An effector peptide from glutathione-S-transferase-pi strongly and selectively blocks mitotic signaling by oncogenic ras-p21

Protein Journal

Volumn 23, Issue 3, 2004, Pages 235-238

  Chie, Lyndon ^a,b   Adler, Victor ^a,c   Friedman, Fred K ^d   Chung, Denise ^b   Pincus, Matthew R ^a,e  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b LONG ISLAND UNIVERSITY   (United States)

^c QRNA Corporation   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

^e SUNY Downstate Medical Center   (United States)

Author keywords

Glutathione S transferase pi; GST pi peptide 34 50; Inhibition; Jun; Jun N terminal kinase; Oncogenic ras p21; Oocyte maturation

Indexed keywords

GLUTATHIONE TRANSFERASE; GLYCINE DERIVATIVE; PROTEIN P21; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; THREONYLISOLEUCYLASPARTYLTHREONYLTRYPTOPHYLMETHIONYLGLUTAMYLGLYCYLLEUCYLLEUCYLLYSYLPROLYLTHREONYLCYSTEINYLLEUCYLTYROSYLGLYCINE; UNCLASSIFIED DRUG; VALINE; GLUTATHIONE TRANSFERASE P1; ISOENZYME; PEPTIDE;

AMINO TERMINAL SEQUENCE; ARTICLE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; MITOGENESIS; MITOSIS RATE; NONHUMAN; ONCOGENE RAS; OOCYTE MATURATION; PROTEIN DOMAIN; SIGNAL TRANSDUCTION; ANIMAL; DRUG ANTAGONISM; FEMALE; METABOLISM; MITOSIS; NEOPLASM; OOCYTE; PHYSIOLOGY; XENOPUS;

ANIMALS; FEMALE; GLUTATHIONE S-TRANSFERASE PI; GLUTATHIONE TRANSFERASE; ISOENZYMES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MITOSIS; NEOPLASMS; ONCOGENE PROTEIN P21(RAS); OOCYTES; PEPTIDES; SIGNAL TRANSDUCTION; XENOPUS;

EID: 16544370500     PISSN: 15723887     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:JOPC.0000026419.54902.bb     Document Type: Article

References (18)

1. Adler, V. and Pincus, M. R. (2003) Ann. Clin. Lab. Sci. 34: 35-46.
2. Adler, V., Pincus, M. R., Brandt-Rauf, P. W., and Ronai, Z. (1995). Proc. Natl. Acad. Sci. U. S. A. 92: 10585-10589.
3. Adler, V., Pincus, M. R., Polotskaya, A., Montano, X., Friedman, F., and Ronai, Z. (1996). J. Biol Chem. 271: 23304-23309.
4. Adler, V., Yin, Z., Fuchs, S., Benezra, M., Rosario, L., Tew, K., et al. (1999). EMBO J. 18: 1321-1334.
5. Amar, S., Glozman, A., Chung, D. L., Alder, V., Ronai, Z., Friedman, F., et al. (1997). Cancer Chemother. Pharmacol. 41: 79-85.
6. Barbacid, M. (1987). Ann. Rev. Biochem. 56: 779-827.
7. Birchmeier, C., Broek, D., and Wigler, M. (1985). Cell 43: 615-621.
8. Deshpande, A. K. and Kung, H-F. (1987). Mol. Cell. Biol. 7: 1285-1288.
9. Chie, L., Friedman, F. K., Duncan, T., Chen, J. M., Chung, D. L., and Pincus, M. R. (2004) Protein J. 23: 229-234.
10. Flatgaard, J. F., Bauer, K. F., and Kauvar, K. M. (1993). Cancer Chemother. Pharmacol. 33: 63-70.
11. Kanovsky, M., Michl, J., Botzolaki, G., Morin, J., Kovac, C., Chung, D. L., et al. (2003). Cancer Chemother. Pharmacol. 52: 202-208.
12. Karin, M. (1995). J. Biol. Chem. 270: 16483-16486.
13. Miura, K., Inouye, Y., Nakamori, H., Iwai, S., Ohtsuka, F., Ikehara, M., et al. (1986). Jpn. J. Cancer Res. (Gann) 77: 45-51.
14. Monaco, R., Friedman, F. K., Hyde, M. J., Chen, J. M., Manolatus, S., Adler, V., et al. (2000). J. Protein Chem. 18: 859-866.
15. Pincus, M. R., Brandt-Rauf, P. W., Michl, J., and Friedman, F. K. (2000). Cancer Invest. 46: 35-53.
16. Pincus, M. R., Brandt-Rauf, P. W., Koslosky, W., and Appruzzese (2001) In: Henry, J. B. (ed.), Clinical Diagnosis and Management by Laboratory Methods, Nineteenth Edition, W. B. Saunders, Philadelphia, pp. 1344-1354.
17. Ranginwale, M., Smith, S., Flom, J., Chie, L., Kanovsky, M., Chung, D., et al. (2001). Exp. Cell Res. 269: 162-169.
18. Villafania, A., Anwar, K., Amar, S., Chung, D., Adler, V., Ronai, Z., et al. (1999). Ann. Clin. Lab. Sci. 30: 61-68.