Evidence for differential binding of isoniazid by Mycobacterium tuberculosis KatG and the isoniazid-resistant mutant KatG(S315T)

Biochemistry

Volumn 37, Issue 45, 1998, Pages 15825-15834

  Wengenack, Nancy L ^a   Todorovic, Smilja ^a,b   Yu, Lian ^a   Rusnak, Frank ^a  

^a MAYO GRADUATE SCHOOL   (United States)

^b UNIVERSITY OF BELGRADE   (Serbia)

Author keywords

[No Author keywords available]

Indexed keywords

ISONIAZID;

ANTIBIOTIC RESISTANCE; ARTICLE; CONFORMATIONAL TRANSITION; DRUG BINDING; DRUG MECHANISM; ELECTRON SPIN RESONANCE; ENZYME ACTIVE SITE; GENE DELETION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TITRIMETRY;

AMINO ACID SUBSTITUTION; BACTERIAL PROTEINS; DRUG RESISTANCE, MICROBIAL; ELECTRON SPIN RESONANCE SPECTROSCOPY; ISONIAZID; KINETICS; MAGNETIC RESONANCE SPECTROSCOPY; MUTAGENESIS, SITE-DIRECTED; MYCOBACTERIUM TUBERCULOSIS; PEROXIDASES; PROTEIN BINDING; SERINE; SPECTROPHOTOMETRY; THREONINE;

MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 0032506053     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi982023k     Document Type: Article

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