Design, synthesis and antiinflammatory activity of novel phthalimide derivatives, structurally related to thalidomide

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 4, 2005, Pages 1169-1172

  Machado, Alexandre Légora ^a   Lima, Lídia Moreira ^a   Araújo Jr, João Xavier ^a   Fraga, Carlos Alberto M ^a   Gonçalves Koatz, Vera Lúcia ^a   Barreiro, Eliezer J ^a,b  

^a FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^b FEDERAL UNIVERSITY OF ALAGOAS   (Brazil)

Author keywords

Antiinflammatory activity; Neutrophils; Phthalimide derivatives; Thalidomide analogues; Tumor necrosis factor

Indexed keywords

PHTHALIMIDE DERIVATIVE; THALIDOMIDE;

ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ARTICLE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; LEUKOCYTE ACTIVATION; LOBAR PNEUMONIA; MOUSE; NEUTROPHIL; NEUTROPHIL CHEMOTAXIS; NONHUMAN; STRUCTURE ANALYSIS;

EID: 16344380786     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.12.012     Document Type: Article

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17. The analytical results for C, H, N of the compounds 4a-d, 5a,b, and 6a,b were within ±0.4% of calculated values
18. Physical and spectroscopic data: Compound 4a: Abstract presented