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Volumn 13, Issue 9, 2007, Pages 2758-2767

Targeted and untargeted CD137L fusion proteins for the immunotherapy of experimental solid tumors

Author keywords

[No Author keywords available]

Indexed keywords

CD137 AGONIST ANTIBODY 2A; HYBRID PROTEIN; PROTEIN ANTIBODY; PROTEIN CD137L; UNCLASSIFIED DRUG;

EID: 34249067482     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-06-2343     Document Type: Article
Times cited : (43)

References (55)
  • 1
    • 33746092947 scopus 로고    scopus 로고
    • Immune suppression in the tumor microenvironment
    • Gajewski TF, Meng Y, Harlin H. Immune suppression in the tumor microenvironment. J Immunother 2006; 29:233-40.
    • (2006) J Immunother , vol.29 , pp. 233-240
    • Gajewski, T.F.1    Meng, Y.2    Harlin, H.3
  • 2
    • 0032477815 scopus 로고    scopus 로고
    • Induction of antigen-specific T cell anergy: An early event in the course of tumor progression
    • O'Carroll KS, Sotomayor E, Montgomery J, et al. Induction of antigen-specific T cell anergy: an early event in the course of tumor progression. Proc Natl Acad Sci U S A 1998;95:1178-83.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , pp. 1178-1183
    • O'Carroll, K.S.1    Sotomayor, E.2    Montgomery, J.3
  • 3
    • 4744355872 scopus 로고    scopus 로고
    • Escape from immunotherapy: Possible mechanisms that influence tumor regression/progression
    • Ahmad M, Rees RC, Ali SA. Escape from immunotherapy: Possible mechanisms that influence tumor regression/progression. Cancer Immunol Immunother 2004;53:844-54.
    • (2004) Cancer Immunol Immunother , vol.53 , pp. 844-854
    • Ahmad, M.1    Rees, R.C.2    Ali, S.A.3
  • 4
    • 16844379997 scopus 로고    scopus 로고
    • Immunosuppressive networks in the tumour environment and their therapeutic relevance
    • Zou W. Immunosuppressive networks in the tumour environment and their therapeutic relevance. Nat Rev Cancer 2005;5:263-74.
    • (2005) Nat Rev Cancer , vol.5 , pp. 263-274
    • Zou, W.1
  • 5
    • 0033524482 scopus 로고    scopus 로고
    • A two-step, two signal model for the primary activation of precursor helper T cells
    • Bretscher PA. A two-step, two signal model for the primary activation of precursor helper T cells. Proc Natl Acad Sci U S A 1999;96:185-90.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 185-190
    • Bretscher, P.A.1
  • 8
    • 0032374052 scopus 로고    scopus 로고
    • Role of 4-1BB in immune responses
    • Vinay DS, Kwon BS. Role of 4-1BB in immune responses. Semin Immunol 1998;10:481-9.
    • (1998) Semin Immunol , vol.10 , pp. 481-489
    • Vinay, D.S.1    Kwon, B.S.2
  • 9
    • 17644389199 scopus 로고    scopus 로고
    • Watts TH. TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol 2005;23:23-8.
    • Watts TH. TNF/TNFR family members in costimulation of T cell responses. Annu Rev Immunol 2005;23:23-8.
  • 10
    • 0027365746 scopus 로고
    • Molecular cloning of a ligand for the inducible T cell gene 4-1BB: A member of an emerging family of cytokines with homology to tumor necrosis factor
    • Goodwin RG, Din WS, Davis-Smith T, et al. Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur J Immunol 1993;23:2631-41.
    • (1993) Eur J Immunol , vol.23 , pp. 2631-2641
    • Goodwin, R.G.1    Din, W.S.2    Davis-Smith, T.3
  • 11
    • 0029819204 scopus 로고    scopus 로고
    • Structural and biological features of the TNF receptor and TNF ligand superfamilies: Interactive signals in the pathobiology of Hodgkin's disease
    • Gruss HJ, Duyster J, Herrmann F. Structural and biological features of the TNF receptor and TNF ligand superfamilies: interactive signals in the pathobiology of Hodgkin's disease. Ann Oncol 1996;7:19-26.
