The importance of cellular environment to function of the CD44 matrix receptor

Current Opinion in Cell Biology

Volumn 9, Issue 5, 1997, Pages 635-642

  Kincade, Paul W ^a   Zheng, Zhong ^a   Katoh, Shigeki ^a   Hanson, Leif ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; HERMES ANTIGEN; HYALURONIC ACID;

CELL MEMBRANE; CELL SURFACE; CYTOPLASM; EXTRACELLULAR MATRIX; HUMAN; LIGAND BINDING; MOLECULAR CLONING; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN GLYCOSYLATION; PROTEIN STRUCTURE; REVIEW;

EID: 0030866280     PISSN: 09550674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0955-0674(97)80116-0     Document Type: Article

References (75)

1. Lesley J, Hyman R, Kincade PW: CD44 and its interaction with the extracellular matrix. Adv Immunol 1993, 54:271-335.
2. Toole BP: Hyaluronan and its binding proteins, the hyaladherins. Curr Opin Cell Biol 1990, 2:839-844.
3. Miyake K, Underhill CB, Lesley J, Kincade PW: Hyaluronate can function as a cell adhesion molecule and CD44 participates in hyaluronate recognition. J Exp Med 1990, 172:69-75.
4. Lesley J, Schulte R, Hyman R: Binding of hyaluronic acid to lymphoid cell lines is inhibited by monoclonal antibodies against Pgp-1. Exp Cell Res 1990, 187:224-233.
5. Aruffo A, Stamenkovic I, Melnick M, Underhill CB, Seed B: CD44 is the principal cell surface receptor for hyaluronate. Cell 1990, 61:1303-1313.
6. Toyama-Sorimachi N, Sorimachi H, Tobita Y, Kitamura F, Yagita H, Suzuki K, Miyasaka M: A novel ligand for CD44 is serglycin, a hematopoietic cell lineage-specific proteoglycan. Possible involvement in lymphoid cell adherence and activation. J Biol Chem 1995, 270:7437-7444.
7. Weber GF, Ashkar S, Glimcher MJ, Cantor H: Receptor-ligand interaction between CD44 and osteopontin (Eta-1). Science 1996, 271:509-512.
8. Jalkanen S, Jalkanen M: Lymphocyte CD44 binds the COOH-terminal heparin-binding domain of fibronectin. J Cell Biol 1992, 116:817-825.
9. Faassen AE, Schrager JA, Klein DJ, Oegema TR, Couchman JR, McCarthy JB: A cell surface chondroitin sulfate proteoglycan, immunologically related to CD44, is involved in type I collagen-mediated melanoma cell motility and invasion. J Cell Biol 1992, 116:521-531.
10. Gallatin WM, Wayner EA, Hoffman PA, St John T, Butcher EC, Carter WG: Structural homology between lymphocyte receptors for high endothelium and class III extracellular matrix receptor. Proc Natl Acad Sci USA 1989, 86:4654-4658.
11. Knutson JR, lida J, Fields GB, McCarthy JB: CD44/chondroitin sulfate proteoglycan and α2β1 integrin mediate human melanoma cell migration on type IV collagen and invasion of basement membranes. Mol Biol Cell 1996, 7:383-396.
12. Zahalka MA, Okon E, Gosslar U, Holzmann B, Naor D: Lymph node (but not spleen) invasion by murine lymphoma is both CD44- and hyaluronate-dependent J Immunol 1995, 154:5345-5355.
13. Rossbach HC, Krizanac-Bengez L, Santos EB, Gooley TA, Sandmaier BM: An antibody to CD44 enhances hematopoiesis in long-term marrow cultures. Exp Hematol 1996, 24:221-227.
14. Khaldoyanidi S, Denzel A, Zöller M: Requirement for CD44 in proliferation and homing of hematopoietic precursor cells. J Leukoc Biol 1996, 60:579-592.
15. Oostendorp RAJ, Spitzer E, Dörmer P: Adhesion of human hematopoietic progenitor cells to bone-marrow-derived stromal cells is enhanced by antibodies to CD44. Acta Haematol 1996, 95:243-247.
16. Henke CA, Roongta U, Mickelson DJ, Knutson JR, McCarthy JB: CD44-related chondroitin sulfate proteoglycan, a cell surface receptor implicated with tumor cell invasion, mediates endothelial cell migration on fibrinogen and invasion into a fibrin matrix. J Clin Invest 1996, 97:2541-2552.
