Tolerance and immunity to MUC1 in a human MUC1 transgenic murine model

Cancer Research

Volumn 58, Issue 2, 1998, Pages 315-321

  Rowse, Gerald J ^a   Tempero, Richard M ^b   VanLith, Michelle L ^b   Hollingsworth, Michael A ^b   Gendler, Sandra J ^a  

^a MAYO CLINIC   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN G; MUCIN; MUCIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER IMMUNOTHERAPY; CONTROLLED STUDY; EPITHELIUM TUMOR; GENE EXPRESSION REGULATION; GENE SWITCHING; HUMAN; HUMAN CELL; IMMUNOLOGICAL TOLERANCE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN GLYCOSYLATION; T LYMPHOCYTE; TUMOR IMMUNITY; TUMOR VOLUME;

ANIMALS; ANTIBODIES, NEOPLASM; ANTIBODY FORMATION; CA-15-3 ANTIGEN; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; HUMANS; IMMUNE TOLERANCE; IMMUNITY, CELLULAR; IMMUNOENZYME TECHNIQUES; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; T-LYMPHOCYTES; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0031963862     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (33)

1. Gendler, S. J., Lancaster, C. A., Taylor-Papadimitriou, J., Duhig, T., Peat, N., Burchell, J., Pemberton, L., Lalani, E. N., and Wilson, D. Molecular cloning and expression of human tumor-associated polymorphic epithelial mucin. J. Biol. Chem., 265: 15286-15293, 1990.
2. Gendler, S. J., Taylor-Papadimitriou, J., Duhig, T., Rothbard, J., and Burchell, J. A highly immunogenic region of a human polymorphic epithelial mucin expressed by carcinomas is made up of tandem repeats. J. Biol. Chem., 263: 12820-12823, 1988.
3. Lan, M. S., Batra, S. K., Qi, W-N., Metzgar, R. S., and Hollingsworth, M. A. Cloning and sequencing of a human pancreatic apomucin cDNA. J. Biol. Chem., 265: 15294-15299, 1990.
4. Gendler, S. J., and Spicer, A. P. Epithelial mucin genes. Annu. Rev. Physiol., 57: 607-634, 1995.
5. Barnd, D. L., Lan, M. S., Metzgar, R. S., and Finn, O. J. Specific, major histocompatibility complex-unrestricted recognition of tumor-associated mucins by human cytotoxic T cells. Proc. Natl. Acad. Sci. USA, 86: 7159-7163, 1989.
6. Jerome, K. R., Domenech, N., and Finn, O. J. Tumor-specific cytotoxic T cell clones from patients with breast and pancreatic adenocarcinoma recognize EBV-immortalized B cells transfected with polymorphic epithelial mucin complementary DNA. J. Immunol., 151: 1654-1662, 1993.
7. Kotera, Y., Fontenot, J. D., Pecher, G., Metzgar, V., and Finn, O. J. Humoral immunity against a tandem repeat epitope of human MUC1 in sera from breast, pancreas and colon cancer patients. Cancer Res., 54: 2856-2860, 1994.
8. Taylor-Papadimitriou, J. Report on the first international workshop on carcinoma-associated mucins. Int. J. Cancer, 49: 1-5, 1991
9. Xing, P. X., Prenzoska, J., Quelch, K., and McKenzie, I. F. Second generation anti-MUC1 peptide monoclonal antibodies. Cancer Res., 52: 2310-2317, 1992.
10. Zhang, S., Graeber, L. A., Helling, V., Ragupathi, V., Adluri, S., Lloyd, K. O., and Livingston, P. O. Augmenting the immunogenicity of synthetic MUC1 peptide vaccines in mice. Cancer Res., 56: 3315-3319, 1996.
11. Spicer, A. P., Parry, G., Patton, S., and Gendler, S. J. Molecular cloning and analysis of the mouse homologue of the tumor-associated mucin, MUC1, reveals conservation of potential O-glycosylation sites, transmembrane, and cytoplasmic domains and a loss of minisatellite-like polymorphism. J. Biol. Chem., 266: 15099-15109, 1991.
12. Apostolopoulos, V., Xing, P. X., and McKenzie, I. F. C. Murine immune response to cells transfected with human MUC1: immunization with cellular and synthetic antigens. Cancer Res., 54: 5186-5193, 1994.
13. Graham, R. A., Burchell, J. M., Beverley, P., and Taylor-Papadimitriou, J. Intramuscular immunization with MUC1 cDNA can protect C57 mice challenged with MUC1-expressing syngeneic mouse tumour cells. Int. J. Cancer, 65: 664-670, 1996.