    • (1996) Ann Oncol , vol.7 , pp. 19-26
    • Gruss, H.J.1    Duyster, J.2    Herrmann, F.3
  • 12
    • 0028330326 scopus 로고
    • Genomic organization and chromosomal localization of the T-cell antigen 4-1BB
    • Kwon BS, Kozak CA, Kim KK, Pickard RT. Genomic organization and chromosomal localization of the T-cell antigen 4-1BB. J Immunol 1994;152:2256-62.
    • (1994) J Immunol , vol.152 , pp. 2256-2262
    • Kwon, B.S.1    Kozak, C.A.2    Kim, K.K.3    Pickard, R.T.4
  • 13
    • 0344247505 scopus 로고
    • cDNA sequences of two inducible T-cell genes
    • Kwon BS, Weissman SM. cDNA sequences of two inducible T-cell genes. Proc Natl Acad Sci U S A 1989; 86:1963-7.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 1963-1967
    • Kwon, B.S.1    Weissman, S.M.2
  • 14
    • 0028899550 scopus 로고
    • ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages
    • Schwarz H, Valbracht J, Tuckwell J, von Kempis J, Lotz M. ILA, the human 4-1BB homologue, is inducible in lymphoid and other cell lineages. Blood 1995; 85:1043-52.
    • (1995) Blood , vol.85 , pp. 1043-1052
    • Schwarz, H.1    Valbracht, J.2    Tuckwell, J.3    von Kempis, J.4    Lotz, M.5
  • 15
    • 20244386539 scopus 로고
    • Molecular and biological characterization of human 4-1BB and its ligand
    • Alderson MR, Smith CA, Tough TW, et al. Molecular and biological characterization of human 4-1BB and its ligand. Eur J Immunol 1994;24:2219-27.
    • (1994) Eur J Immunol , vol.24 , pp. 2219-2227
    • Alderson, M.R.1    Smith, C.A.2    Tough, T.W.3
  • 16
    • 0036199305 scopus 로고    scopus 로고
    • Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells
    • Futagawa T, Akiba H, Kodama T, et al. Expression and function of 4-1BB and 4-1BB ligand on murine dendritic cells. Int Immunol 2002;14:275-86.
    • (2002) Int Immunol , vol.14 , pp. 275-286
    • Futagawa, T.1    Akiba, H.2    Kodama, T.3
  • 17
    • 0028009709 scopus 로고
    • 4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-mu-primed splenic B cells
    • Pollok KE, Kim YJ, Hurtado J, Zhou Z, Kim KK, Kwon BS. 4-1BB T-cell antigen binds to mature B cells and macrophages, and costimulates anti-mu-primed splenic B cells. Eur J Immunol 1994;24:367-74.
    • (1994) Eur J Immunol , vol.24 , pp. 367-374
    • Pollok, K.E.1    Kim, Y.J.2    Hurtado, J.3    Zhou, Z.4    Kim, K.K.5    Kwon, B.S.6
  • 18
    • 0035423265 scopus 로고    scopus 로고
    • 4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy
    • Cannons JL, Lau P, Ghumman B, et al. 4-1BB ligand induces cell division, sustains survival, and enhances effector function of CD4 and CD8 T cells with similar efficacy. J Immunol 2001;167:1313-24.
    • (2001) J Immunol , vol.167 , pp. 1313-1324
    • Cannons, J.L.1    Lau, P.2    Ghumman, B.3
  • 20
    • 0041975924 scopus 로고    scopus 로고
    • 4-1BB enhances CD8+ T cell expansion by regulating cell cycle progression through changes in expression of cyclins D and E and cyclin-dependent kinase inhibitor p27kip1
    • Lee HW, Nam KO, Park SJ, Kwon BS. 4-1BB enhances CD8+ T cell expansion by regulating cell cycle progression through changes in expression of cyclins D and E and cyclin-dependent kinase inhibitor p27kip1. Eur J Immunol 2003;33:2133-41.