17. Legras S, Levesque J-P, Charrad R, Morimoto K, Le Bousse C, Clay D, Jasmin C, Smadja-Joffe F: CD44-mediated adhesiveness of human hematopoietic progenitors to hyaluronan is modulated by cytokines. Blood 1997, 89:1905-1914.
18. Masellis-Smith A, Belch AR, Mant MJ, Turley EA, Pilarski LM: Hyaluronan-dependent motility of B cells and leukemic plasma cells in blood, but not of bone marrow plasma cells, in multiple myeloma: alternate use of receptor for hyaluronan-mediated motility (RHAMM) and CD44. Blood 1996, 87:1891-1899.
19. Moffat FL Jr, Han T, Li ZM, Peck MD, Falk RE, Spalding PB, Jy WC, Ahn YS, Chu AJ, Bourguignon LYW: Involvement of CD44 and the cytoskeletal linker protein ankyrin in human neutrophil bacterial phagocytosis. J Cell Physiol 1996, 168:638-647.
20. Pericle F, Sconocchia G, Titus JA, Segal DM: CD44 is a cytotoxic triggering molecule on human polymorphonuclear cells. J Immunol 1996, 157:4657-4663.
21. Mikecz K, Brennan FR, Kim JH, Giant TT: Anti-CD44 treatment abrogates tissue oedema and leukocyte infiltration in murine arthritis. Nat Med 1995, 1:558-563.
22. McKee CM, Penno MB, Cowman M, Burdick MD, Strieter RM, Bao C, Noble PW: Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. J Clin Invest 1996, 98:2403-2413. Ligation of CD44 receptors elicits a wide variety of biological responses. This paper demonstrates that low molecular weight hyaluronan can initiate inflammatory cytokine production by macrophages.
23. Guo Y, Wu Y, Shinde S, Sy MS, Aruffo A, Liu Y: Identification of a costimulatory molecule rapidly induced by CD40L as CD44H. J Exp Med 1996, 184:955-961. This paper describes a new role for CD44 in B-cell-T-cell communication. The CD44 on activated B cells engages some receptor on T cells that is unlikely to be hyaluronan.
24. Taher TEI, Smit L, Griffioen AW, Schilder-Tol EJM, Borst J, Pals ST: Signaling through CD44 is mediated by tyrosine kinases - association with p56lck in T lymphocytes. J Biol Chem 1996, 271:2863-2867.
25. Galandrini R, Piccoli M, Frati L, Santoni A: Tyrosine kinase-dependent activation of human NK cell functions upon triggering through CD44 receptor. Eur J Immunol 1996, 26:2807-2811.
26. Rafi A, Nagarkatti M, Nagarkatti PS: Hyaluronate-CD44 interactions can induce murine B-cell activation. Blood 1997, 89:2901-2908.
27. Santos-Argumedo L, Kincade PW, Partida-Sánchez S, Parkhouse RME: CD44-stimulated dendrite formation ('spreading') in activated B cells. Immunology 1997, 90:147-153.
28. Günthert U, Stauder R, Mayer B, Terpe H-J, Finke L, Friedrichs K: Are CD44 variant isoforms involved in human tumour progression? Cancer Surv 1995, 24:19-42.
29. Stauder R, Eisterer W, Thaler J, Günthert U: CD44 variant isoforms in non-Hodgkins lymphoma: a new independent prognostic factor. Blood 1995, 85:2885-2899.
30. •] and there is an astonishing number of primary papers that reflect tumor cell specific differences and controversy.
31. ••].
32. ••].
33. ••] for the hyaluronan-binding domain of TSG-6. This is an important advance, because it provides a basis for structure-function studies of all of the hyal-adherins.
34. •].
35. •].
36. Hardwick C, Hoare K, Owens R, Hohn HP, Hook M, Moore D, Cripps V, Austen L, Nance DM, Turley EA: Molecular cloning of a novel hyaluronan receptor that mediates tumor cell motility. J Cell Biol 1992, 117:1343-1350.
37. Yang B, Yang BL, Savani RC, Turley EA: Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein. EMBO J 1994, 13:286-296.
38. Sleeman J, Rudy W, Hofmann M, Moll J, Herrlich P, Ponta H: Regulated clustering of variant CD44 proteins increases their hyaluronate binding capacity. J Cell Biol 1996, 135:1139-1150. Several interesting issues relating to CD44 are considered in this paper, including receptor aggregation, possible participation of the transmembrane domain in receptor function, and CD44 glycosylation.
