BM-derived cell therapies for cardiovascular disease

Cytotherapy

Volumn 9, Issue 4, 2007, Pages 305-315

  Cannon III, R O ^a   Dunbar, C E ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZACITIDINE; CD133 ANTIGEN; CD34 ANTIGEN; FIBRONECTIN; GRANULOCYTE COLONY STIMULATING FACTOR; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; VASCULOTROPIN RECEPTOR 2;

ACUTE CORONARY SYNDROME; ACUTE HEART INFARCTION; ALLOGENEIC HEMATOPOIETIC STEM CELL TRANSPLANTATION; ANGINA PECTORIS; ANGIOGENESIS; AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION; BUERGER DISEASE; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CELL DIFFERENTIATION; CELL SURVIVAL; CLINICAL TRIAL; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY DISEASE; CORONARY STENT; ENDOTHELIUM CELL; ENDOTHELIUM INJURY; EXERCISE; HEART ASSIST DEVICE; HEART CELL CULTURE; HEART FAILURE; HEART INFARCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART MUSCLE REVASCULARIZATION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMAN; IN-STENT RESTENOSIS; INTRACORONARY INFUSION; LIMB ISCHEMIA; MESENCHYMAL STEM CELL TRANSPLANTATION; MULTIPOTENT STEM CELL; NONHUMAN; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRIORITY JOURNAL; REGENERATION; REVIEW; SIDE EFFECT; ST SEGMENT ELEVATION; STEM CELL MOBILIZATION; TRANSLUMINAL CORONARY ANGIOPLASTY;

ANIMALS; BONE MARROW CELLS; CARDIOVASCULAR DISEASES; CLINICAL TRIALS; ENDOTHELIUM, VASCULAR; HUMANS; STEM CELLS; TISSUE THERAPY;

EID: 34347210351     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1080/14653240701431176     Document Type: Review

References (88)

