Synthesis, 3D-QSAR, and docking studies of 1-phenyl-1H-1,2,3-triazoles as selective antagonists for β3 over α1β2γ2 GABA receptors

Bioorganic and Medicinal Chemistry

Volumn 15, Issue 15, 2007, Pages 5090-5104

  Alam, Mohammad Sayed ^a   Huang, Jia ^a   Ozoe, Fumiyo ^a   Matsumura, Fumio ^b   Ozoe, Yoshihisa ^a  

^a SHIMANE UNIVERSITY   (Japan)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

3D QSAR; Antagonist; GABA receptor; Homology model; Phenyltriazoles

Indexed keywords

1 (2,6 DIBROMO 4 TRIFLUOROMETHYLPHENYL) 5 METHYL 4 PROPYL 1H 1,2,3 TRIAZOLE; 1 (2,6 DICHLORO 4 TRIFLUOROMETHYLPHENYL) 4 ETHYL 5 METHYL 1H 1,2,3 TRIAZOLE; 1 (2,6 DICHLORO 4 TRIFLUOROMETHYLPHENYL) 4 ETHYL 5 PROPYL 1H 1,2,3 TRIAZOLE; 1 (2,6 DICHLORO 4 TRIFLUOROMETHYLPHENYL) 4 HYDROXYMETHYL 5 PROPYL 1H 1,2,3 TRIAZOLE; 1 (2,6 DICHLORO 4 TRIFLUOROMETHYLPHENYL) 4 METHYL 5 PROPYL 1H 1,2,3 TRIAZOLE; 1 (2,6 DICHLORO 4 TRIFLUOROMETHYLPHENYL) 4,5 DIETHYL 1H 1,2,3 TRIAZOLE; 1 (2,6 DICHLORO 4 TRIFLUOROMETHYLPHENYL) 4,5 DIPROPYL 1H 1,2,3 TRIAZOLE; 1 (2,6 DICHLORO 4 TRIFLUOROMETHYLPHENYL) 5 ETHYL 4 METHYL 1H 1,2,3 TRIAZOLE; 1 (2,6 DICHLORO 4 TRIFLUOROMETHYLPHENYL) 5 ETHYL 4 PROPYL 1H 1,2,3 TRIAZOLE; 1 (2,6 DICHLORO 4 TRIFLUOROMETHYLPHENYL) 5 HYDROXYMETHYL 4 PROPYL 1H 1,2,3 TRIAZOLE; 1 (2,6 DICHLORO 4 TRIFLUOROMETHYLPHENYL) 5 METHYL 4 PROPYL 1H 1,2,3 TRIAZOLE; 4 AMINOBUTYRIC ACID RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR BLOCKING AGENT; 4 CHLOROMETHYL 1 (2,6 DICHLORO 4 TRIFLUOROMETHYLPHENYL) 5 PROPYL 1H 1,2,3 TRIAZOLE; 4' ETHYNYL 4 PROPYLBICYCLOORTHOBENZOATE; 5 CHLOROMETHYL 1 (2,6 DICHLORO 4 TRIFLUOROMETHYLPHENYL) 4 PROPYL 1H 1,2,3 TRIAZOLE; BENZENE; BENZOIC ACID DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING SITE; COMPARATIVE STUDY; CONTROLLED STUDY; ELECTROCHEMICAL ANALYSIS; EMBRYO; HOUSE FLY; HUMAN; HUMAN CELL; HYDROPHOBICITY; INSECT; INSECTICIDAL ACTIVITY; LD 50; NONHUMAN; NUCLEOTIDE SEQUENCE; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RECEPTOR BLOCKING; SEQUENCE HOMOLOGY; SYNTHESIS;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; GABA ANTAGONISTS; HOUSEFLIES; INSECTICIDES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; TRIAZOLES;

HEXAPODA;

EID: 34249936082     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.05.039     Document Type: Article

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