T-cell recognition of tumor-associated carbohydrates: The nature of the glycan moiety plays a decisive role in determining glycopeptide immunogenicity

Cancer Research

Volumn 57, Issue 15, 1997, Pages 3214-3222

  Galli Stampino, Luisa ^a   Meinjohanns, Ernst ^b   Frische, Klaus ^b   Meldal, Morten ^b   Jensen, Teis ^c   Werdelin, Ole ^c   Mouritsen, Søren ^a,d  

^a M and E Biotech A/S   (Denmark)

^b CARLSBERG LABORATORY   (Denmark)

^c UNIVERSITY OF COPENHAGEN   (Denmark)

^d M and E A/S   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CANCER VACCINE; CARBOHYDRATE; GLYCAN; GLYCOPEPTIDE;

AMINO ACID SEQUENCE; ANTIGEN RECOGNITION; ARTICLE; BINDING COMPETITION; CARBOHYDRATE ANALYSIS; CARBOHYDRATE METABOLISM; CELL PROLIFERATION; DATA ANALYSIS; GLYCOSYLATION; IMMUNE RESPONSE; MAJOR HISTOCOMPATIBILITY COMPLEX; PRIORITY JOURNAL; PROTEIN STRUCTURE; T LYMPHOCYTE;

ANIMALS; ANTIGENS, TUMOR-ASSOCIATED, CARBOHYDRATE; BINDING, COMPETITIVE; CELL DIVISION; GLYCOPEPTIDES; HEMOGLOBINS; HISTOCOMPATIBILITY ANTIGENS CLASS II; MICE; MICE, INBRED CBA; MODELS, STRUCTURAL; PEPTIDE FRAGMENTS; T-LYMPHOCYTES;

EID: 0030854842     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Hakomori, S-I. Aberrant glycosylation in tumors and tumor-associated carbohydrate antigens. Adv. Cancer Res., 52: 257-331, 1989.
2. Springer, G. F. T and Tn, general carcinoma autoantigens. Science (Washington DC), 224: 1198-1206, 1984.
3. Hirohashi, S., Clausen, H., Yamada, T., Shimosato, Y., and Hakomori, S-I. Blood group A cross-reacting epitope defined by monoclonal antibodies NCC-LU-35 and -81 expressed in cancer of blood group O or B individuals: its identification as Tn antigen. Proc. Natl. Acad. Sci. USA, 82: 7039-7043, 1985.
4. Yang, J-M., Byrd, J. C., Siddiki, B. B., Chung, Y-S., Okuno, M., Sowa, M., Kim, Y. S., Matta, K. L., and Brockhausen, I. Alterations of O-glycan biosynthesis in human colon cancer tissues. Glycobiology, 4: 873-884, 1994.
5. MacLean, G. D., Bowen-Yacyshyn, M. B., Samuel, J., Meikle, A., Stuart, G., Nation, J., Poppema, S., Jerry, M., Koganty, R., Wong, T., and Longenecker, B. M. Active immunization of human ovarian cancer patients against a common carcinoma (Thomsen-Friedenreich) determinant using a synthetic carbohydrate antigen. J. Immunother., 11: 292-305, 1992.