메뉴 건너뛰기




Volumn 142, Issue 2, 2007, Pages 71-82

The molecular mechanisms of melanoma tumorigenesis: An update

Author keywords

AKT; Genes, p53; Melanoma; MITF protein, human; PI 3K

Indexed keywords

B RAF KINASE; MICROPHTHALMIA ASSOCIATED TRANSCRIPTION FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; RAS PROTEIN;

EID: 34250866796     PISSN: 03920488     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (1)

References (93)
  • 2
    • 0037358510 scopus 로고    scopus 로고
    • Modeling gene-environment interactions in malignant melanoma
    • Merlino G, Noonan FP. Modeling gene-environment interactions in malignant melanoma. Trends Mol Med 2003;9:102-8.
    • (2003) Trends Mol Med , vol.9 , pp. 102-108
    • Merlino, G.1    Noonan, F.P.2
  • 4
    • 16844385347 scopus 로고    scopus 로고
    • Melanoma genetics and the development of rational therapeutics
    • Chudnovsky Y, Khavari PA, Adams AE. Melanoma genetics and the development of rational therapeutics. J Clin Invest 2005;115:813-24.
    • (2005) J Clin Invest , vol.115 , pp. 813-824
    • Chudnovsky, Y.1    Khavari, P.A.2    Adams, A.E.3
  • 5
    • 0023742620 scopus 로고
    • Cytogenetic analysis of melanocytes from premalignant nevi and melanomas
    • Cowan JM, Halaban R, Francke U. Cytogenetic analysis of melanocytes from premalignant nevi and melanomas. J Natl Cancer Inst 1988;80:1159-64.
    • (1988) J Natl Cancer Inst , vol.80 , pp. 1159-1164
    • Cowan, J.M.1    Halaban, R.2    Francke, U.3
  • 7
    • 0027403953 scopus 로고
    • Cutaneous malignant melanoma and atypical moles associated with a constitutional rearrangement of chromosomes 5 and 9
    • Petty EM, Bolognia JL, Bale AE, Yang-Feng T. Cutaneous malignant melanoma and atypical moles associated with a constitutional rearrangement of chromosomes 5 and 9. Am J Med Genet 1993;45:77-80.
    • (1993) Am J Med Genet , vol.45 , pp. 77-80
    • Petty, E.M.1    Bolognia, J.L.2    Bale, A.E.3    Yang-Feng, T.4
  • 8
    • 0028275733 scopus 로고
    • Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers
    • Nobori T, Miura K, Wu DJ, Lois A, Takabayashi K, Carson DA. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature 1994;368:753-6.
    • (1994) Nature , vol.368 , pp. 753-756
    • Nobori, T.1    Miura, K.2    Wu, D.J.3    Lois, A.4    Takabayashi, K.5    Carson, D.A.6
  • 9
    • 0028085975 scopus 로고
    • Analysis of the p 16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus
    • Kamb A, Shattuck-Eidens D, Eeles R, Liu Q, Gruis NA, Ding W et al. Analysis of the p 16 gene (CDKN2) as a candidate for the chromosome 9p melanoma susceptibility locus. Nat Genet 1994;8:23-6.
    • (1994) Nat Genet , vol.8 , pp. 23-26
    • Kamb, A.1    Shattuck-Eidens, D.2    Eeles, R.3    Liu, Q.4    Gruis, N.A.5    Ding, W.6
  • 12
    • 33747332544 scopus 로고    scopus 로고
    • Malignant melanoma: Genetics and therapeutics in the genomic era
    • Chin L, Garraway LA, Fisher DE. Malignant melanoma: genetics and therapeutics in the genomic era. Genes Dev 2006;20:2149-82.
    • (2006) Genes Dev , vol.20 , pp. 2149-2182
    • Chin, L.1    Garraway, L.A.2    Fisher, D.E.3
  • 13
    • 27744479216 scopus 로고    scopus 로고
    • Cutaneous melanoma susceptibility and progression genes
    • de Snoo FA, Hayward NK. Cutaneous melanoma susceptibility and progression genes. Cancer Lett 2005;230:153-86.
    • (2005) Cancer Lett , vol.230 , pp. 153-186
    • de Snoo, F.A.1    Hayward, N.K.2
  • 14
    • 0032900535 scopus 로고    scopus 로고
    • Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma
    • Liu L, Dilworth D, Gao L, Monzon J, Summers A, Lassam N et al. Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma. Nat Genet 1999;21:128-32.