1. Beltrami, AP, Barlucchi, L. and Torella, D. (2003) Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell, 114, pp. 763-766.
2. + cardioblasts enter fully differentiated cardiomyocyte lineages. Nature, 433, pp. 647-653.
3. Poss, KD, Wilson, LG and Keating, MT. (2002) Heart regeneration in zebrafish. Science, 298, pp. 2188-2190.
4. Krause, DS, Theise, ND and Collector, MI (2001) Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell, 105, pp. 369-377.
5. LaGasse, E., Connors, H. and Al-Dhalimy, M. (2000) Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat Med, 6, pp. 1229-1234.
6. Tisdale, JF and Dunbar, CE. (2002) Plasticity and hematopoiesis: Circe's transforming potion?. Curr Opin Hematol, 9, pp. 268-273.
7. Asahara, T., Murohara, T. and Sullivan, A. (1997) Isolation of putative progenitor endothelial cells for angiogenesis. Science, 275, pp. 964-967.
8. Asahara, T., Masuda, H. and Takahashi, T. (1999) Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res, 85, pp. 221-228.
9. Shi, Q., Rafii, S. and Wu, MH (1998) Evidence for circulating bone marrow-derived endothelial cells. Blood, 92, pp. 362-367.
10. Lin, Y., Weisdorf, DJ, Solovey, A. and Hebbel, RP. (2000) Origins of circulating endothelial cells and endothelial outgrowth from blood. J Clin Invest, 105, pp. 71-77.
11. Takahashi, T., Kalka, C. and Masuda, H. (1999) Ischemia- and cytokine-induced mobilization of bone marrow-derived endothelial progenitor cells for neovascularization. Nat Med, 5, pp. 434-438.
12. Gill, M., Dias, S. and Hattori, K. (2001) Vascular trauma induces rapid but transient mobilization of VEGFR(+)ACC133(+) endothelial precursor cells. Circ Res, 88, pp. 167-174.
13. + cells identifies a population of functional endothelial precursors. Blood, 95, pp. 952-958.
14. Gehling, UM, Ergun, S. and Schumacher, U. (2000) In vitro differentiation of endothelial cells from AC133-positive cells. Blood, 95, pp. 3106-3112.
15. Takatoku, M. and Sellers, SE (2003) Analysis of origin and optimization of expansion and transduction of circulating peripheral blood endothelial progenitor cells in the rhesus macaque model. Hum Gene Ther, 13, pp. 2041-2050.
16. Rehman, J., Orschell, CM and March, KL. (2003) Peripheral blood 'endothelial progenitor cells' are derived from monocyte/macrophages and secrete angiogenic growth factors. Circulation, 107, pp. 1164-1169.
17. Urbich, C., Heeschen, C. and Aicher, A. (2003) Relevance of monocytic features for neovascularization capacity of circulating endothelial progenitor cells. Circulation, 108, pp. 2511-2516.
18. Yoder, MC, Mead, LE and Prater, D. (2006) Re-defining endothelial progenitor cells via clonal analysis and hematopoietic stem/progenitor cell principals. Blood, 109, pp. 1801-1809.
19. Rafii, S. and Lyden, D. (2003) Therapeutic stem and progenitor cell transplantation for organ vascularization and regeneration. Nat Med, 9, pp. 702-712.
20. Ribatti, D. (2007) The discovery of endothelial progenitor cells. An historical review. Leuk Res, 31, pp. 439-444.
21. Hill, JM, Zalos, G. and Halcox, JP (2003) Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med, 348, pp. 593-600.
22. Vasa, M., Fichtlscherer, S. and Aicher, A. (2001) Number and migratory activity of circulating endothelial cells inversely correlate with risk factors for coronary artery disease. Circ Res, 89, pp. 1-7.
23. Dimmeler, S., Aicher, A. and Vasa, M. (2001) HMG-CoA reductase inhibitors (statins) increase endothelial progenitor cells via the PI3-kinase/Akt pathway. J Clin Invest, 108, pp. 391-397.
24. Llevadot, J., Murasawa, S. and Kureishi, Y. (2001) HMG-CoA reductase inhibitor mobilizes bone marrow-derived endothelial progenitor cells. J Clin Invest, 108, pp. 399-405.
25. Vasa, M., Fichtlscherer, S. and Adler, K. (2001) Increase in circulating endothelial progenitor cells by statin therapy in patients with stable coronary artery disease. Circulation, 103, pp. 2885-2890.
26. Laufs, U., Werner, N. and Link, A. (2004) Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation, 109, pp. 220-226.
27. Aicher, A., Heeschen, C. and Mildner-Rihm, C. (2003) Essential role of endothelial nitric oxide synthase for mobilization of stem and progenitor cells. Nat Med, 9, pp. 1370-1376.
28. Kaul, M. and Yan, B. (2002) S-nitrosylation of matrix metalloproteinases: Signaling pathway to neuronal cell death. Science, 297, pp. 1186-1190.
29. Heissig, B., Hattori, K. and Dias, S. (2002) Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell, 109, pp. 625-637.
30. Melino, G., Bernassola, F. and Knight, RA (1997) S-nitrosylation regulates apoptosis. Nature, 388, pp. 432-433.
31. Orlic, D., Kajstura, J. and Chimenti, S. (2001) Bone marrow cells regenerate infarcted myocardium. Nature, 410, pp. 701-705.
32. Jackson, KA, Majka, SM and Wang, H. (2001) Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J Clin Invest, 107, pp. 1355-1356.
33. Kocher, AA, Schuster, MD and Szabolcs, MJ (2001) Neovascularization of ischemic myocardium by human bone marrow-derived angioblasts prevents cardiomyocyte apoptosis, reduces remodeling and improves cardiac function. Nat Med, 7, pp. 430-436.