39. Telen MJ, Udani M, Washington MK, Levesque MC, Lloyd E, Rao N: A blood group-related polymorphism of CD44 abolishes a hyaluronan-binding consensus sequence without preventing hyaluronan binding. J Biol Chem 1996, 271:7147-7153.
40. Peach RJ, Hollenbaugh D, Stamenkovic I, Aruffo A: Identification of hyaluronic acid binding sites in the extracellular domain of CD44. J Cell Biol 1993, 122:257-264.
41. Liao HX, Lee DM, Levesque MC, Haynes BF: N-terminal and central regions of the human CD44 extracellular domain participate in cell surface hyaluronan binding. J Immunol 1995, 155:3938-3945.
42. Katoh S, Zheng Z, Oritani K, Shimozato T, Kincade PW: Glycosylation of CD44 negatively regulates its recognition of hyaluronan. J Exp Med 1995, 182:419-429.
43. Lesley J, English N, Perschl A, Gregoroff J, Hyman R: Variant cell lines selected for alterations in the function of the hyaluronan receptor CD44 show differences in glycosylation. J Exp Med 1995, 182:431-437.
44. Romans M, Bassols A, David G: Effect of transforming growth factor-1 and basic fibroblast growth factor on the expression of cell surface proteoglycans in human lung fibroblasts. Enhanced glycanation and fibronectin-binding of CD44 proteoglycan, and down-regulation of glypican. Biochem J 1995, 310:73-81.
45. •,42,43] and may reflect the importance of cell type to CD44 functions.
46. Zheng Z, Katoh S, He Q, Oritani K, Miyake K, Lesley J, Hyman R, Hamik A, Parkhouse RME, Farr AG, Kincade PW: Monoclonal antibodies to CD44 and their influence on hyaluronan recognition. J Cell Biol 1995, 130:485-495.
47. Nakano T, Matsui T, Ota T: Benzy-α-GalNAc inhibits sialylation of O-glycosidic sugar chains on CD44 and enhances experimental metastatic capacity in B16BL6 melanoma cells. Anticancer Res 1996, 16:3577-3584.
48. Bennett KL, Modrell B, Greenfield B, Bartolazzi A, Stamenkovic I, Peach R, Jackson DG, Spring F, Aruffo A: Regulation of CD44 binding to hyaluronan by glycosylation of variably spliced exons. J Cell Biol 1995, 131:1623-1633.
49. Takahashi K, Stamenkovic I, Cutler M, Dasgupta A, Tanabe KK: Keratan sulfate modification of CD44 modulates adhesion to hyaluronate. J Biol Chem 1996, 271:9490-9496.
50. Dasgupta A, Takahashi K, Cutler M, Tanabe KK: O-linked glycosylation modifies CD44 adhesion to hyaluronate in colon carcinoma cells. Biochem Biophys Res Commun 1996, 227:110-117.
51. Gunthert U, Hofmann M, Rudy W, Reber S, Zoller M, Haubmann I, Matzku S, Wenzel A, Ponta H, Herrlich P: A new variant of glycoprotein CD44 confers metastatic potential to rat carcinoma cells. Cell 1991, 65:13-24.
52. Stamenkovic I, Aruffo A, Amiot M, Seed B: The hematopoietic and epithelial forms of CD44 are distinct polypeptides with different adhesion potentials for hyaluronate-bearing cells. EMBO J 1991, 10:343-348.
53. He Q, Lesley J, Hyman R, Ishihara K, Kincade PW: Molecular isoforms of murine CD44 and evidence that the membrane proximal domain is not critical for hyaluronate recognition. J Cell Biol 1992, 119:1711-1719.
54. Dougherty GJ, Cooper DL, Memory JF, Chiu RK: Ligand binding specificity of alternatively spliced CD44 isoforms. Recognition and binding of hyaluronan by CD44R1. J Biol Chem 1994, 269:9074-9078.
55. Van der Voort R, Manten-Horst E, Smit L, Ostermann E, Van den Berg F, Pals ST: Binding of cell-surface expressed CD44 to hyaluronate is dependent on splicing and cell type. Biochem Biophys Res Commun 1995, 214:137-144.
56. Yu Q, Toole BP: A new alternatively spliced exon between v9 and v10 provides a molecular basis for synthesis of soluble CD44. J Biol Chem 1996, 271:20603-20607. The extraordinary diversity of CD44 isoforms includes one variant that may be secreted.