    • (1999) Nat Genet , vol.21 , pp. 128-132
    • Liu, L.1    Dilworth, D.2    Gao, L.3    Monzon, J.4    Summers, A.5    Lassam, N.6
  • 16
    • 0031879641 scopus 로고    scopus 로고
    • CDKN2A germline mutations in U.K. patients with familial melanoma and multiple primary melanomas
    • MacKie RM, Andrew N, Lanyon WG, Connor JM. CDKN2A germline mutations in U.K. patients with familial melanoma and multiple primary melanomas. J Invest Dermatol 1998;111:269-72.
    • (1998) J Invest Dermatol , vol.111 , pp. 269-272
    • MacKie, R.M.1    Andrew, N.2    Lanyon, W.G.3    Connor, J.M.4
  • 18
    • 0034945349 scopus 로고    scopus 로고
    • CDKN2A germline splicing mutation affecting both p16(ink4) and p14(arf) RNA processing in a melanoma/neurofibroma kindred
    • Petronzelli F, Sollima D, Coppola G, Martini-Neri ME, Neri G, Genuardi M. CDKN2A germline splicing mutation affecting both p16(ink4) and p14(arf) RNA processing in a melanoma/neurofibroma kindred. Genes Chromosomes Cancer 2001;31:398-401.
    • (2001) Genes Chromosomes Cancer , vol.31 , pp. 398-401
    • Petronzelli, F.1    Sollima, D.2    Coppola, G.3    Martini-Neri, M.E.4    Neri, G.5    Genuardi, M.6
  • 19
    • 0142072167 scopus 로고    scopus 로고
    • Germline splicing mutations of CDKN2A predispose to melanoma
    • Loo JC, Liu L, Hao A, Gao L, Agatep R, Shennan M et al. Germline splicing mutations of CDKN2A predispose to melanoma. Oncogene 2003;22:6387-94.
    • (2003) Oncogene , vol.22 , pp. 6387-6394
    • Loo, J.C.1    Liu, L.2    Hao, A.3    Gao, L.4    Agatep, R.5    Shennan, M.6
  • 20
    • 0027769876 scopus 로고
    • A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4
    • Serrano M, Hannon GJ, Beach D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature 1993;366:704-7.
    • (1993) Nature , vol.366 , pp. 704-707
    • Serrano, M.1    Hannon, G.J.2    Beach, D.3
  • 22
    • 0032549704 scopus 로고    scopus 로고
    • The Ink4a tumor suppressor gene product, p 19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
    • Pomerantz J, Schreiber-Agus N, Liegeois NJ, Silverman A, Alland L, Chin L et al. The Ink4a tumor suppressor gene product, p 19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 1998;92:713-23.
    • (1998) Cell , vol.92 , pp. 713-723
    • Pomerantz, J.1    Schreiber-Agus, N.2    Liegeois, N.J.3    Silverman, A.4    Alland, L.5    Chin, L.6
  • 23
    • 0032549711 scopus 로고    scopus 로고
    • ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
    • Zhang Y, Xiong Y, Yarbrough WG. ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways. Cell 1998;92:725-34.
    • (1998) Cell , vol.92 , pp. 725-734
    • Zhang, Y.1    Xiong, Y.2    Yarbrough, W.G.3
  • 24
    • 10644230100 scopus 로고    scopus 로고
    • Impaired processing of DNA photoproducts and ultraviolet hypermutability with loss of p16INK4a or p19ARF
    • Sarkar-Agrawal P, Vergilis I, Sharpless NE, DePinho RA, Runger TM. Impaired processing of DNA photoproducts and ultraviolet hypermutability with loss of p16INK4a or p19ARF. J Natl Cancer Inst 2004;96:1790-3.
    • (2004) J Natl Cancer Inst , vol.96 , pp. 1790-1793
    • Sarkar-Agrawal, P.1    Vergilis, I.2    Sharpless, N.E.3    DePinho, R.A.4    Runger, T.M.5
  • 26
    • 0035817687 scopus 로고    scopus 로고
    • Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice
    • Krimpenfort P, Quon KC, Mooi WJ, Loonstra A, Berns A. Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice. Nature 2001;413:83-6.