34. Orlic, D., Kajstura, J. and Chimenti, S. (2001) Mobilized bone marrow cells repair the infarcted heart improving function and survival. Proc Natl Acad Sci USA, 98, pp. 10344-10349.
35. Norol, F., Merlet, P. and Isnard, R. (2003) Influence of mobilized stem cells on myocardial infarct repair in a nonhuman primate model. Blood, 102, pp. 4361-4368.
36. Dimmeler, S., Zeiher, AM and Schneider, MD. (2005) Unchain my heart: The scientific foundation of cardiac repair. J Clin Invest, 115, pp. 572-583.
37. Balsam, LB, Wagers, AJ and Christensen, JL (2004) Haematopoietic stem cells adopt mature haematopoietic fates in ischemic myocardium. Nature, 428, pp. 668-673.
38. Murry, CE, Soonpaa, MH and Reinecke, H. (2004) Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature, 428, pp. 664-668.
39. Nygren, JM, Jovinge, S. and Breitbach, M. (2004) Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation. Nat Med, 10, pp. 494-501.
40. Camargo, FD, Green, R. and Capetanaki, Y. (2003) Single hematopoietic stem cells generate skeletal muscle through myeloid intermediates. Nat Med, 9, pp. 1520-1527.
41. Dexter, TM, Allen, TD and Lajtha, LG. (1977) Conditions controlling the proliferation of hematopoietic stem cells in vitro. J Cell Physiol, 91, pp. 335-344.
42. Sutherland, HJ, Lansdorp, PM and Henkelman, DH (1990) Functional characterization of individual human hematopoietic stem cells cultured at limiting dilution on supportive marrow stromal layers. Proc Natl Acad Sci USA, 87, pp. 3584-3588.
43. Pittenger, MF, Mackay, AM and Beck, SC (1999) Multilineage potential of adult human mesenchymal stem cells. Science, 284, pp. 143-147.
44. Makino, S., Fukuda, K. and Miyoshi, S. (1999) Cardiomyocytes can be generated from marrow stromal cells in vitro. J Clin Invest, 103, pp. 697-705.
45. Hakuno, D., Fukuda, K. and Makino, S. (2002) Bone marrow-derived regenerated cardiomyocytes (CMG cells) express functional adrenergic and muscarinic receptors. Circulation, 105, pp. 380-386.
46. Le, BLanc K. and Pittenger, M. (2005) Mesenchymal stem cells: Progress towards promise. Cytotherapy, 7, pp. 36-45.
47. Jiang, Y., Jahagirdar, BN and Reinhardt, RL (2002) Pluripotency of mesenchymal stem cells derived from adult marrow. Nature, 418, pp. 41-49.
48. Pelacho, B., Aranguren, XL and Mazo, M. (2007) Plasticity and cardiovascular applications of multipotent adult progenitor cells. Nat Clin Pract Cardiovasc Med, 4, p. S15.
49. Pittenger, MF and Martin, BJ. (2004) Mesenchymal stem cells and their potential as cardiac therapeutics. Circ Res, 95, pp. 9-20.
50. Nagaya, N., Kangawa, K. and Itoh, T. (2005) Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation, 112, pp. 1128-1135.
51. Hattan, N., Kawaguchi, H. and Ando, K. (2005) Purified cardiomyocytes from bone marrow mesenchymal stem cells produce stable intracardiac grafts in mice. Cardiovasc Res, 65, pp. 334-344.
52. Silva, GV, Litovsky, S. and Assad, JA (2005) Mesenchymal stem cells differentiate into an endothelial phenotype, enhance vascular density, and improve heart function in a canine chronic ischemia model. Circulation, 111, pp. 150-156.
53. Dick, AJ, Guttman, MA and Raman, VK (2003) Magnetic resonance fluoroscopy allows targeted delivery of mesenchymal stem cells to infarct borders in swine. Circulation, 108, pp. 2899-2904.
54. Kawada, H., Fujita, J. and Kinjo, K. (2004) Nonhematopoietic mesenchymal stem cells can be mobilized and differentiate after myocardial infarction. Blood, 104, pp. 3581-3587.
55. Wexler, SA, Donaldson, C. and Denning-Kendall, P. (2003) Adult bone marrow is a rich source of human mesenchymal 'stem' cells but umbilical cord and mobilized adult blood are not. Br J Haematol, 121, pp. 368-374.
56. Lee, OK, Kuo, TK and Chen, WM (2003) Isolation of multipotent mesenchymal stem cells from umbilical cord blood. Blood, 103, pp. 1669-1675.
57. Kawamoto, A., Iwasaki, H. and Kusano, K. (2006) CD34-positive cells exhibit increased potency and safety for therapeutic neovascularization alter myocardial infarction compared with total mononuclear cells. Circulation, 114, pp. 2163-2169.
58. Chein, KR. (2004) Lost in translation. Nature, 428, pp. 607-608.
59. Strauer, BE, Brehm, M. and Zeus, T. (2002) Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation, 106, pp. 1913-1918.
60. Assmus, B., Schachinger, V. and Teupe, C. (2002) Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI). Circulation, 106, pp. 3009-3017.
61. Stamm, C., Westphal, B. and Kleine, HD (2003) Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet, 361, pp. 45-46.
62. Wollert, KC, Meyer, GP and Lotz, J. (2004) Intracoronary autologous bone-marrow cell transfer after myocardial infarction: The BOOST randomized controlled clinical trial. Lancet, 364, pp. 141-148.
63. Meyer, GP, Wollert, KC and Lotz, J. (2006) Intracoronary bone marrow cell transfer after myocardial infarction. Eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration trial). Circulation, 113, pp. 1287-1295.
64. Janssens, S., Dubois, C. and Bogaert, J. (2006) Autologous bone marrow-derived stem-cell transfer in patients with ST-elevation myocardial infarction: Double-blind, randomized controlled trial. Lancet, 367, pp. 113-121.
