Potent nonpeptide antagonists of the bradykinin B1 receptor: Structure-activity relationship studies with novel diaminochroman carboxamides

Journal of Medicinal Chemistry

Volumn 50, Issue 9, 2007, Pages 2200-2212

  Biswas, Kaustav ^a   Li, Aiwen ^a   Chen, Jian Jeffrey ^a   D'Amico, Derin C ^a   Fotsch, Christopher ^a   Han, Nianhe ^a   Human, Jason ^a   Liu, Qingyian ^a   Norman, Mark H ^a   Riahi, Bobby ^a   Yuan, Chester ^a   Suzuki, Hideo ^b   Mareska, David A ^b   Zhan, James ^b   Clarke, David E ^b   Toro, Andras ^b   Groneberg, Robert D ^b   Burgess, Laurence E ^b   Lester Zeiner, Dianna ^a   Biddlecome, Gloria ^a   Manning, Barton H ^a   Arik, Leyla ^a   Dong, Hong ^a   Huang, Ming ^a   Kamassah, Augustus ^a   Loeloff, Richard ^a   Sun, Hong ^a   Hsieh, Feng Yin ^a   Kumar, Gondi ^a   Ng, Gordon Y ^a   Hungate, Randall W ^a   Askew, Benny C ^a,c   Johnson, Eileen ^a   more..

^a AMGEN INC   (United States)

^b ARRAY BIOPHARMA INC   (United States)

^c Sereno Research Institute Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4 FLUOROPHENYL) N [7 (PIPERIDIN 1 YLMETHYL)CHROMAN 4 YL] 3 [3 (TRIFLUOROMETHYL)PHENYLSULFONAMIDO]PROPANAMIDE; AMIDE; BENZYL DERIVATIVE; BRADYKININ B1 RECEPTOR; BRADYKININ B1 RECEPTOR ANTAGONIST; CHROMAN DERIVATIVE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE; SULFONAMIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD PRESSURE; CHIRALITY; CHRONIC PAIN; DISTRIBUTION VOLUME; DRUG CLEARANCE; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; IN VIVO STUDY; INFLAMMATION; MALE; NONHUMAN; PAIN; RABBIT; RAT; STEREOSPECIFICITY; STRUCTURE ACTIVITY RELATION; TISSUE INJURY;

AMIDES; ANALGESICS; ANIMALS; BENZOPYRANS; BLOOD PRESSURE; CALCIUM; CHO CELLS; CHROMANS; CRICETINAE; CRICETULUS; HUMANS; INFLAMMATION; MALE; MICROSOMES; PAIN; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, BRADYKININ B1; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 34247626261     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm070055c     Document Type: Article

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