Relationship between cytocidal activity and glutathione-S-transferase inhibition using doxorubicin coupled to stereoisomers of glutathione with different substrate specificity

Anti-Cancer Drugs

Volumn 12, Issue 6, 2001, Pages 549-554

  Hashizume, Yukio ^a   Asakura, Tadashi ^a   Oikawa, Tadao ^b   Yamauchi, Takahiro ^b   Soda, Kenji ^b   Ohkawa, Kiyoshi ^a  

^a JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b KANSAI UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cytotoxicity; Glutathione doxorubicin conjugate; Glutathione S transferase; Stereoisomer of glutathione

Indexed keywords

DOXORUBICIN; GLUTATHIONE TRANSFERASE; GLYCOPROTEIN P; SERUM ALBUMIN;

ARTICLE; BINDING SITE; CANCER CHEMOTHERAPY; CYTOTOXICITY; DETOXIFICATION; DRUG POTENCY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME SPECIFICITY; MULTIDRUG RESISTANCE; PHENOTYPE; PRIORITY JOURNAL; STEREOISOMERISM;

ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING SITES; CASPASE 3; CASPASES; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; ENZYME INHIBITORS; GLUTATHIONE; GLUTATHIONE TRANSFERASE; RATS; STEREOISOMERISM; SUBSTRATE SPECIFICITY; TUMOR CELLS, CULTURED;

EID: 0034928653     PISSN: 09594973     EISSN: None     Source Type: Journal    
DOI: 10.1097/00001813-200107000-00009     Document Type: Article

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