메뉴 건너뛰기




Volumn 10, Issue 5, 2004, Pages 494-501

Bone marrow-derived hematopoietic cells generate cardiomyocytes at a low frequency through cell fusion, but not transdifferentiation

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; BONE MARROW CELL; BONE MARROW TRANSPLANTATION; CELL DIFFERENTIATION; CELL FUSION; CHIMERA; HEART MUSCLE CELL; HEMATOPOIETIC CELL; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL;

EID: 2442675144     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm1040     Document Type: Article
Times cited : (934)

References (47)
  • 2
    • 0033598374 scopus 로고    scopus 로고
    • Dystrophin expression in the mdx mouse restored by stem cell transplantation
    • Gussoni, E. et al. Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature 401, 390-394 (1999).
    • (1999) Nature , vol.401 , pp. 390-394
    • Gussoni, E.1
  • 3
    • 0033553591 scopus 로고    scopus 로고
    • Bone marrow as a potential source of hepatic oval cells
    • Petersen, B.E. et al. Bone marrow as a potential source of hepatic oval cells. Science 284, 1168-1170 (1999).
    • (1999) Science , vol.284 , pp. 1168-1170
    • Petersen, B.E.1
  • 4
    • 0034532106 scopus 로고    scopus 로고
    • Turning blood into brain: Cells bearing neuronal antigens generated in vivo from bone marrow
    • Mezey, E., Chandross, K.J., Harta, G., Maki, R.A. & McKercher, S.R. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 290, 1779-1782 (2000).
    • (2000) Science , vol.290 , pp. 1779-1782
    • Mezey, E.1    Chandross, K.J.2    Harta, G.3    Maki, R.A.4    McKercher, S.R.5
  • 5
    • 0034531907 scopus 로고    scopus 로고
    • From marrow to brain: Expression of neuronal phenotypes in adult mice
    • Brazelton, T.R., Rossi, F.M., Keshet, G.I. & Blau, H.M. From marrow to brain: expression of neuronal phenotypes in adult mice. Science 290, 1775-1779 (2000).
    • (2000) Science , vol.290 , pp. 1775-1779
    • Brazelton, T.R.1    Rossi, F.M.2    Keshet, G.I.3    Blau, H.M.4
  • 6
    • 0033694301 scopus 로고    scopus 로고
    • Purified hematopoietic stem cells can differentiate into hepatocytes in vivo
    • Lagasse, E, et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nat. Med. 6, 1229-1234 (2000).
    • (2000) Nat. Med. , vol.6 , pp. 1229-1234
    • Lagasse, E.1
  • 7
    • 0035810240 scopus 로고    scopus 로고
    • Bone marrow cells regenerate infarcted myocardium
    • Orlic, D. et al. Bone marrow cells regenerate infarcted myocardium. Nature 410, 701-705 (2001).
    • (2001) Nature , vol.410 , pp. 701-705
    • Orlic, D.1
  • 8
    • 0034988491 scopus 로고    scopus 로고
    • Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells
    • Jackson, K.A. et al. Regeneration of ischemic cardiac muscle and vascular endothelium by adult stem cells. J. Clin. Invest. 107, 1395-1402 (2001).
    • (2001) J. Clin. Invest. , vol.107 , pp. 1395-1402
    • Jackson, K.A.1
  • 9
    • 0035496938 scopus 로고    scopus 로고
    • Bone marrow origin of hematopoietic progenitors and stem cells in murine muscle
    • Kawada, H. & Ogawa, M. Bone marrow origin of hematopoietic progenitors and stem cells in murine muscle. Blood 98, 2008-2013 (2001).
    • (2001) Blood , vol.98 , pp. 2008-2013
    • Kawada, H.1    Ogawa, M.2
  • 10
    • 0037183884 scopus 로고    scopus 로고
    • Little evidence for developmental plasticity of adult hematopoietic stem cells
    • Wagers, A.J., Sherwood, R.I., Christensen, J.L. & Weissman, I.L. Little evidence for developmental plasticity of adult hematopoietic stem cells. Science 297, 2256-2259 (2002).
    • (2002) Science , vol.297 , pp. 2256-2259
    • Wagers, A.J.1    Sherwood, R.I.2    Christensen, J.L.3    Weissman, I.L.4
  • 11
    • 0037162802 scopus 로고    scopus 로고
    • Failure of bone marrow cells to transdifferentiate into neural cells in vivo
    • Castro, R.F. et al. Failure of bone marrow cells to transdifferentiate into neural cells in vivo. Science 297, 1299 (2002).
