Rapid Formation of Compound II and a Tyrosyl Radical in the Y229F Mutant of Mycobacterium tuberculosis Catalase-peroxidase Disrupts Catalase but Not Peroxidase Function

Journal of Biological Chemistry

Volumn 278, Issue 45, 2003, Pages 44121-44127

  Yu, Shengwei ^b   Girotto, Stefania ^b   Zhao, Xiangbo ^b   Magliozzo, Richard S ^a  

^a CITY UNIVERSITY OF NEW YORK   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYSIS; DISEASES; ENZYMES; FREE RADICALS; PARAMAGNETIC RESONANCE;

KINETIC COUPLING;

BIOCHEMISTRY;

3 CHLOROPERBENZOIC ACID; AMINO ACID; CATALASE; HEME DERIVATIVE; HYDROGEN PEROXIDE; MUTANT PROTEIN; OXYFERRYL HEME INTERMEDIATE; OXYFERRYL IRON PROTOPORPHYRIN IX; OXYPEROXIDASE; PERACETIC ACID; PEROXIDASE; PROTOPORPHYRIN; RADICAL; RECOMBINANT PROTEIN; TYROSINE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ARTICLE; CATALYSIS; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MECHANISM; GENE OVEREXPRESSION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; OPTICS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; SITE DIRECTED MUTAGENESIS; STEADY STATE; STOPPED FLOW METHOD; WILD TYPE;

BACTERIAL PROTEINS; CATALASE; ELECTRON SPIN RESONANCE SPECTROSCOPY; ESCHERICHIA COLI; FREE RADICALS; GENE EXPRESSION; HEME; IRON; MUTAGENESIS; MYCOBACTERIUM TUBERCULOSIS; PEROXIDASE; PEROXIDASES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; TYROSINE;

ACTINOBACTERIA (CLASS); BACTERIA (MICROORGANISMS); MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS; UNCULTURED ACTINOMYCETE;

EID: 0242497993     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M304757200     Document Type: Article

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