Cyclopropylamino acid amide as a pharmacophoric replacement for 2,3-diaminopyridine. Application to the design of novel bradykinin B1 receptor antagonists

Journal of Medicinal Chemistry

Volumn 49, Issue 4, 2006, Pages 1231-1234

  Wood, Michael R ^a   Schirripa, Kathy M ^a   Kim, June J ^a   Wan, Bang Lin ^a   Murphy, Kathy L ^a   Ransom, Richard W ^a   Chang, Raymond S L ^a   Tang, Cuyue ^a   Prueksaritanont, Thomayant ^a   Detwiler, Theodore J ^a   Hettrick, Lisa A ^a   Landis, Elizabeth R ^a   Leonard, Yvonne M ^a   Krueger, Julie A ^a   Lewis, Sidney D ^a   Pettibone, Douglas J ^a   Freidinger, Roger M ^a   Bock, Mark G ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,3 DIAMINOPYRIDINE; BRADYKININ B1 RECEPTOR ANTAGONIST; CYCLOPROPANE DERIVATIVE; PYRIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CHRONIC PAIN; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DESIGN; DRUG HALF LIFE; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ENANTIOMER; INFLAMMATION; NONHUMAN; RAT; RECEPTOR BLOCKING;

AMIDES; ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; BIOLOGICAL AVAILABILITY; CYCLOPROPANES; DRUG DESIGN; HUMANS; MOLECULAR CONFORMATION; PYRIDINES; RATS; RECEPTOR, BRADYKININ B1; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33144464965     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0511280     Document Type: Article

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