    • (2001) Nature , vol.413 , pp. 83-86
    • Krimpenfort, P.1    Quon, K.C.2    Mooi, W.J.3    Loonstra, A.4    Berns, A.5
  • 29
  • 31
    • 0035119327 scopus 로고    scopus 로고
    • Evidence for three tumor suppressor loci on chromosome 9p involved in melanoma development
    • Pollock PM, Welch J, Hayward NK. Evidence for three tumor suppressor loci on chromosome 9p involved in melanoma development. Cancer Res 2001;61:1154-61.
    • (2001) Cancer Res , vol.61 , pp. 1154-1161
    • Pollock, P.M.1    Welch, J.2    Hayward, N.K.3
  • 32
    • 11144356953 scopus 로고    scopus 로고
    • Identification of five chromosomal regions involved in predisposition to melanoma by genome-wide scan in the MeLiM swine model
    • Geffirotin C, Crechet F, Le Roy P, Le Chalony C, Leplat JJ, Iannuccelli N et al. Identification of five chromosomal regions involved in predisposition to melanoma by genome-wide scan in the MeLiM swine model. Int J Cancer 2004;110:39-50.
    • (2004) Int J Cancer , vol.110 , pp. 39-50
    • Geffirotin, C.1    Crechet, F.2    Le Roy, P.3    Le Chalony, C.4    Leplat, J.J.5    Iannuccelli, N.6
  • 33
    • 0032788149 scopus 로고    scopus 로고
    • A locus linked to p16 modifies melanoma risk in Dutch familial atypical multiple mole melanoma (FAMMM) syndrome families
    • van der Velden PA, Sandkuijl LA, Bergman W, Hille ET, Frants RR, Gruis NA. A locus linked to p16 modifies melanoma risk in Dutch familial atypical multiple mole melanoma (FAMMM) syndrome families. Genome Res 1999;9:575-80.
    • (1999) Genome Res , vol.9 , pp. 575-580
    • van der Velden, P.A.1    Sandkuijl, L.A.2    Bergman, W.3    Hille, E.T.4    Frants, R.R.5    Gruis, N.A.6
  • 34
    • 0029664339 scopus 로고    scopus 로고
    • Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma
    • Zuo L, Weger J, Yang Q, Goldstein AM, Tucker MA, Walker GJ et al. Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma. Nat Genet 1996;12:97-9.
    • (1996) Nat Genet , vol.12 , pp. 97-99
    • Zuo, L.1    Weger, J.2    Yang, Q.3    Goldstein, A.M.4    Tucker, M.A.5    Walker, G.J.6
  • 35
    • 6844226190 scopus 로고    scopus 로고
    • Prevalence of p16 and CDK4 germline mutations in 48 melanomaprone families in France. The French Familial Melanoma Study Group
    • Soufir N, Avril MF, Chompret A, Demenais F, Bombled J, Spatz A et al. Prevalence of p16 and CDK4 germline mutations in 48 melanomaprone families in France. The French Familial Melanoma Study Group. Hum Mol Genet 1998;7:209-16.
    • (1998) Hum Mol Genet , vol.7 , pp. 209-216
    • Soufir, N.1    Avril, M.F.2    Chompret, A.3    Demenais, F.4    Bombled, J.5    Spatz, A.6
  • 40
    • 0036150409 scopus 로고    scopus 로고
    • CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases
    • Schuster EF, Stoger R. CHD5 defines a new subfamily of chromodomain-SWI2/SNF2-like helicases. Mamm Genome 2002;13:117-9.
    • (2002) Mamm Genome , vol.13 , pp. 117-119
    • Schuster, E.F.1    Stoger, R.2
  • 42
    • 0037331353 scopus 로고    scopus 로고
    • Microsatellite analysis at 1p36.3 in malignant melanoma of the skin: Fine mapping in search of a possible tumour suppressor gene region
    • Poetsch M, Dittberner T, Woenckhaus C. Microsatellite analysis at 1p36.3 in malignant melanoma of the skin: fine mapping in search of a possible tumour suppressor gene region. Melanoma Res 2003; 13:29-33.
    • (2003) Melanoma Res , vol.13 , pp. 29-33
    • Poetsch, M.1    Dittberner, T.2    Woenckhaus, C.3
  • 44
    • 0034837773 scopus 로고    scopus 로고
    • MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations
    • Box NF, Duffy DL, Chen W, Stark M, Martin NG, Sturm RA et al. MC1R genotype modifies risk of melanoma in families segregating CDKN2A mutations. Am J Hum Genet 2001;69:765-73.
