Cytotoxic T lymphocytes derived from bone marrow mononuclear cells of multiple myeloma patients recognize an underglycosylated form of MUC1 mucin

International Immunology

Volumn 9, Issue 5, 1997, Pages 791-798

  Noto, Hisaya ^a   Takahashi, Tohru ^a   Makiguchi, Yusuke ^a   Hayashi, Toshiaki ^a   Hinoda, Yuji ^a   Imai, Kohzoh ^a  

^a SAPPORO MEDICAL UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

HLA unrestricted; O glycosylation; Underglycosylation

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; MONOCLONAL ANTIBODY; MUCIN; T LYMPHOCYTE RECEPTOR; TUMOR ANTIGEN;

ANIMAL CELL; ANTIGEN ANTIBODY REACTION; ARTICLE; BONE MARROW CELL; BREAST CARCINOMA; CELL LINE; CLINICAL ARTICLE; COLON CARCINOMA; CONTROLLED STUDY; CYTOLYSIS; CYTOTOXIC T LYMPHOCYTE; GENETIC TRANSFECTION; GLYCOSYLATION; HUMAN; HUMAN CELL; LYMPHOCYTE ACTIVATION; MONONUCLEAR CELL; MOUSE; MULTIPLE MYELOMA; MYELOMA CELL; NONHUMAN; PRIORITY JOURNAL;

ANTIBODIES, BLOCKING; ANTIBODIES, MONOCLONAL; BONE MARROW; BONE MARROW CELLS; BREAST NEOPLASMS; CA-15-3 ANTIGEN; CARCINOMA; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; CYTOTOXICITY TESTS, IMMUNOLOGIC; GLYCOSYLATION; HUMANS; LEUKOCYTES, MONONUCLEAR; MULTIPLE MYELOMA; T-LYMPHOCYTES, CYTOTOXIC; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0030996555     PISSN: 09538178     EISSN: None     Source Type: Journal    
DOI: 10.1093/intimm/9.5.791     Document Type: Article

References (41)

