Transcription activation by a PNA-Peptide chimera in a mammalian cell extract

Chemistry and Biology

Volumn 10, Issue 10, 2003, Pages 909-916

  Liu, Bo ^a   Han, Ying ^a   Ferdous, Anwarul ^a   Corey, David R ^a   Kodadek, Thomas ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAMMALIA; SACCHAROMYCES; SACCHAROMYCES CEREVISIAE;

EID: 0142198529     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2003.09.008     Document Type: Article

References (36)

1. Koleske A.J., Young R.A. An RNA polymerase II holoenzyme responsive to activators. Nature. 368:1994;466-469.
2. Kim Y.-L., Bjorklund S., Li Y., Sayre M.H., Kornberg R.D. A multiprotein mediator of transcriptional activation and its interaction with the C-terminal repeat domain of RNA polymerase II. Cell. 77:1994;599-608.
3. Björkland S., Kim Y.-J. Mediator of transcriptional regulation. Trends Biochem. Sci. 9:1996;335-337.
4. Jenuwein T., Allis C.D. Translating the histone code. Science. 293:2001;1074-1080.
5. Ptashne M. How eukaryotic transcriptional activators work. Nature. 335:1988;683-689.
6. Struhl K. Transcriptional enhancement by acidic activators. Biochim. Biophys. Acta. 1288:1996;015-017.
7. Hampsey M., Reinberg D. RNA polymerase II as a control panel for multiple coactivator complexes. Curr. Opin. Genet. Dev. 9:1999;132-139.
8. Malik S., Roeder R.G. Transcriptional regulation through Mediator-like coactivators in yeast and metazoan cells. Trends Biochem. Sci. 25:2000;277-283.
9. Denison C., Kodadek T. Small molecule-based strategies for controlling gene expression. Chem. Biol. 5:1998;R129-R145.
10. White S., Szewczyk J.W., Turner J.M., Baird E.E., Dervan P.B. Recognition of the four Watson-Crick base pairs in the DNA minor groove by synthetic ligands. Nature. 391:1998;468-471.
11. White S., Baird E.E., Dervan P.B. On the pairing rules in the minor groove of DNA by pyrrole-imidazole polyamides. Chem. Biol. 4:1997;569-578.
12. Gottesfeld J.M., Neely L., Trauger J.W., Baird E.E., Dervan P.B. Regulation of gene expression by small molecules. Nature. 387:1997;202-205.
13. Nielsen P.E., Egholm M., Berg R.H., Buchardt O. Sequence-selective recognition of DNA by strand displacement with a thymine-substitute polyamide. Science. 254:1991;1497-1500.
14. Nielsen P.E. Design of sequence-specific DNA-binding ligands. Chem. Eur. J. 3:1997;505-508.
15. Arora P.S., Ansari A.Z., Best T.P., Ptashne M., Dervan P.B. Design of artificial transcriptional activators with rigid poly-L-proline linkers. J. Am. Chem. Soc. 124:2002;13067-13071.
16. Ansari A.Z., Mapp A.K., Nguyen D.H., Dervan P.B., Ptashne M. Towards a minimal motif for artificial transcriptional activators. Chem. Biol. 8:2001;583-592.
17. Mapp A.K., Ansari A.Z., Ptashne M., Dervan P.B. Activation of gene expression by small molecule transcription factors. Proc. Natl. Acad. Sci. USA. 97:2000;3930-3935.
18. Stanojevic D., Young R.A. A highly potent artificial transcription factor. Biochemistry. 41:2002;7209-7216.
19. Han Y., Kodadek T. Peptides selected to bind the Gal80 repressor are potent transcriptoinal activation domains in yeast. J. Biol. Chem. 275:2000;14979-14984.
20. Frangioni J.V., LaRiccia L.M., Cantley L.C., Montminy M.R. Minimal activators that bind the KIX domain of p300/CBP identified by phage display screening. Nat. Biotechnol. 18:2000;1080-1085.
21. Liu B., Han Y., Corey D.R., Kodadek T. Towards synthetic transcription activators. recruitment of transcription factors to DNA by a PNA-peptide chimera J. Am. Chem. Soc. 124:2002;1838-1839.
22. Jeong C.-J., Yang S.-H., Xie Y., Zhang L., Johnston S.A., Kodadek T. Evidence that Gal11 protein is one of two targets of the Gal4 activation domain in the mediator. Biochemistry. 40:2001;9421-9427.
23. Lee Y.C., Park J.M., Min S., Han S.J., Kim Y.-J. An activator binding module of yeast RNA polymerase II holoenzyme. Mol. Cell. Biol. 19:1999;2967-2976.
24. Johnston M. A model fungal gene regulatory mechanism. the GAL genes of Saccharomyces cerevisiae Microbiol. Rev. 51:1987;458-476.
25. Griffith M.C., Risen L.M., Greig M.J., Lesnik E.A., Sprankle K.G., Griffey R.H., Kiely J.S., Freier S.M. Single and bis peptide nucleic acids as triplexing agaents. binding and stoichiometry J. Am. Chem. Soc. 117:1995;831-832.
26. Demidov V.V., Yavnilovich M.V., Belotserkovskii B.P., Frank-Kamenetskii M.D., Nielsen P.E. Kinetics and mechanism of polyamide ("peptide") nucleic acid binding to duplex DNA. Proc. Natl. Acad. Sci. USA. 92:1995;2637-2641.
27. Ferdous A., Gonzalez F., Sun L., Kodadek T., Johnston S.A. The 19S regulatory particle of the proteasome is required for efficient transcription elongation by RNA polymerase II. Mol. Cell. 7:2001;981-991.
28. Natesan S., Molinari E., Rivera V.M., Rickles R.J., Gilman M. A general strategy to enhance the potency of chimeric transcriptional activators. Proc. Natl. Acad. Sci. USA. 96:1999;13898-13903.
29. Hope I.A., Mahadevan S., Struhl K. Structural and functional characterization of the short acidic transcriptional activation region of yeast GCN4 protein. Nature. 333:1988;635-640.
30. Kuhn H., Demidov V.V., Nielsen P.E., Frank-Kamenetskii M.D. An experimental study of mechanism and specificity of peptide nucleic acid (PNA) binding to duplex DNA. J. Mol. Biol. 286:1999;1337-1345.
31. Hansen G.I., Bentin T.H., Larsen J., Nielsen P.E. Structural isomers of bis-PNA bound to a target in duplex DNA. J. Mol. Biol. 307:2001;67-74.
32. Croston G.E., Laybourn P.L., Paranjape S.M., Kadonaga J.T. Mechanism of transcriptional antirepression by GAL4-VP16. Genes Dev. 6:1992;2270-2281.
33. Ma J., Ptashne M. A new class of yeast transcriptional activators. Cell. 51:1987;113-119.
34. Giniger E., Ptashne M. Transcription in yeast activated by a putative amphipathic α helix linked to a DNA binding unit. Nature. 330:1987;670-673.
35. Hershko A., Ciechanover A. The ubiquitin system. Annu. Rev. Biochem. 67:1998;425-479.
36. Maratani M., Tansey W.P. How the ubiquitin-proteasome system controls transcription. Nat. Rev. Mol. Cell Biol. 4:2003;192-201.