Mechanisms of the thapsigargin-induced Ca2+ entry in in situ endothelial cells of the porcine aortic valve and the endothelium-dependent relaxation in the porcine coronary artery

British Journal of Pharmacology

Volumn 131, Issue 1, 2000, Pages 115-123

  Kuroiwa Matsumoto, M ^a   Hirano, K ^a   Ahmed, A ^a   Kawasaki, J ^a   Nishimura, J ^a   Kanaide, H ^a  

^a KYUSHU UNIVERSITY   (Japan)

Author keywords

Endothelial cells; Endothelium dependent relaxation; Thapsigargin

Indexed keywords

15 HYDROXY 11ALPHA,9ALPHA EPOXYMETHANOPROSTA 5,13 DIENOIC ACID; CALCIUM; CYTOCHROME P450; ECONAZOLE; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; FURA 2; INDOMETACIN; N(G) NITROARGININE; NICKEL; NITRIC OXIDE; PERTUSSIS TOXIN; POTASSIUM ION; THAPSIGARGIN; THROMBOXANE A2 RECEPTOR STIMULATING AGENT; WORTMANNIN;

ANIMAL CELL; ANIMAL TISSUE; AORTA VALVE; ARTERY TONE; ARTICLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CONTROLLED STUDY; CORONARY ARTERY DILATATION; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIUM CELL; FLUOROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SWINE;

EID: 0033817539     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703548     Document Type: Article

References (50)

1. Front-surface fluorometry with fura-2 and effects of nitroglycerin on cytosolic calcium concentrations and on tension in the coronary artery of the pig
2. 2+ stores
3. 2+ influx to pertussis toxin in porcine endothelial ceils in situ
4. 2+-transient in endothelial cells in situ
5. Inhibition of thapsigargin induced calcium entry by microinjected guanine nucleotide analogues. Evidence for the involvement of a small G-protein in capacitative calcium entry
6. 2+ entry
7. Hyperpolarization and increased free calcium in acetylcholine-stimulated endothelial cells
8. Acetylcholine releases endothelium-derived hyperpolarizing factor and EDRF from rat blood vessels
9. Bradykinin-induced increases in cytosolic calcium and ionic currents in cultured bovine aortic endothelial cells
10. Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation
11. 2+ with fura-2
12. Calcium-dependent and calcium-independent activation of the endothelial NO synthase
13. Regulation of endothelium-derived nitric oxide production by the protein kinase Akt
14. Endothelium-derived relaxing and contracting factors
15. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine
16. 2+ entry in human and bovine endothelial cells
17. Bioassay of prostacyclin and endothelium-derived relaxing factor (EDRF) from porcine aortic endothelial cells
18. 2+ indicators with greatly improved fluorescence properties
19. 2+] of endothelial cells in situ and relaxes porcine coronary artery
20. Intracellular calcium, currents, and stimulus-response coupling in endothelial cells
21. 2+ transients in endothelium-dependent relaxation of pig coronary artery, and effects of captopril
22. Effects of diltiazem on calcium concentration in the cytosol and on force of contractions in porcine coronary arterial strips
23. Capacitative calcium entry is inhibited in vascular endothelial cells by disruption of cytoskeletal microfilaments
24. Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide
25. Thapsigargin-induced endothelium-dependent triphasic regulation of vascular tone in the porcine renal artery
26. 2+]i in smooth muscle strips using front-surface fluorimetry
27. Endothelium-derived vasoactive factors: II. Endothelium-dependent contraction
28. 2+ entry in endothelial cell
29. Endothelium-derived hyperpolarizing factor
30. 2+ influx and protein tyrosine phosphorylation in endothelial cells is inhibited by herbimycin A
31. Role of GTP-protein and endothelium in contraction induced by ethanol in pig coronary artery
32. Mechanism of endothelium-dependent relaxation induced by substance P in the coronary artery of the pig
33. 2+ transport pathways in thymic lymphocytes by econazole, miconazole, and SKF 96365
34. Mechanism of relaxation induced by thrombin in pig coronary arterial strips with endothelium
35. 2+ transients and nitric oxide production in endothelial cells ex vivo
36. Hyperpolarization as a mechanism for endothelium-dependent relaxations in the porcine coronary artery
37. Stimulus-secretion coupling in vascular endothelial cells
38. Direct regulation of smooth muscle contractile elements by second messengers
39. Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
40. Store depletion and calcium influx
41. 2+-dependent nonselective cation pathway are discriminated by genistein in mouse pancreatic acinar cells
42. TRP, inositol 1,4,5-trisphosphate receptors, and capacitative calcium entry
43. Capacitative calcium entry channels
44. 2+ store depletion in dimethyl BAPTA-loaded human platelets increases protein tyrosin phosphorylation in the absence of a rise in cytosolic calcium
45. 2+ entry and protein-tyrosine phosphorylation are inhibited by the tyrosin kinase inhibitors genistein and methyl-2,5-dihydroxycinnamate in fura-2 loaded human platelets
46. 2+-ATPase of sarcoplasmic reticulum
47. 2+-ATPase
48. Econazole inhibits thapsigargin-induced platelet calcium influx by mechanisms other than cytochrome P-450 inhibition
49. 2+ entry in endothelial cells by myosin light-chain kinase inhibitor
50. Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells