterologous expression systems. Am J Physiol Heart Circ Physiol 281, H2575-H2584.
85. Murshid A & Presley JF (2004). ER-to-Golgi transport and cytoskeletal interactions in animal cells. Cell Mol Life Sci 61, 133-145.
86. Naisbitt S, Valtschanoff J, Allison DW, Sala C, Kim E, Craig AM, Weinberg RJ & Sheng M (2000). Interaction of the postsynaptic density-95/guanylate kinase domain-associated protein complex with a light chain of myosin-V and dynein. J Neurosci 20, 4524-4534.
87. Napp J, Monje F, Stuhmer W & Pardo LA (2005). Glycosylation of Eag1 (Kv10.1) potassium channels - Intracellular trafficking and functional consequences. J Biol Chem 280, 29506-29512.
88. Nerbonne JM & Guo WN (2002). Heterogeneous expression of voltage-gated potassium channels in the heart: Roles in normal excitation and arrhythmias. J Cardiovasc Electrophysiol 13, 406-409.
89. Nesti E, Everill B & Morielli AD (2004). Endocytosis as a mechanism for tyrosine kinase dependent suppression of a voltage gated potassium channel. Mol Biol Cell 15, 4073-4088.
90. Nufer O, Guldbrandsen S, Degen M, Kappeler F, Paccaud JP, Tani K & Hauri HP (2002). Role of cytoplasmic C-terminal amino acids of membrane proteins in ER export. J Cell Sci 115, 619-628.
91. Nufer O & Hauri HP (2003). ER export: Call 14-3-3. Curr Biol 13, R391-R393.
92. O'Connell KMS & Tamkun MM (2005). Targeting of voltage-gated potassium channel isoforms to distinct cell surface microdomains. J Cell Sci 118, 2155-2166.
93. O'Kelly I, Butler MH, Zilberberg N & Goldstein SAN (2002). Forward transport: 14-3-3 binding overcomes retention in endoplasmic reticulum by dibasic signals. Cell 111, 577-588.
94. Paulussen A, Raes A, Matthijs G, Snyders DJ, Cohen N & Aerssens J (2002). A novel mutation (T65P) in the PAS domain of the human potassium channel HERG results in the long QT syndrome by trafficking deficiency. J Biol Chem 277, 48610-48616.
95. Petrecca K, Miller DM & Shrier A (2000). Localization and enhanced current density of the Kv4.2 potassium channel by interaction with the actin-binding protein filamin. J Neurosci 20, 8736-8744.
96. + channel β subunits. Ann N Y Acad Sci 868, 344-355.
97. Presley JF, Cole NB, Schroer TA, Hirschberg K, Zaal KJ & Lippincott-Schwartz J (1997). ER-to-Golgi transport visualized in living cells. Nature 389, 81-85.
98. + channel block and disruption of protein trafficking by fluoxetine and norfluoxetine. Br J Pharmacol 149, 481-489.
99. + channels KCNQ1 and ERG1 in the rat heart. Am J Physiol Heart Circ Physiol 286, H1300-H1309.
100. Robinson JM & Deutsch C (2005). Coupled tertiary folding and oligomerization of the T1 domain of Kv channels. Neuron 45, 223-232.
101. Rossenbacker T, Mubagwa K, Jongbloed RJ, Vereecke J, Devriendt K, Gewillig M, Carmeliet E, Collen D, Heidbuchel H & Carmeliet P (2005). Novel mutation in the Per-Arnt-Sim domain of KCNH2 causes a malignant form of long-QT syndrome. Circulation 111, 961-968.
102. Ruiz-Gomez A, Mellstrom B, Tornero D, Morato E, Savignac M, Holguin H, Aurrekoetxea K, Gonzalez P, Gonzalez-Garcia C, Cena V, Mayor F & Naranjo JR (2007). G protein-coupled receptor kinase 2-mediated phosphorylation of downstream regulatory element antagonist modulator regulates membrane trafficking of Kv4.2 potassium channel. J Biol Chem 282, 1205-1215.
103. Schafer DA (2004). Regulating actin dynamics at membranes: A focus on dynamin. Traffic 5, 463-469.
104. Seeber S, Becker K, Rau T, Eschenhagen T, Becker CM & Herkert M (2000). Transient expression of NMDA receptor subunit NR2B in the developing rat heart. J Neurochem 75, 2472-2477.
105. Setou M, Nakagawa T, Seog DH & Hirokawa N (2000). Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science 288, 1796-1802.
