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Volumn 20, Issue 2, 2007, Pages 103-108

The role of metabotropic glutamate receptors in drug reward, motivation and dependence

Author keywords

[No Author keywords available]

Indexed keywords

COCAINE; GLUTAMIC ACID; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 3; METABOTROPIC RECEPTOR 5; NICOTINE; AMINO ACID RECEPTOR BLOCKING AGENT; AMINO ACID RECEPTOR STIMULATING AGENT;

EID: 34250349668     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2007.20.2.1083435     Document Type: Review
Times cited : (14)

References (38)
  • 1
    • 0032031305 scopus 로고    scopus 로고
    • Neurobiological similarities in depression and drug dependence: A self-medication hypothesis
    • Markou, A., Kosten, T.R. and Koob, G.F. Neurobiological similarities in depression and drug dependence: A self-medication hypothesis. Neuropsychopharmacology 1998, 18: 135-74.
    • (1998) Neuropsychopharmacology , vol.18 , pp. 135-174
    • Markou, A.1    Kosten, T.R.2    Koob, G.F.3
  • 2
    • 0035199891 scopus 로고    scopus 로고
    • Drug addiction, dysregulation of reward, and allostasis
    • Koob, G.F. and Le Moal, M. Drug addiction, dysregulation of reward, and allostasis. Neuropsychopharmacology 2001, 24: 97-129.
    • (2001) Neuropsychopharmacology , vol.24 , pp. 97-129
    • Koob, G.F.1    Le Moal, M.2
  • 3
    • 0004235298 scopus 로고
    • American Psychiatric Association, 4th ed. American Psychiatric Press, Washington DC
    • American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders, 4th ed. American Psychiatric Press, Washington DC, 1994.
    • (1994) Diagnostic and Statistical Manual of Mental Disorders
  • 4
    • 2142757234 scopus 로고    scopus 로고
    • The ups and downs of addiction: Role of metabotropic glutamate receptors
    • Kenny, P.J. and Markou, A. The ups and downs of addiction: Role of metabotropic glutamate receptors. Trends Pharmacol Sci 2004, 25: 265-72.
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 265-272
    • Kenny, P.J.1    Markou, A.2
  • 5
    • 0030995878 scopus 로고    scopus 로고
    • Pharmacology and functions of metabotropic glutamate receptors
    • Conn, P.J. and Pin, J.-P. Pharmacology and functions of metabotropic glutamate receptors. Annu Rev Pharmacol Toxicol 1997, 37: 205-37.
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 205-237
    • Conn, P.J.1    Pin, J.-P.2
  • 6
    • 0343933624 scopus 로고
    • Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats
    • Di Chiara, G. and Imperato, A. Drugs abused by humans preferentially increase synaptic dopamine concentrations in the mesolimbic system of freely moving rats. Proc Natl Acad Sci U S A 1988, 85: 5274-8.
    • (1988) Proc Natl Acad Sci U S A , vol.85 , pp. 5274-5278
    • Di Chiara, G.1    Imperato, A.2
  • 7
    • 14644405541 scopus 로고    scopus 로고
    • Unmanageable motivation in addiction: A pathology in prefrontal-accumbens glutamate transmission
    • Kalivas, P.W., Volkow, N. and Seamans, J. Unmanageable motivation in addiction: A pathology in prefrontal-accumbens glutamate transmission. Neuron 2005, 45: 647-50.
    • (2005) Neuron , vol.45 , pp. 647-650
    • Kalivas, P.W.1    Volkow, N.2    Seamans, J.3
  • 8
    • 0035503254 scopus 로고    scopus 로고
    • The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior
    • McFarland, K. and Kalivas, P.W. The circuitry mediating cocaine-induced reinstatement of drug-seeking behavior. J Neurosci 2001, 21: 8655-63.
    • (2001) J Neurosci , vol.21 , pp. 8655-8663
    • McFarland, K.1    Kalivas, P.W.2
  • 9
    • 0037413624 scopus 로고    scopus 로고
    • Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour
    • Sutton, M.A., Schmidt, E.F., Choi, K.-H. et al. Extinction-induced upregulation in AMPA receptors reduces cocaine-seeking behaviour. Nature 2003, 421: 70-5.
    • (2003) Nature , vol.421 , pp. 70-75
    • Sutton, M.A.1    Schmidt, E.F.2    Choi, K.-H.3
  • 10
    • 21844443565 scopus 로고    scopus 로고
