Antigen-driven clonal proliferation, somatic hypermutation, and selection of B lymphocytes infiltrating human ductal breast carcinomas

Cancer Research

Volumn 63, Issue 12, 2003, Pages 3275-3280

  Nzula, Sazini ^a   Going, James J ^a   Stott, David I ^a  

^a UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN;

ANTIGEN FUNCTION; ARTICLE; B LYMPHOCYTE; BREAST CARCINOMA; CASE REPORT; CELL ACTIVITY; CELL MATURATION; CELL PROLIFERATION; CELL SELECTION; CONTROLLED STUDY; CORRELATION ANALYSIS; GENE AMPLIFICATION; GENE EXPRESSION; GENE LOCUS; GENE MUTATION; GENE REARRANGEMENT; GENE SEQUENCE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOGLOBULIN GENE; IMMUNOGLOBULIN VH GENE; IMMUNOHISTOCHEMISTRY; IMMUNOSTIMULATION; LYMPHOCYTE CLONE; LYMPHOCYTE MIGRATION; LYMPHOCYTIC INFILTRATION; MOLECULAR CLONING; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; SEQUENCE ANALYSIS; SOMATIC HYPERMUTATION; TUMOR ASSOCIATED LEUKOCYTE; TUMOR CELL;

ANTIBODY AFFINITY; ANTIGENS, NEOPLASM; B-LYMPHOCYTES; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; CELL DIVISION; CELL MOVEMENT; CLONE CELLS; FEMALE; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; GENES, IMMUNOGLOBULIN; HUMANS; IMMUNOGLOBULIN VARIABLE REGION; LYMPHOCYTE ACTIVATION; LYMPHOCYTES, TUMOR-INFILTRATING; SEQUENCE ANALYSIS, DNA; SOMATIC HYPERMUTATION, IMMUNOGLOBULIN;

EID: 0038407404     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (30)

