Bioprocess development for the production of a recombinant MUC1 fusion protein expressed by CHO-K1 cells in protein-free medium

Journal of Biotechnology

Volumn 110, Issue 1, 2004, Pages 51-62

  Link, T ^a   Backstrom M ^b   Graham, R ^c   Essers, R ^a   Zorner K ^a   Gatgens J ^a   Burchell, J ^c   Taylor Papadimitriou, J ^c   Hansson, G C ^b   Noll, T ^a,d  

^a FORSCHUNGSZENTRUM JÜLICH   (Germany)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

^d HAHN MEITNER INSTITUT   (Germany)

Author keywords

CHO K1 cells; MUC1; Oxygen uptake rate; Perfusion culture; pO2; Serum free adaptation

Indexed keywords

CELL CULTURE; OXIDATION; PH EFFECTS; PHOSPHORUS COMPOUNDS; PROTEINS; TUMORS;

BIPROCESS DEVELOPMENT; GLYCOSYLATION;

BIOTECHNOLOGY;

HYBRID PROTEIN; IMMUNOGLOBULIN FC FRAGMENT; MUCIN 1;

ANIMAL CELL; ARTICLE; BIOPROCESS; CELL DENSITY; CELL GROWTH; CHINESE HAMSTER; CORRELATION ANALYSIS; CULTURE MEDIUM; GLYCOSYLATION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; OXYGEN CONSUMPTION; PH; PRIORITY JOURNAL; PRODUCTIVITY; PROTEIN DEGRADATION; PROTEIN EXPRESSION;

ANIMALS; BIOREACTORS; BIOTECHNOLOGY; CA-15-3 ANTIGEN; CELL COUNT; CELL CULTURE TECHNIQUES; CELL LINE; CHO CELLS; CRICETINAE; CULTURE MEDIA, SERUM-FREE; GENE EXPRESSION; GLUCOSE; GLUTAMINE; GLYCOSYLATION; HUMANS; HYDROGEN-ION CONCENTRATION; RECOMBINANT FUSION PROTEINS; TIME FACTORS;

EID: 11144354528     PISSN: 01681656     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2003.12.008     Document Type: Article

References (36)