65. Schachinger, V., Erbs, S. and Elsasser, A. (2006) Intracoronary bone marrow-derived progenitor cells in acute myocardial infarction. N Engl J Med, 355, pp. 1210-1221.
66. Lunde, K., Solheim, S. and Aakhus, S. (2006) Intracoronary injection of mononuclear bone marrow cells in acute myocardial infarction. N Engl J Med, 355, pp. 1199-1209.
67. Assmus, B., Honold, J. and Scachinger, V. (2006) Transcoronary transplantation of progenitor cells after myocardial infarction. N Engl J Med, 355, pp. 1222-1232.
68. Hofmann, M., Wollert, KC and Meyer, GP (2005) Monitoring of bone marrow cell homing into the infarcted human myocardium. Circulation, 111, pp. 2198-2202.
69. Perin, EC, Dohmann, HFR and Borojevic, R. (2003) Transendocardial, autologous bone marrow cell transplantation for severe, chronic ischemic heart failure. Circulation, 108361, pp. 2294-2302.
70. Fuchs, S., Satler, LF and Kornowski, R. (2003) Catheter-based autologous bone marrow myocardial injection in no-option patients with advanced coronary artery disease: A feasibility study. J Am Coll Cardiol, 41, pp. 1721-1724.
71. Seiler, C., Pohl, T. and Wustmann, K. (2001) Promotion of collateral growth by granulocyte-macrophage colony-stimulating factor in patients with coronary artery disease: A randomized, double-blind, placebo-controlled study. Circulation, 104, pp. 2012-2017.
72. Hill, JM, Syed, MA and Arai, AA (2005) Outcomes and risks of granulocyte colony-stimulating factor administration to patients with severe coronary artery disease. J Am Coll Cardiol, 46, pp. 1643-1648.
73. Zbinden, S., Zbinden, R. and Meier, P. (2005) Safety and efficacy of subcutaneous-only granulocyte-macrophage colony-stimulating factor for collateral growth promotion in patients with coronary artery disease. J Am Coll Cardiol, 46, pp. 1636-1642.
74. Kang, H-J, Kim, H-S and Zhang, S-Y (2004) Effects of intracoronary infusion of peripheral blood stem-cells mobilized with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction: The MAGIC cell randomized clinical trial. Lancet, 363, pp. 751-756.
75. Ince, H., Petzsch, M. and Kleine, HD (2005) Preservation from left ventricular remodeling by front-integrated revascularization and stem cell liberation in evolving acute myocardial infarction by use of granulocyte-colony-stimulating factor (FIRSTLINE-AMI). Circulation, 112, pp. 3097-3106.
76. Valgimgli, M., Rigolin, GM and Cittanti, C. (2005) Use of granulocyte-colony stimulating factor during acute myocardial infarction to enhance bone marrow stem cell mobilization in humans: Clinical and angiographic safety profile. Eur Heart J, 26, pp. 1838-1845.
77. Zohlnhofer, D., Ott, I. and Mehilli, J. (2006) Stem cell mobilization by granulocyte colony-stimulating factor in patients with acute myocardial infarction: A randomized controlled trial. JAMA, 295, pp. 1003-1010.
78. Tateishi-Yuyama, E., Matsubara, H. and Murohara, T. (2002) Therapeutic angiogenesis for patients with limb ischaemia by autologous transplantation of bone-marrow cells: A pilot study and a randomized controlled trial. Lancet, 360, pp. 427-435.
79. Miyamoto, K., Nishigami, K. and Nagaya, N. (2006) Unblinded pilot study of autologous transplantation of bone marrow mononuclear cells in patients with thromboangitis obliterans. Circulation, 114, pp. 2679-2684.
80. Wall, ST, Walker, JC and Healy, KE (2006) Theoretical impact of the injection of material into the myocardium: A finite element model simulation. Circulation, 114, pp. 2627-2635.
81. Csaky, KG, Baffi, JZ and Byrnes, GA (2004) Recruitment of marrow-derived endothelial cells to experimental choroidal neovascularization by local expression of vascular endothelial growth factor. Exp Eye Res, 78, pp. 1107-1116.
82. Lee, IG, Chae, SL and Kim, JC. (2006) Involvement of circulating endothelial progenitor cells and vasculogenic factors in the pathogenesis of diabetic retinopathy. Eye, 20, pp. 546-552.
83. Sheriden, CM, Rice, D. and Hiscott, PS (2006) The presence of AC133-positive cells suggests a possible role of endothelial progenitor cells in the formation of choroidal neovascularization. Invest Ophthalmol Vis Sci, 47, pp. 1642-1645.
84. Sato, M., Saiura, A. and Kunisato, A. (2002) Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis. Nat Med, 8, pp. 403-409.
85. Silvestre, J-S, Gojova, A. and Brun, V. (2003) Transplantation of bone marrow-derived mononuclear cells in ischemia apolipoprotein e-knockout mice accelerates atherosclerosis without altering plaque composition. Circulation, 108, pp. 2839-2842.
86. George, J., Afek, A. and Abashidze, A. (2005) Transfer of endothelial progenitor and bone marrow cells influences atherosclerotic plaque size and composition in apolipoprotein E knockout mice. Arterioscler Thromb Vasc Biol, 25, pp. 2636-2641.
87. Kopp, HG, Ramos, CA and Rafii, S. (2006) Contribution of endothelial progenitors and proangiogenic hematopoietic cells to vascularization of tumor and ischemic tissue. Curr Opin Hematol, 13, pp. 175-181.
88. + cells in the endothelium of tumor vessels in the mouse brain. Neurosurgery, 59, pp. 374-382.