Altered complex formation between p21waf, p27kip and their partner G1 cyclins determines the stimulatory or inhibitory Transforming Growth Factor-β1 growth response of human fibroblasts

International Journal of Oncology

Volumn 14, Issue 5, 1999, Pages 905-910

  Dkhissi, Fatima ^a   Raynal, Stéphane ^a   Lawrence, David A ^a,b  

^a CNRS   (France)

^b DRR   (France)

Author keywords

G1 cyclins; Human fibroblasts; p21waf; p27kip; Proliferation; TGF 1

Indexed keywords

CDK2 PROTEIN, HUMAN; CDK4 PROTEIN, HUMAN; CDKN1A PROTEIN, HUMAN; CELL CYCLE PROTEIN; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE 4; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 1B; CYCLIN G; CYCLINE; MICROTUBULE ASSOCIATED PROTEIN; ONCOPROTEIN; PROTEIN SERINE THREONINE KINASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; CELL CULTURE; CELL DIVISION; CELL LINE; CYTOLOGY; DRUG EFFECT; FIBROBLAST; HUMAN; METABOLISM; PHYSIOLOGY; SIMIAN VIRUS 40; VIRUS CELL TRANSFORMATION;

CDC2-CDC28 KINASES; CELL CYCLE PROTEINS; CELL DIVISION; CELL LINE, TRANSFORMED; CELL TRANSFORMATION, VIRAL; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE 4; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; FIBROBLASTS; HUMANS; MICROTUBULE-ASSOCIATED PROTEINS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; SIMIAN VIRUS 40; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEINS;

EID: 0033125841     PISSN: 10196439     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Alexandrow MG and Moses HL: Transforming growth factor-β and cell cycle regulation. Cancer Res 55: 1452-1457, 1995.
2. Lawrence DA: Transforming growth factor-β: a general review. Eur Cytokine Netw 7: 363-374, 1996.
3. Derynck R: TGF-β-receptor-mediated signaling. Trends Biochem Sci 19: 548-553, 1994.
4. Okadome T, Yamashita H, Franzén P, Morén A and Heldin C-H: Distinct roles of the intracellular domains of transforming growth factor-β type I and type II receptors in signal transduction. J Biol Chem 269: 30753-30756, 1994.
5. Ventura F, Doody J, Liu F, Wrana JL and Massagué J: Reconstitution and transphosphorylation of TGF-β receptor complexes. EMBO J 13: 5581-5589, 1994.
6. Heldin C-H, Miyazono K and Ten Dijke P: TGF-β signalling from cell membrane to nucleus through SMAD proteins. Nature 390: 465-471, 1997.
7. Massagué J and Polyak K: Mammalian antiproliferative signals and their targets. Curr Opin Genet Dev 5: 91-96, 1995.
8. Hirai H, Roussel MF, Kato JY, Ashmun RA and Sherr CJ: Novel INK4 proteins, p19 and p18, are specific inhibitors of the cyclin D-dependent kinase CDK4 and CDK6. Mol Cell Biol 15: 2672-2681, 1995.
9. Russo AA, Tong L, Lee JO, Jeffrey PD and Pavletich NP: Structural basis for inhibition of the cyclin-dependent kinase Cdk6 by the tumour suppressor p16Ink4a. Nature 395: 237-243, 1998.
10. Pietenpol JA, Holt JT, Stein RW and Moses HL: Transforming growth factor-β1 suppression of c-myc gene transcription: role in inhibition of keratinocyte proliferation. Proc Natl Acad Sci USA 87: 3758-3762, 1990.
11. Koike M, Ishino K, Huh N and Kuroki T: Growth inhibition of SV40-transformed human keratinocytes by TGF-βs is not linked to dephosphorylation of the Rb gene product. Biochem Biophys Res Commun 201: 673-681, 1994.
12. Ong G, Sikora K and Gullick WJ: Inactivation of the retinoblastoma gene does not lead to loss of TGF-β receptors or response to TGF-β in breast cancer cell lines. Oncogene 6: 761-763, 1991.
13. Leof EB, Proper JA, Goustin AS, Shipley GD, Di Corletto PE and Moses HL: Induction of c-sis mRNA and activity similar to platelet-derived growth factor by transforming growth factor-β: a proposed model for indirect mitogenesis involving autocrine activity. Proc Natl Acad Sci USA 83: 2453-2457, 1986.
14. De Groot RP, Kranenburg O, De Wit L, van den Eijinden-van-Raaij J, Mummery C, van der Eb AJ and Zantema A: Adenovirus E1A antagonizes both negative and positive growth signals elicited by TGF-β1. Cell Growth Differ 6: 531-540, 1995.
15. Ravitz MJ and Wenner CE: Cyclin-dependent kinase regulation during G1 phase and cell cycle regulation by TGF-β. Adv Cancer Res 71: 165-207, 1997.
16. Benzakour O, Merzak A, Dooghe Y, Pironin M, Lawrence DA and Vigier P: Transforming growth factor-beta stimulates mitogenically mouse NIH3T3 fibroblasts and those cells transformed by the EJ-H-ras oncogene. Growth Factors 6: 265-275, 1992.
17. Ravitz MJ, Yan S, Herr KD and Wenner CE: Transforming growth factor-β-induced activation of cyclin E-cdk2 kinase and down-regulation of p27kip1 in C3H10T1/2 mouse fibroblasts. Cancer Res 55: 1413-1416, 1995.
18. Dkhissi F, Raynal S, Jullien P and Lawrence DA: Growth stimulation of murine fibroblasts by TGF-β1 depends on the expression of a functional p53 protein. Oncogene 18: 703-711, 1999.
19. Raynal S, Jullien P and Lawrence DA: Transforming growth factor-β1 enhances serum-induced dephosphorylation of the P53 protein in cell lines growth-inhibited by this factor. Growth Factors 11: 197-203, 1994.
20. Vindelov LL, Christensen IJ and Nissen NI: Standardization of high-resolution flow cytometric DNA analysis by the simultaneous use of chicken and trout red blood cells as internal reference standards. Cytometry 3: 328-331, 1983.
21. Chomczynski P and Sacchi N: Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159, 1987.
22. Land H, Parada LF and Weinberg RA: Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes. Nature 304: 596-602, 1983.
23. Raynal S and Lawrence DA: Differential effects of transforming growth-β1 on protein levels of p21waf and cdk-2 and on cdk-4 kinase activity in human RD and CCL64 mink lung cells. Int J Oncol 7: 337-341, 1995.
24. Koff A, Ohtsuki M, Polyak K, Roberts JM and Massagué J: Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGF-β. Science 260: 536-539, 1993.
25. Reynisdottir I, Polyak K, Iavarone A and Massague J: Kip/Cip and Ink4 Cdk inhibitors cooperate to induce cell cycle arrest in response to TGF-β. Genes Dev 9: 1831-1845, 1995.
26. Kamesaki H, Nishizawa K, Michaud GY, Cossman J and Kiyono T: TGF-β1 induces the cyclin-dependent kinase inhibitor p27kip mRNA and protein in murine B cells. J Immunol 160: 770-777, 1998.
27. Manfredi JJ and Prives C: The transforming activity of simian virus 40 large tumor antigen. Biochim Biophys Acta 1198: 65-83, 1994.