    • (2003) Eur J Immunol , vol.33 , pp. 2133-2141
    • Lee, H.W.1    Nam, K.O.2    Park, S.J.3    Kwon, B.S.4
  • 21
    • 0030845586 scopus 로고    scopus 로고
    • 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses
    • Shuford WW, Klussman K, Tritchler DD, et al. 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses. J Exp Med 1997;186:47-55.
    • (1997) J Exp Med , vol.186 , pp. 47-55
    • Shuford, W.W.1    Klussman, K.2    Tritchler, D.D.3
  • 22
    • 0036175995 scopus 로고    scopus 로고
    • 4-1BB (CD137) controls the clonal expansion and survival of CD8 T cells in vivo but does not contribute to the development of cytotoxicity
    • Cooper D, Bansal-Pakala P, Croft M. 4-1BB (CD137) controls the clonal expansion and survival of CD8 T cells in vivo but does not contribute to the development of cytotoxicity. Eur J Immunol 2002;32: 521-9.
    • (2002) Eur J Immunol , vol.32 , pp. 521-529
    • Cooper, D.1    Bansal-Pakala, P.2    Croft, M.3
  • 23
    • 0037090182 scopus 로고    scopus 로고
    • In vivo triggering through 4-1BB enables Th-independent priming of CTL in the presence of an intact CD28 costimulatory pathway
    • Diehl L, van Mierlo GJ, den Boer AT, et al. In vivo triggering through 4-1BB enables Th-independent priming of CTL in the presence of an intact CD28 costimulatory pathway. J Immunol 2002;168:3755-62.
    • (2002) J Immunol , vol.168 , pp. 3755-3762
    • Diehl, L.1    van Mierlo, G.J.2    den Boer, A.T.3
  • 24
    • 0031906785 scopus 로고    scopus 로고
    • Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: Synergy with the CD28 co-stimulatory pathway
    • Melero I, Bach N, Hellstrom KE, Aruffo A, Mittler RS, Chen L. Amplification of tumor immunity by gene transfer of the co-stimulatory 4-1BB ligand: synergy with the CD28 co-stimulatory pathway. Eur J Immunol 1998;28:1116-21.
    • (1998) Eur J Immunol , vol.28 , pp. 1116-1121
    • Melero, I.1    Bach, N.2    Hellstrom, K.E.3    Aruffo, A.4    Mittler, R.S.5    Chen, L.6
  • 25
    • 0031007143 scopus 로고    scopus 로고
    • Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors
    • Melero I, Shuford WW, Newby SA, et al. Monoclonal antibodies against the 4-1BB T-cell activation molecule eradicate established tumors. Nat Med 1997;3:682-5.
    • (1997) Nat Med , vol.3 , pp. 682-685
    • Melero, I.1    Shuford, W.W.2    Newby, S.A.3
  • 26
    • 0034536944 scopus 로고    scopus 로고
    • + murine squamous cell carcinoma and the requirements of co-stimulatory molecules on tumour and host cells
    • + murine squamous cell carcinoma and the requirements of co-stimulatory molecules on tumour and host cells. Immunology 2000;101:541-7.
    • (2000) Immunology , vol.101 , pp. 541-547
    • Mogi, S.1    Sakurai, J.2    Kohsaka, T.3
  • 27
    • 0036195860 scopus 로고    scopus 로고
    • Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors
    • Wilcox RA, Flies DB, Zhu G, et al. Provision of antigen and CD137 signaling breaks immunological ignorance, promoting regression of poorly immunogenic tumors. J Clin Invest 2002;109:651-9.
    • (2002) J Clin Invest , vol.109 , pp. 651-659
    • Wilcox, R.A.1    Flies, D.B.2    Zhu, G.3
  • 29
    • 0037108355 scopus 로고    scopus 로고
    • + cytolytic T cells and responsiveness to IL-2 but not cytolytic activity
    • + cytolytic T cells and responsiveness to IL-2 but not cytolytic activity. J Immunol 2002;169:4230-6.
