Th1-like cytokine production profile and individual specific alterations in TCRBV-gene usage of T cells from newly diagnosed type 1 diabetes patients after stimulation with β-cell antigens

Journal of Autoimmunity

Volumn 10, Issue 6, 1997, Pages 589-598

  Kallan, Aram A ^a   Duinkerken, Gaby ^a   De Jong, Rolien ^a   Van Den Elsen, Peter ^a   Hutton, John C ^b   Martin, Stephan ^c   Roep, Bart O ^a   De Vries, René R P ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF COLORADO   (United States)

^c NONE

Author keywords

B cell antigens; Cytokine production; T cells; TCRBV gene usage; Type 1 diabetes

Indexed keywords

CYTOKINE; TETANUS TOXOID;

ANTIGEN RECOGNITION; ANTIGEN SPECIFICITY; ARTICLE; AUTOIMMUNITY; DRUG RECEPTOR BINDING; GENE EXPRESSION REGULATION; GENE MUTATION; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNOSTIMULATION; INSULIN DEPENDENT DIABETES MELLITUS; PANCREAS ISLET BETA CELL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0031465874     PISSN: 08968411     EISSN: None     Source Type: Journal    
DOI: 10.1006/jaut.1997.0167     Document Type: Article

References (52)

1. Atkinson M.A., Maclaren N.K. Mechanisms of disease - the pathogenesis of insulin-dependent diabetes mellitus. N. Engl. J. Med. 331:1994;1428-1436.
2. Bottazzo G.F., Dean B.M., McNally J.M., MacKay E.H., Swift P.G.F., Gamble D.R. In situ characterization of autoimmune phenomena and expression of HLA class II molecules in the pancreas in diabetic insulitis. N. Engl. J. Med. 313:1985;353-360.
3. Stiller C.R., Dupre J., Gent M., Jenner M.R., Keown P.A., Laupacis A., Martell R., Rodger N.W., Graffenfried B.V., Wolfe B.M.J. Effects of cyclosporin immunosuppression in insulin-dependent diabetes mellitus of recent onset. Science. 223:1984;1362-1367.
4. Sibley R., Sutherland D.E.R., Goetz F., Michael A.F. Recurrent diabetes mellitus in the pancreas iso- and allograft. A light and electron microscopic and immunohistochemical analysis of four cases. Lab. Invest. 53:1985;132-144.
5. Murray J.S., Madri J., Pasqualini T., Bottomly K. Functional CD4 T cell subset interplay in an intact immune system. J. Immunol. 150:1993;4270-4276.
6. Rivkin E., Vella M.J., Lahita R.G. A heterogeneous immune response to an smd-like epitope by sle patients. J. Autoimmun. 7:1994;119-132.
7. Wierenga E.A., Snoek M., de Groot C., Chretien I., Bos J.D., Janse H.M., Kapsenberg M.L. Evidence for compartmentalization of functional subsets of CD2+ T lymphocytes in atopic patients. J. Immunol. 144:1990;4651-4656.
8. Haanen J.B., de Waal Malefyt R., Res P.C., Kraakman E.M., Ottenhoff T.H., de Vries R.R.P., Spits H. Selection of a human T helper type 1-like T cell subset by mycobacteria. J. Exp. Med. 174:1991;583-592.
9. Romagnani S. Induction of TH1 and TH2 responses: a key role for the 'natural' immune response? Immunol. Today. 13:1992;379-381.
10. Shehadeh N.N., LaRosa F., Lafferty K.J. Altered cytokine activity in adjuvant inhibition of autoimmune diabetes. J. Autoimmun. 6:1993;291-300.
11. Elias D., Reshef T., Birk O.S., Van der Zee R., Walker M.D., Cohen I.R. Vaccination against autoimmune mouse diabetes in young NOD mice with a T-cell epitope of the human 65-kDa heat shock protein. Proc. Natl. Acad. Sci. USA. 88:1991;3088-3091.
12. Qin H.Y., Sadelain M.W., Hitchon C., Lauzon J., Singh B. Complete Freund's adjuvant-induced T cells prevent the development and adoptive transfer of diabetes in nonobese diabetic mice. J. Immunol. 150:1993;2072-2080.
13. Wogensen L., Lee M.S., Sarvetnick N. Production of interleukin-10 by islet cells accelerates immune-mediated destruction of beta-cells in nonobese diabetic mice. J. Exp. Med. 179:1994;1379-1384.
14. Rapoport M.J., Jaramillo A., Zipris D., Lazarus A.H., Serreze D.V., Leiter E.H., Cyopick P., Danska J.S., Delovitch T.L. Interleukin-4 reverses T-cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice. J. Exp. Med. 178:1993;87-99.
