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Volumn 49, Issue 2, 2006, Pages 261-270

The rise and fall of insulin secretion in type 1 diabetes mellitus

Author keywords

Autoimmunity; C peptide; Insulin secretion; Natural history; Type 1 diabetes

Indexed keywords

C PEPTIDE; INSULIN;

EID: 31844443761     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-005-0100-8     Document Type: Review
Times cited : (86)

References (59)
  • 1
    • 20544443927 scopus 로고    scopus 로고
    • Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes
    • Keymeulen B, Vandemeulebroucke E, Ziegler et al (2005) Insulin needs after CD3-antibody therapy in new-onset type 1 diabetes. N Engl J Med 352:2598-2608
    • (2005) N Engl J Med , vol.352 , pp. 2598-2608
    • Keymeulen, B.1    Vandemeulebroucke, E.2    Ziegler3
  • 2
    • 0035944844 scopus 로고    scopus 로고
    • Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): A randomised, double-blind, phase II trial
    • Raz I, Elias D, Avron A, Tamir M, Metzger M, Cohen IR (2001) Beta-cell function in new-onset type 1 diabetes and immunomodulation with a heat-shock protein peptide (DiaPep277): a randomised, double-blind, phase II trial. Lancet 358:1749-1753
    • (2001) Lancet , vol.358 , pp. 1749-1753
    • Raz, I.1    Elias, D.2    Avron, A.3    Tamir, M.4    Metzger, M.5    Cohen, I.R.6
  • 3
    • 0037198420 scopus 로고    scopus 로고
    • Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus
    • Herold KC, Hagopian W, Auger JA et al (2002) Anti-CD3 monoclonal antibody in new-onset type 1 diabetes mellitus. N Engl J Med 346:1692-1698
    • (2002) N Engl J Med , vol.346 , pp. 1692-1698
    • Herold, K.C.1    Hagopian, W.2    Auger, J.A.3
  • 4
    • 20044375937 scopus 로고    scopus 로고
    • A single course of anti-CD3 monoclonal antibody hOKT3 {gamma} 1 (Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of Type 1 diabetes
    • Herold KC, Gitelman SE, Masharani U et al (2005) A single course of anti-CD3 monoclonal antibody hOKT3 {gamma} 1 (Ala-Ala) results in improvement in C-peptide responses and clinical parameters for at least 2 years after onset of Type 1 diabetes. Diabetes 54:1763-1769
    • (2005) Diabetes , vol.54 , pp. 1763-1769
    • Herold, K.C.1    Gitelman, S.E.2    Masharani, U.3
  • 5
    • 0037198427 scopus 로고    scopus 로고
    • Effects of insulin in relatives of patients with type 1 diabetes mellitus
    • Diabetes Prevention Trial - Type 1 Diabetes Study Group (2002) Effects of insulin in relatives of patients with type 1 diabetes mellitus. N Engl J Med 346:1685-1691
    • (2002) N Engl J Med , vol.346 , pp. 1685-1691
  • 6
    • 18144391496 scopus 로고    scopus 로고
    • Effects of oral insulin in relatives of patients with type 1 diabetes: The Diabetes Prevention Trial-Type 1
    • Skyler JS, Krischer JP, Wolfsdorf J et al (2005) Effects of oral insulin in relatives of patients with type 1 diabetes: the Diabetes Prevention Trial-Type 1. Diabetes Care 28:1068-1076
    • (2005) Diabetes Care , vol.28 , pp. 1068-1076
    • Skyler, J.S.1    Krischer, J.P.2    Wolfsdorf, J.3
  • 7
    • 2642648673 scopus 로고    scopus 로고
    • Successful islet autotransplantation in humans: Functional insulin secretory reserve as an estimate of surviving islet cell mass
    • Teuscher AU, Kendall DM, Smets YF, Leone JP, Sutherland DE, Robertson RP (1998) Successful islet autotransplantation in humans: functional insulin secretory reserve as an estimate of surviving islet cell mass. Diabetes 47:324-330
