Rational design, synthesis and biological evaluation of thiadiazinoacridines: A new class of antitumor agents

Bioorganic and Medicinal Chemistry

Volumn 11, Issue 3, 2003, Pages 399-405

  Antonini, Ippolito ^a   Polucci, Paolo ^a,d   Magnano, Amelia ^a   Cacciamani, Diego ^a   Konieczny, Marek T ^b   Paradziej Łukowicz, Jolanta ^c   Martelli, Sante ^a  

^a UNIVERSITY OF CAMERINO   (Italy)

^b MEDICAL UNIVERSITY OF GDANSK   (Poland)

^c GDANSK UNIVERSITY OF TECHNOLOGY   (Poland)

^d PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BIS[2 (DIMETHYLAMINO)ETHYL] 10 METHOXY 6 NITRO 2,3 DIHYDRO 1H 2 LAMBDA 4 [1,2,6]THIADIAZINO[3,4,5 K]ACRIDIN 2 ONE; 3 [2 (DIMETHYLAMINO)ETHYL] 10 METHOXY 6 NITRO 2,7 DIHYDRO 3H 2 LAMBDA 4 [1,2,6]THIADIAZINO[3,4,5 K]ACRIDIN 2 ONE; 3 [2 (DIMETHYLAMINO)ETHYL] 6 NITRO 2,7 DIHYDRO 3H 2 LAMBDA 4 [1,2,6]THIADIAZINO[3,4,5 K]ACRIDIN 2 ONE; 3 [3 (DIMETHYLAMINO)PROPYL] 6 NITRO 2,7 DIHYDRO 3H 2 LAMBDA 4 [1,2,6]THIADIAZINO[3,4,5 K]ACRIDIN 2 ONE; ACRIDINE DERIVATIVE; ANTINEOPLASTIC AGENT; CHLORINE DERIVATIVE; CISPLATIN; CYTOTOXIC AGENT; TETRACYCLINE DERIVATIVE; THIADIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL STRAIN HT29; COLON ADENOCARCINOMA; CONTROLLED STUDY; COVALENT BOND; CYCLIZATION; DRUG DESIGN; DRUG DNA BINDING; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; FLUOROMETRY; HUMAN; HUMAN CELL; IN VIVO STUDY; LEUKEMIA CELL LINE; MOUSE; NONHUMAN; OVARY CARCINOMA;

MURINAE;

EID: 0037293510     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00442-X     Document Type: Article

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