15. Lee M.S., Wogensen L., Shizuru J., Oldstone M.B., Sarvetnick N. Pancreatic islet production of murine interleukin-10 does not inhibit immune-mediated tissue destruction. J. Clin. Invest. 93:1994;1332-1338.
16. Katz J.D., Benoist C., Mathis D. T helper cell subsets in insulin-dependent diabetes. Science. 268:1995;1185-1188.
17. +beta islet cell-reactive T cell clones that suppress autoimmune diabetes in nonobese diabetic mice. J. Exp. Med. 182:1995;87-97.
18. Chosich N., Harrison L.C. Suppression of diabetes-mellitus in the non-obese diabetic (NOD) mouse by an autoreactive (Anti-I-A(g7)) islet-derived CD4+ T-cell line. Diabetologia. 36:1993;716-721.
19. Harrison L.C., Honeyman M.C., De Aizpurua H.J., Schmidli R.S., Colman P.G., Tait B.D., Cram D.S. Inverse relation between humoral and cellular immunity to glutamic acid decarboxylase in subjects at risk of insulin-dependent diabetes. Lancet. 341:1993;1365-1369.
20. Roep B.O., Duinkerken G., Schreuder G.M., Kolb H., de Vries R.R., Martin S. HLA-associated inverse correlation between T cell and antibody responsiveness to islet autoantigen in recent-onset insulin-dependent diabetes mellitus. Eur. J. Immunol. 26:1996;1285-1289.
21. Zamvil S.S., Steinman L. The T lymphocyte in experimental allergic encephalomyelitis. Ann. Rev. Immunol. 8:1990;579-621.
22. Vandenbark A.A., Hashim G., Offner H. Immunization with a synthetic T-cell receptor V-region peptide protects against experimental autoimmune encephalomyelitis. Nature. 341:1989;541-544.
23. Acha-Orbea H., Mitchell D.J., Timmermann L., Wraith D.C., Tausch G.S., Waldor M.K., Zamvil S.S., McDevitt H.O., Steinman L. Limited heterogeneity of T cell receptors from lymphocytes mediating autoimmune encephalomyelitis allows specific immune intervention. Cell. 54:1988;263-273.
24. Schwartz R.H. T lymphocyte recognition of antigen in association with gene products of the major histocompatibility complex. Annu. Rev. Immunol. 3:1985;237-261.
25. Candéias S., Katz J., Benoist C., Mathis D., Haskins K. Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors. Proc. Natl. Acad. Sci. USA. 88:1991;6167-6170.
26. Maeda T., Sumida T., Kurasawa K., Tomioko H., Itoh I., Yoshida S., Koike T. T-lymphocyte-receptor repertoire of infiltrating T lymphocytes into NOD mouse pancreas. Diabetes. 40:1991;1580-1585.
27. Surakhan A., Gombert J.M., Olivi M., Bach J.F., Carnaud C., Garchon H.J. Anchored polymerase chain reaction based analysis of the V beta repertoire in the non-obese diabetic (NOD) mouse. Eur. J. Immunol. 24:1994;1750-1756.
28. Edouard P., Thivolet C., Bedossa P., Olivi M., Legrand B., Bendelac A., Bach J.F., Carnaud C. Evidence for a preferential V-beta usage by the T-cells which adoptively transfer diabetes in Nod mice. Eur. J. Immunol. 23:1993;727-733.
29. Galley K.A., Danska J.S. Peri-islet infiltrates of young non-obese diabetic mice display restricted TCR beta-chain diversity. J. Immunol. 154:1995;2969-2982.
30. Simone E., Daniel D., Schloot N., Gottlieb P., Babu S., Kawasaki E., Wegmann D., Eisenbarth G.S. T cell receptor restriction of diabetogenic autoimmune NOD T cells. Proc. Natl. Acad. Sci. USA. 94:1997;2518-2521.
31. Hanninen A., Jalkanen S., Salmi M., Toikkanen S., Nikolakaros G., Simell O. Macrophages, T-cell receptor usage, and endothelial cell activation in the pancreas at the onset of insulin-dependent diabetes-mellitus. J. Clin. Invest. 90:1992;1901-1910.
32. Somoza N., Vargas F., Rouramir C., Vivespi M., Fernandezfigueras M.T., Ariza A., Gomis R., Bragado R., Marti M., Jaraquemada D., Pujol-Borrell R. Pancreas in recent onset insulin-dependent diabetes mellitus - changes in HLA, adhesion molecules and autoantigens, restricted T cell receptor V beta usage, and cytokine profile. J. Immunol. 153:1994;1360-1377.
33. Conrad B., Weidmann E., Trucco G., Rudert W.A., Behboo R., Ricordi C., Rodriquezrilo H., Finegold D., Trucco M. Evidence for superantigen involvement in insulin-dependent diabetes mellitus aetiology. Nature. 371:1994;351-355.