    • Cystine/glutamate exhange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking
    • Moran, M.M., McFarland, K., Melendez, R.I., Kalivas, P.W. and Seamans, J.K. Cystine/glutamate exhange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking. J Neurosci 2005, 25: 6389-93.
    • (2005) J Neurosci , vol.25 , pp. 6389-6393
    • Moran, M.M.1    McFarland, K.2    Melendez, R.I.3    Kalivas, P.W.4    Seamans, J.K.5
  • 12
    • 33845195481 scopus 로고    scopus 로고
    • Nicotine dependence perpetuating tobacco smoking may be treatable by drugs acting at metabotropic glutamate receptors
    • Markou, A. Nicotine dependence perpetuating tobacco smoking may be treatable by drugs acting at metabotropic glutamate receptors. Discov Med 2004, 4: 246-54.
    • (2004) Discov Med , vol.4 , pp. 246-254
    • Markou, A.1
  • 13
    • 33845211109 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor antagonists: Novel therapeutics for nicotine dependence and depression?
    • Markou, A. Metabotropic glutamate receptor antagonists: Novel therapeutics for nicotine dependence and depression? Biol Psychiatry 2007, 61: 17-22.
    • (2007) Biol Psychiatry , vol.61 , pp. 17-22
    • Markou, A.1
  • 14
    • 0034867765 scopus 로고    scopus 로고
    • Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice
    • Chiamulera, C, Epping-Jordan, M.P., Zocchi, A. et al. Reinforcing and locomotor stimulant effects of cocaine are absent in mGluR5 null mutant mice. Nat Neurosci 2001, 4: 873-4.
    • (2001) Nat Neurosci , vol.4 , pp. 873-874
    • Chiamulera, C.1    Epping-Jordan, M.P.2    Zocchi, A.3
  • 15
    • 17744400697 scopus 로고    scopus 로고
    • Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats
    • Kenny, P.J., Boutrel, B., Gasparini, F., Koob, G.F. and Markou, A. Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats. Psychopharmacology (Berl) 2005, 179: 247-54.
    • (2005) Psychopharmacology (Berl) , vol.179 , pp. 247-254
    • Kenny, P.J.1    Boutrel, B.2    Gasparini, F.3    Koob, G.F.4    Markou, A.5
  • 16
    • 17744365745 scopus 로고    scopus 로고
    • The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats
    • Schroeder, J.P., Overstreet, D.H. and Hodge, C.W. The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats. Psychopharmacology 2005, 179: 262-70.
    • (2005) Psychopharmacology , vol.179 , pp. 262-270
    • Schroeder, J.P.1    Overstreet, D.H.2    Hodge, C.W.3
  • 17
    • 0038240644 scopus 로고    scopus 로고
    • The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice
    • Paterson, N.E., Semenova, S., Gasparini, F. and Markou, A. The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice. Psychopharmacology (Berl) 2003, 167: 257-64.
    • (2003) Psychopharmacology (Berl) , vol.167 , pp. 257-264
    • Paterson, N.E.1    Semenova, S.2    Gasparini, F.3    Markou, A.4
  • 18
    • 19244387486 scopus 로고    scopus 로고
    • Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking
    • Tessari, M., Pilla, M., Andreoli, M., Hutcheson, D.M. and Heidbreder, C.A. Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking. Eur J Pharmacol 2004, 499: 121-33.
    • (2004) Eur J Pharmacol , vol.499 , pp. 121-133
    • Tessari, M.1    Pilla, M.2    Andreoli, M.3    Hutcheson, D.M.4    Heidbreder, C.A.5
  • 19
    • 17744383991 scopus 로고    scopus 로고
    • The metabotropic glutamate 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats
    • Paterson, N.E. and Markou, A. The metabotropic glutamate 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats. Psychopharmacology (Berl) 2005, 179: 255-61.
    • (2005) Psychopharmacology (Berl) , vol.179 , pp. 255-261
    • Paterson, N.E.1    Markou, A.2
  • 21
    • 0037337238 scopus 로고    scopus 로고
    • The mGluRS antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse
    • McGeehan, A.J. and Olive, M.F. The mGluRS antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse. Synapse 2003, 47: 240-2.
    • (2003) Synapse , vol.47 , pp. 240-242
    • McGeehan, A.J.1    Olive, M.F.2
  • 22