    • (2001) Am J Hum Genet , vol.69 , pp. 765-773
    • Box, N.F.1    Duffy, D.L.2    Chen, W.3    Stark, M.4    Martin, N.G.5    Sturm, R.A.6
  • 45
  • 46
    • 0037442752 scopus 로고    scopus 로고
    • Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation
    • Satyamoorthy K, Li G, Gerrero MR, Brose MS, Volpe P, Weber BL et al. Constitutive mitogen-activated protein kinase activation in melanoma is mediated by both BRAF mutations and autocrine growth factor stimulation. Cancer Res 2003;63:756-9.
    • (2003) Cancer Res , vol.63 , pp. 756-759
    • Satyamoorthy, K.1    Li, G.2    Gerrero, M.R.3    Brose, M.S.4    Volpe, P.5    Weber, B.L.6
  • 47
    • 0035819040 scopus 로고    scopus 로고
    • Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development
    • Li G, Schaider H, Satyamoorthy K, Hanakawa Y, Hashimoto K, Herlyn M. Downregulation of E-cadherin and Desmoglein 1 by autocrine hepatocyte growth factor during melanoma development. Oncogene 2001;20:8125-35.
    • (2001) Oncogene , vol.20 , pp. 8125-8135
    • Li, G.1    Schaider, H.2    Satyamoorthy, K.3    Hanakawa, Y.4    Hashimoto, K.5    Herlyn, M.6
  • 51
    • 2942533921 scopus 로고    scopus 로고
    • Microarray expression profiling in melanoma reveals a BRAF mutation signature
    • Pavey S, Johansson P, Packer L, Taylor J, Stark M, Pollock PM, et al. Microarray expression profiling in melanoma reveals a BRAF mutation signature. Oncogene 2004;23:4060-7.
    • (2004) Oncogene , vol.23 , pp. 4060-4067
    • Pavey, S.1    Johansson, P.2    Packer, L.3    Taylor, J.4    Stark, M.5    Pollock, P.M.6
  • 52
    • 13444258032 scopus 로고    scopus 로고
    • BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma
    • Patton EE, Widlund HR, Kutok JL, Kopani KR, Amatruda JF, Murphey RD et al. BRAF mutations are sufficient to promote nevi formation and cooperate with p53 in the genesis of melanoma. Curr Biol 2005;15:249-54.
    • (2005) Curr Biol , vol.15 , pp. 249-254
    • Patton, E.E.1    Widlund, H.R.2    Kutok, J.L.3    Kopani, K.R.4    Amatruda, J.F.5    Murphey, R.D.6
  • 54
    • 30444441778 scopus 로고    scopus 로고
    • V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors
    • Grbovic OM, Basso AD, Sawai A, Ye Q, Friedlander P, Solit D et al. V600E B-Raf requires the Hsp90 chaperone for stability and is degraded in response to Hsp90 inhibitors. Proc Natl Acad Sci U S A 2006;103:57-62.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 57-62
    • Grbovic, O.M.1    Basso, A.D.2    Sawai, A.3    Ye, Q.4    Friedlander, P.5    Solit, D.6
  • 55
    • 24344487227 scopus 로고    scopus 로고
    • Constitutive activation of the mitogen-activated protein kinase signaling pathway in acral melanomas
    • Takata M, Goto Y, Ichii N, Yamaura M, Murata H, Koga H et al. Constitutive activation of the mitogen-activated protein kinase signaling pathway in acral melanomas. J Invest Dermatol 2005;125:318-22.
    • (2005) J Invest Dermatol , vol.125 , pp. 318-322
    • Takata, M.1    Goto, Y.2    Ichii, N.3    Yamaura, M.4    Murata, H.5    Koga, H.6
  • 56
    • 0142024483 scopus 로고    scopus 로고
    • Rap1 GTPase: Functions, regulation, and malignancy
    • Hattori M, Minato N. Rap1 GTPase: functions, regulation, and malignancy. J Biochem (Tokyo) 2003;134:479-84.
    • (2003) J Biochem (Tokyo) , vol.134 , pp. 479-484
    • Hattori, M.1    Minato, N.2
  • 57
    • 33748054771 scopus 로고    scopus 로고
    • Gao L, Feng Y, Bowers R, Becker-Hapak M, Gardner J, Council L et al. Ras-associated protein-1 regulates extracellular signal-regulated kinase activation and migration in melanoma cells: two processes important to melanoma tumorigenesis and metastasis. Cancer Res 2006;66:7880-8.
    • Gao L, Feng Y, Bowers R, Becker-Hapak M, Gardner J, Council L et al. Ras-associated protein-1 regulates extracellular signal-regulated kinase activation and migration in melanoma cells: two processes important to melanoma tumorigenesis and metastasis. Cancer Res 2006;66:7880-8.
  • 59
    • 0038313706 scopus 로고    scopus 로고
    • Rap1 activity is elevated in malignant astrocytomas independent of tuberous sclerosis complex-2 gene expression
    • Lau N, Uhlmann EJ, Von Lintig FC, Nagy A, Boss GR, Gutmann DH et al. Rap1 activity is elevated in malignant astrocytomas independent of tuberous sclerosis complex-2 gene expression. Int J Oncol 2003;22:195-200.
    • (2003) Int J Oncol , vol.22 , pp. 195-200
    • Lau, N.1    Uhlmann, E.J.2    Von Lintig, F.C.3    Nagy, A.4    Boss, G.R.5    Gutmann, D.H.6
  • 61
    • 0032560506 scopus 로고    scopus 로고
    • Mitogenic and oncogenic properties of the small G protein Rap1b
    • Altschuler DL, Ribeiro-Neto F. Mitogenic and oncogenic properties of the small G protein Rap1b. Proc Natl Acad Sci U S A 1998;95:7475-9.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 7475-7479
    • Altschuler, D.L.1    Ribeiro-Neto, F.2
  • 63
    • 0029810125 scopus 로고    scopus 로고
    • Twelve amplified and expressed genes localized in a single domain in glioma
    • Fischer U, Meltzer P, Meese E. Twelve amplified and expressed genes localized in a single domain in glioma. Hum Genet 1996;98:625-8.
    • (1996) Hum Genet , vol.98 , pp. 625-628
    • Fischer, U.1    Meltzer, P.2    Meese, E.3
  • 64
    • 0029021621 scopus 로고
    • Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity
    • Wienecke R, Konig A, DeClue JE. Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity. J Biol Chem 1995;270:16409-14.
    • (1995) J Biol Chem , vol.270 , pp. 16409-16414
    • Wienecke, R.1    Konig, A.2    DeClue, J.E.3
  • 65
    • 10744228326 scopus 로고    scopus 로고
    • Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice
    • Ishida D, Kometani K, Yang H, Kakugawa K, Masuda K, Iwai K et al. Myeloproliferative stem cell disorders by deregulated Rap1 activation in SPA-1-deficient mice. Cancer Cell 2003;4:55-65.
    • (2003) Cancer Cell , vol.4 , pp. 55-65
    • Ishida, D.1    Kometani, K.2    Yang, H.3    Kakugawa, K.4    Masuda, K.5    Iwai, K.6
  • 68
    • 0032953808 scopus 로고    scopus 로고
    • Mutational and expression analysis of the p73 gene in melanoma cell lines
    • Tsao H, Zhang X, Majewski P, Haluska FG. Mutational and expression analysis of the p73 gene in melanoma cell lines. Cancer Res 1999;59:172-4.
    • (1999) Cancer Res , vol.59 , pp. 172-174
    • Tsao, H.1    Zhang, X.2    Majewski, P.3    Haluska, F.G.4
  • 69
    • 0038456399 scopus 로고    scopus 로고
    • PTEN signaling pathways in melanoma
    • Wu H, Goel V, Haluska FG. PTEN signaling pathways in melanoma. Oncogene 2003;22:3113-22.
    • (2003) Oncogene , vol.22 , pp. 3113-3122
    • Wu, H.1    Goel, V.2    Haluska, F.G.3
  • 71
    • 0030777104 scopus 로고    scopus 로고
    • Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma
    • Guldberg P, thor Straten P, Birck A, Ahrenkiel V, Kirkin AF, Zeuthen J. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma. Cancer Res 1997;57:3660-3.
    • (1997) Cancer Res , vol.57 , pp. 3660-3663
    • Guldberg, P.1    thor Straten, P.2    Birck, A.3    Ahrenkiel, V.4    Kirkin, A.F.5    Zeuthen, J.6
  • 72
    • 0032474749 scopus 로고    scopus 로고
    • Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines
    • Tsao H, Zhang X, Benoit E, Haluska FG. Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines. Oncogene 1998;16:3397-402.