    • (1998) Diabetes , vol.47 , pp. 324-330
    • Teuscher, A.U.1    Kendall, D.M.2    Smets, Y.F.3    Leone, J.P.4    Sutherland, D.E.5    Robertson, R.P.6
  • 8
    • 0022545869 scopus 로고
    • The limitations to and valid use of C-peptide as a marker of the secretion of insulin
    • Polonsky K, Frank B, Pugh W et al (1986) The limitations to and valid use of C-peptide as a marker of the secretion of insulin. Diabetes 35:379-386
    • (1986) Diabetes , vol.35 , pp. 379-386
    • Polonsky, K.1    Frank, B.2    Pugh, W.3
  • 9
    • 0022572232 scopus 로고
    • Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients
    • Polonsky KS, Licinio-Paixao J, Given BD et al (1986) Use of biosynthetic human C-peptide in the measurement of insulin secretion rates in normal volunteers and type I diabetic patients. J Clin Invest 77:98-105
    • (1986) J Clin Invest , vol.77 , pp. 98-105
    • Polonsky, K.S.1    Licinio-Paixao, J.2    Given, B.D.3
  • 10
    • 0023850277 scopus 로고
    • Quantitative study of insulin secretion and clearance in normal and obese subjects
    • Polonsky KS, Given BD, Hirsch L et al (1988) Quantitative study of insulin secretion and clearance in normal and obese subjects. J Clin Invest 81:435-441
    • (1988) J Clin Invest , vol.81 , pp. 435-441
    • Polonsky, K.S.1    Given, B.D.2    Hirsch, L.3
  • 11
    • 0023916553 scopus 로고
    • Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus
    • Polonsky KS, Given BD, Hirsch LJ et al (1988) Abnormal patterns of insulin secretion in non-insulin-dependent diabetes mellitus. N Engl J Med 318:1231-1239
    • (1988) N Engl J Med , vol.318 , pp. 1231-1239
    • Polonsky, K.S.1    Given, B.D.2    Hirsch, L.J.3
  • 12
    • 10744229777 scopus 로고    scopus 로고
    • Insulin secretion in type 1 diabetes
    • Steele C, Hagopian WA, Gitelman S et al (2004) Insulin secretion in type 1 diabetes. Diabetes 53:426-433
    • (2004) Diabetes , vol.53 , pp. 426-433
    • Steele, C.1    Hagopian, W.A.2    Gitelman, S.3
  • 13
    • 0034042959 scopus 로고    scopus 로고
    • Islet growth and development in the adult
    • Bonner-Weir S (2000) Islet growth and development in the adult. J Mol Endocrin 24:297-302
    • (2000) J Mol Endocrin , vol.24 , pp. 297-302
    • Bonner-Weir, S.1
  • 14
    • 0030903840 scopus 로고    scopus 로고
    • Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat
    • Scaglia L, Cahill CJ, Finegood DT, Bonner-Weir S (1997) Apoptosis participates in the remodeling of the endocrine pancreas in the neonatal rat. Endocrinology 138:1736-1741
    • (1997) Endocrinology , vol.138 , pp. 1736-1741
    • Scaglia, L.1    Cahill, C.J.2    Finegood, D.T.3    Bonner-Weir, S.4
  • 15
    • 25444455671 scopus 로고    scopus 로고
    • Regulation of pancreatic beta cell mass
    • Bouwens L, Rooman I (2005) Regulation of pancreatic beta cell mass. Physiol Rev 85:1255-1270
    • (2005) Physiol Rev , vol.85 , pp. 1255-1270
    • Bouwens, L.1    Rooman, I.2
  • 16
    • 0028987251 scopus 로고
    • (Perspective) Dynamics of β-cell mass in the growing rat pancreas: Estimation with a simple mathematical model
    • Finegood DT, Scaglia L, Bonner-Weir S (1995) (Perspective) Dynamics of β-cell mass in the growing rat pancreas: estimation with a simple mathematical model. Diabetes 44:249-256
