Activity of endothelium-derived hyperpolarizing factor is augmented in monocrotaline-induced pulmonary hypertension of rat lungs

Journal of Vascular Research

Volumn 44, Issue 4, 2007, Pages 325-335

  Morio, Yoshiteru ^a   Homma, Noriyuki ^a   Takahashi, Hideki ^a   Yamamoto, Akihito ^a   Nagaoka, Tetsutaro ^a   Sato, Koichi ^a   Muramatsu, Masashi ^a   Fukuchi, Yoshinosuke ^a  

^a JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Ca2+ sensitive K+ channel; Endothelial nitric oxide synthase; Endothelium derived hyperpolarizing factor; Monocrotaline; Pulmonary hypertension

Indexed keywords

APAMIN; CALCIUM SENSITIVE POTASSIUM CHANNEL; CHARYBDOTOXIN; CYTOCHROME P450; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; MESSENGER RNA; MONOCROTALINE; POTASSIUM CHANNEL; SULFAPHENAZOLE; THAPSIGARGIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; CONTROLLED STUDY; LUNG CIRCULATION; LUNG ENDOTHELIUM; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PULMONARY HYPERTENSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; VASODILATATION;

ANIMALS; ANTI-INFECTIVE AGENTS; APAMIN; BIOLOGICAL FACTORS; CHARYBDOTOXIN; CYCLIC GMP; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; EPOPROSTENOL; HYPERTENSION, PULMONARY; HYPERTROPHY, RIGHT VENTRICULAR; MALE; MONOCROTALINE; NEUROTOXINS; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SULFAPHENAZOLE; THAPSIGARGIN; VASCULAR CELL ADHESION MOLECULE-1; VASODILATION;

EID: 34250773333     PISSN: 10181172     EISSN: None     Source Type: Journal    
DOI: 10.1159/000101778     Document Type: Article

References (65)

