Nuclear factor of activated T cells and early growth response-I cooperate to mediate tissue factor gene induction by vascular endothelial growth factor in endothelial cells

Thrombosis and Haemostasis

Volumn 97, Issue 6, 2007, Pages 988-997

  Schabbauer, Gernot ^a   Schweighofer, Bernhard ^a   Mechtcheriakova, Diana ^a   Lucerna, Markus ^a   Binder, Bernd R ^a   Hofer, Erhard ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

DSCR 1; EGR 1; Endothelial cells; NFAT; Tissue factor; VEGF

Indexed keywords

CALCINEURIN INHIBITOR; CALCIUM CHELATING AGENT; CYCLOSPORIN A; EARLY GROWTH RESPONSE FACTOR 1; ETHYLENE GLYCOL 1,2 BIS(2 AMINOPHENYL) ETHER N,N,N',N' TETRAACETIC ACID; MESSENGER RNA; THROMBOPLASTIN; TRANSCRIPTION FACTOR NFAT; VASCULOTROPIN;

ADENOVIRUS; ARTICLE; ASSAY; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE CONTROL; GENE INDUCTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOLECULAR INTERACTION; NEGATIVE FEEDBACK; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; SIGNAL TRANSDUCTION; UPREGULATION;

CALCINEURIN; CALCIUM; CELLS, CULTURED; CHELATING AGENTS; CYCLOSPORINE; EARLY GROWTH RESPONSE PROTEIN 1; EGTAZIC ACID; ENDOTHELIAL CELLS; EPIDERMAL GROWTH FACTOR; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MUSCLE PROTEINS; NFATC TRANSCRIPTION FACTORS; PROMOTER REGIONS (GENETICS); REPRESSOR PROTEINS; RNA, MESSENGER; SIGNAL TRANSDUCTION; THROMBOPLASTIN; TIME FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A;

EID: 34250620067     PISSN: 03406245     EISSN: None     Source Type: Journal    
DOI: 10.1160/TH07-01-0037     Document Type: Article

References (49)

