An EPR study of the peroxyl radicals induced by hydrogen peroxide in the haem proteins

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1546, Issue 2, 2001, Pages 365-378

  Svistunenko, Dimitri A ^a  

^a UNIVERSITY OF ESSEX   (United Kingdom)

Author keywords

Electron paramagnetic resonance; Haemoglobin; Myoglobin; Peroxide; Peroxyl; Radical; Tryptophan

Indexed keywords

HEMOGLOBIN A; HEMOGLOBIN BETA CHAIN; HEMOPROTEIN; HYDROGEN PEROXIDE; METMYOGLOBIN; OXYGEN; PEROXY RADICAL; STYRENE OXIDE; TRYPTOPHAN;

ARTICLE; CHEMICAL REACTION; CHEMICAL REACTION KINETICS; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; ELECTRON SPIN RESONANCE; HUMAN; LOW TEMPERATURE; NONHUMAN; OXIDATION; PH; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN STRUCTURE; REACTION ANALYSIS; SPECIES DIFFERENCE;

COLD; ELECTRON SPIN RESONANCE SPECTROSCOPY; HUMANS; HYDROGEN PEROXIDE; METHEMOGLOBIN; METMYOGLOBIN; MODELS, MOLECULAR; OXIDATION-REDUCTION; PEROXIDES; TRYPTOPHAN;

CETACEA; EQUUS CABALLUS; PHYSETER CATODON;

EID: 0035820321     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(01)00157-1     Document Type: Article

References (64)