1. Campbell WB, Harder DR: Prologue: EDHF - what is it? Am J Physiol Heart Circ Physiol 2001;280:H2413-H2416.
2. Dora KA: Cell-cell communication in the vessel wall. Vasc Med 2001;6:43-50.
3. Feletou M, Vanhoutte PM: Endothelium-dependent hyperporalization of vascular smooth muscle cells. Acta Pharmacol Sin 2000;21:1-18.
4. Triggle CR, Ding H: Endothelium-derived hyperporalizing factor: is there a novel chemical mediator? Clin Exp Pharmacol Physiol 2002;29:153-160.
5. Beny JL, Schaad O: An evaluation of potassium ions as endothelium-derived hyperpolarizing factor in porcine coronary arteries. Br J Pharmacol 2000;131:965-973.
6. Chauhan SD, Nilsson H, Ahluwalia A, Hobbs AJ: Release of C-type natriuretic peptide accounts for endothelium-derived hyperpolarizing factor. Proc Natl Acad Sci USA 2003;100:1426-1431.
7. + is an endothelium-derived hyperpolarizing factor in rat arteries. Nature 1998;396:269-272.
8. Gauthier KM, Deeter C, Krishna UM, Reddy YK, Bondlela M, Falck JR, Campbell WB: 14,15-Epoxyeicosa-5(Z)-enoic acid: a selective epoxyeicosatrienoic acid antagonist that inhibits endothelium-dependent hyperpolarization and relaxation in coronary arteries. Circ Res 2002;90:1028-1036.
9. Matoba T, Shimokawa H, Kubota H, Morikawa K, Fujiki T, Kunihiro I, Mukai Y, Hirakawa Y, Takeshita A: Hydrogen peroxide is an endothelium-derived hyperpolarizing factor in human mesenteric arteries. Biochem Biophys Res Commun 2002;290:909-913.
10. Pratt PF, Li P, Hillard CJ, Kurian J, Campbell WB: Endothelium- independent, ouabain-sensitive relaxation of bovine coronary arteries by EETs. Am J Physiol Heart Circ Physiol 2001;280:H1113-H1121.
11. Morio Y, Carter EP, Oka M, McMurtry IF: EDHF-mediated vasodilation involves different mechanisms in normotensive and hypertensive rat lungs. Am J Physiol Heart Circ Physiol 2003;284:H1762-H1770.
12. Ca channels in cerebral EDHF-mediated dilations. Am J Physiol Heart Circ Physiol 2003;285:H1590-H1599.
13. + channels provide different facets of endothelium-dependent hyperpolarization in rat mesenteric artery. J Physiol 2003;553:183-189.
14. + currents underlying the action of endothelium-derived hyperpolarizing factor in guinea-pig, rat and human blood vessels. J Physiol 2001;531:359-373.
15. Doughty JM, Plane F, Langton PD: Charybdotoxin and apamin block EDHF in rat mesenteric artery if selectively applied to the endothelium. Am J Physiol 1999;276:H1107-H1112.
16. +-channels suppresses EDHF-mediated vasodilation. Br J Pharmacol 2003;138:594-601.
17. +-channel inhibitors in rat isolated mesenteric arteries. Br J Pharmacol 2003;138:1031-1035.
18. + channel in porcine coronary artery endothelium: relevance to EDHF. Br J Pharmacol 2002;135:1133-1143.
19. Freitas MR, Schott C, Corriu C, Sassard J, Stoclet JC, Andriantsitohaina R: Heterogeneity of endothelium-dependent vasorelaxation in conductance and resistance arteries from Lyon normotensive and hypertensive rats. J Hypertens 2003;21:1505-1512.
20. Hill CE, Hickey H, Sandow SL: Role of gap junctions in acetylcholine-induced vasodilation of proximal and distal arteries of the rat mesentery. J Auton Nerv Syst 2000;81:122-127.
21. Hill CE, Phillips JK, Sandow SL: Heterogeneous control of blood flow amongst different vascular beds. Med Res Rev 2001;21:1-60.
22. Hwa JJ, Ghibaudi L, Williams P, Chatterjee M: Comparison of acetylcholine-dependent relaxation in large and small arteries of rat mesenteric vascular bed. Am J Physiol 1994;266:H952-H958.
23. Sandow SL, Hill CE: Incidence of myoendothelial gap junctions in the proximal and distal mesenteric arteries of the rat is suggestive of a role in endothelium-derived hyperpolarizing factor-mediated responses. Circ Res 2000;86:341-346.
24. Shimokawa H, Yasutake H, Fujii K, Owada MK, Nakaike R, Fukumoto Y, Takayanagi T, Nagao T, Egashira K, Fujishima M, Takeshita A: The importance of the hyperpolarizing mechanism increases as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation. J Cardiovasc Pharmacol 1996;28:703-711.