34. Roep B.O., Arden S.D., de Vries R.R.P., Hutton J.C. T-cell clones from a type-1 diabetes patient respond to insulin secretory granule proteins. Nature. 345:1990;632-634.
35. Martin S., Kardorf J., Schulte B., Lampeter E.F., Gries F.A., Melchers I., Wagner R., Bertrams J., Roep B.O., Pfutzner A., Pietropaolo M., Kolb H. Autoantibodies to the islet antigen ICA69 occur in IDDM and in rheumatoid arthritis. Diabetologia. 38:1995;351-355.
36. Roep B.O., Kallan A.A., Hazenbos W.L., Bruining G.J., Bailyes E.M., Arden S.D., Hutton J.C., de Vries R.R.P. T-cell reactivity to 38 kD insulin-secretory-granule protein in patients with recent-onset type 1 diabetes. Lancet. 337:1991;1439-1441.
37. Atkinson M.A., Kaufman D.L., Campbell L., Gibbs K.A., Shah S.C., Bu D.F., Erlander M.G., Tobin A.J., Maclaren N.K. Response of peripheral-blood mononuclear cells to glutamate decarboxylase in insulin-dependent diabetes. Lancet. 339:1992;458-459.
38. Mutis T., Kraakman E.M., Cornelisse Y.E., Haanen J.B., Spits H., de Vries R.R.P., Ottenhoff T.H. Analysis of cytokine production by Mycobacterium-reactive T cells. Failure to explain Mycobacterium leprae-specific nonresponsiveness of peripheral blood T cells from lepromatous leprosy patients. J. Immunol. 150:1993;4641-4651.
39. +subsets of lymphocytes-T in monozygotic twins. J. Immunol. 150:1993;2033-2045.
40. Rabinovitch A. Immunoregulatory and cytokine imbalances in the pathogenesis of IDDM. Therapeutic intervention by immunostimulation? Diabetes. 43:1994;613-621.
41. +T-cell subset that inhibits this autoimmune potential. J. Exp. Med. 177:1993;627-636.
42. Campbell I.L., Iscaro A., Harrison L.C. IFN-g and tumor necrosis factor-alpha. Cytotoxicity to murine islets of Langerhans. J. Immunol. 141:1988;2325-2329.
43. Soldevila G., Buscema M., Doshi M., James R.F., Bottazzo G.F., Pujol-Borrell R. Cytotoxic effect of IFN-gamma plus TNF-alpha on human islet cells. J. Autoimmun. 4:1991;291-306.
44. Pugliese A., Gianani R., Moromisato R., Awdeh Z.L., Alper C.A., Erlich H.A., Jackson R.A., Eisenbarth G.S. Hla-dqb1*0602 is associated with dominant protection from diabetes even among islet cell antibody-positive first-degree relatives of patients with IDDM. Diabetes. 44:1995;608-613.
45. Kontiainen S., Toomath R., Lowder J., Feldmann M. Selective activation of T cells in newly diagnosed insulin-dependent diabetic patients: evidence for heterogeneity of T cell receptor usage. Clin. Exp. Immunol. 83:1991;347-351.
46. Wong F.S., Hibberd M.L., Millward B.A., Demaine A.G. Peripheral TCR Vβ expression is not restricted in newly-diagnosed type 1 diabetes. Autoimmunity. 15 (suppl):1993;52-52.
47. Malhotra U., Spielman R., Concannon P. Variability in T-cell receptor Vbeta-gene usage in human peripheral blood lymphocytes - studies of identical twins, siblings, and insulin-dependent diabetes mellitus patients. J. Immunol. 149:1992;1802-1808.
48. Hibberd M.L., Wong F.S., Nicholson L.B., Demaine A.G. Analysis of human T-cell receptor V-beta gene usage following immunization to tetanus toxoid in vivo. Immunology. 79:1993;398-402.
49. Durinovic-Bellò I., Steinle A., Ziegler A.G., Schendel D.J. HLA-DQ-restricted, islet-specific T-cell clones of a type I diabetic patient - T-cell receptor sequence similarities to insulitis-inducing T-cells of nonobese diabetic mice. Diabetes. 43:1994;1318-1325.
50. Bergman B., Haskins K. Islet-specific T cell clones from the NOD mouse respond to beta-granule antigen. Diabetes. 43:1994;197-203.
51. Sorger S.B., Paterson Y., Fink P.J., Hedrick S.M. T cell receptor junctional region and the MHC molecule affect recognition of antigenic peptides by T cell clones. J. Immunol. 144:1990;1127-1135.
52. Danska J.S., Livingstone A.M., Paragas V., Ishihara T., Fathman C.G. The presumptive CDR3 regions of both the T cell receptor alpha and beta chains determine T cell specificity for myoglobin peptides. J. Exp. Med. 172:1990;27-33.