1. Ben-Hur, H., Cohen, O., Schneider, D., Gurevich, P., Halperin, R., Bala, U., Mozes, M., and Zusman, I. The role of lymphocytes and macrophages in human breast tumorigenesis: An immunohistochemical and morphometric study. Anticancer Res., 22: 1231-1238, 2002.
2. Di Girolamo, V., Laguens, R. P., Coronato, S., Salas, M., Spinelli, O., Portiansky, E., and Laguens, G. Quantitative and functional study of breast cancer axillary lymph nodes and those draining other malignant tumours. J. Exp. Clin. Cancer Res., 19: 155-159, 2000.
3. Hansen, M. H., Nielsen, H., and Ditzel, H. J. Translocation of an intracellular antigen to the surface of medullary breast cancer cells early in apoptosis allows for an antigen-driven antibody response elicited by tumour-infiltrating B cells. J. Immunol., 169: 2701-2711, 2002.
4. Lazzaro, B., Anderson, A. E., Kajdacsy-Balla, A., and Hessner, M. J. Antigenic characterization of medullary carcinoma of breast cancer: HLA-DR expression in lymph node positive cases. Appl. Immunohistochem. Mol. Morphol., 9: 234-241, 2001.
5. Hadden, J. W. The immunology and immunotherapy of breast cancer: An update. Int. J. Immunopharmacol., 21: 79-101, 1999.
6. Balch, C. M., Riley, L. B., Bae, Y. J., Salmeron, M. A., Platsoucas, C. D., von Eschenbach, A., and Itoh, K. Patterns of human tumour-infiltrating lymphocytes in 120 human cancers. Arch. Surg., 125: 200-205, 1990.
7. Menard, S., Tomasic, G., Casalini, P., Balsari, A., Pilotti, S., Cascinelli, N., Salvadori, B., Colnaghi, M. I., and Rilke, F. Lymphoid infiltration as a prognostic variable for early-onset breast carcinomas. Clin. Cancer Res., 3: 817-819, 1997.
8. Whitford, P., Mallon, E. A., George, W. D., and Campbell, A. M. Flow cytometric analysis of tumour infiltrating lymphocytes in breast cancer. Br. J. Cancer, 62: 971-975, 1990.
9. Chin, Y., Janssens, J., Bleus, J., Vandepitte, J., Vandenbrande, J., and Raus, J. Characterization of tumour infiltrating lymphocytes in human breast cancer. Eur. J. Cancer Prev., 2 (Suppl. 3): 27-31, 1993.
10. Durie, F. H., Campbell, A. M., Lee, W. R., and Damato, B. E. Analysis of lymphocytic infiltration in uveal melanoma. Investig. Ophthalmol. Vis. Sci., 31: 2106-2110, 1990.
11. Durie, F. H. George, W. D., Campbell, A. M., and Damato, B. E. Analysis of clonality of tumour infiltrating lymphocytes in breast cancer and uveal melanoma. Immunol. Lett., 33: 263-269, 1992.
12. Schwartzentruber, D. J., Solomon, D., Rosenberg, S. A., and Topalian, S. L. Charecterization of lymphocytes infiltrating human breast cancer: Specific immune reactivity detected by measuring cytokine secretion. J. Immunother., 12: 1-12, 1992.
13. Alam, S. M., Clark, J. S., George, W. D., and Campbell A. M. Altered lymphocyte populations in tumour invaded nodes of breast cancer patients. Immunol. Lett., 35: 229-234, 1993.
14. Lake, D. F., Huynh, W. C., and Hersh, E. M. Natural and induced human antibody response to cancer. Cancer Investig., 18: 480-489, 2000.
15. Marks, J. D., Tristem, M., Karpas, A., and Winter, G. Oligonucleotide primers for polymerase chain reaction amplification of human immunoglobulin variable genes and design of family-specific oligonucleotide probes. Eur. J. Immunol., 21: 985-991, 1991.
16. Sims, G. P., Shiono, H., Willcox, N., and Stott, D. I. Somatic hypermutation and selection of B cells in thymic germinal centers responding to acetylcholine receptor in myasthenia gravis. J. Immunol., 167: 1935-1944, 2001.
17. Tomlison, I. M., Williams, S. C. Ignatovich, O., Corbett, S. J., and Winter, G. Human VBASE directory of immunoglobulin genes. Cambridge, UK: MRC Centre for Protein Engineering, 1997.
18. H segments. J. Mol. Biol., 227: 799-817, 1992.
19. Brezinschek, H. P., Brezinschek, R. I., and Lipsky, P. E. Analysis of the heavy chain repertoire of human peripheral B cells using single-cell polymerase chain reaction. J. Immunol., 155: 190-202, 1995.
20. Rajewsky, K. Clonal selection and learning in the antibody system. Nature (Lond.), 381: 751-758, 1996.
21. Li, L., Zhang, X., Kovacic, S., Long, A. J., Bourque, K., Wood, C. R., and Choi, Y. S. Identification of a follicular dendritic cell molecule that stimulates germinal center B cell growth. J. Exp. Med., 191: 1077-1083, 2000.
22. van Nierop, K., and de Groot, C. Human follicular dendritic cells: Function, origin and development. Semin. Immunol., 14: 251-257, 2002.
23. Stott, D. I., Hiepe, F., Hummel, M., Steinhauser, G., and Berek, C. Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease. The salivary glands of patients with Sjogren's syndrome. J. Clin. Investig. 102: 938-946, 1998.
24. Randen, I., Mellbye, O. J., Forre, O., and Natvig, J. B. The identification of germinal centres and follicular dendritic cell networks in rheumatoid synovial tissue. Scand. J. Immunol., 41: 481-486, 1995.
25. Berek, C., Berger, A., and Apel, M. Maturation of the immune response in germinal centers. Cell, 67: 1121-1129, 1991.
26. Jacob, J., and Kelsoe, G. In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl) acetyl. II. A common clonal origin for peroilar lymphoid sheath-associated foci and germinal centers. J. Exp. Med., 176: 679-688, 1992.
27. Jacob, J., Kelsoe, G., Rajewsky, K., and Weiss, U. Intraclonal generation of antibody mutants in germinal centres. Nature, 354: 389-392, 1991.
28. Brezinschek, H. P., Foster, S. J., Brezinschek, R. I., Dorner, T., Domiati-Saad, R., and Lipsky, P. E. Analysis of the human VH gene repertoire. Differential effects of selection and somatic hypermutation on human peripheral CD5(+)/IgM+ and CD5(-)/IgM+ B cells. J. Clin. Investig., 99: 2488-2501, 1997.
29. Chang, B. and Casali, P. The CDR1 sequences of a major proportion of human germline 1g VH genes are inherently susceptible to amino acid replacement. Immunol. Today, 15: 367-373, 1994.
30. Coronella, J. A., Spier, C., Welch, M., Trevor, K. T., Stopeck, A. T., Villar, H., and Hersh, E. M. Antigen-driven oligoclonal expansion of tumour-infiltrating B cells in infiltrating ductal carcinoma of the breast. J. Immunol., 169: 1829-1836, 2002.