A-kinase anchoring proteins and neuronal signaling mechanisms

Genes and Development

Volumn 17, Issue 13, 2003, Pages 1557-1568

  Carnegie, Graeme K ^a   Scott, John D ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A KINASE ANCHORING PROTEIN 150; A KINASE ANCHORING PROTEIN 350; A KINASE ANCHORING PROTEIN 75; A KINASE ANCHORING PROTEIN 79; CG NAP PROTEIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE ANCHORING PROTEIN; PHOSPHOPROTEIN PHOSPHATASE; PROTEIN; PROTEIN KINASE; PROTEIN WAVE 1; UNCLASSIFIED DRUG; YOTIAO PROTEIN;

CELL COMPARTMENTALIZATION; CELLULAR DISTRIBUTION; COMPLEX FORMATION; ENZYME LOCALIZATION; HUMAN; MOLECULAR MODEL; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN VARIANT; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BINDING SITES; CARRIER PROTEINS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HUMANS; MODELS, BIOLOGICAL; MODELS, MOLECULAR; NEURONS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION;

EID: 0038001261     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1095803     Document Type: Review

References (148)

1. Adams, S.R., Harootunian, A.T., Buechler, Y.J., Taylor, S.S., and Tsien, R.Y. 1991. Fluorescence ratio imaging of cyclic AMP in single cells. Nature 349: 694-697.
2. Alto, N.M., Soderling, J., and Scott, J.D. 2002. Rab32 is an A-kinase anchoring protein and participates in mitochondrial dynamics. J. Cell Biol. 158: 659-668.
3. Alto, N.M., Soderling, S.H., Hoshi, N., Langeberg, L.K., Fayos, R., Jennings, P.A., and Scott, J.D. 2003. Bioinformatic design of A-kinase anchoring protein-in silico: A potent and selective peptide antagonist of type II protein kinase A anchoring. Proc. Natl. Acad. Sci. 100: 4445-4450.
4. CE) of type I protein kinase A from Caenorhabditis elegans. J. Biol. Chem. 273: 14633-14643.
5. Bacskai, B.J., Hochner, B., Mahaut-Smith, M., Adams, S.R., Kaang, B.-K., Kandel, E.R., and Tsien, R.Y. 1993. Spatially resolved dynamics of cAMP and protein kinase A subunits in aplysia sensory neurons. Science 260: 222-226.
6. Banky, P., Newlon, M.G., Roy, M., Garrod, S., Taylor, S.S., and Jennings, P.A. 2000. Isoform-specific differences between the type I-α and II-α cyclic AMP-dependent protein kinase anchoring domains revealed by solution NMR. J. Biol. Chem. 275: 35146-35152.
7. Barford, D., Hu, S.H., and Johnson, L.N. 1991. Structural mechanism for glycogen phosphorylase control by phosphorylation and AMP. J. Mol. Biol. 218: 233-260.
8. Barsony, J. and Marks, S.J. 1990. Immunocytology on microwave-fixed cells reveals rapid and agonist-specific changes in subcellular accumulation patterns for cAMP or cGMP. Proc. Natl. Acad. Sci. 87: 1188-1192.
9. Bauman, A.L. and Scott, J.D. 2002. Kinase- and phosphatase-anchoring proteins: Harnessing the dynamic duo. Nat. Cell Biol. 4: 203-206.
10. Bear, J.E., Rawls, J.F., and Saxe III, C.L. 1998. SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development. J. Cell Biol. 142: 1325-1335.
11. Beavo, J.A. and Brunton, L.L. 2002. Cyclic nucleotide research - Still expanding after half a century. Nat. Rev. Mol. Cell Biol. 3: 710-718.
12. Brandon, E.P., Gerhold, K.A., Qi, M., McKnight, G.S., and Idzerda, R.L. 1995. Derivation of novel embryonic stem cell lines and targeting of cyclic AMP-dependent protein kinase genes. Recent Prog. Horm. Res. 50: 403-408.
13. Brandon, E.P., Idzerda, R.L., and McKnight, G.S. 1997. PKA isoforms, neural pathways, and behaviour: Making the connection. Curr. Opin. Neurobiol. 7: 397-403.
14. Brandon, N.J., Jovanovic, J.N., Colledge, M., Kittler, J.T., Brandon, J.M., Scott, J.D., and Moss, S.J. 2003. A-kinase anchoring protein 79/150 facilitates the phosphorylation of GABA(A) receptors by cAMP-dependent protein kinase via selective interaction with receptor β subunits. Mol. Cell Neurosci. 22: 87-97.
