Lactate treatment causes NF-κB activation and CD44 shedding in cultured trabecular meshwork cells

Investigative Ophthalmology and Visual Science

Volumn 48, Issue 4, 2007, Pages 1615-1621

  Miller, Adam M ^a   Nolan, Michael J ^a,b   Choi, John ^a   Koga, Tomoyo ^b   Shen, Xiang ^b   Yue, Beatrice Y J T ^b   Knepper, Paul A ^a,b,c,d  

^a CHILDREN'S MEMORIAL HOSPITAL   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

^d NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HERMES ANTIGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTIC ACID; MATRIX METALLOPROTEINASE 14; PROTEIN P50; TRYPAN BLUE; CD44 PROTEIN, HUMAN; TRANSCRIPTION FACTOR RELA; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CELL CULTURE; CELL GROWTH; CELL MEMBRANE; CELL STRESS; CELL VIABILITY; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FETAL CALF SERUM; HUMAN; HUMAN CELL; INCUBATION TIME; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; STATISTICAL SIGNIFICANCE; TRABECULAR MESHWORK; WESTERN BLOTTING; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECT; METABOLISM; MIDDLE AGED; TIME;

ADULT; ANTIGENS, CD44; BLOTTING, WESTERN; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; LACTIC ACID; MATRIX METALLOPROTEINASE 14; MIDDLE AGED; TIME FACTORS; TRABECULAR MESHWORK; TRANSCRIPTION FACTOR RELA;

EID: 34248382123     PISSN: 01460404     EISSN: None     Source Type: Journal    
DOI: 10.1167/iovs.06-1086     Document Type: Article

References (53)

