Induction of apoptosis in estrogen dependent and independent breast cancer cells by the marine terpenoid dehydrothyrsiferol

Biochemical Pharmacology

Volumn 65, Issue 9, 2003, Pages 1451-1461

  Pec, Martina K ^a   Aguirre, Amable ^a   Moser Thier, Karin ^b   Fernández, Javier J ^c   Souto, Maria L ^c   Dorta, Javier ^a   Diáz González, Federico ^d   Villar, Jesús ^a  

^a HOSPITAL UNIVERSITARIO NUESTRA SEÑORA DE CANDELARIA   (Spain)

^b UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSIDAD DE LA LAGUNA   (Spain)

^d HOSPITAL UNIVERSITARIO DE CANARIAS   (Spain)

Author keywords

Apoptosis; BrdU incorporation; Breast cancer; Cell cycle distribution of apoptotic cells; Dehydrothyrsiferol (DT); Marine anticancer compound

Indexed keywords

ANTIMITOTIC AGENT; BROXURIDINE; COLCHICINE; DEHYDROTHYRSIFEROL; DNA; DNA FRAGMENT; DOXORUBICIN; ESTROGEN; ESTROGEN RECEPTOR; LIPOCORTIN 5; MITOGENIC AGENT; POLYETHER; TERPENOID; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CARCINOMA; CANCER CELL; CELL CYCLE; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL LABELING; CELL LINE; CELL POPULATION; CONCENTRATION (PARAMETERS); CYTOTOXICITY; FLOW CYTOMETRY; HORMONE DEPENDENCE; HORMONE SENSITIVITY; HUMAN; HUMAN CELL; MARINE ENVIRONMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; TIME;

EID: 0038403750     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-2952(03)00123-0     Document Type: Article

References (17)

1. Sasco A.J. Epidemiology of breast cancer, an environmental disease? APMIS. 109:2001;321-332.
2. Neven P., Vergote I. Tamoxifen, screening and new estrogen receptor modulators. Baillieres Best Pract. Res. Clin. Obstet. Gynaecol. 15:2001;365-380.
3. Ikeda T., Jinno H., Masamura S., Matsui A., Tajima G., Hohjoh T., Tokura H., Mitsui Y., Asaga S., Muto T., Fujiwara K., Kirajima M. Current status of adjuvant endocrine therapy for hormone responsive breast cancer. Gan To Kagaku Ryoho. 28:2001;902-908.
4. Thompson E.W., Paik S., Brünner N., Sommers C.L., Zugmaier G., Clarke R., Shima T.B., Torri J., Donahue S., Lippman M.E., Martin G.R., Dickson R.B. Association of increased basement membrane invasiveness with absence of estrogen receptor and expression of vimentin in human breast cancer cell lines. J. Cell Physiol. 150:1992;534-544.
5. Hengartner MO. The biochemistry of apoptosis. In: Heemels M-T, Dhand R, editors. Apoptosis. Nature insight, vol. 407. Nature; 2000. p. 769-816.
6. Norte M., Fernández J.J., Souto M.L., Gavín J.A., García-Grávalos M.D. Thyrsenols A and B, two unusual polyether squalene derivatives. Tetrahedron. 53:1997;3173-3178.
7. Matsuzawa S., Kawamura T., Mitsuhashi S., Suzuki T., Matsuo Y., Suzuki M., Mizuno Y., Kikuchi K. Thyrsiferol 23-acetate and its derivatives induce apoptosis in various T- and B-leukemia cells. Bioorg. Med. Chem. 7:1999;381-387.
8. Darzynkiewicz Z., Juan G., Li X., Gorczyca W., Murakami T., Traganos F. Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis). Cytometry. 27:1997;1-20.
9. Pec M.K., Moser-Thier K., Fernández J.J., Souto M.L., Kubista E. Growth inhibition by dehydrothyrsiferol - a non-Pgp modulator, derived from a marine red alga - in human breast cancer cell lines. Int. J. Oncol. 14:1999;739-743.
10. Engeland M.V., Nieland L.J.W., Ramaekers F.C.S., Schutte B., Reutelingsperger C.P.M. Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure. Cytometry. 31:1998;1-9.
11. Martin S.J., Reutelingsperger C.P.M., McGahon A.J., Rader J.A., Van Schie R.C.A.A., LaFace D.M., Green D.R. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiation stimulus: inhibition of overexpression of Bcl-2 and Abl. J. Exp. Med. 182:1995;1545-1556.
12. Iwahana M., Ochi Y., Ejima A. Antiproliferative activity and mechanism of action of DZ-3358, a novel pyrimidinyl pyrazole derivative. Anticancer Res. 20:2000;785-795.
13. Booser D.J., Hortobagyi G.N. Anthracycline antibiotics in cancer therapy. Focus on drug resistance. Drugs. 47:1994;223-258.
14. Shtil A.A., Mandlekar S., Yu R., Walter R.J., Hagen K., Tan T.H., Roninson I.B., Kong A.N. Differential regulation of mitogen-activated protein kinases by microtubule-binding agents in human breast cancer cells. Oncogene. 18:1999;377-384.
15. cdc2 phosphorylation of survivin. PNAS. 97:2000;13103-13107.
16. Huang S.C., Huang C.Y.F., Lee T.C. Induction of mitosis-mediated apoptosis by sodium arsenite in HeLa S3 cells. Biochem. Pharmacol. 60:2000;771-780.
17. Cattaneo-Pangrazzi R.M.C., Schott H., Wunderli-Allenspach H., Derighetti M., Schwendener R.A. Induction of cell cycle-dependent cytotoxicity and apoptosis by new heterodinucleoside phosphate dimers of 5-fluorodeoxyuridine in PC-3 human prostate cancer cells. Biochem. Pharmacol. 60:2000;1887-1896.