15. Bregman, D.B., Bhattacharyya, N., and Rubin, C.S. 1989. High affinity binding protein for the regulatory subunit of cAMP-dependent protein kinase II-B. Cloning, characterization, and expression of cDNAs for rat brain P150. J. Biol. Chem. 264: 4648-4656.
16. Bregman, D.B., Hirsch, A.H., and Rubin, C.S. 1991. Molecular characterization of bovine brain P75, a high affinity binding protein for the regulatory subunit of cAMP-dependent protein kinase II β. J. Biol. Chem. 266: 720-7213.
17. Burack, W.R. and Shaw, A.S. 2000. Signal transduction: Hanging on a scaffold. Curr. Opin. Cell Biol. 12: 211-216.
18. Burns-Hamuro, L.L., Ma, Y., Kammerer, S., Reineke, U., Self, C., Cook, C., Olson, G.L., Cantor, C.R., Braun, A., and Taylor, S.S. 2003. Designing isoform-specific peptide disruptors of protein kinase A localization. Proc. Natl. Acad. Sci. 100: 4072-4077.
19. 2+ channel activity by cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. 94: 11067-11072.
20. Cantley, L.C., Auger, K.R., Carpenter, C., Duckworth, B., Graziani, A., Kapeller, R., and Soltoff, S. 1991. Oncogenes and signal transduction. Cell 64: 281-302.
21. Carr, D.W. and Scott, J.D. 1992. Blotting and band-shifting: Techniques for studying protein-protein interactions. Trends Biochem. Sci. 17: 246-249.
22. Carr, D.W., Stofko-Hahn, R.E., Fraser, I.D.C., Bishop, S.M., Acott, T.S., Brennan, R.G., and Scott, J.D. 1991. Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif. J. Biol. Chem. 266: 14188-14192.
23. Carr, D.W., Hausken, Z.E., Fraser, I.D., Stofko-Hahn, R.E., and Scott, J.D. 1992a. Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. J. Biol. Chem. 267: 13376-13382.
24. Carr, D.W., Stofko-Hahn, R.E., Fraser, I.D.C., Cone, R.D., and Scott, J.D. 1992b. Localization of the cAMP-dependent protein kinase to the postsynaptic densities by A-kinase anchoring proteins: Characterization of AKAP79. J. Biol. Chem. 24: 16816-16823.
25. Cho, K., Brown, M.W., and Bashir, Z.I. 2002. Mechanisms and physiological role of enhancement of mGlu5 receptor function by group II mGlu receptor activation in rat perirhinal cortex. J. Physiol. 540: 895-906.
26. Chrivia, J.C., Uhler, M.D., and McKnight, G.S. 1988. Characterization of genomic clones coding for the Ca and Cb subunits of mouse cAMP-dependent protein kinase. J. Biol. Chem. 263: 5739-5744.
27. Coghlan, V.M., Langeberg, L.K., Fernandez, A., Lamb, N.J.C., and Scott, J.D. 1994. Cloning and characterization of AKAP95, a nuclear protein that associates with the regulatory subunit of type II cAMP-dependent protein kinase. J. Biol. Chem. 269: 7658-7665.
28. Coghlan, V.M., Perrino, B.A., Howard, M., Langeberg, L.K., Hicks, J.B., Gallatin, W.M., and Scott, J.D. 1995. Association of protein kinase A and protein phosphatase 2B with a common anchoring protein. Science 267: 108-112.
29. Cohen, P. 1999. The development and therapeutic potential of protein kinase inhibitors. Curr. Opin. Chem. Biol. 3: 459-465.
30. -. 2000. The regulation of protein function by multisite phosphorylation - A 25 year update. Trends Biochem. Sci. 25:596-601.
31. Colledge, M. and Scott, J.D. 1999. AKAPs: From structure to function. Trends Cell Biol. 9: 216-221.
32. Colledge, M., Dean, R.A., Scott, G.K., Langeberg, L.K., Huganir, R.L., and Scott, J.D. 2000. Targeting of PKA to glutamate receptors through a MAGUK-AKAP complex. Neuron 27: 107-119.
33. Cong, M., Perry, S.J., Lin, F.T., Fraser, I.D., Hu, L.A., Chen, W., Pitcher, J.A., Scott, J.D., and Lefkowitz, R.J. 2001. Regulation of membrane targeting of the G protein-coupled receptor kinase 2 by Protein Kinase A and its anchoring protein AKAP79. J. Biol. Chem. 276: 15192-15199.