106. + channel surface expression through effects early in biosynthesis. Neuron 16, 843-852.
107. Shikano S, Coblitz B, Wu M & Li M (2006). 14-3-3 proteins: regulation of endoplasmic reticulum localization and surface expression of membrane proteins. Trends Cell Biol 16, 370-375.
108. Shikano S & Li M (2003). Membrane receptor trafficking: Evidence of proximal and distal zones conferred by two independent endoplasmic reticulum localization signals. Proc Natl Acad Sci U S A 100, 5783-5788.
109. Standley S, Roche KW, McCallum J, Sans N & Wenthold RJ (2000). PDZ domain suppression of an ER retention signal in NMDA receptor NR1 splice variants. Neuron 28, 887-898.
110. Stockklausner C & Klocker N (2003). Surface expression of inward rectifier potassium channels is controlled by selective Golgi export. J Biol Chem 278, 17000-17005.
111. + channels. FEBS Letts 493, 129-133.
112. Sun HY, Liu XD, Xiong QJ, Shikano S & Li M (2006). Chronic inhibition of cardiac Kir2.1 and hERG potassium channels by celastrol with dual effects on both ion conductivity and protein trafficking. J Biol Chem 281, 5877-5884.
113. Takai K, Yoshida Y & Yamada H (2005). Regulatory mechanisms of dynamin-dependent endocytosis. J Biochem 137, 243-247.
114. + channel, Kv4.2, localizes predominantly to the transverse-axial tubular system of the rat myocyte. J Mol Cell Cardiol 32, 1361-1369.
115. + channel surface expression and clustering. J Cell Biol 148, 147-158.
116. Trimmer JS & Rhodes KJ (2004). Localization of voltage-gated ion channels in mammalian brain. Ann Rev Physiol 66, 477-519.
117. Wang Z, Eldstrom JR, Jantzi J, Moore ED & Fedida D (2004). Increased focal Kv4.2 channel expression at the plasma membrane is the result of actin depolymerization. Am J Physiol Heart Circ Physiol 286, H749-H759.
118. Watanabe I, Zhu J, Recio-Pinto E & Thornhill WB (2004). Glycosylation affects the protein stability and cell surface expression of Kv1.4 but not Kv1.1 potassium channels. A pore region determinant dictates the effect of glycosylation on trafficking. J Biol Chem 279, 8879-8885.
119. + channel regulatory protein, KChAP. J Biol Chem 273, 11745-11751.
120. Wu HJ, Nash JE, Zamorano P & Garner CC (2002). Interaction of SAP97 with minus-end-directed actin motor myosin VI - Implications for AMPA receptor trafficking. J Biol Chem 277, 30928-30934.
121. Yoshihisa T, Barlowe C & Schekman R (1993). Requirement for a GTPase-activating protein in vesicle budding from the endoplasmic-reticulum. Science 259, 1466-1468.
122. Yuan H, Michelsen K & Schwappach B (2003). 14-3-3 dimers probe the assembly status of multimeric membrane proteins. Curr Biol 13, 638-646.
123. Zerangue N, Malan MJ, Fried SR, Dazin PF, Jan YN, Jan LY & Schwappach B (2001). Analysis of endoplasmic reticulum trafficking signals by combinatorial screening in mammalian cells. Proc Natl Acad Sci U S A 98, 2431-2436.
124. Zerangue N, Schwappach B, Jan YN & Jan LY (1999). A new ER trafficking signal regulates the subunit stoichiometry of plasma membrane K ATP channels. Neuron 22, 537-548.
125. Zhou ZF, Gong QM & January CT (1999). Correction of defective protein trafficking of a mutant HERG potassium channel in human long QT syndrome - Pharmacological and temperature effects. J Biol Chem 274, 31123-31126.
126. Zhou JS, Shin HG, Yi JX, Shen WZ, Williams CP & Murray KT (2002). Phosphorylation and putative ER retention signals are required for protein kinase A-mediated potentiation of cardiac sodium current. Circ Res 91, 540-546.
127. Zhu J, Watanabe I, Gomez B & Thornhill WB (2003). Trafficking of Kv1.4 potassium channels: Interdependence of a pore region determinant and a cytoplasmic C-terminal VXXSL determinant in regulating cell-surface trafficking. Biochem J 375, 761-768.
128. Zinsmaier KE & Bronk P (2001). Molecular chaperones and the regulation of neurotransmitter exocytosis. Biochem Pharmacol 62, 1-11.