    • (1995) Diabetes , vol.44 , pp. 249-256
    • Finegood, D.T.1    Scaglia, L.2    Bonner-Weir, S.3
  • 17
    • 0024364978 scopus 로고
    • Increased insulin secretion in puberty: A compensatory response to reductions in insulin sensitivity
    • Caprio S, Plewe G, Diamond MP et al (1989) Increased insulin secretion in puberty: a compensatory response to reductions in insulin sensitivity. J Pediatr 114:963-967
    • (1989) J Pediatr , vol.114 , pp. 963-967
    • Caprio, S.1    Plewe, G.2    Diamond, M.P.3
  • 18
    • 0022652051 scopus 로고
    • Impaired insulin action in puberty. A contributing factor to poor glycemic control in adolescents with diabetes
    • Amiel SA, Sherwin RS, Simonson DC, Lauritano AA, Tamborlane WV (1986) Impaired insulin action in puberty. A contributing factor to poor glycemic control in adolescents with diabetes. N Engl J Med 315:215-219
    • (1986) N Engl J Med , vol.315 , pp. 215-219
    • Amiel, S.A.1    Sherwin, R.S.2    Simonson, D.C.3    Lauritano, A.A.4    Tamborlane, W.V.5
  • 19
    • 0034748341 scopus 로고    scopus 로고
    • Dihydrotestosterone treatment in adolescents with delayed puberty: Does it explain insulin resistance of puberty?
    • Saad RJ, Keenan BS, Danadian K, Lewy VD, Arslanian SA (2001) Dihydrotestosterone treatment in adolescents with delayed puberty: does it explain insulin resistance of puberty? J Clin Endocrinol Metab 86:4881-4886
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4881-4886
    • Saad, R.J.1    Keenan, B.S.2    Danadian, K.3    Lewy, V.D.4    Arslanian, S.A.5
  • 20
    • 0035512070 scopus 로고    scopus 로고
    • Longitudinal study on pubertal insulin resistance
    • Goran MI, Gower BA (2001) Longitudinal study on pubertal insulin resistance. Diabetes 50:2444-2450
    • (2001) Diabetes , vol.50 , pp. 2444-2450
    • Goran, M.I.1    Gower, B.A.2
  • 21
  • 23
    • 14044270224 scopus 로고    scopus 로고
    • Limited accuracy of surrogates of insulin resistance during puberty in obese and lean children at risk for altered glucoregulation
    • Brandou F, Brun JF, Mercier J (2005) Limited accuracy of surrogates of insulin resistance during puberty in obese and lean children at risk for altered glucoregulation. J Clin Endocrinol Metab 90:761-767
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 761-767
    • Brandou, F.1    Brun, J.F.2    Mercier, J.3
  • 24
    • 0032860997 scopus 로고    scopus 로고
    • Insulin resistance during puberty: Results from clamp studies in 357 children
    • Moran A, Jacobs DR Jr, Steinberger J et al (1999) Insulin resistance during puberty: results from clamp studies in 357 children. Diabetes 48:2039-2044
    • (1999) Diabetes , vol.48 , pp. 2039-2044
    • Moran, A.1    Jacobs Jr., D.R.2    Steinberger, J.3
  • 26
    • 0031158813 scopus 로고    scopus 로고
    • Insulin secretion and sensitivity in black versus white prepubertal healthy children
    • Arslanian S, Suprasongsin C, Janosky JE (1997) Insulin secretion and sensitivity in black versus white prepubertal healthy children. J Clin Endocrinol Metab 82:1923-1927
    • (1997) J Clin Endocrinol Metab , vol.82 , pp. 1923-1927
    • Arslanian, S.1    Suprasongsin, C.2    Janosky, J.E.3
  • 27
    • 3142672131 scopus 로고    scopus 로고
    • Preservation of C-peptide secretion in subjects at high risk of developing type 1 diabetes mellitus - A new surrogate measure of non-progression?