    • (2002) Science , vol.297 , pp. 1299
    • Castro, R.F.1
  • 12
    • 0037022328 scopus 로고    scopus 로고
    • Muscle-derived hematopoietic stem cells are hematopoietic in origin
    • McKinney-Freeman, S.L. et al. Muscle-derived hematopoietic stem cells are hematopoietic in origin. Proc. Natl. Acad. Sci. USA 99, 1341-1346 (2002).
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 1341-1346
    • McKinney-Freeman, S.L.1
  • 13
    • 0037100322 scopus 로고    scopus 로고
    • Analysis of the hematopoietic potential of muscle-derived cells in mice
    • Geiger, H. etal. Analysis of the hematopoietic potential of muscle-derived cells in mice. Blood 100, 721-723 (2002).
    • (2002) Blood , vol.100 , pp. 721-723
    • Geiger, H.1
  • 14
    • 0037041428 scopus 로고    scopus 로고
    • Changing potency by spontaneous fusion
    • Ying, Q.L., Nichols, J., Evans, E.P. & Smith, A.G. Changing potency by spontaneous fusion. Nature 416, 545-548 (2002).
    • (2002) Nature , vol.416 , pp. 545-548
    • Ying, Q.L.1    Nichols, J.2    Evans, E.P.3    Smith, A.G.4
  • 15
    • 0037041427 scopus 로고    scopus 로고
    • Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion
    • Terada, N. et al. Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 416, 542-545 (2002).
    • (2002) Nature , vol.416 , pp. 542-545
    • Terada, N.1
  • 16
    • 0037464574 scopus 로고    scopus 로고
    • Cell fusion is the principal source of bone-marrow-derived hepatocytes
    • Wang. X. et al. Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 422, 897-901 (2003).
    • (2003) Nature , vol.422 , pp. 897-901
    • Wang, X.1
  • 17
    • 0037464545 scopus 로고    scopus 로고
    • Transplanted bone marrow regenerates liver by cell fusion
    • Vassilopoulos, G., Wang, P.R. & Russell, D.W. Transplanted bone marrow regenerates liver by cell fusion. Nature 422, 901-904 (2003).
    • (2003) Nature , vol.422 , pp. 901-904
    • Vassilopoulos, G.1    Wang, P.R.2    Russell, D.W.3
  • 18
    • 0242584006 scopus 로고    scopus 로고
    • Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes
    • Alvarez-Dolado, M. et al. Fusion of bone-marrow-derived cells with Purkinje neurons, cardiomyocytes and hepatocytes. Nature 425, 968-973 (2003).
    • (2003) Nature , vol.425 , pp. 968-973
    • Alvarez-Dolado, M.1
  • 19
    • 0035956418 scopus 로고    scopus 로고
    • Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo
    • Priller, J. et al. Neogenesis of cerebellar Purkinje neurons from gene-marked bone marrow cells in vivo. J. Cell Biol. 155, 733-738 (2001).
    • (2001) J. Cell Biol. , vol.155 , pp. 733-738
    • Priller, J.1
  • 20
    • 0035805055 scopus 로고    scopus 로고
    • Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell
    • Krause, D.S. et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105, 369-377 (2001).
    • (2001) Cell , vol.105 , pp. 369-377
    • Krause, D.S.1
  • 21
    • 0036968715 scopus 로고    scopus 로고
    • Kinetics of liver repopulation after bone marrow transplantation
    • Wang, X. et al. Kinetics of liver repopulation after bone marrow transplantation. Am. J. Pathol. 161, 565-574 (2002).
    • (2002) Am. J. Pathol. , vol.161 , pp. 565-574
    • Wang, X.1
  • 22
    • 0037012139 scopus 로고    scopus 로고
    • Chimerism of the transplanted heart
    • Quaini, F. et al. Chimerism of the transplanted heart. N. Engl. J. Med. 346, 5-15 (2002).
    • (2002) N. Engl. J. Med. , vol.346 , pp. 5-15
    • Quaini, F.1
  • 23
    • 0037023632 scopus 로고    scopus 로고
    • Evidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human hearts
    • Laflamme, M.A., Myerson, D., Saffitz, J.E. & Murry, C.E. Evidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human hearts. Circ. Res. 90: 634-640 (2002).
    • (2002) Circ. Res. , vol.90 , pp. 634-640
    • Laflamme, M.A.1    Myerson, D.2    Saffitz, J.E.3    Murry, C.E.4
  • 24
    • 0037112338 scopus 로고    scopus 로고
    • Biological progression from adult bone marrow to mononucleate muscle stem cell to multinucleate muscle fiber in response to injury
    • LaBarge, M.A. & Blau, H.M. Biological progression from adult bone marrow to mononucleate muscle stem cell to multinucleate muscle fiber in response to injury. Cell 111, 589-601 (2002).
