Nuclease stability of LNA oligonucleotides and LNA-DNA chimeras

Nucleosides, Nucleotides and Nucleic Acids

Volumn 22, Issue 5-8, 2003, Pages 1041-1043

  Frieden, Miriam ^a   Hansen, Henrik F ^a   Koch, Troels ^a  

^a Santaris Pharma AS   (Denmark)

Author keywords

L LNA; LNA; Nuclease stability

Indexed keywords

ENDONUCLEASE; EXONUCLEASE; LOCKED NUCLEIC ACID; NUCLEASE; NUCLEIC ACID; OLIGONUCLEOTIDE; UNCLASSIFIED DRUG;

CHIMERA; CONFERENCE PAPER; ENZYME STABILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROLYSIS; MASS SPECTROMETRY;

DNA; DRUG STABILITY; ENDORIBONUCLEASES; EXONUCLEASES; OLIGODEOXYRIBONUCLEOTIDES; OLIGONUCLEOTIDES, ANTISENSE; PHOSPHODIESTERASE I; SUBSTRATE SPECIFICITY;

EID: 0141819348     PISSN: 15257770     EISSN: None     Source Type: Journal    
DOI: 10.1081/NCN-120022731     Document Type: Conference Paper

References (4)

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2. Singh, S.; Nielsen, P.; Koshkin, A.; Wengel, J. LNA (Locked Nucleic Acids): Synthesis and high-affinity nucleic acid recognition. Chem. Commun. 1998, 455-456.
3. Obika, S.; Nanbu, D.; Hari, Y.; Andoh, J.; Morio, K.; Doi, T.; Imanishi, T. Stability and structural features of the duplexes containing analogues with a fixed N-type conformation, 2′-O,4′-C-methyleneribonucleosides. Tetrahedron Lett. 1998, 39, 5401-5404.
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