    • Schatz D, Cuthbertson D, Atkinson M et al (2004) Preservation of C-peptide secretion in subjects at high risk of developing type 1 diabetes mellitus - a new surrogate measure of non-progression? Pediatr Diabetes 5:72-79
    • (2004) Pediatr Diabetes , vol.5 , pp. 72-79
    • Schatz, D.1    Cuthbertson, D.2    Atkinson, M.3
  • 28
    • 0038155702 scopus 로고    scopus 로고
    • Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles
    • Bruning JC, Winnay J, Bonner-Weir S, Taylor SI, Accili D, Kahn CR (1997) Development of a novel polygenic model of NIDDM in mice heterozygous for IR and IRS-1 null alleles. Cell 88:561-572
    • (1997) Cell , vol.88 , pp. 561-572
    • Bruning, J.C.1    Winnay, J.2    Bonner-Weir, S.3    Taylor, S.I.4    Accili, D.5    Kahn, C.R.6
  • 29
    • 0031913829 scopus 로고    scopus 로고
    • Role of apoptosis in failure of β cell mass compensation for insulin resistance and β cell defects in the male Zucker diabetic fatty (ZDF) rat
    • Pick A, Clark J, Kubstrup C, Pugh W, Bonner-Weir S, Polonsky K (1998) Role of apoptosis in failure of β cell mass compensation for insulin resistance and β cell defects in the male Zucker diabetic fatty (ZDF) rat. Diabetes 47:358-364
    • (1998) Diabetes , vol.47 , pp. 358-364
    • Pick, A.1    Clark, J.2    Kubstrup, C.3    Pugh, W.4    Bonner-Weir, S.5    Polonsky, K.6
  • 30
    • 0028330011 scopus 로고
    • Transplanted beta cell response to increased metabolic demand. Changes in beta cell replication and mass
    • Montana E, Bonner-Weir S, Weir GC (1994) Transplanted beta cell response to increased metabolic demand. Changes in beta cell replication and mass. J Clin Invest 93:1577-1582
    • (1994) J Clin Invest , vol.93 , pp. 1577-1582
    • Montana, E.1    Bonner-Weir, S.2    Weir, G.C.3
  • 31
    • 0024508097 scopus 로고
    • Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion
    • Bonner-Weir S, Deery D, Leahy JL, Weir GC (1989) Compensatory growth of pancreatic beta-cells in adult rats after short-term glucose infusion. Diabetes 38:49-53
    • (1989) Diabetes , vol.38 , pp. 49-53
    • Bonner-Weir, S.1    Deery, D.2    Leahy, J.L.3    Weir, G.C.4
  • 32
    • 0027449197 scopus 로고
    • A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development
    • Bonner-Weir S, Baxter LA, Schuppin GT, Smith FE (1993) A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 42:1715-1720
    • (1993) Diabetes , vol.42 , pp. 1715-1720
    • Bonner-Weir, S.1    Baxter, L.A.2    Schuppin, G.T.3    Smith, F.E.4
  • 33
    • 0037312829 scopus 로고    scopus 로고
    • Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy
    • De Leon DD, Deng S, Madani R, Ahima RS, Drucker DJ, Stoffers DA (2003) Role of endogenous glucagon-like peptide-1 in islet regeneration after partial pancreatectomy. Diabetes 52:365-371
    • (2003) Diabetes , vol.52 , pp. 365-371
    • De Leon, D.D.1    Deng, S.2    Madani, R.3    Ahima, R.S.4    Drucker, D.J.5    Stoffers, D.A.6
  • 34
    • 0033513455 scopus 로고    scopus 로고
    • Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats
    • Xu G, Stoffers DA, Habener JF, Bonner-Weir S (1999) Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats. Diabetes 48:2270-2276
    • (1999) Diabetes , vol.48 , pp. 2270-2276
    • Xu, G.1    Stoffers, D.A.2    Habener, J.F.3    Bonner-Weir, S.4
  • 35
    • 0033790973 scopus 로고    scopus 로고
    • Is the paradoxical first trimester drop in insulin requirement due to an increase in C-peptide concentration in pregnant Type I diabetic women?