1. Hareuveni, M., Tsarfaty, I., Zaretsky, J., Kotkes, P., Horev, J., Zrihan, S., Weiss, M., Green, S., Lathe, R., Keyder, I. and Wreschner, D. H. 1990. A transcribed gene, containing a variable number of tandem repeats, codes for a human epithelial tumor antigen. cDNA cloning, expression of the transfected gene and over-expression in breast cancer tissue. Eur. J. Biochem. 189:475.
2. Lan, M. S., Batra, S. K., Qui, W.-N., Metzgar, R. S. and Hollingsworth, M. A. 1990 Cloning and sequencing of a human pancreatic tumor mucin cDNA. J. Biol. Chem. 265:5573.
3. Merlo, G. R., Siddiqui, J., Cropp, C., Liscia, D. S., Lidereau, R., Callahan, R. and Kufe, D. 1989. Frequent alteration of the DF3 tumor-associated antigen gene in primary human breast carcinomas. Cancer Res. 49:6996.
4. Pandy, P., Kharbanda, S. and Kufe, D. 1995. Association of the DF3/MUC1 breast cancer antigen with Grb2 and Sos/Ras exchange protein. Cancer Res. 55:4000.
5. Rughetti, A., Turchi, V., Ghetti, C. A., Scambia, G., Panici, P. B., Roncucci, G., Mancuso, S., Frati, L. and Nuti, M. 1993. Human B-cell immune response to polymorphic epithelial mucin. Cancer Res. 53:2457.
6. Kotera, Y., Fontenot, J. D., Pecher, G., Metzgar, R. S. and Finn, O. J. 1994. Humoral immunity against a tandem epitope of human mucin MUC1-1 in sera from breast, pancreatic, and colon cancer patients. Cancer Res. 54:2856.
7. Hinoda, Y., Nakagawa, N., Nakamura, H., Makiguchi, Y., Itoh, F., Adachi, M., Yabana, T., Imai, K. and Yachi, A. 1993. Detection of a circulating antibody against a peptide epitope on a mucin core protein, MUC1, in ulcerative colitis. Immunol. Lett. 35:163.
8. Barnd, D. L., Lan, M, S., Metzgar, R. S. and Finn, O. J. 1989. Specific, major histocompatibility complex-unrestricted recognition of tumor-associated mucins by human cytotoxic T cells. Proc. Natl Acad. Sci. USA 86:7159.
9. Jerome, K. R., Barnd, D. L., Bedt, K. M., Boyer, C. M., Taylor-Papadimitriou, J., Mckenzie, I. F., Bast, R. C. and Finn, O. J. 1991. Cytotoxic T-lymphocytes derived from patients with breast adenocarcinoma recognize an epitope present on the protein core of a mucin molecule preferentially expressed by malignant cells. Cancer Res. 51:2908.
10. Ioannides, C. G., Fisk, B., Jerome, K. R., Irimura, Wharton, T. J. and Finn, O. J. 1993. Cytotoxic T cells form ovarian malignant tumors can recognize polymorphic epithelial mucin core peptides. J. Immunol. 151:3693.
11. Duperry, C., Klein, B., Durie, B. G. M., Zhang, X., Jourdan, M., Poncelet, P., Favier, F., Vincent, C., Brochier, J., Lenoir, G. and Bataille, R. 1989. Phenotype analysis of human myeloma cell lines. Blood 73:566.
12. Takahashi, T., Makiguchi, Y., Hinoda, Y., Kakiuchi, H., Nakagawa, N., Imai, K. and Yachi, A. 1994. Expression of MUC1 on myeloma cells and induction of HLA-unrestricted cytotoxic T lymphocytes against MUC1 from a multiple myeloma patient. J. Immunol. 153:2102.
13. Yoshida, M., Kimura, A., Numano, F. and Sasazuki, T. 1992. Polymerase chain reaction based analysis of polymorphism in the HLA-B gene. Hum. Immunol. 34:257.
14. Felnandez-Vina, M., Lazaro, A. M., Sun, Y., Miller, S., Forero, L. and Stanstny, P. 1995. Population diversity of B-locus alleles observed by high-resolution DNA typing. Tissue Antigens 45:153.
15. Bunce, M., O'Neil, C. M., Barnardo, M. C., Krausa, P., Browning, M. J., Morris, P. J. and Welsh, K. I. 1995. Phototyping: comprehensive DNA typing for HLA-A, B, C, DRB1, DRB3, DRB4, DRB5 and DQB1 by PCR with 144 primer mixes utilizing sequence-specific primers (PCR-SSP). Tissue Antigens 46:355.
16. Levine, J. E. and Yang, S. S. 1994. SSOP typing of the Tenth International Histocompatibility Workshop reference cell lines for HLA-C alleles. Tissue Antigens 44:174.
17. Ng, J., Hurley, C. K., Baxter-Lowe, L. A., Chopek, M., Coppo, P. A., Hegland, J., KuKuruga, D., Monos, D., Rosner, G., Schmeckpper, Yang, S. S., Dupont, B. and Hartzman, R. J. 1993. Large-scale oligonucleotide typing for DRB1/3/4/ and HLA-DQB1 is highly accurate, specific, and reliable. Tissue Antigens 43:473.
18. Hinoda, Y., Nakagawa, N., Ohe, Y., Kakiuchi, H., Tsujisaki, M., Imai, K. and Yachi, A. 1990. Recognition of the polypeptide core of mucin by monoclonal antibody MUSE11 against an adenocarcinoma-associated antigen. Jpn. J. Cancer Res. 81:1206.
19. Takahashi, T., Imai, K., Sugiyama, T., Sasaki, T. and Yachi, A. 1990. Preparation of anti-T idiotype monoclonal antibody reacting with human T leukemic cell lines and with a small percentage of peripheral T lymphocytes. Clin. Exp. Immunol. 82:590.
20. Batra, S. K., Kern, H. F., Worlock, A. J., Metzgar, R. S. and Hollingworth, M. A. 1991. Transfection of the human Muc 1 mucin gene into a poorly differentiated human pancreatic tumor line, Pane1 : integration, expression and ultrastructural changes. J. Cell Sci. 100:841.