    • (1998) Oncogene , vol.16 , pp. 3397-3402
    • Tsao, H.1    Zhang, X.2    Benoit, E.3    Haluska, F.G.4
  • 74
    • 14944352371 scopus 로고    scopus 로고
    • Prognostic significance of activated Akt expression in melanoma: A clinicopamologic study of 292 cases
    • Dai DL, Martinka M, Li G. Prognostic significance of activated Akt expression in melanoma: a clinicopamologic study of 292 cases. J Clin Oncol 2005;23:1473-82.
    • (2005) J Clin Oncol , vol.23 , pp. 1473-1482
    • Dai, D.L.1    Martinka, M.2    Li, G.3
  • 76
    • 33644513730 scopus 로고    scopus 로고
    • Beyond PTEN mutations: The PI3K pathway as an integrator of multiple inputs during tumorigenesis
    • Cully M, You H, Levine AJ, Mak TW. Beyond PTEN mutations: the PI3K pathway as an integrator of multiple inputs during tumorigenesis. Nat Rev Cancer 2006;6:184-92.
    • (2006) Nat Rev Cancer , vol.6 , pp. 184-192
    • Cully, M.1    You, H.2    Levine, A.J.3    Mak, T.W.4
  • 77
    • 28844448182 scopus 로고    scopus 로고
    • Oncogenic PI3K deregulates transcription and translation
    • Bader AG, Kang S, Zhao L, Vogt PK. Oncogenic PI3K deregulates transcription and translation. Nat Rev Cancer 2005;5:921-9.
    • (2005) Nat Rev Cancer , vol.5 , pp. 921-929
    • Bader, A.G.1    Kang, S.2    Zhao, L.3    Vogt, P.K.4
  • 79
    • 33747882661 scopus 로고    scopus 로고
    • MITF: Master regulator of melanocyte development and melanoma oncogene
    • Levy C, Khaled M, Fisher DE. MITF: master regulator of melanocyte development and melanoma oncogene. Trends Mol Med 2006; 12:406-14.
    • (2006) Trends Mol Med , vol.12 , pp. 406-414
    • Levy, C.1    Khaled, M.2    Fisher, D.E.3
  • 80
    • 0028091741 scopus 로고
    • Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences
    • Steingrimsson E, Moore KJ, Lamoreux ML, Ferre-D'Amare AR, Burley SK, Zimring DC et al. Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences. Nat Genet 1994;8:256-63.
    • (1994) Nat Genet , vol.8 , pp. 256-263
    • Steingrimsson, E.1    Moore, K.J.2    Lamoreux, M.L.3    Ferre-D'Amare, A.R.4    Burley, S.K.5    Zimring, D.C.6
  • 81
    • 12144254034 scopus 로고    scopus 로고
    • MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A
    • Loercher AE, Tank EM, Delston RB, Harbour JW. MITF links differentiation with cell cycle arrest in melanocytes by transcriptional activation of INK4A. J Cell Biol 2005;168:35-40.
    • (2005) J Cell Biol , vol.168 , pp. 35-40
    • Loercher, A.E.1    Tank, E.M.2    Delston, R.B.3    Harbour, J.W.4
  • 82
    • 13944273767 scopus 로고    scopus 로고
    • Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression
    • Carreira S, Goodall J, Aksan I, La Rocca SA, Galibert MD, Denat L et al. Mitf cooperates with Rb1 and activates p21Cip1 expression to regulate cell cycle progression. Nature 2005;433:764-9.
    • (2005) Nature , vol.433 , pp. 764-769
    • Carreira, S.1    Goodall, J.2    Aksan, I.3    La Rocca, S.A.4    Galibert, M.D.5    Denat, L.6
  • 83
    • 24144477947 scopus 로고    scopus 로고
    • Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation
    • Wellbrock C, Marais R. Elevated expression of MITF counteracts B-RAF-stimulated melanocyte and melanoma cell proliferation. J Cell Biol 2005;170:703-8.
    • (2005) J Cell Biol , vol.170 , pp. 703-708
    • Wellbrock, C.1    Marais, R.2
  • 84
    • 21844478747 scopus 로고    scopus 로고
    • Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma
    • Garraway LA, Widlund HR, Rubin MA, Getz G, Berger AJ, Ramaswamy S et al. Integrative genomic analyses identify MITF as a lineage survival oncogene amplified in malignant melanoma. Nature 2005;436:117-22.