    • Ilic S, Jovanovic L, Wollitzer AO (2000) Is the paradoxical first trimester drop in insulin requirement due to an increase in C-peptide concentration in pregnant Type I diabetic women? Diabetologia 43:1329-1330
    • (2000) Diabetologia , vol.43 , pp. 1329-1330
    • Ilic, S.1    Jovanovic, L.2    Wollitzer, A.O.3
  • 36
    • 0023748369 scopus 로고
    • Recovery of beta-cell function postpartum in a patient with insulin-dependent diabetes mellitus
    • Singer F, Horlick M, Poretsky L (1988) Recovery of beta-cell function postpartum in a patient with insulin-dependent diabetes mellitus. N Y State J Med 88:496-498
    • (1988) N Y State J Med , vol.88 , pp. 496-498
    • Singer, F.1    Horlick, M.2    Poretsky, L.3
  • 37
    • 0035196651 scopus 로고    scopus 로고
    • Insulin resistance syndrome in childhood: Associations of the euglycemic insulin clamp and fasting insulin with fatness and other risk factors
    • Sinaiko AR, Jacobs DR Jr, Steinberger J et al (2001) Insulin resistance syndrome in childhood: associations of the euglycemic insulin clamp and fasting insulin with fatness and other risk factors. J Pediatr 139:700-707
    • (2001) J Pediatr , vol.139 , pp. 700-707
    • Sinaiko, A.R.1    Jacobs Jr., D.R.2    Steinberger, J.3
  • 38
    • 31844443691 scopus 로고    scopus 로고
    • Natural history of β-cell function in Type 1 diabetes
    • Sherry NA, Tsai EB, Herold KC (2005) Natural history of β-cell function in Type 1 diabetes. Diabetes 54 (Suppl 2):S32-S39
    • (2005) Diabetes , vol.54 , Issue.2 SUPPL.
    • Sherry, N.A.1    Tsai, E.B.2    Herold, K.C.3
  • 39
    • 0027090336 scopus 로고
    • Growth hormone and insulin interactions
    • Caprio S, Boulware D, Tamborlane V (1992) Growth hormone and insulin interactions. Horm Res 38 (Suppl 2):47-49
    • (1992) Horm Res , vol.38 , Issue.2 SUPPL. , pp. 47-49
    • Caprio, S.1    Boulware, D.2    Tamborlane, V.3
  • 40
    • 0032910989 scopus 로고    scopus 로고
    • Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse
    • Sreenan S, Pick AJ, Levisetti M, Baldwin AC, Pugh W, Polonsky KS (1999) Increased beta-cell proliferation and reduced mass before diabetes onset in the nonobese diabetic mouse. Diabetes 48:989-996
    • (1999) Diabetes , vol.48 , pp. 989-996
    • Sreenan, S.1    Pick, A.J.2    Levisetti, M.3    Baldwin, A.C.4    Pugh, W.5    Polonsky, K.S.6
  • 41
    • 3342971027 scopus 로고    scopus 로고
    • Impact of degree of obesity on surrogate estimates of insulin resistance
    • Kim SH, Abbasi F, Reaven GM (2004) Impact of degree of obesity on surrogate estimates of insulin resistance. Diabetes Care 27:1998-2002
    • (2004) Diabetes Care , vol.27 , pp. 1998-2002
    • Kim, S.H.1    Abbasi, F.2    Reaven, G.M.3
  • 42
    • 0017664756 scopus 로고
    • C-peptide response to glucagon. A test for the residual beta-cell function in diabetes mellitus
    • Faber OK, Binder C (1977) C-peptide response to glucagon. A test for the residual beta-cell function in diabetes mellitus. Diabetes 26:605-610
    • (1977) Diabetes , vol.26 , pp. 605-610
    • Faber, O.K.1    Binder, C.2
  • 43
    • 9144268894 scopus 로고    scopus 로고
    • C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: Report of an ADA workshop, 21-22 October 2001
