Serum 27-hydroxycholesterol in patients with primary biliary cirrhosis suggests alteration of cholesterol catabolism to bile acids via the acidic pathway

Journal of Lipid Research

Volumn 39, Issue 12, 1998, Pages 2477-2482

  Del Puppo, M ^a   Kienle, M Galli ^a   Petroni, M L ^a   Crosignani, A ^a   Podda, M ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

27 hydroxycholesterol; 7 hydroxycholesterol; Bile acid synthesis; Cholesterol metabolism; Cholesterol transport; Dietary sterols; Hypercholesterolemia; Lathosterol; Mass spectrometry

Indexed keywords

BILE ACID; CHOLESTEROL DERIVATIVE;

ADULT; AGED; ARTICLE; BILE FLOW; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; CLINICAL ARTICLE; FEMALE; HUMAN; MALE; PRIMARY BILIARY CIRRHOSIS; PRIORITY JOURNAL;

AGED; BILE ACIDS AND SALTS; CHOLESTEROL; FEMALE; HUMANS; HYDROXYCHOLESTEROLS; INTESTINAL ABSORPTION; LIVER CIRRHOSIS, BILIARY; MALE; MIDDLE AGED; PHYTOSTEROLS; SITOSTEROLS;

EID: 0032440397     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (14)

1. Neuberger, J. 1997. Primary biliary cirrhosis. Lancet. 350: 875-879.
2. Miettinen, T. A. 1972. Lipid absorption, bile acids and cholesterol metabolism in patients with chronic liver disease. Gut. 13: 682-689.
3. Nikkilä, K., K. Hockerstedt, and T. A. Miettinen. 1991. High cholestanol and low campesterol-to-sitosterol ratio in serum of patients with primary biliary cirrhosis before liver transplantation. Hepatology. 13: 663-669.
4. Kempen, H. J. M., J. F. C. Glatz, J. A. Gevers Leuven, H. A. van der Voort, and M. B. Katan. 1988. Serum lathosterol concentration is an indicator of whole-body cholesterol synthesis in humans. J. Lipid Res. 29: 1149-1155.
5. Tilvis, R. S., and T. A. Miettinen. 1986. Serum plant sterols and their relation to cholesterol absorption. Am. J. Clin. Nutr. 43: 92-97.
6. Nikkilä, K., K. Hockerstedt, and T. A. Miettinen. 1992. Serum and hepatic cholestanol, squalene and noncholesterol sterols in man: a study on liver transplantation. Hepatology. 15: 863-870.
7. Bertolotti, M., N. Abate, P. Loria, M. Dilengite, F. Carubbi, A. Pinetti, A. Digrisolo, and N. Carulli. 1991. Regulation of bile acid synthesis in humans: effect of treatment with bile acids, cholestyramine or simvastatin on cholesterol 7α-hydroxylation rates in vivo. Hepatology. 14: 830-837.
8. Vlahcevic, Z. R., D. M. Heuman, and P. B. Hylemon. 1991. Regulation of bile acid synthesis. Hepatology. 13: 590-600.
9. Bertolotti, M., N. Carulli, D. Menozzi, F. Zironi, A. Digrisolo, A. Pinetti, and M. G. Baldini. 1986. In vivo evaluation of cholesterol 7α-hydroxylation in humans: effect of disease and drug treatment. J. Lipid Res. 27: 1278-1286.
10. Danielsson, H. 1974. Effect of biliary obstruction on formation and metabolism of bile acids in the rat. Steroids. 22: 567-577.
11. Dueland, S., J. Reichen, G. T. Everson, and R. A. Davis. 1991. Regulation of cholesterol and bile acid homeostasis in bile-obstructed rats. Biochem. J. 280: 373-377.
12. Oda, H., H. Yamashita, K. Kosahara, S. Kuroki, and F. Nakayama. 1990. Esterified and total 7α-hydroxycholesterol in human serum as an indicator for hepatic bile acid synthesis. J. Lipid Res. 31: 2209-2218.
13. Axelson, M., and J. Sjovall. 1990. Potential bile acid precursors in plasma: possible indicators of biosynthetic pathways to cholic and chenodeoxycholic acids in man. J. Steroid Biochem. 36: 631-640.
14. Princen, H. M. G., P. Meijer, B. G. Wolthers, R. J. Vonk, and F. Kuipers. 1991. Cyclosporin A blocks bile acid synthesis in cultured hepatocytes by specific inhibition of chenodeoxycholic acid synthesis. Biochem. J. 275: 501-505.