34. Corbin, J.D. and Keely, S.L. 1977. Characterization and regulation of heart adenosine 3′: 5′-monophosphate-dependent protein kinase isozymes. J. Biol. Chem. 252: 910-918.
35. Corbin, J.D., Soderling, T.R., and Park, C.R. 1973. Regulation of adenosine 3′,5′-monophosphate-dependent protein kinase. J. Biol. Chem. 248: 1813-1821.
36. Dart, C. and Leyland, M.L. 2001. Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, Kir2.1. J. Biol. Chem. 276: 20499-20505.
37. Davare, M.A., Dong, F., Rubin, C.S., and Hell, J.W. 1999. The A-kinase anchor protein MAP2B and cAMP-dependent protein kinase are associated with class C L-type calcium channels in neurons. J. Biol. Chem. 274: 30280-30287.
38. Dell'Acqua, M.L. and Scott, J.D. 1997. Protein kinase A anchoring. J. Biol. Chem. 272: 12881-12884.
39. Dell'Acqua, M.L., Faux, M.C., Thorburn, J., Thorburn, A., and Scott, J.D. 1998. Membrane-targeting sequences on AKAP79 bind phosphatidylinositol-4,5-bisphosphate. EMBO J. 17: 2246-2260.
40. Dell'Acqua, M.L., Dodge, K.L., Tavalin, S.J., and Scott, J.D. 2002. Mapping the protein phosphatase-2B anchoring site on AKAP79. Binding and inhibition of phosphatase activity are mediated by residues 315-360. J. Biol. Chem. 277: 48796-48802.
41. de Rooij, J., Rehmann, H., van Triest, M., Cool, R.H., Wittinghofer, A., and Bos, J.L. 2000. Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs. J. Biol. Chem. 275: 20829-20836.
42. Diviani, D., Langeberg, L.K., Doxsey, S.J., and Scott, J.D. 2000. Pericentrin anchors protein kinase A at the centrosome through a newly identified RII-binding domain. Curr. Biol. 10: 417-420.
43. Diviani, D., Soderling, J., and Scott, J.D. 2001. AKAP-Lbc anchors protein kinase A and nucleates Gα 12-selective Rho-mediated stress fiber formation. J. Biol. Chem. 276: 44247-44257.
44. Dodge, K. and Scott, J.D. 2000. AKAP79 and the evolution of the AKAP model. FEBS Lett. 476: 58-61.
45. Dodge, K.L., Khouangsathiene, S., Kapiloff, M.S., Mouton, R., Hill, E.V., Houslay, M.D., Langeberg, L.K., and Scott, J.D. 2001. mAKAP assembles a protein kinase A/PDE4 phosphodiesterase cAMP signaling module. EMBO J. 20: 1921-1930.
46. Dransfield, D.T., Bradford, A.J., Smith, J., Martin, M., Roy, C., Mangeat, P.H., and Goldenring, J.R. 1997a. Ezrin is a cyclic AMP-dependent protein kinase anchoring protein. EMBO J. 16: 101-109.
47. Dransfield, D.T., Yeh, J.L., Bradford, A.J., and Goldenring, J.R. 1997b. Identification and characterization of a novel A-kinase-anchoring-protein (AKAP120) from rabbit gastric parietal cells. Biochem. J. 322: 801-808.
48. Eden, S., Rohatgi, R., Podtelejnikov, A.V., Mann, M., and Kirschner, M.W. 2002. Mechanism of regulation of WAVE1-induced actin nucleation by Rac1 and Nck. Nature 418: 790-793.
49. Endris, V., Wogatzky, B., Leimer, U., Bartsch, D., Zatyka, M., Latif, F., Maher, E.R., Tariverdian, G., Kirsch, S., Karch, D., et al. 2002. The novel Rho-GTPase activating gene MEGAP/srGAP3 has a putative role in severe mental retardation. Proc. Natl. Acad. Sci. 99: 11754-11759.
50. 2+/calmodulin. J. Biol. Chem. 272: 17038-17044.
51. Faux, M.C., Rollins, E.N., Edwards, A.S., Langeberg, L.K., Newton, A.C., and Scott, J.D. 1999. Mechanism of A-kinase-anchoring protein 79 (AKAP79) and protein kinase C interaction. Biochem. J. 343: 443-452.