    • (2002) Cell , vol.111 , pp. 589-601
    • LaBarge, M.A.1    Blau, H.M.2
  • 25
    • 0037364517 scopus 로고    scopus 로고
    • In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion
    • Ianus, A., Holz, G.G., Theise, N.D. & Hussain, M.A. In vivo derivation of glucose-competent pancreatic endocrine cells from bone marrow without evidence of cell fusion. J. Clin. Invest. 111, 843-850 (2003).
    • (2003) J. Clin. Invest. , vol.111 , pp. 843-850
    • Ianus, A.1    Holz, G.G.2    Theise, N.D.3    Hussain, M.A.4
  • 26
    • 17944371854 scopus 로고    scopus 로고
    • Mobilized bone marrow cells repair the infarcted heart, improving function and survival
    • Orlic, D. et al. Mobilized bone marrow cells repair the infarcted heart, improving function and survival. Proc. Natl. Acad. Sci. USA 98, 10344-10349 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 10344-10349
    • Orlic, D.1
  • 27
    • 0037044406 scopus 로고    scopus 로고
    • Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans
    • Strauer, B.E. et al. Repair of infarcted myocardium by autologous intracoronary mononuclear bone marrow cell transplantation in humans. Circulation 106, 1913-1918 (2002).
    • (2002) Circulation , vol.106 , pp. 1913-1918
    • Strauer, B.E.1
  • 28
    • 0037058848 scopus 로고    scopus 로고
    • Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI)
    • Assmus, B. et al. Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI). Circulation 106, 3009-3017 (2002).
    • (2002) Circulation , vol.106 , pp. 3009-3017
    • Assmus, B.1
  • 29
    • 0037417501 scopus 로고    scopus 로고
    • Autologous bone-marrow stem-cell transplantation for myocardial regeneration
    • Stamm, C. et al. Autologous bone-marrow stem-cell transplantation for myocardial regeneration. Lancet 361, 45-46 (2003).
    • (2003) Lancet , vol.361 , pp. 45-46
    • Stamm, C.1
  • 30
    • 0035976526 scopus 로고    scopus 로고
    • Physiological migration of hematopoietic stem and progenitor cells
    • Wright, D.E., Wagers, A.J., Gulati, A.P., Johnson, F.L. & Weissman, I.L. Physiological migration of hematopoietic stem and progenitor cells. Science 294, 1933-1936 (2001).
    • (2001) Science , vol.294 , pp. 1933-1936
    • Wright, D.E.1    Wagers, A.J.2    Gulati, A.P.3    Johnson, F.L.4    Weissman, I.L.5
  • 31
    • 0034283746 scopus 로고    scopus 로고
    • Interleukin-3 supports expansion of long-term multi-lineage repopulating activity after multiple stem cell divisions in vitro
    • Bryder, D. & Jacobsen, S.E. Interleukin-3 supports expansion of long-term multi-lineage repopulating activity after multiple stem cell divisions in vitro. Blood 96, 1748-1755 (2000).
    • (2000) Blood , vol.96 , pp. 1748-1755
    • Bryder, D.1    Jacobsen, S.E.2
  • 34
    • 0033835829 scopus 로고    scopus 로고
    • The role of cytokines and adhesion molecules for mobilization of peripheral blood stem cells
    • Kronenwett, R., Martin, S. & Haas, R. The role of cytokines and adhesion molecules for mobilization of peripheral blood stem cells. Stem Cells 18, 320-330 (2000).
    • (2000) Stem Cells , vol.18 , pp. 320-330
    • Kronenwett, R.1    Martin, S.2    Haas, R.3
  • 35
    • 0035382483 scopus 로고    scopus 로고
    • Allogenic peripheral blood stem cell transplantation
    • Bensinger, W.I. & Storb, R. Allogenic peripheral blood stem cell transplantation. Rev. Clin. Exp. Hematol. 5, 67-86 (2001).
    • (2001) Rev. Clin. Exp. Hematol. , vol.5 , pp. 67-86
    • Bensinger, W.I.1    Storb, R.2
  • 36
    • 0030990991 scopus 로고    scopus 로고
    • Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of β-galactosidase in mouse embryos and hematopoietic cells
    • Zambrowicz, B.P. et al. Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of β-galactosidase in mouse embryos and hematopoietic cells. Proc. Natl. Acad. Sci. USA 94, 3789-3794 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 3789-3794
    • Zambrowicz, B.P.1
  • 37
    • 0032407328 scopus 로고    scopus 로고
    • Cardiac specific expression of the green fluorescent protein during early murine embryonic development
    • Fleischmann, M. et al. Cardiac specific expression of the green fluorescent protein during early murine embryonic development. FEBS Lett. 440, 370-376 (1998).
