Optical biosensor based on arrays of waveguide microcantilevers

Proceedings of SPIE - The International Society for Optical Engineering

Volumn 6477, Issue , 2007, Pages

  Zinoviev, Kirill ^a   Plaza, Jose Antonio ^a   Cadarso, Victor ^a   Dominguez, Carlos ^a   Lechuga, Laura M ^a  

^a INSTITUTO DE MICROELECTRÓNICA DE BARCELONA   (Spain)

Author keywords

Biosensing; Microcantilevers; Optical waveguides

Indexed keywords

ATOMIC FORCE MICROSCOPY; BIOSENSORS; CANTILEVER BEAMS; MICROOPTICS; NANOMECHANICS; OPTICAL WAVEGUIDES; TRANSDUCERS;

BIOSENSING; MICROCANTILEVERS; OPTICAL CANTILEVERS;

OPTICAL SENSORS;

EID: 34248665283     PISSN: 0277786X     EISSN: None     Source Type: Conference Proceeding    
DOI: 10.1117/12.698176     Document Type: Conference Paper

References (23)

1. L. G. Carrascosa, M. Moreno, M. Alvarez, L. M. Lechuga, "Nanomechanical biosensors: a new sensing tool," Trends in Analytical Chemistry, Vol. 25, 196-206 (2006)
2. N. V. Lavrik, M. J. Sepaniak, P. G. Datskos, "Cantilever transducers as a platform for chemical and biological sensors," Rev. Sci. Instrum. vol. 75, 2229-2253 (2004)
3. K. M. Hansen, T. Thundat, "Microcantilever biosensors," Methods, vol. 37, 57-64, (2005)
4. Mechanics of Materials , S. Timoshenko, J. M. Gere, 1st edition, D. Van Nostrand Company, 1972
5. G.G. Stoney, Proc. Roy. Soc. Lond. Vol. A82, 172 (1909)
6. Y. Arntz, J. D. Seelig, H. P. Lang, J. Zhang, P. Hunziker, J. P. Ramseyer, E. Meyer, M. Hegner and Ch. Gerber, "Label-free protein assay based on a nanomechanical cantilever array," Nanotechnology, vol. 14, 86-90 (2003)
7. N. Backmann, Ch. Zahnd, F. Huber, A. Bietsch, A. Pluckthun, H.-P. Lang, H.-J. Guntherodt, M. Hegner, and Ch. Gerber, "A label-free immunosensor array using single-chain antibody fragments," PNAS, vol. 102, 14587-14592 (2005)
8. L.M. Lechuga, J.Tamayo, M. Álvarez, L.G. Carrascosa, A. Yufera, R. Doldán, E. Peralías, A. Rueda, J.A. Plaza, K. Zinoviev and C Domínguez, A. Zaballos, M. Moreno and C. Martínez-A, D. Wenn, N. Harris, C. Bringer, V. Bardinal, T. Camps, "A highly sensitive microsystem based on nanomechanical biosensors for Genomics applications," Sensors and Actuators B, Vol. 118, 2-10 (2006)
9. M. Yue, H. Lin, D. E. Dedrick, S. Satyanarayana, A. Majumdar, A. S. Bedekar, J. W. Jenkins, S. Sundaram, "A 2-D microcantilever array for multiplexed biomolecular analysis," J. Microelectromech. Syst., vol. 13, 290-299 (2004)
10. T. Fukuma, M. Kimura, K. Kobayashi, K. Matsushige, H. Yamada, "Development of low noise cantilever deflection sensor for multienvironment frequency-modulation atomic force microscopy," Rev. Sci. Instrum. vol. 76, 053704 (2005)
11. C. Schonenberger and S. F. Alvarado, "A differential interferometer for force microscopy," Rev. Sci. Instrum. vol. 60, 3131-3134 (1989)
12. J. Thaysen A. Boisen, O. Hansen, S. Bouwstra, "Atomic force microscopy probe with piezoresistive read-out and a highly symmetrical Wheatstone bridge arrangement," Sensors and actuators A; Physical, vol. 83, 47-53 (2000)
13. G. Shekhawat, S.-H. Tark, V. P. Dravid, "MOSFET-Embedded Microcantilevers for Measuring Deflection in Biomolecular Sensors," Science, vol. 311, 1592 (2006)
14. C. Kocabas, A. Aydinli, "Design and analysis of an integrated optical sensor for scanning force microscopies", IEEE Sensor J. vol. 5, 411-418 (2005)
15. G. G. Yaralioglu, A. Atatar, S. R. Manalis, and C. F. Quate, "Analysis and design of an interdigital cantilever as a displacement sensor," J. Appl. Phys., vol. 83, 7405-7415 (1998)
16. R. Budakian and S. J. Putterman, "Force detection using a fiber-optic cantilever," Appl. Phys. Lett. vol. 81, 2100-2102 (2002)
17. J. Mertens, M. Álvarez, and J. Tamayo, "Real-time profile of microcantilevers for sensing applications," Appl. Phys. Lett. Vol. 87, 234102 (2005)
18. S. Jeon and T. Thundat, "Instant curvature measurement for microcantilever sensors," Appl. Phys. Lett. Vol. 85, 1083 (2004)
19. M. Alvarez, J. Tamayo. "Optical sequential readout of microcantilever arrays for biological detection," Sensors and Actuators B, vol. 106, 687-690 (2005).
20. K. Zinoviev, C. Dominguez, J.A. Plaza, V. Cadarso L.M. Lechuga, "A novel optical waveguide microcantilever sensor for the detection of nanomechanical forces," J. Lightwave Technol., vol. 24 , 2132-2140 (2005)
21. S. L. Biswal, D. Raorane, A. Chaiken, H. Birecki, and A. Majumdar, "Nanomechanical Detection of DNA Melting on Microcantilever Surfaces," Anal. Chem. vol. 78, 7104-7109 (2006)
22. R. McKendry, J. Zhang, Y. Arntz, T. Strunz, M. Hegner, H.P. Lang, M. K. Baller, U. Certa, E. Meyer, H.-J. Güntherodt, and C. Gerber, "Multiple label free biodetection and quantitative DNA-binding assays on a nanomechanical cantilever array," PNAS, vol. 99, 9783-9788 (2002)
23. G. Wu, R. H. Datar, K. M. Hansen, T. Thundat, R. J. Cote, and A. Majumdar, "Bioassay of prostate-specific antigen (PSA) using microcantilevers," Nature Biotechnology, vol. 19, 856 (2001)