25. Bauersachs J, Popp R, Hecker M, Sauer E, Fleming I, Busse R: Nitric oxide attenuates the release of endothelium-derived hyperpolarizing factor. Circulation 1996;94:3341-3347.
26. Corriu C, Feletou M, Puybasset L, Bea ML, Berdeaux A, Vanhoutte PM: Endothelium-dependent hyperpolarization in isolated arteries taken from animals treated with NO-synthase inhibitors. J Cardiovasc Pharmacol 1998;32:944-950.
27. Brandes RP, Schmitz-Winnenthal FH, Feletou M, Godecke A, Huang PL, Vanhoutte PM, Busse R: An endothelium-derived hyperpolarizing factor distinct from NO and prostacyclin is a major endothelium-dependent vasodilator in resistance vessels of wild-type and endothelial NO synthase knockout mice. Proc Natl Acad Sci USA 2000;97:9747-9752.
28. Scotland RS, Chauhan S, Vallance PJT, Ahluwalia A: An endothelium-derived hyperpolarizing factor-like factor moderates myogenic constriction of mesenteric resistance arteries in the absence of endothelial nitric oxide synthase-derived nitric oxide. Hypertension 2001;38:833-839.
29. Earley S, Pastuszyn A, Walker BR: Cytochrome P-450 epoxygenase products contribute to attenuated vasoconstriction after chronic hypoxia. Am J Physiol Heart Circ Physiol 2003;285:H127-H136.
30. Pokreisz P, Fleming I, Kiss L, Barbosa-Sicard E, Fisslthaler B, Falck JR, Hammock BD, Kim IH, Szelid Z, Vermeersch P, Gillijns H, Pellens M, Grimminger F, van Zonneveld AJ, Collen D, Busse R, Janssens S: Cytochrome P450 epoxygenase gene function in hypoxic pulmonary vasoconstriction and pulmonary vascular remodeling. Hypertension 2006;47:762-770.
31. Abe K, Shimokawa H, Morikawa K, Uwatoku T, Oi K, Matsumoto Y, Hattori T, Nakashima Y, Kaibuchi K, Sueishi K, Takeshita A: Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. Circ Res 2004;94:385-393.
32. Hironaka E, Hongo M, Sakai A, Mawatari E, Terasawa F, Okumura N, Yamazaki A, Ushiyama Y, Yazaki Y, Kinoshita O: Serotonin receptor antagonist inhibits monocrotaline-induced pulmonary hypertension and prolongs survival in rats. Cardiovasc Res 2003;60:692-699.
33. Nishimura T, Faul JL, Berry GJ, Vaszar LT, Qui D, Pearl RG, Kao PN: Simvastatin attenuates smooth muscle neointimal proliferation and pulmonary hypertension in rats. Am J Respir Crit Care Med 2002;166:1403-1408.
34. Zhao YD, Campbell AI, Robb M, Ng D, Stewart DJ: Protective role of angiopoietin-1 in experimental pulmonary hypertension. Circ Res 2003;92:984-991.
35. Kanno S, Wu YJ, Lee PC, Billiar TR, Ho C: Angiotensin-converting enzyme inhibitor preserves p21 and endothelial nitric oxide synthase expression in monocrotaline-induced pulmonary arterial hypertension in rats. Circulation 2001;104:945-950.
36. Nakazawa H, Hori M, Ozaki H, Karaki H: Mechanisms underlying the impairment of endothelium-dependent relaxation in the pulmonary artery of monocrotaline-induced pulmonary hypertensive rats. Br J Pharmacol 1999;128:1098-1104.
37. Tyler RC, Muramatsu M, Abman SH, Stelzner TJ, Rodman DM, Bloch KD, McMurtry IF: Variable expression of endothelial NO synthase in three forms of rat pulmonary hypertension. Am J Physiol 1999;276:L297-L303.
38. Fukao M, Hattori Y, Kanno M, Sakuma I, Kitabatake A: Thapsigargin- and cyclopiazonic acid-induced endothelium-dependent hyperpolarization in rat mesenteric artery. Br J Pharmacol 1995;115:987-992.
39. 2+ entry in in situ endothelial cells of the porcine aortic valve and the endothelium-dependent relaxation in the porcine coronary artery. Br J Pharmacol 2000;131:115-123.
40. 2+ release from ryanodyne-sensitive store contributes to mechanism of hypoxic vasoconstriction in rat lungs. J Appl Physiol 2002;92:527-534.
41. ATP channel. Am J Physiol Lung Cell Mol Physiol 2000;278:L434-L442.
42. Oka M, Hasunuma K, Webb SA, Stelzner TJ, Rodman DM, McMurtry IF: EDRF suppresses an unidentified vasoconstrictor mechanism in hypertensive rat lungs. Am J Physiol 1993;264:L587-L597.
43. Muramatsu M, Rodman DM, Oka M, McMurtry IF: Endothelin-1 mediates nitro-L-arginine vasoconstriction of hypertensive rat lungs. Am J Physiol 1997;272:L807-L812.
