Selective binding of the truncated form of the chemokine CKβ8 (25-99) to CC chemokine receptor 1 (CCR1)

Biochemical Pharmacology

Volumn 59, Issue 5, 2000, Pages 591-596

  Berkhout, Theo A ^a   Gohil, Jayneeta ^a   Gonzalez, Pilar ^a   Nicols, Charlotte L ^a   Moores, Kitty E ^a   MacPhee, Colin H ^a   White, John R ^b   Groot, Pieter H E ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b Molecular Immunology Department   (United States)

Author keywords

Chemokine; Chemokine receptor; CK 8; Human CC chemokine receptor 1 (CCR1); Ligand binding; Monocytes

Indexed keywords

BETA CHEMOKINE; CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CCR 1; IODINE 125; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; RANTES; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; CELL MEMBRANE; CHO CELL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SELECTIVITY; HUMAN; HUMAN CELL; LIGAND BINDING; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING;

ANIMALS; BINDING, COMPETITIVE; CHEMOKINES, CC; CHO CELLS; CRICETINAE; HUMANS; IODINE RADIOISOTOPES; MONOCYTES; PEPTIDES; RECEPTORS, CHEMOKINE; TRANSFECTION;

EID: 0033985115     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(99)00354-8     Document Type: Article

References (20)

1. Baggiolini M. Chemokines and leukocyte traffic. Nature. 392:1998;565-568.
2. Legler D.F., Loetscher M., Roos R.S., Clark-Lewis I., Baggiolini M., Moser B. B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J Exp Med. 187:1998;655-660.
3. Kelner G.S., Kennedy J., Bacon K.B., Kleyensteuber S., Largaespada D.A., Jenkins N.A., Copeland N.G., Bazan J.F., Moore K.W., Schall T.J. Lymphotactin A cytokine that represents a new class of chemokine . Science. 266:1994;1395-1399.
4. Kennedy J., Kelner G.S., Kleyensteuber S., Schall T.J., Weiss M.C., Yssel H., Schneider P.V., Cocks B.G., Bacon K.B., Zlotnik A. Molecular cloning and functional characterization of human lymphotactin. J Immunol. 155:1995;203-209.
5. Yoshida T., Imai T., Kakizaki M., Nishimura M., Takagi S., Yoshie O. Identification of single C motif-1/lymphotactin receptor XCR1. J Biol Chem. 273:1998;16551-16554.
6. Pan Y., Lloyd C., Zhou H., Dolich S., Deeds J., Gonzalo J.A., Vath J., Gosselin M., Ma J.Y., Dussault B., Woolf E., Alperin G., Culpepper J., Gutierrezramos J.C., Gearing D. Neurotactin, a membrane-anchored chemokine up-regulated in brain inflammation. Nature. 387:1997;611-617.
7. Schall T. Fractalkine - A strange attractor in the chemokine landscape. Immunol Today. 18:1997;147.
8. 3CR1, which mediates both leukocyte migration and adhesion. Cell. 91:1997;521-530.
9. Patel V.P., Kreider B.L., Li Y.L., Li H.D., Leung K., Salcedo T., Nardelli B., Pippalla V., Gentz S., Thotakura R., Parmelee D., Gentz R., Garotta G. Molecular and functional characterization of 2 novel human C-C chemokines as inhibitors of 2 distinct classes of myeloid progenitors. J Exp Med. 185:1997;1163-1172.
10. Youn B.S., Zhang S.M., Lee E.K., Park D.H., Broxmeyer H.E., Murphy P.M., Locati M., Pease J.E., Kim K.K., Antol K., Kwon B.S. Molecular cloning of leukotactin-1 A novel human beta-chemokine, a chemoattractant for neutrophils, monocytes, and lymphocytes, and a potent agonist at CC chemokine receptors 1 and 3 . J Immunol. 159:1997;5201-5205.
11. Youn B.S., Zhang S.M., Broxmeyer H.E., Cooper S., Antol K., Fraser M., Kwon B.S. Characterization of CKbeta8 and CKbeta8-1 Two alternatively spliced forms of human beta-chemokine, chemoattractants for neutrophils, monocytes, and lymphocytes, and potent agonists at CC chemokine receptor 1 . Blood. 91:1998;3118-3126.
12. Youn B.S., Zhang S., Broxmeyer H.E., Antol K., Fraser M.J. Jr, Hangoc G., Kwon B.S. Isolation and characterization of LMC, a novel lymphocyte and monocyte chemoattractant human CC chemokine, with myelosuppressive activity. Biochem Biophys Res Commun. 247:1998;217-222.
13. Forssmann U., Delgado M.B., Uguccioni M., Loetscher P., Garotta G., Baggiolini M. Ckbeta8, a novel CC chemokine that predominantly acts on monocytes. FEBS Lett. 408:1997;211-216.
14. Macphee C.H., Appelbaum E.R., Johanson K., Moores K.E., Imburgia C.S., Fornwald J., Berkhout T., Brawner M., Groot P.E., O'Donnell K., O'Shannessy D., Scott G., White J.R. Identification of a truncated form of the CC chemokine ck-beta-8 demonstrating greatly enhanced biological activity. J Immunol. 161:1998;6273-6279.
15. Berkhout T.A., Sarau H.M., Moores K., White J.R., Elshourbagy N., Appelbaum E., Reape R.J., Brawner M., Makwana J., Foley J.J., Schmidt D.B., Imburgia C., McNulty D., Matthews J., O'Donnell K., O'Shannessy D., Scott M., Groot P.E., Macphee C. Cloning, in vitro expression, and functional characterization of a novel human CC chemokine of the monocyte chemotactic protein (MCP) family (MCP-4) that binds and signals through the CC chemokine receptor 2B. J Biol Chem. 272:1997;16404-16413.
16. Wang J.M., McVicar D.W., Oppenheim J.J., Kelvin D.J. Identification of RANTES receptors on human monocytic cells Competition for binding and desensitization by homologous chemotactic cytokines . J Exp Med. 177:1993;699-705.
17. Hastrup H., Schwartz T.W. Septide and neurokinin A are high-affinity ligands on the NK-1 receptor Evidence from homologous versus heterologous binding analysis . FEBS Lett. 399:1996;264-266.
18. Proudfoot A.E., Power C.A., Hoogewerf A., Montjovent M.O., Borlat F., Wells T.N. Characterisation of the RANTES/MIP-1 alpha receptor (CC CKR-1) stably transfected in HEK 293 cells and the recombinant ligands. FEBS Lett. 376:1995;19-23.
19. Keane M.P., Arenberg D.A., Moore B.B., Addison C.L., Strieter R.M. CXC chemokines and angiogenesis/angiostasis. Proc Assoc Am Physicians. 110:1998;288-296.
20. Wells T.N., Peitsch M.C. The chemokine information source Identification and characterization of novel chemokines using the WorldWideWeb and expressed sequence tag databases . J Leukoc Biol. 61:1997;545-550.