1. The mechanism of metmyoglobin oxidation
2. Animo acid free radicals in oxidised metmyoglobin
3. Free radical produced in the reaction of metmyoglobin with hydrogen peroxide
4. Identification of initiating agents in myoglobin-induced lipid-peroxidation
5. Identification of a globin free radical in equine myoglobin treated with peroxides
6. Direct detection of a globin-derived radical in leghemoglobin treated with peroxides
7. Detection and reactions of the globin radical in haemoglobin
8. Reduction of ferrylmyoglobin and ferrylhemoglobin by nitric-oxide - A protective mechanism against ferryl hemoprotein-induced oxidations
9. An EPR investigation of human methaemoglobin oxidation by hydrogen peroxide: Methods to quantify all paramagnetic species observed in the reaction
10. Electron spin resonance study on peroxidase- and oxidase-reactions of horse radish peroxidase and methemoglobin
11. Electron-spin resonance-spectrum of Tyr-151 free-radical formed in reactions of sperm whale metmyoglobin with ethyl hydroperoxide and potassium iridate
12. A long-lived tyrosyl radical from the reaction between horse metmyoglobin and hydrogen peroxide
13. Location of free electrons in porphin ring complexes
14. Studies on cytochrome c peroxidase. IX. The reaction of ferrimyoglobin with hydroperoxides and a comparison of peroxide-induced compounds of ferrimyoglobin and cytochrome c peroxidase
15. 2
16. Reaction of myoglobin with hydrogen-peroxide forms a peroxyl radical which oxidizes substrates
17. A hydrogen-donating monohydroxamate scavenges ferryl myoglobin radicals
18. 2 yields persistent ferryl iron and protein based radicals
19. Peroxidation of a specific tryptophan of metmyoglobin by hydrogen peroxide
20. Direct evidence for a tyrosine radical in the reaction of cytochrome c oxidase with hydrogen peroxide
21. Myoglobin-induced oxidative damage: Evidence for radical transfer from oxidized myoglobin to other proteins and antioxidants
22. Formation of long-lived radicals on proteins by radical transfer from heme enzymes - A common process?
23. Detection of peroxyl and alkoxyl radicals produced by reaction of hydroperoxides with heme-proteins by electron-spin resonance spectroscopy
24. Electron spin resonance studies of spin-trapped free radicals produced by reaction of metmyoglobins with hydrogen peroxide
25. ESR spin-trapping studies of free-radicals generated by hydrogen-peroxide activation of metmyoglobin
26. The myoglobin-derived radical formed on reaction of metmyoglobin with hydrogen-peroxide is not a tyrosine peroxyl radical
27. Self-peroxidation of metmyoglobin results in formation of an oxygen-reactive tryptophan-centered radical
28. Site-specific spin trapping of tyrosine radicals in the oxidation of metmyoglobin by hydrogen peroxide
29. 2. Involvement of a thiyl radical produced at cysteine 110
30. Change with temperature of the ESR spectra of peroxy radicals trapped in irradiated polytetrafluoroethylene
31. Electron spin resonance spectra of peroxy radicals trapped in a γ-irradiated single crystal of trifluoroacetamide
32. E.s.r. studies of peroxy radicals in polyethylene. 1. Temperature dependence of spectra and molecular motion of radical sites
33. Analysis of the ESR spectra of irradiated liver and hepatoma specimens
34. Study of g anisotropy associated with molecular motion in the triphenylmethylperoxy radical. An environmental probe
35. Electron spin resonance studies on normal human uterus and cervix and on benign and malignant uterine tumors
36. Paramagnetic centers formed in mouse blood gamma-irradiated at 77 K
37. An ESR investigation of the reactions of glutathione, cysteine and penicillamine thiyl radicals: Competitive formation of RSO·, R·, RSSR-·, and RSS·
38. Study of lipid peroxyl radicals in urea clathrate crystals. Oxygen-17 coupling and rotational averaging
39. Application of radiation and electron spin resonance spectroscopy to the study of ferryl myoglobin
40. Characterization of enzyme-like activity of human hemoglobin. Properties of the hemoglobin-P-450 reductase-coupled aniline hydroxylase system
41. Role of NADPH and the NADPH-dependent methemoglobin reductase in the hydroxylase activity of human erythrocytes
42. The role of hemoglobin in the N-oxidation of 4-chloroaniline
43. Substrate specificity of the monooxygenase activity of hemoglobin
44. Demethylation in erythrocytes: A reaction involving hemoglobin
45. The mechanism of superoxide anion generation by the interaction of phenylhydrazine with hemoglobin
46. Styrene oxidation to styrene oxide in human blood erythrocytes and lymphocytes
47. N-Phenylprotoporphyrin IX formation in the hemoglobin-phenylhydrazine reaction. Evidence for a protein-stabilized iron-phenyl intermediate
48. Interactions of heme proteins with hydrogen peroxide: Protein crosslinking and covalent binding of benzo[a]pyrene and 17 beta-estradiol
49. Epoxidation of styrene by hemoglobin and myoglobin-transfer of oxidizing equivalents to the protein surface
50. Is hemoglobin a catalyst for sulfoxidation of chlorpromazine - An investigation with isolated purified hemoglobin and hemoglobin in monooxygenase and peroxidase mimicking systems
51. Mechanistic aspects of the oxidation of phenothiazine-derivatives by methemoglobin in the presence of hydrogen-peroxide
52. Peroxidase activity of oxyhaemoglobin in vitro
53. Initiation of membranal lipid-peroxidation by activated metmyoglobin and methemoglobin
54. Hemoglobin and myoglobin in their reactions with ligands
55. A new method for quantitation of spin concentration by EPR spectroscopy: Application to methemoglobin and metmyoglobin
56. High resolution crystal structures and comparisons of T state deoxyhaemoglobin and two liganded T-state haemoglobins: T(α-oxy)haemoglobin and T(met)haemoglobin
57. A myoglobin variant with a polar substitution in a conserved hydrophobic cluster in the heme binding pocket
58. Crystal structures of myoglobin-ligand complexes at near-atomic resolution
59. High-resolution study of the three-dimensional structure of horse heart metmyoglobin
60. New EPR methods for the study of very slow motion: Application to spin-labeled hemoglobin
61. Characterization of the rat hemoglobin thiyl free radical formed upon reaction with phenylhydrazine
62. The globin-based free radical of ferryl hemoglobin is detected in normal human blood
63. Oxidation of chlorpromazine by methemoglobin in the presence of hydrogen-peroxide-formation of chlorpromazine radical cation and its covalent binding to methemoglobin