52. Feliciello, A., Gottesman, M.E., and Avvedimento, E.V. 2001. The biological functions of A-kinase anchor proteins. J. Mol. Biol. 308: 99-114.
53. Fischer, E.H. and Krebs, E.G. 1955. Conversion of phosphorylase b to phosphorylase a in muscle extracts. J. Biol. Chem. 216: 121-132.
54. Fraser, I.D., Tavalin, S.J., Lester, L.B., Langeberg, L.K., Westphal, A.M., Dean, R.A., Marrion, N.V., and Scott, J.D. 1998. A novel lipid-anchored A-kinase Anchoring Protein facilitates cAMP-responsive membrane events. EMBO J. 17: 2261-2272.
55. Fraser, I., Cong, M., Kim, J., Rollins, E., Daaka, Y., Lefkowitz, R., and Scott, J. 2000. Assembly of an AKAP/β2-adrenergic receptor signaling complex facilitates receptor phosphorylation and signaling. Curr. Biol. 10: 409-412.
56. 2+ channels requires membrane targeting of PKA and phosphorylation of channel subunits. Neuron 19: 185-196.
57. Gibbs, C.S., Knighton, D.R., Sowadski, J.M., Taylor, S.S., and Zoller, M.J. 1992. Systematic mutational analysis of cAMP-dependent protein kinase identifies unregulated catalytic subunits and defines regions important for the recognition of the regulatory subunit. J. Biol. Chem. 267: 4806-4814.
58. Gillingham, A.K. and Munro, S. 2000. The PACT domain, a conserved centrosomal targeting motif in the coiled-coil proteins AKAP450 and pericentrin. EMBO Rep. 1: 524-529.
59. Goodman, R.H. and Smolik, S. 2000. CBP/p300 in cell growth, transformation, and development. Genes & Dev. 14: 1553-1577.
60. Gray, P.C., Tibbs, V.C., Catterall, W.A., and Murphy, B.J. 1997. Identification of a 15-kDa cAMP-dependent protein kinase-anchoring protein associated with skeletal muscle L-type calcium channels. J. Biol. Chem. 272: 6297-6302.
61. Gray, P.C., Johnson, B.D., Westenbroek, R.E., Hays, L.G., Yates, J.R., Scheuer, T., Catterall, W.A., and Murphy, B.J. 1998. Primary structure and function of an A kinase anchoring protein associated with calcium channels. Neuron 20: 1017-1026.
62. Harada, A., Teng, J., Takei, Y., Oguchi, K., and Hirokawa, N. 2002. MAP2 is required for dendrite elongation, PKA anchoring in dendrites, and proper PKA signal transduction. J. Cell Biol, 158: 541-549.
63. Herberg, F.W., Maleszka, A., Eide, T., Vossebein, L., and Tasken, K. 2000. Analysis of A-Kinase Anchoring Protein (AKAP) interaction with Protein Kinase A (PKA) regulatory subunits: PKA isoform specificity in AKAP binding. J. Mol. Biol. 298: 329-339.
64. Hoshi, N., Zhang, J.-S., Omaki, M., Takeuchi, T., Yokoyama, S., Wanaverbecq, N., Langeberg, L., Yoneda, Y., Scott, J.D., Brown, D.A., et al. 2003. AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists. Nature Neurosci. 6: 564-571.
65. Houslay, M.D. 2001. PDE4 cAMP-specific phosphodiesterases. Prog. Nucleic. Acid Res. Mol. Biol. 69: 249-315.
66. Huang, L.J., Durick, K., Weiner, J.A., Chun, J., and Taylor, S.S. 1997a. D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain. Proc. Natl. Acad. Sci. 94: 11184-11189.
67. -. 1997b. Identification of a novel dual specificity protein kinase A anchoring protein, D-AKAP1. J. Biol. Chem. 272: 8057-8064.
68. Huang, L.J., Wang, L., Ma, Y., Durick, K., Perkins, G., Deerinck, T.J., Ellisman, M.H., and Taylor, S.S. 1999. NH2-Terminal targeting motifs direct dual specificity A-kinase-anchoring protein 1 (D-AKAP1) to either mitochondria or endoplasmic reticulum. J. Cell Biol. 145: 951-959.
69. 2+ channel and modulates its function. J. Biol. Chem. 277: 4079-4087.
70. Hunter, T. 1987. A thousand and one protein kinases. Cell 50: 823-829.
71. -. 1995. Protein kinases and phosphatases: The yin and yang of protein phosphorylation and signaling. Cell 80: 225-236.