14. Lalani, E. N., Berdichevsky, F., Boshell, V., Shearer, M., Wilson, D., Stauss, H., Gendler, S. J., and Taylor-Papadimitriou, J. Expression of the gene coding for a human mucin in mouse mammary tumor cells can affect their tumorigenicity. J. Biol. Chem., 266: 15420-15426, 1991.
15. Disis, M. L., and Cheever, M. A. Oncogenic proteins as tumor antigens. Curr. Opin. Immunol., 8: 637-642, 1996.
16. Robbins, P. F., and Kawakami, Y. Human tumor antigens recognized by T cells. Curr. Opin. Immunol., 8: 628-636, 1996.
17. Jones, L. A., Chin, L. T., Longo, D. L., and Kruisbeek, A. D. Peripheral clonal elimination of functional T cells. Science (Washington DC), 250: 1726-1729, 1990.
18. Kappler, J. W., Roehm, N., and Marrack, P. T cell tolerance by clonal elimination in the thymus. Cell, 49: 273-280, 1987.
19. Mondino, A., Khoruts, A., and Jenkins, M. K. The anatomy of T-cell activation and tolerance. Proc. Natl. Acad. Sci. USA, 93: 2245-2252, 1996.
20. Goodnow, C. C., Crosbie, J., Adelstein, S., Lavoie, T. B., Smith-Gill, S. J., Brink, R. A., Pritchard-Briscoe, H., Wotherspoon, J. S., Loblay, R. H., Raphael, K., Trent, R. J., and Basten, A. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature (Lond.), 334: 676-682, 1988.
21. Nemazee, D. A., and Burki, K. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature (Lond.), 337: 562-566, 1989.
22. Yule, T. D., Basten, A., and Allen, P. M. Hen egg-white lysozyme-specific T cells elicited in hen egg-white lysozyme-transgenic mice retain an imprint of self-tolerance. J. Immunol., 151: 3057-3069, 1993.
23. Peat, N., Gendler, S. J., Lalani, E-N., Duhig, T., and Taylor-Papadimitriou, J. Tissue-specific expression of a human polymorphic epithelial mucin (MUC1) in transgenic mice. Cancer Res., 52: 1954-1960, 1992.
24. Talmadge, J. E., Talmadge, C. B., Zbar, B., McEwen, R., Meeker, A. K., and Tribble, H. In vivo immunologic selection of class I major histocompatibility complex gene deletion variants from the B16-BL6 melanoma. J. Natl. Cancer Inst., 78: 1215-1221, 1987.
25. Gunning, P., Leavitt, J., Muscat, G., Ng, S-Y., and Kedes, L. A human β-actin expression vector system directs high-level accumulation of antisense transcripts. Proc. Natl. Acad. Sci. USA, 84: 4831-4835, 1987.
26. Burdick, M. D., Harris, A., Reid, C. J., Iwamura, T., and Hollingsworth, M. A. Oligosaccharides expressed on MUC1 produced by pancreatic and colon tumor cell lines. J. Biol. Chem., 272: 24198-24202, 1997.
27. Pemberton, L., Taylor-Papadimitriou, J., and Gendler, S. J. Antibodies to the cytoplasmic domain of the MUC1 mucin show conservation throughout mammals Biochem. Biophys. Res. Commun., 185: 167-175, 1992.
28. Fontenot, J. D., Tjandra, N., Bu, D., Ho, C., Montelaro, R. C., and Finn, O. J. Biophysical characterization of one-, two-, and three-tandem repeats of human mucin (MUC1) protein core. Cancer Res., 53: 5386-5394, 1993.
29. Fontenot, J. D., Finn, O. J., Dales, N., Andrews, P. C., and Montelaro, R. C. Synthesis of large multi-determinate immunogens using the poly-proline β-turn helix motif. Pept. Res., 6: 330-336, 1993.
30. Spicer, A. P., Rowse, G. J., Lidner, T. K., and Gendler, S. J. Delayed mammary tumor progression in Muc1 null mice. J. Biol. Chem., 270: 30093-30101, 1995.
31. Adelstein, S., Pritchard-Briscoe, H., Anderson, T. A., Crosbie, J., Gammon, G. Loblay, R. H., Basten, A., and Goodnow, C. C. Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen. Science (Washington DC), 251: 1223-1225, 1991.
32. Milich, D. R., Jones, J. E., Hughes, J. L., Maruyama, T., Price, J., Melhado, I., and Jirik, F. Extrathymic expression of the intracellular hepatitis B core antigen results in T cell tolerance in transgenic mice. J. Immunol., 152: 455-466, 1994.
33. Rowse, G. J., Tempero, R., Hollingsworth, M. A., and Gendler, S. J. MUC1 peptide immunogens produce different antibody responses in native and MUC1 transgenic mice. In: J. Taylor Papadimitriou (ed.), 4th International Workshop on Carcinoma Associated Mucins, p. 83. Cambridge, UK: Imperial Cancer Research Fund, 1996.