    • 0036951025 scopus 로고    scopus 로고
    • Morphine conditioned reward is inhibited by MPEP, the mGluRS antagonist
    • Popik, P. and Wrobel, M. Morphine conditioned reward is inhibited by MPEP, the mGluRS antagonist. Neuropharmacology 2002, 43: 1210-7.
    • (2002) Neuropharmacology , vol.43 , pp. 1210-1217
    • Popik, P.1    Wrobel, M.2
  • 23
    • 4644335722 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 5 localized in the limbic forebrain is critical for the development of morphine-induced rewarding effect in mice
    • Aoki, T, Narita, M., Shibasaki, M. and Suzuki, T. Metabotropic glutamate receptor 5 localized in the limbic forebrain is critical for the development of morphine-induced rewarding effect in mice. Eur J Neurosci 2004, 20: 1633-8.
    • (2004) Eur J Neurosci , vol.20 , pp. 1633-1638
    • Aoki, T.1    Narita, M.2    Shibasaki, M.3    Suzuki, T.4
  • 24
    • 8844238423 scopus 로고    scopus 로고
    • Effects of MPEP on locomotion, sensitization an conditioned reward induced by cocaine or morphine
    • Herzig, V. and Schmidt, W.J. Effects of MPEP on locomotion, sensitization an conditioned reward induced by cocaine or morphine. Neuropharmacol 2004, 47: 973-84.
    • (2004) Neuropharmacol , vol.47 , pp. 973-984
    • Herzig, V.1    Schmidt, W.J.2
  • 25
    • 26644459703 scopus 로고    scopus 로고
    • Glutamatergic neurotransmission and protein kinase C play a role in neuron-glia communication during the development of methamphetamine-induced psychological dependence
    • Miyatake, M., Narita, M., Shibasaki, M., Nakamura, A. and Suzuki, T. Glutamatergic neurotransmission and protein kinase C play a role in neuron-glia communication during the development of methamphetamine-induced psychological dependence. Eur J Neurosci 2005, 22: 1476-88.
    • (2005) Eur J Neurosci , vol.22 , pp. 1476-1488
    • Miyatake, M.1    Narita, M.2    Shibasaki, M.3    Nakamura, A.4    Suzuki, T.5
  • 26
    • 24944590000 scopus 로고    scopus 로고
    • Effects of MPEP on expression of food-, MDMA- or amphetamine-conditioned place preference in rats
    • Herzig, V., Capuani, E.M., Kovar, K.A. and Schmidt, W.J. Effects of MPEP on expression of food-, MDMA- or amphetamine-conditioned place preference in rats. Addict Biol 2005, 10: 243-9.
    • (2005) Addict Biol , vol.10 , pp. 243-249
    • Herzig, V.1    Capuani, E.M.2    Kovar, K.A.3    Schmidt, W.J.4
  • 27
    • 33745788419 scopus 로고    scopus 로고
    • Cocaine cues and dopamine in dorsal striatum: Mechanism of craving in cocaine addiction
    • Volkow, N.D., Wang, G.J., Telang, F. et al. Cocaine cues and dopamine in dorsal striatum: Mechanism of craving in cocaine addiction. J Neurosci 2006, 26: 6583-8.
    • (2006) J Neurosci , vol.26 , pp. 6583-6588
    • Volkow, N.D.1    Wang, G.J.2    Telang, F.3
  • 28
    • 11144305241 scopus 로고    scopus 로고
    • B receptor agonist CGP44532 decreased nicotine self-administration, and acute administration decreased cue-reinstatement of nicotine-seeking in rats
    • B receptor agonist CGP44532 decreased nicotine self-administration, and acute administration decreased cue-reinstatement of nicotine-seeking in rats. Neuropsychopharmacology 2005, 30: 119-28.
    • (2005) Neuropsychopharmacology , vol.30 , pp. 119-128
    • Paterson, N.E.1    Froestl, W.2    Markou, A.3
  • 29
    • 0028953965 scopus 로고
    • Repeated administration of cocaine or amphetamine alters neuronal responses to glutamate in the mesoaccumbens dopamine system
    • White, F.J., Hu, X.T., Zhang, X.F. and Wolf, M.E. Repeated administration of cocaine or amphetamine alters neuronal responses to glutamate in the mesoaccumbens dopamine system. J Pharmacol Exp Ther 1995, 273: 445-54.
    • (1995) J Pharmacol Exp Ther , vol.273 , pp. 445-454
    • White, F.J.1    Hu, X.T.2    Zhang, X.F.3    Wolf, M.E.4
  • 30
    • 0042433248 scopus 로고    scopus 로고
    • Group II metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/eainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats
    • Kenny, P.J., Gasparini, F. and Markou, A. Group II metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/eainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats. J Pharmacol Exp Ther 2003, 306: 1068-76.
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 1068-1076
    • Kenny, P.J.1    Gasparini, F.2    Markou, A.3
  • 31
    • 0037743546 scopus 로고    scopus 로고
    • Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse
    • Baker, D.A., McFarland, K. Lake, R.W. et al. Neuroadaptations in cystine-glutamate exchange underlie cocaine relapse. Nat Neurosci 2003, 6: 743-9.
    • (2003) Nat Neurosci , vol.6 , pp. 743-749
    • Baker, D.A.1    McFarland, K.2    Lake, R.W.3
  • 32
    • 33751093065 scopus 로고    scopus 로고
    • Upregulation of ionotropic glutamate receptor subunits within specific mesocorticolimbic regions during chronic nicotine self-administration
    • in press
    • Wang, F., Chen, H., Steketee, J.D. and Sharp, B.M. Upregulation of ionotropic glutamate receptor subunits within specific mesocorticolimbic regions during chronic nicotine self-administration. Neuropsychopharmacology 2006, in press.
    • (2006) Neuropsychopharmacology
    • Wang, F.1    Chen, H.2    Steketee, J.D.3    Sharp, B.M.4
  • 33
    • 0037693859 scopus 로고    scopus 로고
    • Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug- seeking behavior
    • McFarland, K., Lapish, C.C. and Kalivas, P.W. Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug- seeking behavior. J Neurosci 2003, 23: 3531-7.
    • (2003) J Neurosci , vol.23 , pp. 3531-3537
    • McFarland, K.1    Lapish, C.C.2    Kalivas, P.W.3
  • 34
    • 2442672865 scopus 로고    scopus 로고
    • Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: Comparison between cocaine and a potent behavioral reinforcer
    • Baptista, M.A., Martin-Fardon, R. and Weiss F. Preferential effects of the metabotropic glutamate 2/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: Comparison between cocaine and a potent behavioral reinforcer. J Neurosci 2004, 24: 4723-7.
    • (2004) J Neurosci , vol.24 , pp. 4723-4727
    • Baptista, M.A.1    Martin-Fardon, R.2    Weiss, F.3
  • 35
    • 21344434071 scopus 로고    scopus 로고
    • The novel mGluR2/3 agonist LY379268 attenuates cue-induced reinstatement of heroin seeking
    • Bossert, J.M., Busch, R.F. and Gray, S.M. The novel mGluR2/3 agonist LY379268 attenuates cue-induced reinstatement of heroin seeking. Neuroreport 2005, 16: 1013-6.
    • (2005) Neuroreport , vol.16 , pp. 1013-1016
    • Bossert, J.M.1    Busch, R.F.2    Gray, S.M.3
  • 36
    • 23644451337 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue-and schedule-induced reinstatement of nicotine self-administration behavior in rats
    • Bespalov, A.Y., Dravolina, O.A., Sukhanov, I. et al. Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue-and schedule-induced reinstatement of nicotine self-administration behavior in rats. Neuropharmacology 2005, 49(Suppl. 1): 167-78.
    • (2005) Neuropharmacology , vol.49 , Issue.SUPPL. 1 , pp. 167-178
    • Bespalov, A.Y.1    Dravolina, O.A.2    Sukhanov, I.3
  • 37
    • 33645025726 scopus 로고    scopus 로고
    • Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking
    • Backstrom, P. and Hyytia, P. Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. Neuropsychopharmacology 2006, 31: 778-86.
    • (2006) Neuropsychopharmacology , vol.31 , pp. 778-786
    • Backstrom, P.1    Hyytia, P.2
  • 38
    • 17744373871 scopus 로고    scopus 로고
    • The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: A comparison
    • Ballard, T.M., Woolley, M.L., Prinssen, E., Huwyler, J., Porter, R. and Spooren, W. The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: A comparison. Psychopharmacology (Berl) 2005, 179: 218-29.
    • (2005) Psychopharmacology (Berl) , vol.179 , pp. 218-229
    • Ballard, T.M.1    Woolley, M.L.2    Prinssen, E.3    Huwyler, J.4    Porter, R.5    Spooren, W.6


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