    • (2005) Nature , vol.436 , pp. 117-122
    • Garraway, L.A.1    Widlund, H.R.2    Rubin, M.A.3    Getz, G.4    Berger, A.J.5    Ramaswamy, S.6
  • 86
    • 0034698141 scopus 로고    scopus 로고
    • The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes
    • Carreira S, Liu B, Goding CR. The gene encoding the T-box factor Tbx2 is a target for the microphthalmia-associated transcription factor in melanocytes. J Biol Chem 2000;275:21920-7.
    • (2000) J Biol Chem , vol.275 , pp. 21920-21927
    • Carreira, S.1    Liu, B.2    Goding, C.R.3
  • 87
    • 16844387097 scopus 로고    scopus 로고
    • Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas
    • Vance KW, Carreira S, Brosch G, Goding CR. Tbx2 is overexpressed and plays an important role in maintaining proliferation and suppression of senescence in melanomas. Cancer Res 2005;65:2260-8.
    • (2005) Cancer Res , vol.65 , pp. 2260-2268
    • Vance, K.W.1    Carreira, S.2    Brosch, G.3    Goding, C.R.4
  • 88
    • 10944228764 scopus 로고    scopus 로고
    • Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF
    • Du J, Widlund HR, Horstmann MA, Ramaswamy S, Ross K, Huber WE et al. Critical role of CDK2 for melanoma growth linked to its melanocyte-specific transcriptional regulation by MITF. Cancer Cell 2004;6:565-76.
    • (2004) Cancer Cell , vol.6 , pp. 565-576
    • Du, J.1    Widlund, H.R.2    Horstmann, M.A.3    Ramaswamy, S.4    Ross, K.5    Huber, W.E.6
  • 89
    • 22244467409 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1{alpha} is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells
    • Busca R, Berra E, Gaggioli C, Khaled M, Bille K, Marchetti B et al. Hypoxia-inducible factor 1{alpha} is a new target of microphthalmia-associated transcription factor (MITF) in melanoma cells. J Cell Biol 2005;170:49-59.
    • (2005) J Cell Biol , vol.170 , pp. 49-59
    • Busca, R.1    Berra, E.2    Gaggioli, C.3    Khaled, M.4    Bille, K.5    Marchetti, B.6
  • 90
    • 33744531154 scopus 로고    scopus 로고
    • c-Met expression is regulated by Mitf in the melanocyte lineage
    • McGill GG, Haq R, Nishimura EK, Fisher DE. c-Met expression is regulated by Mitf in the melanocyte lineage. J Biol Chem 2006;281:10365-73.
    • (2006) J Biol Chem , vol.281 , pp. 10365-10373
    • McGill, G.G.1    Haq, R.2    Nishimura, E.K.3    Fisher, D.E.4
  • 91
    • 33745288277 scopus 로고    scopus 로고
    • Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene
    • Kim M, Gans JD, Nogueira C, Wang A, Paik JH, Feng B et al. Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene. Cell 2006;125:1269-81.
    • (2006) Cell , vol.125 , pp. 1269-1281
    • Kim, M.1    Gans, J.D.2    Nogueira, C.3    Wang, A.4    Paik, J.H.5    Feng, B.6
  • 92
    • 0032523833 scopus 로고    scopus 로고
    • Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization
    • Bastian BC, LeBoit PE, Hamm H, Brocker EB, Pinkel D. Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization. Cancer Res 1998;58:2170-5.
    • (1998) Cancer Res , vol.58 , pp. 2170-2175
    • Bastian, B.C.1    LeBoit, P.E.2    Hamm, H.3    Brocker, E.B.4    Pinkel, D.5
  • 93
    • 12844264129 scopus 로고    scopus 로고
    • Genomic alterations in primary cutaneous melanomas detected by metaphase comparative genomic hybridization with laser capture or manual microdissection: 6p gains may predict poor outcome
    • Namiki T, Yanagawa S, Izumo T, Ishikawa M, Tachibana M, Kawakami Y et al. Genomic alterations in primary cutaneous melanomas detected by metaphase comparative genomic hybridization with laser capture or manual microdissection: 6p gains may predict poor outcome. Cancer Genet Cytogenet 2005;157:1-11.
    • (2005) Cancer Genet Cytogenet , vol.157 , pp. 1-11
    • Namiki, T.1    Yanagawa, S.2    Izumo, T.3    Ishikawa, M.4    Tachibana, M.5    Kawakami, Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.