72. -. 2000. Signaling - 2000 and beyond. Cell 100: 113-127.
73. Itoh, T.J., Hisanaga, S., Hosoi, T., Kishimoto, T., and Hotani, H. 1997. Phosphorylation states of microtubule-associated protein 2 (MAP2) determine the regulatory role of MAP2 in microtubule dynamics. Biochemistry 36: 12574-12582.
74. Johnson, L.N. and Barford, D. 1990. Glycogen phosphorylase. The structural basis of the allosteric response and comparison with other allosteric proteins. J. Biol. Chem. 265: 2409-2412.
75. Johnson, L.N. and O'Reilly, M. 1996. Control by phosphorylation. Curr. Opin. Struct. Biol. 6: 762-769.
76. Jordan, J.D., Landau, E.M., and Iyengar, R. 2000. Signaling networks: The origins of cellular multitasking. Cell 103: 193-200.
77. Kammerer, S., Bums-Hamuro, L.L., Ma, Y., Hamon, S.C., Canaves, J.M., Shi, M.M., Nelson, M.R., Sing, C.F., Cantor, C.R., Taylor, S.S., et al. 2003. Amino acid variant in the kinase binding domain of dual-specific A kinase-anchoring protein 2: A disease susceptibility polymorphism. Proc. Natl. Acad. Sci. 100: 4066-4071.
78. Kapiloff, M.S. 2002. Contributions of protein kinase A anchoring proteins to compartmentation of cAMP signaling in the heart. Mol. Pharmacol. 62: 193-199.
79. Kaupp, U.B. and Seifert, R. 2002. Cyclic nucleotide-gated ion channels. Physiol. Rev. 82: 769-824.
80. Keryer, G., Rios, R.M., Landmark, B.F., Skalhegg, B., Lohmann, S.M., and Bornens, M. 1993. A high-affinity binding protein for the regulatory subunit of cAMP-dependent protein kinase II in the centrosome of human cells. Exp. Cell Res. 204: 230-240.
81. Kind, P.C. and Neumann, P.E. 2001. Plasticity: Downstream of glutamate. Trends Neurosci. 24: 553-555.
82. Klauck, T.M., Faux, M.C., Labudda, K., Langeberg, L.K., Jaken, S., and Scott, J.D. 1996. Coordination of three signaling enzymes by AKAP79, a mammalian scaffold protein. Science 271: 1589-1592.
83. Krebs, E.G. 1985. The phosphorylation of proteins: A major mechanism for biological regulation. Biochem. Soc. Trans. 13: 813-820.
84. Kussel-Andermann, P., El-Amraoui, A., Safieddine, S., Hardelin, J.P., Nouaille, S., Camonis, J., and Petit, C. 2000. Unconventional myosin VIIA is a novel A-kinase-anchoring protein. J. Biol. Chem. 275: 29654-29659.
85. Lee, D.C., Carmichael, D.F., Krebs, E.G., and McKnight, G.S. 1983. Isolation of cDNA clone for the type I regulatory subunit of bovine cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. 80: 3608-3612.
86. Lee, H.K., Kameyama, K., Huganir, R.L., and Bear, M.F. 1998. NMDA induces long-term synaptic depression and dephosphorylation of the GluR1 subunit of AMPA receptors in hippocampus. Neuron 21: 1151-1162.
87. Lester, L.B., Langeberg, L.K., and Scott, J.D. 1997. Anchoring of protein kinase A facilitates hormone-mediated insulin secretion. Proc. Natl. Acad. Sci. 94: 14942-14947.
88. Li, H., Degenhardt, B., Tobin, D., Yao, Z.X., Tasken, K., and Papadopoulos, V. 2001. Identification, localization, and function in steroidogenesis of PAP7: A peripheral-type benzodiazepine receptor- and PKA (RIα)-associated protein. Mol. Endocrinol. 15: 2211-2228.
89. Lin, J.W., Wyszynski, M., Madhavan, R., Sealock, R., Kim, J.U., and Sheng, M. 1998. Yotiao, a novel protein of neuromuscular junction and brain that interacts with specific splice variants of NMDA receptor subunit NR1. J. Neurosci. 18: 2017-2027.
90. Livesey, S.A., Kemp, B.E., Re, C.A., Partridge, N.C., and Martin, T.J. 1982. Selective hormonal activation of cyclic AMP-dependent protein kinase isoenzymes in normal and malignant osteoblasts. J. Biol. Chem. 257: 14983-14987.