1. Altschuler Y., Kinlough C.L., Poland P.A., Bruns J.B., Apodaca G., Weisz O.A., Hughey R.P. Mol. Biol. Cell. 11:2000;819-831.
2. Backstrom, M., Link, T., Olson, F.J., Karlsson, H., Graham, R., Picco, G., Burchell, J., Taylor-Papadimitriou, J., Noll, T., Hansson, G.C., 2003. Biochem. J. 376, 677-686.
3. Balin A.K., Goodman D.B.P., Rasmussen H., Cristofalo V.J. J. Cell. Physiol. 89:1976;235-249.
4. Barnabé N., Butler M. Cytotechnology. 34(1-2):2000;47-57.
5. Bohnenkamp H., Hilbert U., Noll T. Cytotechnology. 38:2002;135-145.
6. Bragonzi A., Distefano G., Buckberry L.D., Acerbis G., Foglieni C., Lamotte D., Campi G., Marc A., Soria M.R., Jenkins N., Monaco L. Biochim. Biophys. Acta. 1474:2000;273-282.
7. Burchell J., Taylor-Papadimitriou J., Boshell M., Gendler S.J., Duhig T. Int. J. Cancer. 44:1989;691-696.
8. Burchell J., Taylorpapadimitriou J. Epithelial Cell Biol. 2:1993;155-162.
9. Carmeliet P., Dor Y., Herbert J.M., Fukumura D., Brusselmans K., Dewerchin M., Neeman M., Bono F., Abramovitch R., Maxwell P., Koch C.J., Ratcliffe P., Moons L., Jain R.K., Collen D., Keshert E., Keshet E. Nature. 394:1998;485-490.
10. Castilho L.R., Anspach F.B., Deckwer W.D. Biotechnol. Prog. 18:2002;776-781.
11. Chu L., Robinson D.K. Curr. Opin. Biotechnol. 12:2001;180-187.
12. Dalziel M., Whitehouse C., McFarlane I., Brockhausen I., Gschmeissner S., Schwientek T., Clausen H., Burchell J.M., Taylor-Papadimitriou J. J. Biol. Chem. 276:2001;11007-11015.
13. Dowd J.E., Kwok K.E., Piret J.M. Biotechnol. Bioeng. 75:2001;252-256.
14. Garber K. Nat. Biotechnol. 18:2000;1133.
15. Gendler S.J., Lancaster C.A., Taylor-Papadimitriou J., Duhig T., Peat N., Burchell J., Pemberton L., Lalani E.N., Wilson D. J. Biol. Chem. 265:1990;15286-15293.
16. Goochee C.F., Monica T. Biotechnology (NY). 8:1990;421-427.
17. Gottesman M. Meth. Enzymol. 151:1987;3-8.
18. Hinojosa-Kurtzberg A.M., Johansson M.E., Madsen C.S., Hansson G.C., Gendler S.J. Am. J. Physiol. Gastrointest. Liver Physiol. 15:2003;15.
19. Jenkins N., Parekh R.B., James D.C. Nat. Biotechnol. 14:1996;975-981.
20. Konstantinov K.B., Tsai Y., Moles D., Matanguihan R. Biotechnol. Prog. 12:1996;100-109.
21. Kunkel J.P., Jan D.C., Butler M., Jamieson J.C. Biotechnol. Prog. 16:2000;462-470.
22. Lloyd K.O., Burchell J., Kudryashov V., Yin B.W., Taylor-Papadimitriou J. J. Biol. Chem. 271:1996;33325-33334.
23. Miller, W.M., Blanch, H.W., Wilke, C.R., 1986. Abstracts of Papers of the American Chemical Society, vol. 192, p. 90-MBTD.
24. Miller W.M., Wilke C.R., Blanch H.W. J. Cell Physiol. 132:1987;524-530.
25. Moller H., Serttas N., Paulsen H., Burchell J.M., Taylor-Papadimitriou J., Meyer B. Eur. J. Biochem. 269:2002;1444-1455.
26. Norum L.F., Varaas T., Kierulf B., Nustad K. Tumour Biol. 19(Suppl. 1):1998;134-146.
27. Petrakou E., Murray A., Price M. Tumour Biol. 19(Suppl. 1):1998;21-29.
28. Ryll T., Dutina G., Reyes A., Gunson J., Krummen L., Etcheverry T. Biotechnol. Bioeng. 69:2000;440-449.
29. Seagroves T.N., Ryan H.E., Lu H., Wouters B.G., Knapp M., Thibault P., Laderoute K., Johnson R.S. Mol. Cell Biol. 21:2001;3436-3444.
30. Spencer D.I., Price M.R., Tendler S.J., De Matteis C.I., Stadie T., Hanisch F.G. Cancer Lett. 100:1996;11-15.
31. Taylor-Papadimitriou J., Burchell J., Miles D.W., Dalziel M. Biochim. Biophys. Acta. 1455:1999;301-313.
32. Weikert S., Papac D., Briggs J., Cowfer D., Tom S., Gawlitzek M., Lofgren J., Mehta S., Chisholm V., Modi N., Eppler S., Carroll K., Chamow S., Peers D., Berman P., Krummen L. Nat. Biotechnol. 17:1999;1116-1121.
33. Yang J.D., Angelillo Y., Chaudhry M., Goldenberg C., Goldenberg D.M. Biotechnol. Bioeng. 69:2000;74-82.
34. Zhou W.C. Cytotechnology. 24(2):1999;99-108.
35. Zhou W.C., Rehm J., Hu W.S. Biotechnol. Bioeng. 46:1995;579-587.
36. Zupke C., Sinskey A.J., Stephanopoulos G. Appl. Microbiol. Biotechnol. 44:1995;27-36.