    • Palmer JP, Fleming GA, Greenbaum CJ et al (2004) C-peptide is the appropriate outcome measure for type 1 diabetes clinical trials to preserve beta-cell function: report of an ADA workshop, 21-22 October 2001. Diabetes 53:250-264
    • (2004) Diabetes , vol.53 , pp. 250-264
    • Palmer, J.P.1    Fleming, G.A.2    Greenbaum, C.J.3
  • 44
    • 0023230972 scopus 로고
    • Residual beta-cell function in children with IDDM: Reproducibility of testing and factors influencing insulin secretory reserve
    • Clarson C, Daneman D, Drash AL, Becker DJ, Ehrlich RM (1987) Residual beta-cell function in children with IDDM: reproducibility of testing and factors influencing insulin secretory reserve. Diabetes Care 10:33-38
    • (1987) Diabetes Care , vol.10 , pp. 33-38
    • Clarson, C.1    Daneman, D.2    Drash, A.L.3    Becker, D.J.4    Ehrlich, R.M.5
  • 45
    • 0017740757 scopus 로고
    • C-peptide in juvenile diabetics beyond the postinitial remission period. Relation to clinical manifestations at onset of diabetes, remission and diabetic control
    • Ludvigsson J, Heding LG, Larsson Y, Leander E (1977) C-peptide in juvenile diabetics beyond the postinitial remission period. Relation to clinical manifestations at onset of diabetes, remission and diabetic control. Acta Paediatr Scand 66:177-184
    • (1977) Acta Paediatr Scand , vol.66 , pp. 177-184
    • Ludvigsson, J.1    Heding, L.G.2    Larsson, Y.3    Leander, E.4
  • 46
    • 0023750455 scopus 로고
    • Factors influencing the magnitude, duration, and rate of fall of B-cell function in type 1 (insulin-dependent) diabetic children followed for two years from their clinical diagnosis
    • Wallensteen M, Dahlquist G, Persson B et al (1988) Factors influencing the magnitude, duration, and rate of fall of B-cell function in type 1 (insulin-dependent) diabetic children followed for two years from their clinical diagnosis. Diabetologia 31:664-669
    • (1988) Diabetologia , vol.31 , pp. 664-669
    • Wallensteen, M.1    Dahlquist, G.2    Persson, B.3
  • 47
    • 0026755253 scopus 로고
    • Homogeneity in pattern of decline of beta-cell function in IDDM. Prospective study of 204 consecutive cases followed for 7.4 yr
    • Snorgaard O, Lassen LH, Binder C (1992) Homogeneity in pattern of decline of beta-cell function in IDDM. Prospective study of 204 consecutive cases followed for 7.4 yr. Diabetes Care 15:1009-1013
    • (1992) Diabetes Care , vol.15 , pp. 1009-1013
    • Snorgaard, O.1    Lassen, L.H.2    Binder, C.3
  • 48
    • 20344363171 scopus 로고    scopus 로고
    • Six-year follow-up of pancreatic beta cell function in adults with latent autoimmune diabetes
    • Yang L, Zhou ZG, Huang G, Ouyang LL, Li X, Yan X (2005) Six-year follow-up of pancreatic beta cell function in adults with latent autoimmune diabetes. World J Gastroenterol 11:2900-2905
    • (2005) World J Gastroenterol , vol.11 , pp. 2900-2905
    • Yang, L.1    Zhou, Z.G.2    Huang, G.3    Ouyang, L.L.4    Li, X.5    Yan, X.6
  • 49
    • 0017646011 scopus 로고
    • B-cell function and blood glucose control in insulin dependent diabetics within the first month of insulin treatment
    • Faber OK, Binder C (1977) B-cell function and blood glucose control in insulin dependent diabetics within the first month of insulin treatment. Diabetologia 13:263-268
    • (1977) Diabetologia , vol.13 , pp. 263-268
    • Faber, O.K.1    Binder, C.2