1. Yue BYJT. Cellular mechanisms in the trabecular meshwork affecting aqueous humor outflow pathway. In: Albert D, Jakobiec F, eds. Principles and Practice of Ophthalmology. 2nd ed. Philadelphia: WB Sauders Co.; 1999;2596-2613.
2. Wong HR, Ryan M, Wispe JR. Stress response decreases NF-kappaB nuclear translocation and increases I-kappaBalpha expression in A549 cells. J Clin Invest. 1997;99:2423-2428.
3. Wang N, Chintala SK, Fini ME, Schuman JS. Activation of a tissue-specific stress response in the aqueous outflow pathway of the eye defines the glaucoma disease phenotype. Nat Med. 2001;7:304-309.
4. Wang N, Chintala SK, Fini ME, Schuman JS. Ultrasound activates the TM ELAM-1/IL-1/NF-κB response: a potential mechanism for intraocular pressure reduction after phacoemulsification. Invest Ophthalmol Vis Sci. 2003;44:1977-1981.
5. Ferri N, Garton KJ, Raines EW. An NF-kappaB-dependent transcriptional program is required for collagen remodeling by human smooth muscle cells. J Biol Chem. 2003;278:19757-19764.
6. Yager JY, Thornhill JA. The effect of age on susceptibility to hypoxic-ischemic brain damage. Neurosci Biobehav Rev. 1997;21:167-174.
7. Terwel D, Bothmer J, Wolf E, Meng F, Jolles J. Affected enzyme activities in Alzheimer's disease are sensitive to antemortem hypoxia. J Neurol Sci. 1998;161:47-56.
8. Brooks SE, Gu X, Kaufmann PM, Marcus DM, Caldwell RB. Modulation of VEGF production by pH and glucose in retinal Muller cells. Curr Eye Res. 1998;17:875-882.
9. Lenaz G, Bovina C, D'Aurelio M, et al. Role of mitochondria in oxidative stress and aging. Ann NY Acad Sci. 2002;959:199-213.
10. Stern R, Shuster S, Neudecker BA, Formby B. Lactate stimulates fibroblast expression of hyaluronan and CD44: the Warburg effect revisited. Exp Cell Res. 2002;276:24-31.
11. Cichy J, Pure E. The liberation of CD44. J Cell Biol. 2003;161:839-843.
12. Gunthert U, Johansson B. CD44: A protein family involved in autoimmune diseases and apoptosis. Immunologist. 2000;8:106-109.
13. Nakamura H, Suenaga N, Taniwaki K, et al. Constitutive and induced CD44 shedding by ADAM-like proteases and membrane-type 1 matrix metalloproteinase. Cancer Res. 2004;64:876-882.
14. Stoeck A, Keller S, Riedle S, et al. A role for exosomes in the constitutive and stimulus-induced ectodomain cleavage of L1 and CD44. Biochem J. 2006;393:609-618.
15. Blobel CP. Functional and biochemical characterization of ADAMs and their predicted role in protein ectodomain shedding. Inflamm Res. 2002;51:83-84.
16. Arribas J, Borroto A. Protein ectodomain shedding. Chem Rev. 2002;102:4627-4638.
17. Huovila AP, Turner AJ, Pelto-Huikko M, Karkkainen I, Ortiz RM. Shedding light on ADAM metalloproteinases. Trends Biochem Sci. 2005;30:413-422.
18. Choi J, Miller AM, Nolan MJ, et al. Soluble CD44 is cytotoxic to trabecular meshwork and retinal ganglion cells in vitro. Invest Ophthalmol Vis Sci. 2005;46:214-222.
19. Knepper PA, Goossens W, Mayanil CSK. CD44H localization in primary open-angle glaucoma. Invest Ophthalmol Vis Sci. 1998;39:673-680.
20. Knepper PA, Mayanil CS, Goossens W, et al. Aqueous humor in primary open-angle glaucoma contains an increased level of CD44S. Invest Ophthalmol Vis Sci. 2002;43:133-139.
21. Zhou L, Zhang SR, Yue BY. Adhesion of human trabecular meshwork cells to extracellular matrix proteins: roles and distribution of integrin receptors. Invest Ophthalmol Vis Sci. 1996;37:104-113.
22. Degoutte F, Jouanel P, Filaire E. Energy demands during a judo match and recovery. Br J Sports Med. 2003;37:245-249.
23. Gustafsson T, Puntschart A, Kaijser L, Jansson E, Sundberg CJ. Exercise-induced expression of angiogenesis-related transcription and growth factors in human skeletal muscle. Am J Phys. 1999;276:H679-H685.
24. Mertens S, Noll T, Spahr R, Krutzfeldt A, Piper HM. Energetic response of coronary endothelial cells to hypoxia. Am J Physiol. 1990;258:H689-H694.
25. Formby B, Stern R. Lactate-sensitive response elements in genes involved in hyaluronan catabolism. Biochem Biophys Res Commun. 2003;305:203-208.
26. de Baernardinis E, Bonomi L, di Comite P. The chemical composition of the human aqueous humor in normal and pathological conditions. Exp Eye Res. 1965;4:179-186.
27. Chen F, Castranova V, Shi, X, Demers LM. New insights into the role of nuclear factor-kappa-B, a ubiquitous transcription factor in the initiation of diseases. Clin Chem. 1999;45:7-17.