    • (1998) FEBS Lett. , vol.440 , pp. 370-376
    • Fleischmann, M.1
  • 38
    • 0037150159 scopus 로고    scopus 로고
    • Cellular cardiomyoplasty improves survival after myocardial injury
    • Roell, W. et al. Cellular cardiomyoplasty improves survival after myocardial injury. Circulation 105, 2435-2441 (2002).
    • (2002) Circulation , vol.105 , pp. 2435-2441
    • Roell, W.1
  • 39
    • 0038369014 scopus 로고    scopus 로고
    • Temporal patterns of bone marrow cell differentiation following transplantation in doxorubicin-induced cardiomyopathy
    • Agbulut, O. et al. Temporal patterns of bone marrow cell differentiation following transplantation in doxorubicin-induced cardiomyopathy. Cardiovasc. Res. 58, 451-459 (2003).
    • (2003) Cardiovasc. Res. , vol.58 , pp. 451-459
    • Agbulut, O.1
  • 40
    • 0142027772 scopus 로고    scopus 로고
    • Cardiac progenitor cells from adult myocardium: Homing, differentiation, and fusion after infarction
    • Oh, H. et al. Cardiac progenitor cells from adult myocardium: homing, differentiation, and fusion after infarction. Proc. Natl. Acad. Sci. USA 100, 12313-12318 (2003).
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 12313-12318
    • Oh, H.1
  • 41
    • 12144286350 scopus 로고    scopus 로고
    • Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction; the MAGIC cell randomised clinical trial
    • Kang, H.-J. et al. Effects of intracoronary infusion of peripheral blood stem-cells mobilised with granulocyte-colony stimulating factor on left ventricular systolic function and restenosis after coronary stenting in myocardial infarction; the MAGIC cell randomised clinical trial. Lancet 363, 751-756 (2004).
    • (2004) Lancet , vol.363 , pp. 751-756
    • Kang, H.-J.1
  • 42
    • 1542345697 scopus 로고    scopus 로고
    • Risk to the coronary arteries of intracoronary stem cell infusion and G-CSIF cytokine therapy
    • Matsubara, H. Risk to the coronary arteries of intracoronary stem cell infusion and G-CSIF cytokine therapy. Lancet 363, 746-747 (2004).
    • (2004) Lancet , vol.363 , pp. 746-747
    • Matsubara, H.1
  • 43
    • 0035849588 scopus 로고    scopus 로고
    • Mobilization of endothelial progenitor cells in patients with acute myocardial infarction
    • Shintani, S. et al. Mobilization of endothelial progenitor cells in patients with acute myocardial infarction. Circulation 103, 2776-2779 (2001).
    • (2001) Circulation , vol.103 , pp. 2776-2779
    • Shintani, S.1
  • 44
    • 1942517003 scopus 로고    scopus 로고
    • Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium
    • Balsam, L.B. et al. Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature 428, 664-668 (2004).
    • (2004) Nature , vol.428 , pp. 664-668
    • Balsam, L.B.1
  • 45
    • 1942517003 scopus 로고    scopus 로고
    • Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts
    • Murry, C.E. et al. Haematopoietic stem cells do not transdifferentiate into cardiac myocytes in myocardial infarcts. Nature 428, 668-673 (2004).
    • (2004) Nature , vol.428 , pp. 668-673
    • Murry, C.E.1
  • 46
    • 0037083763 scopus 로고    scopus 로고
    • Cellular cardiomyoplasty in a transgenic mouse model
    • Roell, W, et al. Cellular cardiomyoplasty in a transgenic mouse model. Transplantation 73, 462-465 (2002).
    • (2002) Transplantation , vol.73 , pp. 462-465
    • Roell, W.1
  • 47
    • 0033485342 scopus 로고    scopus 로고
    • Lymphoid-restricted development from multipotent candidate murine stem cells: Distinct and complimentary functions of the c-kit and flt3- ligands
    • Borge, O.J., Adolfsson, J. & Jacobsen, A.M. Lymphoid-restricted development from multipotent candidate murine stem cells: distinct and complimentary functions of the c-kit and flt3- ligands. Blood 94, 3781-3790 (1999).
    • (1999) Blood , vol.94 , pp. 3781-3790
    • Borge, O.J.1    Adolfsson, J.2    Jacobsen, A.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.