    • (2002) J Immunol , vol.169 , pp. 4230-4236
    • Wilcox, R.A.1    Tamada, K.2    Strome, S.E.3    Chen, L.4
  • 30
    • 2342604967 scopus 로고    scopus 로고
    • Murine CD8 lymphocyte expansion in vitro by artificial antigen-presenting cells expressing CD137L (4-1BBL) is superior to CD28, and CD137L expressed on neuroblastoma expands CD8 tumour-reactive effector cells in vivo
    • Yan X, Johnson BD, Orentas RJ. Murine CD8 lymphocyte expansion in vitro by artificial antigen-presenting cells expressing CD137L (4-1BBL) is superior to CD28, and CD137L expressed on neuroblastoma expands CD8 tumour-reactive effector cells in vivo. Immunology 2004;112:105-16.
    • (2004) Immunology , vol.112 , pp. 105-116
    • Yan, X.1    Johnson, B.D.2    Orentas, R.J.3
  • 31
    • 1542787537 scopus 로고    scopus 로고
    • Tumor expression of 4-1BB ligand sustains tumor lytic T cells
    • Zhang H, Merchant MS, Chua KS, et al. Tumor expression of 4-1BB ligand sustains tumor lytic T cells. Cancer Biol Ther 2003;2:579-86.
    • (2003) Cancer Biol Ther , vol.2 , pp. 579-586
    • Zhang, H.1    Merchant, M.S.2    Chua, K.S.3
  • 35
    • 17444421193 scopus 로고    scopus 로고
    • Costimulation by CD137/4-1BB inhibits T cell apoptosis and induces Bcl-xL and c-FLIP (short) via phosphatidylinositol 3-kinase and AKT/protein kinase B
    • Starck L, Scholz C, Dorken B, Daniel PT. Costimulation by CD137/4-1BB inhibits T cell apoptosis and induces Bcl-xL and c-FLIP (short) via phosphatidylinositol 3-kinase and AKT/protein kinase B. Eur J Immunol 2005;35:1257-66.
    • (2005) Eur J Immunol , vol.35 , pp. 1257-1266
    • Starck, L.1    Scholz, C.2    Dorken, B.3    Daniel, P.T.4
  • 36
    • 0033560179 scopus 로고    scopus 로고
    • 4-1BBL cooperates with B7-1 and B7-2 in converting a B cell lymphoma cell line into a long-lasting antitumor vaccine
    • Guinn BA, DeBenedette MA, Watts TH, Berinstein N. L. 4-1BBL cooperates with B7-1 and B7-2 in converting a B cell lymphoma cell line into a long-lasting antitumor vaccine. J Immunol 1999;162: 5003-10.
    • (1999) J Immunol , vol.162 , pp. 5003-5010
    • Guinn, B.A.1    DeBenedette, M.A.2    Watts, T.H.3    Berinstein, N.L.4
  • 37
    • 20044395957 scopus 로고    scopus 로고
    • Autoimmunity in a phase I trail of a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and montanide ISA 51 for patients with resected stages III and IV melanoma
    • Sanderson K, Scotland R, Lee P, et al. Autoimmunity in a phase I trail of a fully human anti-cytotoxic T-lymphocyte antigen-4 monoclonal antibody with multiple melanoma peptides and montanide ISA 51 for patients with resected stages III and IV melanoma. J Clin Oncol 2005;23:741-50.
    • (2005) J Clin Oncol , vol.23 , pp. 741-750
    • Sanderson, K.1    Scotland, R.2    Lee, P.3
  • 38
    • 0023784524 scopus 로고
    • A novel method for the detection of necrotic lesions in human cancers
    • Epstein AL, Chen FM, Taylor CR. A novel method for the detection of necrotic lesions in human cancers. Cancer Res 1988;48:5842-8.