28. Agapova OA, Kaufman PL, Hernandez MR. Androgen receptor and NFkB expression in human normal and glaucomatous optic nerve head astrocytes in vitro and in experimental glaucoma. Exp Eye Res. 2006;82:1053-1059.
29. Itoh Y, Seiki M. MT1-MMP: a potent modifier of pericellular microenvironment. J Cell Phys. 2006;206:1-8.
30. Toth M, Osenkowski P, Hesek D, et al. Cleavage at the stem region releases an active ectodomain of the membrane type 1 matrix metalloproteinase. Biochem J. 2005;387:497-506.
31. Mori H, Tomari T, Koshikawa N, et al. CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain. EMBO J. 2002;21:3949-3959.
32. Suenaga N, Mori H, Itoh Y, Seiki M. CD44 binding through the hemopexin-like domain is critical for its shedding by membrane-type 1 matrix metalloproteinase. Oncogene. 2005;24:859-868.
33. Endo K, Takino T, Miyamori H, et al. Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration. J Biol Chem. 2003;278:40764-40770.
34. Gabelt BT, Kaufman PL. Changes in aqueous humor dynamics with age and glaucoma. Prog Retin Eye Res. 2005;24:612-637.
35. Filla MS, David G, Weinreb RN, Kaufman PL, Peters DM. Distribution of syndecans 1-4 within the anterior segment of the human eye: expression of a variant syndecan-3 and matrix-associated syndecan-2. Exp Eye Res. 2004;79:61-74.
36. Vittal V, Rose A, Gregory KE, Kelley MJ, Acott TS. Changes in gene expression by trabecular meshwork cells in response to mechanical stretching. Invest Ophthalmol Vis Sci. 2005;46:2857-2868.
37. Covington MD, Burghardt RC, Parrish AR. Ischemia-induced cleavage of cadherins in NRK cells requires MT1-MMP (MMP-14). Am J Physiol. 2006;290:F43-F51.
38. Chang DI, Hosomi N, Lucero J, et al. Activation systems for latent matrix metalloproteinase-2 are upregulated immediately after focal cerebral ischemia. J Cereb Blood Flow Metab. 2003;23:1408-1419.
39. Yoon SO, Park SJ, Yoon SY, Yun CH. Chung AS. Sustained production of H(2)O(2) activates pro-matrix metalloproteinase-2 through receptor tyrosine kinases/phosphatidylinositol 3-kinase/NF-kappa B pathway. J Biol Chem. 2002;277:30271-30282.
40. Haas T, Stitelman D, Davis SJ, Apte SS, Madri JA. Egr-1 mediates extracellular matrix-driven transcription of membrane type 1 matrix metalloproteinase in endothelium. J Biol Chem. 1999;274:22679-22685.
41. Yana I, Weiss SJ. Regulation of membrane type-1 matrix metalloproteinase activation by proprotein convertases. Mol Biol Cell. 2000;11:2387-2401.
42. Itoh Y, Seiki M. MT1-MMP: an enzyme with multidimensional regulation. Trends Biochem Sci. 2004;29:285-289.
43. Kajita M, Itoh Y, Chiba T, et al. Membrane-type 1 matrix metalloproteinase cleaves CD44 and promotes cell migration. J Cell Biol. 2001;153:893-904.
44. Nagano O, Saya H. Mechanism and biological significance of CD44 cleavage. Cancer Sci. 2004;95:930-935.
45. Cui W, Ke JZ, Zhang Q, Ke HZ, Chalouni C, Vignery A. The intracellular domain of CD44 promotes the fusion of macrophages. Blood. 2006;107:796-805.
46. Larkin J, Renukaradhya GJ, Sriram V, Du W, Gervay-Hague J, Brutkiewicz RR. CD44 differentially activates mouse NK T cells and conventional T cells. J Immunol. 2006;177:268-279.
47. Vachon E, Martin R, Plumb J, et al. CD44 is a phagocytic receptor. Blood. 2006;107:4149-4158.
48. Kincade, PW, Zheng Z, Katoh, S, Hanson L. The importance of cellular environment to function of the CD44 matrix receptor. Curr Opin Cell Biol. 1997;9:635-642.
49. Aruffo A. CD44: one ligand, two functions. J Clin Invest. 1996;98:2191-2192.
50. Sherman LS, Rizvi TA, Karyala S, Ratner N. CD44 enhances neuregulin signaling by Schwann cells. J Cell Biol. 2000;150:1071-1083.
51. Gasbarri A, Del Prete F, Girnita L, Martegani MP, Natali PG, Bartolazzi A. CD44s adhesive function spontaneous and PMA-inducible CD44 cleavage are regulated at post-translational level in cells of melanocytic lineage. Melanoma Res. 2003;13:325-337.
52. Kawano Y, Okamoto I, Murakami D, et al. Ras oncoprotein induces CD44 cleavage through phosphoinositide 3-OH kinase and the rho family of small G proteins. J Biol Chem. 2000;275:29628-29635.
53. Ahrens T, Sleeman JP, Schempp CM, et al. Soluble CD44 inhibits melanoma tumor growth by blocking cell surface CD44 binding to hyaluronic acid. Oncogene. 2001;20:3399-3408.