91. Lohmann, S.M., DeCamili, P., Enig, I., and Walter, U. 1984. High-affinity binding of the regulatory subunit (RII) of cAMP-dependent protein kinase to microtubule-associated and other cellular proteins. Proc. Natl. Acad. Sci. 81: 6723-6727.
92. Machesky, L.M. and Insall, R.H. 1998. Scar1 and the related Wiskott-Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2/3 complex. Curr. Biol. 8: 1347-1356.
93. -. 1999. Signaling to actin dynamics. J. Cell Biol. 146: 267-272.
94. Machesky, L.M., Mullins, R.D., Higgs, H.N., Kaiser, D.A., Blanchoin, L., May, R.C., Hall, M.E., and Pollard, T.D. 1999. Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2/3 complex. Proc. Natl. Acad. Sci. 96: 3739-3744.
95. Malenka, R.C. and Nicoll, R.A. 1999. Long-term potentiation - A decade of progress? Science 285: 1870-1874.
96. Malinow, R. and Malenka, R.C. 2002. AMPA receptor trafficking and synaptic plasticity. Annu. Rev. Neurosci. 25: 103-126.
97. Miki, K. and Eddy, E.M. 1999. Single amino acids determine specificity of binding of protein kinase A regulatory subunits by protein kinase A anchoring proteins J. Biol. Chem. 274: 29057-29062.
98. Miki, H., Suetsugu, S., and Takenawa, T. 1998. WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac. EMBO J. 17: 6932-6941.
99. Moita, M.A., Lamprecht, R., Nader, K., and LeDoux, J.E. 2002. A-kinase anchoring proteins in amygdala are involved in auditory fear memory. Nat. Neurosci. 5: 837-838.
100. Moss, S.B. and Gerton, G.L. 2001. A-kinase anchor proteins in endocrine systems and reproduction. Trends Endocrinol. Metab. 12: 434-440.
101. Nagle, D.L., Karim, M.A., Woolf, E.A., Holmgren, L., Bork, P., Misumi, D.J., McGrail, S.H., Dussault Jr., B.J., Perou, C.M., Boissy, R.E., et al. 1996. Identification and mutation analysis of the complete gene for Chediak-Higashi syndrome. Nat. Genet. 14: 307-311.
102. Newlon, M.G., Roy, M., Hausken, Z.E., Scott, J.D., and Jennings, P.A. 1997. The A-kinase anchoring domain of Type IIa cAMP-dependent protein kinase is highly helical. J. Biol. Chem. 272: 23637-23644.
103. Newlon, M.G., Roy, M., Morikis, D., Hausken, Z.E., Coghlan, V., Scott, J.D., and Jennings, P.A. 1999. The molecular basis for protein kinase A anchoring revealed by solution NMR. Nat. Struct. Biol. 6: 222-227.
104. Newlon, M.G., Roy, M., Morikis, D., Carr, D.W., Westphal, R., Scott, J.D., and Jennings, P.A. 2001. A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes. EMBO J. 20: 1651-1662.
105. Oliveria, S.F., Gomez, L.L., and Dell'Acqua, M.L. 2003. Imaging kinase-AKAP79-phosphatase scaffold complexes at the plasma membrane in living cells using FRET microscopy. J. Cell Biol. 160: 101-112.
106. Pawson, T. 1995. Protein modules and signalling networks. Nature 373: 573-580.
107. Pawson, T. and Gish, G.D. 1992. SH2 and SH3 domains: From structure to function. Cell 71: 359-362.
108. Pawson, T. and Nash, P. 2000. Protein-protein interactions define specificity in signal transduction. Genes & Dev. 14: 1027-1047.
109. Pawson, T. and Scott, J.D. 1997. Signaling through scaffold, anchoring, and adaptor proteins. Science 278: 2075-2080.
110. Potter, R.L. and Taylor, S.S. 1979. Correlation of the cAMP binding domain with a site of autophosphorylation on the regulatory subunit of cAMP-dependent protein kinase II from porcine skeletal muscle. J. Biol. Chem. 254: 9000-9005.
111. Potter, R.L., Stafford, P.H., and Taylor, S. 1978. Regulatory subunit of cyclic AMP-dependent protein kinase I from porcine skeletal muscle: Purification and proteolysis. Arch. Biochem. Biophys. 190: 174-180.