    • (1988) Cancer Res , vol.48 , pp. 5842-5848
    • Epstein, A.L.1    Chen, F.M.2    Taylor, C.R.3
  • 40
    • 20144363581 scopus 로고    scopus 로고
    • Pivotal study of iodine-131-labeled chimeric tumor necrosis treatment radioimmunotherapy in patients with advanced lung cancer
    • Chen S, Yu L, Jiang C, et al. Pivotal study of iodine-131-labeled chimeric tumor necrosis treatment radioimmunotherapy in patients with advanced lung cancer. J Clin Oncol 2005;23:1538-47.
    • (2005) J Clin Oncol , vol.23 , pp. 1538-1547
    • Chen, S.1    Yu, L.2    Jiang, C.3
  • 41
    • 0000768305 scopus 로고
    • Radioimmunodetection of necrotic lesions in human tumors using I-131-labeled TNT-1 F(ab′)2 monoclonal antibody
    • Epstein A, Chen D, Ansari A, et al. Radioimmunodetection of necrotic lesions in human tumors using I-131-labeled TNT-1 F(ab′)2 monoclonal antibody. Antibody Immunoconj Radiopharm 1991;4:151-61.
    • (1991) Antibody Immunoconj Radiopharm , vol.4 , pp. 151-161
    • Epstein, A.1    Chen, D.2    Ansari, A.3
  • 42
    • 0031760730 scopus 로고    scopus 로고
    • A new chemically modified chimeric TNT-3 monoclonal antibody directed against DNA for the radioimmunotherapy of solid tumors
    • Hornick JL, Sharifi J, Khawli LA, et al. A new chemically modified chimeric TNT-3 monoclonal antibody directed against DNA for the radioimmunotherapy of solid tumors. Cancer Biother Radiopharm 1998;13: 255-68.
    • (1998) Cancer Biother Radiopharm , vol.13 , pp. 255-268
    • Hornick, J.L.1    Sharifi, J.2    Khawli, L.A.3
  • 43
    • 0032926185 scopus 로고    scopus 로고
    • Pretreatment with a monoclonal antibody/interleukin-2 fusion protein directed against DNA enhances the delivery of therapeutic molecules to solid tumors
    • Hornick JL, Khawli LA, Hu P, Sharifi J, Khanna C, Epstein AL. Pretreatment with a monoclonal antibody/interleukin-2 fusion protein directed against DNA enhances the delivery of therapeutic molecules to solid tumors. Clin Cancer Res 1999;5:51-60.
    • (1999) Clin Cancer Res , vol.5 , pp. 51-60
    • Hornick, J.L.1    Khawli, L.A.2    Hu, P.3    Sharifi, J.4    Khanna, C.5    Epstein, A.L.6
  • 44
    • 1242317071 scopus 로고    scopus 로고
    • Li J, Hu P, Khawli LA.Yun A, Epstein AL. chTNT-3/ hu IL-12 fusion protein for the immunotherapy of experimental solid tumors. Hybrid Hybridomics 2004; 23:1-10.
    • Li J, Hu P, Khawli LA.Yun A, Epstein AL. chTNT-3/ hu IL-12 fusion protein for the immunotherapy of experimental solid tumors. Hybrid Hybridomics 2004; 23:1-10.
  • 45
    • 0038706226 scopus 로고    scopus 로고
    • Generation of human interferon gamma and tumor necrosis factor alpha chimeric TNT-3 fusion proteins
    • Sharifi J, Khawli LA, Hu P, Li J, Epstein AL. Generation of human interferon gamma and tumor necrosis factor alpha chimeric TNT-3 fusion proteins. Hybrid Hybridomics 2002;21:421-32.
    • (2002) Hybrid Hybridomics , vol.21 , pp. 421-432
    • Sharifi, J.1    Khawli, L.A.2    Hu, P.3    Li, J.4    Epstein, A.L.5
  • 46
    • 0041335450 scopus 로고    scopus 로고
    • Chimeric TNT-3 antibody/murine interferon-gamma fusion protein for the immunotherapy of solid malignancies
    • Mizokami MM, Hu P, Khawli LA, Li J, Epstein AL. Chimeric TNT-3 antibody/murine interferon-gamma fusion protein for the immunotherapy of solid malignancies. Hybrid Hybridomics 2003;22:197-207.