44. Muramatsu M, Tyler RC, Rodman DM, McMurtry IF: Thapsigargin stimulates increased NO activity in hypoxic hypertensive rat lungs and pulmonary arteries. J Appl Physiol 1996;80:1336-1344.
45. Takahashi H, Goto N, Kojima Y, Tsuda Y, Morio Y, Muramatsu M, Fukuchi Y: Down-regulation of type II bone morphogenetic protein receptor in hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol 2006;290:L450-L458.
46. Li L, Crockett E, Wang DH, Galligan JJ, Fink GD, Chen AF: Gene transfer of endothelial NO synthase and manganese superoxide dismutase on arterial vascular cell adhesion molecule-1 expression and superoxide production in deoxycorticosterone acetate-salt hypertension. Arterioscler Thromb Vasc Biol 2002;22:249-255.
47. Kobayashi N, Mita S, Yoshida K, Honda T, Kobayashi T, Hara K, Nakano S, Tsubokou Y, Matsuoka H: Celiprolol activates eNOS through the PI3K-Akt pathway and inhibits VCAM-1 via NF-κB induced by oxidative stress. Hypertension 2003;42:1004-1013.
48. Resta TC, Gonzales RJ, Dail WG, Sanders TC, Walker BR: Selective upregulation of arterial endothelial nitric oxide synthase in pulmonary hypertension. Am J Physiol 1997;272:H806-H813.
49. Zhang TT, Cui B, Dai DZ, Su W: CPU 86017, p- chlorobenzyltetrahydroberberine chloride, attenuates monocrotaline-induced pulmonary hypertension by suppressing endothelin pathway. Acta Pharmacol Sin 2005;26:1309-1316.
50. Fagan KA, McMurtry IF, Rodman DM: Nitric oxide synthase in pulmonary hypertension: lessons from knockout mice. Physiol Res 2000;49:539-548.
51. De Caterina R, Libby P, Peng HB, Thannickal VJ, Rajavashisth TB, Gimbrone MA Jr, Shin WS, Liao JK: Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest 1995;96:60-68.
52. Kaminski A, Pohl CB, Sponholz C, Ma N, Stamm C, Vollmar B, Steinhoff G: Up-regulation of endothelial nitric oxide synthase inhibits pulmonary leukocyte migration following lung ischemia-reperfusion in mice. Am J Pathol 2004;164;2241-2249.
53. Sunano S, Watanabe H, Tanaka S, Sekiguchi F, Shimamura K: Endothelium-derived relaxing, contracting and hyperpolarizing factors of mesenteric arteries of hypertensive and normotensive rats. Br J Pharmacol 1999;126:709-716.
54. Vazquez-Perez S, Navarro-Cid J, de las Heras N, Cediel E, Sanz-Rosa D, Ruilope LM, Cachoferio V, Lahera V: Relevance of endothelium-derived hyperpolarizing factor in the effects of hypertension on rat coronary relaxations. J Hypertens 2001;19:539-545.
55. +/+ mice. Br J Pharmacol 2005;145:264-270.
56. Kimura K, Tsuda K, Sasajima H, Shiotani M, Baba A, Hano T, Nishio I: Arterial relaxation mediated by endothelium-derived hyperpolarizing factor in hypertension induced by chronic inhibition of nitric oxide synthesis. Clin Exp Hypertens 1999;21:1203-1221.
57. Sobey CG: Potassium channel function in vascular disease. Arterioscler Thromb Vasc Biol 2001;21:28-38.
58. Cornfield DN, Resnik ER, Herron JM, Abman SH: Chronic intrauterine pulmonary hypertension decreases calcium-sensitive potassium channel mRNA expression. Am J Physiol Lung Cell Mol Physiol 2000;279:L857-L862.
59. 2 sensitivity is decreased in an ovine PPHN model. Am J Physiol Lung Cell Mol Physiol 2002;283:L1103-L1109.
60. + channels in the remission phase of pulmonary hypertension in chronic obstructive pulmonary diseases. Cardiovasc Res 2003;60:326-336.
61. + current of pulmonary arterial smooth muscle in pulmonary hypertension rats. Naunyn Schmiedebergs Arch Pharmacol 2001;364:183-192.
62. Fleming I: Cytochrome P450 and vascular homeostasis. Circ Res 2001;89:753-762.
63. Dong H, Jiang Y, Cole WC, Triggle CR: Comparison of the pharmacological properties of EDHF-mediated vasorelaxation in guinea-pig cerebral and mesenteric resistance vessels. Br J Pharmacol 2000;130:1983-1991.
64. +. Br J Pharmacol 2000;129:811-819.
65. Zhu D, Birks EK, Dawson CA, Patel M, Falck JR, Presberg K, Roman RJ, Jacobs ER: Hypoxic pulmonary vasoconstriction is modified by P-450 metabolites. Am J Physiol Heart Circ Physiol 2000;279:H1526-H1533.