Enzyme-catalyzed mechanism of isoniazid activation in class I and class III peroxidases

Journal of Biological Chemistry

Volumn 279, Issue 37, 2004, Pages 39000-39009

  Pierattelli, Roberta ^a   Banci, Lucia ^a   Eady, Nigel A J ^b   Bodiguel, Jacques ^c   Jones, Jamie N ^b   Moody, Peter C E ^d   Raven, Emma Lloyd ^d   Jamart Grégoire, Brigitte ^c   Brown, Katherine A ^b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c LAB DE CHIM PHYS MACROMOLECULAIRE   (France)

^d UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; BACTERIA; BIOCHEMISTRY; COMPUTATIONAL METHODS; CRYSTAL STRUCTURE; ENZYMES; MOLECULAR BIOLOGY; NUCLEAR MAGNETIC RESONANCE;

ENZYME-CATALYSIS; ISONIAZID ACTIVATION; TUBERCULOSIS;

CATALYSIS;

CATALASE; CATALASE PEROXIDASE; CLASS I HEME PEROXIDASE; CLASS I PEROXIDASE; CLASS III PEROXIDASE; HEME PEROXIDASE; HORSERADISH PEROXIDASE; HORSERADISH PEROXIDASE C; ISONIAZID; PEROXIDASE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; CRYSTAL STRUCTURE; DRUG ACTIVATION; DRUG BINDING; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME METABOLISM; MODEL; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SPECTROSCOPY; STRUCTURE ACTIVITY RELATION;

ANTITUBERCULAR AGENTS; BACTERIAL PROTEINS; BINDING SITES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HEME; HORSERADISH PEROXIDASE; ISONIAZID; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; OXYGEN; PEROXIDASE; PEROXIDASES; PROTEIN BINDING; PROTEIN CONFORMATION; PROTONS; PROTOPORPHYRINS; SOFTWARE;

ARMORACIA RUSTICANA; MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 4644354071     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M402384200     Document Type: Article

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