1. Ferrara N, Gerber HP, LeCouter J. The biology of VEGF and its receptors. Nat Med 2003; 9: 669-676.
2. Yancopoulos GD, Davis S, Gale NW, et al. Vascular-specific growth factors and blood vessel formation. Nature 2000; 407: 242-248.
3. Carmeliet P. Angiogenesis in health and disease. Nat Med 2003; 9: 653-660.
4. Amin DN, Hida K, Bielenberg DR, et al. Tumor endothelial cells express epidermal growth factor receptor (EGFR) but not ErbB3 and are responsive to EGF and to EGFR kinase inhibitors. Cancer Res 2006; 66: 2173-2180.
5. Lucerna M, Mechtcheriakova D, Kadl A, et al. NAB2, a corepressor of EGR-1, inhibits vascular endothelial growth factor-mediated gene induction and angiogenic responses of endothelial cells. J Biol Chem 2003; 278: 11433-11440.
6. Mechtcheriakova D, Schabbauer G, Lucerna M, et al. Specificity, diversity, and convergence in VEGF and TNF-alpha signaling events leading to tissue factor up-regulation via EGR-1 in endothelial cells. Faseb J 2001; 15: 230-242.
7. Mechtcheriakova D, Wlachos A, Holzmuller H, et al. Vascular endothelial cell growth factor-induced tissue factor expression in endothelial cells is mediated by EGR-1. Blood 1999; 93: 3811-3823.
8. Martin DM, Boys CW, Ruf W. Tissue factor: molecular recognition and cofactor function. Faseb J 1995; 9: 852-859.
9. Mackman N. Role of tissue factor in hemostasis, thrombosis, and vascular development. Arterioscler Thromb Vasc Biol 2004; 24: 1015-1022.
10. Mackman N. Regulation of the tissue factor gene. Faseb J 1995; 9: 883-889.
11. Pawlinski R, Mackman N. Tissue factor, coagulation proteases, and protease-activated receptors in endotoxemia and sepsis. Crit Care Med 2004; 32: S293-297.
12. Pawlinski R, Pedersen B, Erlich J, et al. Role of tissue factor in haemostasis, thrombosis, angiogenesis and inflammation: lessons from low tissue factor mice. Thromb Haemost 2004; 92: 444-450.
13. Contrino J, Hair G, Kreutzer DL, et al. In situ detection of tissue factor in vascular endothelial cells: correlation with the malignant phenotype of human breast disease. Nat Med 1996; 2: 209-215.
14. Carmeliet P, Mackman N, Moons L, et al. Role of tissue factor in embryonic blood vessel development. Nature 1996; 383: 73-75.
15. Belting M, Dorrell MI, Sandgren S, et al. Regulation of angiogenesis by tissue factor cytoplasmic domain signaling. Nat Med 2004; 10: 502-509.
16. Chen J, Bierhaus A, Schiekofer S, et al. Tissue factor - a receptor involved in the control of cellular properties, including angiogenesis. Thromb Haemost 2001; 86: 334-345.
17. Ruf W, Mueller BM. Tissue factor in cancer angiogenesis and metastasis. Curr Opin Hematol 1996; 3: 379-384.
18. Moll T, Czyz M, Holzmuller H, et al. Regulation of the tissue factor promoter in endothelial cells. Binding of NF kappa B-, AP-1-, and Sp1-like transcription factors. J Biol Chem 1995; 270: 3849-3857.
19. Winsauer G, de Martin R. Resolution of inflammation: Intracellular feedback loops in the endothelium. Thromb Haemost 2007; 97: 364-369.
20. Wrighton CJ, Hofer-Warbinek R, Moll T, et al. Inhibition of endothelial cell activation by adenovirus-mediated expression of I kappa B alpha, an inhibitor of the transcription factor NF-kappa B. J Exp Med 1996; 183: 1013-1022.
21. Minarm T, Horiuchi K, Miura M, et al. Vascular endothelial growth factor- and thrombin-induced termination factor, Down syndrome critical region-1, attenuates endothelial cell proliferation and angiogenesis. J Biol Chem 2004; 279: 50537-50554.
22. Hesser BA, Liang XH, Camenisch G, et al. Down syndrome critical region protein 1 (DSCR1), a novel VEGF target gene that regulates expression of inflammatory markers on activated endothelial cells. Blood 2004; 104: 149-158.
23. Rothermel B, Vega RB, Yang J, et al. A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. J Biol Chem 2000; 275: 8719-8725.
24. Fuentes JJ, Genesca L, Kingsbury TJ, et al. DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. Hum Mol Genet 2000; 9: 1681-1690.
25. Vega RB, Yang J, Rothermel BA, et al. Multiple domains of MCIP1 contribute to inhibition of calcineurin activity. J Biol Chem 2002; 277: 30401-30407.
26. Lange AW, Molkentin JD, Yutzey KE. DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice. Dev Biol 2004; 266: 346-360.
27. Knappik A, Pluckthun A. An improved affinity tag based on the FLAG peptide for the detection and purification of recombinant antibody fragments. Biotechniques 1994; 17: 754-761.
28. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001; 29: e45.
29. Gruber F, Hufnagl P, Hofer-Warbinek R, et al. Direct binding of Nur77/ NAK-1 to the plasminogen activator inhibitor 1 (PAI-1) promoter regulates TNT alpha -induced PAI-1 expression. Blood 2003; 101: 3042-3048.
30. Sambrook J, Fritsch EF, Maniatis T. Molecular cloning: A laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1989.
31. Lucerna M, Pomyje J, Mechtcheriakova D, et al. Sustained expression of early growth response protein-1 blocks angiogenesis and tumor growth. Cancer Res 2006; 66: 6708-6713.
32. Kehlenbach RH, Dickmanns A, Gerace L. Nucleocytoplasmic shuttling factors including Ran and CRM1 mediate nuclear export of NFAT In vitro. J Cell Biol 1998; 141: 863-874.
33. Armesilla AL, Lorenzo E, Gomez del Arco P, et al. Vascular endothelial growth factor activates nuclear factor of activated T cells in human endothelial cells: a role for tissue factor gene expression. Mol Cell Biol 1999; 19: 2032-2043.
34. Decker EL, Nehmann N, Kampen E, et al. Early growth response proteins (EGR) and nuclear factors of activated T cells (NFAT) form heterodimers and regulate proinflammatory cytokine gene expression. Nucleic Acids Res 2003; 31: 911-921.
35. Decker EL, Skerka C, Zipfel PF. The early growth response protein (EGR-1) regulates interleukin-2 transcription by synergistic interaction with the nuclear factor of activated T cells. J Biol Chem 1998; 273: 26923-26930.
36. Fuentes JJ, Pritchard MA, Estivill X. Genomic organization, alternative splicing, and expression patterns of the DSCR1 (Down syndrome candidate region 1) gene. Genomics 1997; 44: 358-361.
37. Matsumoto T, Bohman S, Dixelius J, et al. VEGF receptor-2 Y951 signaling and a role for the adapter molecule TSAd in tumor angiogenesis. Embo J 2005; 24: 2342-2353.
38. Holmqvist K, Cross MJ, Rolny C, et al. The adaptor protein shb binds to tyrosine 1175 in vascular endothelial growth factor (VEGF) receptor-2 and regulates VEGF-dependent cellular migration. J Biol Chem 2004; 279: 22267-22275.
39. Meyer M, Clauss M, Lepple-Wienhues A, et al. A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases. Embo J 1999; 18: 363-374.
40. Clauss M, Pipp F, Issbrucker K, et al. Dissection of monocyte and endothelial activities by using VEGF-receptor specific ligands. Adv Exp Med Biol 2003; 522: 75-82.
41. Nakagawa K, Zhang Y, Tsuji H, et al. The angiogenic effect of tissue factor on tumors and wounds. Semin Thromb Hemost 1998; 24: 207-210.
42. Siegbahn A, Johnell M, Sorensen BB, et al. Regulation of chemotaxis by the cytoplasmic domain of tissue factor. Thromb Haemost 2005; 93: 27-34.
43. Takahashi T, Yamaguchi S, Chida K, et al. A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells. Embo J 2001; 20: 2768-2778.
44. Takahashi T, Ueno H, Shibuya M. VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells. Oncogene 1999; 18: 2221-2230.
45. Alfonso-Jaume MA, Mahimkar R, Lovett DH. Cooperative interactions between NFAT (nuclear factor of activated T cells) c1 and the zinc finger transcription factors Sp1/Sp3 and Egr-1 regulate MT1-MMP (membrane type 1 matrix metalloproteinase) transcription by glomerular mesangial cells. Biochem J 2004; 380: 735-747.
46. Rothermel BA, Vega RB, Williams RS. The role of modulatory calcineurin-interacting proteins in calcineurin signaling. Trends Cardiovasc Med 2003; 13: 15-21.
47. Ermak G, Harris CD, Davies KJ. The DSCR1 (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium-mediated stress damage, including transient oxidative stress. Faseb J 2002; 16: 814-824.
48. Vega RB, Rothermel BA, Weinheimer CJ, et al. Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy. Proc Natl Acad Sci USA 2003; 100: 669-674.
49. Sakurai Y, Ohgimoto K, Kataoka Y, et al. Essential role of Flk-1 (VEGF receptor 2) tyrosine residue 1173 in vasculogenesis in mice. Proc Natl Acad Sci USA 2005; 102: 1076-1081.