Development of a tracer kinetic plasma input model for (R)-[ 11C]PK11195 brain studies

Journal of Cerebral Blood Flow and Metabolism

Volumn 25, Issue 7, 2005, Pages 842-851

  Kropholler, Marc A ^a   Boellaard, Ronald ^a   Schuitemaker, Alie ^a   Van Berckel, Bart N M ^a,b   Luurtsema, Gert ^a   Windhorst, Albert D ^a   Lammertsma, Adriaan A ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Compartmental models; Microglia; Peripheral benzodiazepine receptor; PET; PK11195

Indexed keywords

BENZODIAZEPINE RECEPTOR; CARBON 11; DRUG METABOLITE; LIGAND; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; TRACER;

ACCURACY; ARTERIAL BLOOD; ARTICLE; BLOOD SAMPLING; BLOOD VOLUME; BRAIN CORTEX; CLINICAL ARTICLE; COMPARTMENT MODEL; CONTROLLED STUDY; DISTRIBUTION VOLUME; GENE EXPRESSION; HUMAN; MICROGLIA; MONITORING; MONTE CARLO METHOD; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOACTIVITY; REPRODUCIBILITY;

BLOOD VOLUME; BRAIN; CARBON RADIOISOTOPES; HUMANS; ISOQUINOLINES; KINETICS; MODELS, BIOLOGICAL; MONTE CARLO METHOD; RADIOACTIVE TRACERS;

EID: 21344472582     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jcbfm.9600092     Document Type: Article

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