  • 51
    • 0023618080 scopus 로고
    • Residual insulin positivity and pancreatic atrophy in relation to duration of chronic type 1 (insulin-dependent) diabetes mellitus and microangiopathy
    • Lohr M, Kloppel G (1987) Residual insulin positivity and pancreatic atrophy in relation to duration of chronic type 1 (insulin-dependent) diabetes mellitus and microangiopathy. Diabetologia 30:757-762
    • (1987) Diabetologia , vol.30 , pp. 757-762
    • Lohr, M.1    Kloppel, G.2
  • 52
    • 0023598589 scopus 로고
    • Residual beta-cell function in children with type 1 diabetes: Measurement and impact on glycemic control
    • Daneman D, Clarson C (1987) Residual beta-cell function in children with type 1 diabetes: measurement and impact on glycemic control. Clin Invest Med 10:484-487
    • (1987) Clin Invest Med , vol.10 , pp. 484-487
    • Daneman, D.1    Clarson, C.2
  • 54
    • 0031560175 scopus 로고    scopus 로고
    • UKPDS 25: Autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes
    • UK Prospective Diabetes Study Group
    • Turner R, Stratton I, Horton V et al (1997) UKPDS 25: autoantibodies to islet-cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes. UK Prospective Diabetes Study Group. Lancet 350:1288-1293
    • (1997) Lancet , vol.350 , pp. 1288-1293
    • Turner, R.1    Stratton, I.2    Horton, V.3
  • 55
    • 0036271765 scopus 로고    scopus 로고
    • Latent autoimmune diabetes in adults
    • Landin-Olsson M (2002) Latent autoimmune diabetes in adults. Ann N Y Acad Sci 958:112-116
    • (2002) Ann N Y Acad Sci , vol.958 , pp. 112-116
    • Landin-Olsson, M.1
  • 56
    • 0028588120 scopus 로고
    • Islet cell antibodies are associated with beta-cell failure also in obese adult onset diabetic patients
    • Gottsater A, Landin-Olsson M, Lernmark A, Fernlund P, Sundkvist G (1994) Islet cell antibodies are associated with beta-cell failure also in obese adult onset diabetic patients. Acta Diabetol 31:226-231
    • (1994) Acta Diabetol , vol.31 , pp. 226-231
    • Gottsater, A.1    Landin-Olsson, M.2    Lernmark, A.3    Fernlund, P.4    Sundkvist, G.5
  • 57
    • 0041591490 scopus 로고    scopus 로고
    • Similar genetic features and different islet cell autoantibody pattern of latent autoimmune diabetes in adults (LADA) compared with adult-onset type 1 diabetes with rapid progression
    • Hosszufalusi N, Vatay A, Rajczy K et al (2003) Similar genetic features and different islet cell autoantibody pattern of latent autoimmune diabetes in adults (LADA) compared with adult-onset type 1 diabetes with rapid progression. Diabetes Care 26:452-457
    • (2003) Diabetes Care , vol.26 , pp. 452-457
    • Hosszufalusi, N.1    Vatay, A.2    Rajczy, K.3
  • 58
    • 0022617990 scopus 로고
    • Type I diabetes mellitus. A chronic autoimmune disease
    • Eisenbarth GS (1986) Type I diabetes mellitus. A chronic autoimmune disease. N Engl J Med 314:1360-1368
    • (1986) N Engl J Med , vol.314 , pp. 1360-1368
    • Eisenbarth, G.S.1
  • 59
    • 0034457490 scopus 로고    scopus 로고
    • Perspective: Postnatal pancreatic beta cell growth
    • Bonner-Weir S (2000) Perspective: postnatal pancreatic beta cell growth. Endocrinology 141:1926-1929
    • (2000) Endocrinology , vol.141 , pp. 1926-1929
    • Bonner-Weir, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.