112. Rall, T.W. and Sutherland, E.W. 1958. Formation of cyclic adenine ribonucleotide by tissue particles. J. Biol. Chem. 232: 1065-1076.
113. Rall, T.W., Sutherland, E.W., and Berthet, J. 1957. The relationships of epinephrine and glucagon to liver phosphorylase. J. Biol. Chem. 224: 463-475.
114. Robinson, R.C., Turbedsky, K., Kaiser, D.A., Marchand, J.B., Higgs, H.N., Choe, S., and Pollard, T.D. 2001. Crystal structure of Arp2/3 complex. Science 294: 1679-1684.
115. Rohatgi, R., Ma, L., Miki, H., Lopez, M., Kirchhausen, T., Takenawa, T., and Kirschner, M.W. 1999. The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell 97: 221-231.
116. Rosenmund, C., Carr, D.W., Bergeson, S.E., Nilaver, G., Scott, J.D., and Westbrook, G.L. 1994. Anchoring of protein kinase A is required for modulation of AMPA/kainate receptors on hippocampal neurons. Nature 368: 853-856.
117. Rubin, C.S. 1994. A kinase anchor proteins and the intracellular targeting of signals carried by cAMP. Biochim. Biophys. Acta. 1224: 467-479.
118. Sarkar, D., Erlichman, J., and Rubin, C.S. 1984. Identification of a calmodulin-binding protein that copurifies with the regulatory subunit of brain protein kinase II. J. Biol. Chem. 259:9840-9846.
119. Schillace, R.V. and Scott, J.D. 1999. Association of the type 1 protein phosphatase PP1 with the A-kinase anchoring protein AKAP220. Curr. Biol. 9: 321-324.
120. Schmidt, P.H., Dransfield, D.T., Claudio, J.O., Hawley, R.G., Trotter, K.W., Milgram, S.L., and Goldenring, J.R. 1999. AKAP350: A multiply spliced A-kinase anchoring protein associated with centrosomes. J. Biol. Chem. 274: 3055-3066.
121. Scott, J.D. 1991. Cyclic nucleotide-dependent protein kinases. Pharmacol. Ther. 50: 123-145.
122. Scott, J.D., Zoller, M.J., Glaccum, M.B., Uhler, M.D., Helfman, D.M., McKnight, G.S., and Krebs, E.G. 1987. The molecular cloning of a type II regulatory subunit of the cAMP-dependent protein kinase from rat skeletal muscle and mouse brain. Proc. Natl. Acad. Sci. 84: 5192-5196.
123. Sheng, M. and Kim, M.J. 2002. Postsynaptic signaling and plasticity mechanisms. Science 298: 776-780.
124. Skalhegg, B.S. and Tasken, K. 2000. Specificity in the cAMP/PKA signaling pathway. Differential expression, regulation, and subcellular localization of subunits of PKA. Front. Biosci. 5: 678-693.
125. Smith, F.D. and Scott, J.D. 2002. Signaling complexes: Junctions on the intracellular information super highway. Curr. Biol. 12: 32-40.
126. Soderling, S.H., Binns, K.L., Wayman, G.A., Davee, S.M., Ong, S.H., Pawson, T., and Scott, J.D. 2002. The WRP component of the WAVE-1 complex attenuates Rac-mediated signalling. Nat. Cell Biol. 4: 970-975.
127. Soderling, S.H., Langeberg, L.K., Soderling, J.A., Davee, S.M., Simerly, R., Raber, J., and Scott, J.D. 2003. Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice. Proc. Natl. Acad. Sci. 100: 1723-1728.
128. Steen, R.L., Martins, S.B., Tasken, K., and Collas, P. 2000. Recruitment of protein phosphatase 1 to the nuclear envelope by A-kinase anchoring protein AKAP149 is a prerequisite for nuclear lamina assembly. J. Cell Biol. 150: 1251-1262.
129. Sudol, M. and Hunter, T. 2000. NeW wrinkles for an old domain. Cell 103: 1001-1004.
130. Suetsugu, S., Miki, H., and Takenawa, T. 1999. Identification of two human WAVE/SCAR homologs as general actin regulatory molecules which associate with the Arp2/3 complex. Biochem. Biophys. Res. Commun. 260: 296-302.
