Update of the preclinical situation of anticancer platinum complexes: Novel design strategies and innovative analytical approaches

Current Medicinal Chemistry

Volumn 12, Issue 18, 2005, Pages 2075-2094

  Galanski, Markus ^a   Jakupec, Michael A ^a   Keppler, Bernhard K ^a  

^a UNIVERSITY OF VIENNA   (Austria)

Author keywords

Anticancer activity; Mechanism of action; Medicinal chemistry; Platinum complexes; Structure activity relationships; Synthesis

Indexed keywords

AMMINEDICHLORO(2 METHYLPYRIDINE)PLATINUM; ANTINEOPLASTIC AGENT; AP 5280; AP 5346; BBR 3005; BBR 3464; BLEOMYCIN; CARBOPLATIN; CISPLATIN; DNA; EPTAPLATIN; ETOPOSIDE; FLUOROURACIL; FOLINIC ACID; GUANOSINE PHOSPHATE; HYDROXYTAMOXIFEN; IPROPLATIN; LOBAPLATIN; NEDAPLATIN; NX 473; OXALIPLATIN; PLATINUM 1,2 DIAMINOCYCLOHEXANE BISNEODECANOATE; PLATINUM COMPLEX; PLATINUM DERIVATIVE; PORPHYRIN DERIVATIVE; PREDNISONE; SATRAPLATIN; SM 11355; TAMOXIFEN; TETRAPLATIN; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ABSORPTION SPECTROSCOPY; ANALYTIC METHOD; ANTINEOPLASTIC ACTIVITY; BIOLOGICAL ACTIVITY; BLADDER CANCER; BLOOD TOXICITY; BONE MARROW SUPPRESSION; BONE MARROW TOXICITY; CANCER INHIBITION; CAPILLARY ELECTROPHORESIS; CHINA; CLINICAL TRIAL; COLORECTAL CANCER; DIARRHEA; DNA ADDUCT; DRUG APPROVAL; DRUG CLASSIFICATION; DRUG CLEARANCE; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DESIGN; DRUG DETERMINATION; DRUG DETOXIFICATION; DRUG DISTRIBUTION; DRUG MECHANISM; DRUG POTENCY; DRUG RESEARCH; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TOLERABILITY; DRUG UPTAKE; ESOPHAGUS CANCER; GASTROINTESTINAL SYMPTOM; GASTROINTESTINAL TOXICITY; GERM CELL TUMOR; HEAD AND NECK CANCER; HIGH THROUGHPUT SCREENING; HUMAN; HYPERSENSITIVITY REACTION; IC 50; IN VITRO STUDY; IN VIVO STUDY; INORGANIC CHEMISTRY; JAPAN; LEUKOPENIA; LIVER TOXICITY; LOW TEMPERATURE PROCEDURES; LUNG CANCER; NAUSEA AND VOMITING; NEPHROTOXICITY; NEUROTOXICITY; NEUTROPENIA; NONHUMAN; OTOTOXICITY; REVIEW; ROENTGEN SPECTROSCOPY; SOLID PHASE SYNTHESIS; SOLID TUMOR; SOUTH KOREA; STRUCTURE ACTIVITY RELATION; SYNCHROTRON RADIATION; THROMBOCYTOPENIA; TUMOR RESISTANCE; UTERINE CERVIX CANCER;

ANTINEOPLASTIC AGENTS; CLINICAL TRIALS; DATABASES; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ELECTROPHORESIS, CAPILLARY; HUMANS; MASS SPECTROMETRY; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; NEOPLASMS; PLATINUM COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 23244459221     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867054637626     Document Type: Review

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