57. Tanaka Y, Adams DH, Hubscher S, Hirano H, Siebenlist U, Shaw S: T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-1. Nature 1993, 361:79-82.
58. Jackson DG, Bell JI, Dickinson R, Timans J, Shields J, Whittle N: Proteoglycan forms of the lymphocyte homing receptor CD44 are alternatively spliced variants containing the v3 exon. J Cell Biol 1995, 128:673-685.
59. Bennett KL, Jackson DG, Simon JC, Tanczos E, Peach R, Modrell B, Stamenkovic I, Plowman G, Aruffo A: CD44 isoforms containing exon V3 are responsible for the presentation of heparin-binding growth factor. J Cell Biol 1995, 128:687-698.
60. Isacke CM: The role of the cytoplasmic domain in regulating CD44 function. J Cell Sci 1994, 107:2353-2359.
61. Perschl A, Lesley J, English N, Hyman R, Trowbridge IS: Transmembrane domain of CD44 is required for its detergent insolubility in fibroblasts. J Cell Sci 1995, 108:1033-1041.
62. •]; S Katoh, PW Kincade, unpublished data). It may also represent a site for lipid attachment [63].
63. Guo YJ, Lin SC, Wang JH, Bigby M, Sy MS: Palmitoylation of CD44 interferes with CD3-mediated signaling in human T lymphocytes, Int Immunol 1994, 6:213-221.
64. Lesley J, He Q, Miyake K, Hamann A, Hyman R, Kincade PW: Requirements for hyaluronic acid binding by CD44: a role for the cytoplasmic domain and activation by antibody. J Exp Med 1992, 175:257-266.
65. Pure E, Camp RL, Peritt D, Panettieri RA Jr, Lazaar AL, Nayak S: Defective phosphorylation and hyaluronate binding of CD44 with point mutations in the cytoplasmic domain. J Exp Med 1995, 181:55-62.
66. Uff CR, Neame SJ, Isacke CM: Hyaluronan binding by CD44 is regulated by a phosphorylation-independent mechanism. Eur J Immunol 1995, 25:1883-1887.
67. Liu DC, Zhang DX, Mon H, Sy MS: Binding of CD44 to hyaluronic acid can be induced by multiple signals and requires the CD44 cytoplasmic domain. Cell Immunol 1996, 174:73-83.
68. Lesley J, Kincade PW, Hyman R: Antibody-induced activation of the hyaluronan receptor function of CD44 requires multivalent binding by antibody. Eur J Immunol 1993, 23:1902-1909.
69. Perschl A, Lesley J, English N, Trowbridge I, Hyman R: Role of CD44 cytoplasmic domain in hyaluronan binding. Eur J Immunol 1995, 25:495-501.
70. Sheikh H, Isacke CM: A di-hydrophobic Leu-Val motif regulates the basolateral localization of CD44 in polarized Madin-Darby canine kidney epithelial cells. J Biol Chem 1996, 271:12185-12190. This report provides a dramatic demonstration that CD44 can localize to a specific region of the plasma membrane. This phenomenon is cell type specific and requires a motif in the CD44 cytoplasmic domain.
71. Naujokas MF, Morin M, Anderson MS, Peterson M, Miller J: The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44. Cell 1993, 74:257-268.
72. Tsukita S, Oishi K, Sato N, Sagara J, Kawai A, Tsukita S: ERM family members as molecular linkers between the cell surface glycoprotein CD44 and actin-based cytoskeletons. J Cell Biol 1994, 126:391-401.
73. Chiu RK, Droll A, Cooper DL, Dougherty ST, Dirks JF, Dougherty GJ: Molecular mechanisms regulating the hyaluronan binding activity of the adhesion protein CD44. J Neurooncol 1995, 26:231-239.
74. Droll A, Dougherty ST, Chiu RK, Dirks JF, McBride WH, Cooper DL, Dougherty GJ: Adhesive interactions between alternatively spliced CD44 isoforms. J Biol Chem 1995, 270:11567-11573.
75. Zheng Z, Cummings RD, Pummill PE, Kincade PW: Growth as a solid tumor or reduced glucose concentrations in culture reversibly induce CD44 mediated hyaluronan recognition by CHO cells. J Clin Invest 1997, 100:in press.