131. Sutherland, E.W. 1972. Studies on the mechanism of hormone action. Science 171: 401-408.
132. Takahashi, M., Shibata, H., Shimakawa, M., Miyamoto, M., Mukai, H., and Ono, Y. 1999. Characterization of a novel giant scaffolding protein, CG-NAP, that anchors multiple signaling enzymes to centrosome and the golgi apparatus. J. Biol. Chem. 274: 17267-17274.
133. Takahashi, M., Mukai, H., Oishi, K., Isagawa, T., and Ono, Y. 2000. Association of immature hypophosphorylated protein kinase C epsilon with an anchoring protein CG-NAP. J. Biol. Chem. 275: 34592-34596.
134. Takahashi, M., Yamagiwa, A., Nishimura, T., Mukai, H., and Ono, Y. 2002. Centrosomal proteins CG-NAP and kendrin provide microtubule nucleation sites by anchoring γ-tubulin ring complex. Mol. Biol. Cell 13: 3235-3245.
135. Tang, W.-J. and Gilman, A.G. 1992. Adenylyl cyclases. Cell 70: 869-872.
136. Tanji, C., Yamamoto, H., Yorioka, N., Kohno, N., Kikuchi, K., and Kikuchi, A. 2002. A-kinase anchoring protein AKAP220 binds to glycogen synthase kinase-3β (GSK-3β) and mediates protein kinase A-dependent inhibition of GSK-3β. J. Biol. Chem. 277: 36955-36961.
137. Tasken, K.A., Collas, P., Kemmner, W.A., Witczak, O., Conti, M., and Tasken, K. 2001. Phosphodiesterase 4D and protein kinase a type II constitute a signaling unit in the centrosomal area. J. Biol. Chem. 276: 21999-22002.
138. Tavalin, S.J., Colledge, M., Hell, J.W., Langeberg, L.K., Huganir, R.L., and Scott, J.D. 2002. Regulation of GluR1 by the Akinase anchoring protein 79 (AKAP79) signaling complex shares properties with long-term depression. J. Neurosci. 22: 3044-3051.
139. Theurkauf, W.E. and Vallee, R.B. 1982. Molecular characterization of the cAMP-dependent protein kinase bound to microtubule-associated protein 2. J. Biol. Chem. 257: 3284-3290.
140. Vijayaraghavan, S., Goueli, S.A., Davey, M.P., and Carr, D.W. 1997. Protein kinase A-anchoring inhibitor peptides arrest mammalian sperm motility. J. Biol. Chem. 272: 4747-4752.
141. Walsh, D.A., Perkins, J.P., and Krebs, E.G. 1968. An adenosine 3′,5′-monophosphate-dependent protein kinase from rabbit skeletal muscle. J. Biol. Chem. 243: 3763-3765.
142. Wang, X., Herberg, F.W., Laue, M.M., Wullner, C., Hu, B., Petrasch-Parwez, E., and Kilimann, M.W. 2000. Neurobeachin: A protein kinase A-anchoring, beige/Chediak-higashi protein homolog implicated in neuronal membrane traffic. J. Neurosci. 20: 8551-8565.
143. Wang, X., Zhong, P., and Yan, Z. 2002. Dopamine D4 receptors modulate GABAergic signaling in pyramidal neurons of prefrontal cortex. J. Neurosci. 22: 9185-9193.
144. Wang, Y., Scott, J.D., McKnight, G.S., and Krebs, E.G. 1991. A constitutively active holoenzyme from the cAMP-dependent protein kinase. Proc. Natl. Acad. Sci. 88: 2446-2450.
145. Westphal, R.S., Tavalin, S.J., Lin, J.W., Alto, N.M., Fraser, I.D., Langeberg, L.K., Sheng, M., and Scott, J.D. 1999. Regulation of NMDA receptors by an associated phosphatase-kinase signaling complex. Science 285: 93-96.
146. Westphal, R.S., Soderling, S.H., Alto, N.M., Langeberg, L.K., and Scott, J.D. 2000. Scar/WAVE-1, a Wiskott-Aldrich syndrome protein, assembles an actin-associated multikinase scaffold. EMBO J. 19: 4589-4600.
147. Witczak, O., Skalhegg, B.S., Keryer, G., Bornens, M., Tasken, K., Jahnsen, T., and Orstavik, S. 1999. Cloning and characterization of a cDNA encoding an A-kinase anchoring protein located in the centrosome, AKAP450. EMBO J. 18: 1858-1868.
148. Zaccolo, M. and Pozzan, T. 2002. Discrete microdomains with high concentration of cAMP in stimulated rat neonatal cardiac myocytes. Science 295: 1711-1715.