New isomeric azine-bridged dinuclear platinum(II) complexes circumvent cross-resistance to cisplatin

Journal of Medicinal Chemistry

Volumn 46, Issue 7, 2003, Pages 1210-1219

  Komeda, Seiji ^a   Kalayda, Ganna V ^a   Lutz, Martin ^b   Spek, Anthony L ^b   Yamanaka, Yasuyuki ^c   Sato, Takaji ^c   Chikuma, Masahiko ^c   Reedijk, Jan ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CHLORIDE; CISPLATIN; GUANOSINE PHOSPHATE; LIGAND; NITRATE; PLATINUM COMPLEX; PYRAZINE; PYRIMIDINE;

ARTICLE; CHEMICAL REACTION; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG CROSS REACTIVITY; DRUG SYNTHESIS; ISOMERISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE; X RAY CRYSTALLOGRAPHY;

5'-GUANYLIC ACID; ANIMALS; ANTINEOPLASTIC AGENTS; CISPLATIN; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; HYDROGEN-ION CONCENTRATION; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MICE; PLATINUM COMPOUNDS; PYRAZINES; PYRIDAZINES; PYRIMIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

EID: 0037468911     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020004+     Document Type: Article

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