21. Kuan, S.-F., Byrd, J. C., Basbaum, C. and Kim, Y. S. 1989. Inhibition of mucin glycosylation by aryl-N-acetyl-a-galactosamides in human colon cancer cells. J. Biol. Chem. 264:19271.
22. Houghton, A. N. 1994. Cancer antigens: immune recognition of self and altered self. J. Exp. Med. 180:1.
23. Nakao, M., Yamana, H., Imai, Y., Toh, Y., Kimura, A., Yanoma, S., Kakegawa, T. and Itoh, K. 1995 HLA A2601-restricted CTL recognize a peptide antigen expressed on squamous cell carcinoma. Cancer Res. 55:4284.
24. Slingluff, C. L., Cox, A. L., Stover, J. M., Moore, M. M., Hunt, D. F. and Engelhard, V. H. 1994. Cyotoxic T-lymphocyte response to autologous human squamous cell cancer of the lung: epitope reconstruction with peptides extracted from HLA-Aw68. Cancer Res. 54:2731.
25. Wolfel, T., Herr, W., Coulie, P., Schmitt, U., Meyer zum Buschenfelde, K.-H. and Knuth, A. 1993. Lysis of human pancreatic adenocarcinoma cells by autologous HLA-class I-restricted cytolytic T-lymphocyte (CTL) clones. Int. J. Cancer 54:636-644.
26. Fisch, P., Weil-Hillman, G., Uppenkamp, M., Hank, J. A., Chen, B. P., Sosman, J. A., Bridges, A., Colamonici, O. R. and Sondel, P. M. 1989. Antigen-specific recognition of autologous leukemia cells and allogeneic class-l MHC antigens by IL-2 activated cytotoxic T cells from a patient with acute T-cell leukemia. Blood 74:343.
27. Sosman, J. A., Oettel, K. R., Smith, S. D., Hank, J. A., Fisch, P. and Sondel, P. M. 1990. Specific recognition of human leukemic cells by allogeneic T cells: II. Evidence for HLA-D restricted determinants present on unrelated nonleukemic cells. Blood 75:2005.
28. Faber, L. M., van Luemburg-Heijs, S. A. P., Willemze, R. and Falkenburg, J. H. F. 1992. Generation of leukemia-reactive cytotoxic T lymphocytes clones from HLA-identical bone marrow donor of a patients with leukemia. J. Exp. Med. 176:1283.
29. Kolb, H. J., Mittermuller, J., Clemm, Ch., Holler, E., Ledderose, G., Brehm, G., Heim, M. and Wilmanns, W. 1990. Donor leukocyte transfusion for treatment of recurrent chronic myelogenous leukemia in marrow transplant patients. Blood 76:2462.
30. Mackinnon, S., Papadopoulos, E. B., Carabasi, M. H., Reich, L., Collins, N. H., Boulad, F., Castro-Malaspina, H., Childs, B. H., Gillio, A. P., Kernan, N. A., Small, T. N., Young, J. W. and O'Reilly, R. J. 1995. Adoptive immunotherapy evaluating escalating doses of donor leukocytes for relapse of chronic myeloid leukemia after bone marrow transplantation: separation of graft-versus-leukemia responses from graft-versus-host disease. Blood 86:1261.
31. Tricot, G., Vesole, D. H., Jagannath, S., Hilton, J., Munshi, N. and Barlogie, B. 1996. Graft-versus-myeloma effect: proof of principle. Blood 87:1196.
32. Massaia, M., Attisano, C., Peola, S., Montacchini, L., Omede, P., Corradini, P., Ferrero, D., Boccadoro, M., Bianchi, A. and Pileri, A. 1993. Rapid generation of antiplasma cell activity in the bone marrow of myeloma patients by CD3-activated T cells. Blood 82:1787.
33. Jerome, K. R., Bu, D. and Finn, O. J. 1992. Expression of tumor associated epitopes on EBV-immortalized B cells and Burkitt's lymphomas transfected with epithelial mucin cDNA. Cancer Res. 52:5985.
34. Burchell, J. and Taylor-Papadimitriou, J. 1993. Effect of modification of carbohydrate side chains on the reactivity of antibodies core-protein epitopes of the MUC1 gene product. Epith. Cell. Biol. 2:155.
35. Jerome, K. R., Domenech, N. and Finn, O. J. 1993. Tumor-specific cytotoxic T cell clones from patients with breast and pancreatic adenocarcinoma recognize EBV-immortalized B cell transfected with polymorphic epithelial mucin complementary DNA. J. Immunol. 151:1654.
36. Hahn, S., Gehri, R. and Erb, P. 1995. Mechanism and biological significance of CD4-mediated cytotoxicity. Immunol. Rev. 146:57.
37. Hata, H., Matsuzaki, H., Takeya, M., Yoshida, M., Sonoki, T., Nagasaki, A., Kuribayashi, N., Kawano, F. and Takatsuki, K. 1995. Expression of Fas/Apo-1 (CD95) and apoptosis in tumor cells from patients with plasma cell disorders. Blood 86:1939.
38. Barlogie, B., Jagannath, S., Vesole, D. and Tricot, G. 1995. Autologous and allogeneic transplantation for multiple myeloma. Semin. Hematol. 32:31.
39. Anderson, K. C., Anderson, J., Soiffer, R., Freeman, A. S., Takvorian, T., Rabinowe, S. N., Robertson, M. J., Spector, N., Blake, K., Murray, C., Freeman, A., Coral, F., Mauch, P., Marcus, K. C., Nadler, N. M. and Ritz, J. 1993. Monoclonal antibody purged bone marrow transplantation therapy for multiple myeloma. Blood 82:2568.
40. Kwak, L. W., Taub, D. D., Duffy, P. L., Bensinger, W. I., Bryant, E. M., Reynolds, C. W. and Longo, D. L. 1995. Transfer of myeloma idiotype-specific immunity from an actively immunized marrow donor. Lancet 345:1016.
41. Goldmacher, V. S., Bourret, L. A., Levine, B. A., Rasmussen, R. A., Pourshadi, M., Lambert, J. M. and Anderson, K. C. 1994. Anti-CD38-blocked ricin: an immunotoxin for the treatment for multiple myeloma. Blood 84:3017.