    • (2003) Hybrid Hybridomics , vol.22 , pp. 197-207
    • Mizokami, M.M.1    Hu, P.2    Khawli, L.A.3    Li, J.4    Epstein, A.L.5
  • 48
    • 0037829431 scopus 로고    scopus 로고
    • LEC/chTNT-3 fusion protein for the immunotherapy of experimental solid tumors
    • Li J, Hu P, Khawli LA, Epstein AL. LEC/chTNT-3 fusion protein for the immunotherapy of experimental solid tumors. J Immunother 2003;26:320-31.
    • (2003) J Immunother , vol.26 , pp. 320-331
    • Li, J.1    Hu, P.2    Khawli, L.A.3    Epstein, A.L.4
  • 49
    • 33746045735 scopus 로고    scopus 로고
    • H60/ TNT-3 fusion protein activates NK cells in vitro and improves immunotherapeutic outcome in murine syngeneic tumor models
    • Flanagan ML, Khawli LA, Hu P, Epstein AL. H60/ TNT-3 fusion protein activates NK cells in vitro and improves immunotherapeutic outcome in murine syngeneic tumor models. J Immunother 2006;29: 274-83.
    • (2006) J Immunother , vol.29 , pp. 274-283
    • Flanagan, M.L.1    Khawli, L.A.2    Hu, P.3    Epstein, A.L.4
  • 50
    • 15244348992 scopus 로고    scopus 로고
    • Complex memory T-cell phenotypes revealed by coexpression of CD62L and CCR7
    • Unsoeld H, Pircher H. Complex memory T-cell phenotypes revealed by coexpression of CD62L and CCR7. J Virol 2005;79:4510-3.
    • (2005) J Virol , vol.79 , pp. 4510-4513
    • Unsoeld, H.1    Pircher, H.2
  • 51
    • 32944470811 scopus 로고    scopus 로고
    • Solid tumors "melt" from the inside after successful CD8 T cell attack
    • Blohm U, Potthoff D, van der Kogel AJ, Pircher H. Solid tumors "melt" from the inside after successful CD8 T cell attack. Eur J Immunol 2006;36:468-77.
    • (2006) Eur J Immunol , vol.36 , pp. 468-477
    • Blohm, U.1    Potthoff, D.2    van der Kogel, A.J.3    Pircher, H.4
  • 53
    • 0033743984 scopus 로고    scopus 로고
    • Cell death induction by CTL: Perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells
    • Hayashida M, Kawano H, Nakano T, Shiraki K, Suzuki A. Cell death induction by CTL: Perforin/granzyme B system dominantly acts for cell death induction in human hepatocellular carcinoma cells. Exp Biol Med (Maywood) 2000;225:143-50.
    • (2000) Exp Biol Med (Maywood) , vol.225 , pp. 143-150
    • Hayashida, M.1    Kawano, H.2    Nakano, T.3    Shiraki, K.4    Suzuki, A.5
  • 54
    • 23044467642 scopus 로고    scopus 로고
    • Induction of higher avidity human CTLs by vector-mediated enhanced costimulation of antigen-presenting cells
    • Yang S, Tsang K-Y, Schlom J. Induction of higher avidity human CTLs by vector-mediated enhanced costimulation of antigen-presenting cells. Clin Cancer Res 2005;11:5603-15.
    • (2005) Clin Cancer Res , vol.11 , pp. 5603-5615
    • Yang, S.1    Tsang, K.-Y.2    Schlom, J.3
  • 55
    • 4344718859 scopus 로고    scopus 로고
    • 4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function
    • Lee SJ, Myers L, Muralimohan G, et al. 4-1BB and OX40 dual costimulation synergistically stimulate primary specific CD8 T cells for robust effector function. J Immunol 2004;173:3002-12.
    • (2004) J Immunol , vol.173 , pp. 3002-3012
    • Lee, S.J.1    Myers, L.2    Muralimohan, G.3


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