SSR240612 [(2R)-2-[((3R)-3-(1,3-Benzodioxol-5-yl)-3-{[(6-methoxy-2-naphthyl)sulfonyl] amino}propanoyl)amino]-3-(4-{[2R,6S)-2,6-dimethylpiperidi nyl]methyl}phenyl)-N-isopropyl-N-methylpropanamide Hydrochloride], a New Nonpeptide Antagonist of the Bradykinin B1 Receptor: Biochemical and Pharmacological Characterization

Journal of Pharmacology and Experimental Therapeutics

Volumn 309, Issue 2, 2004, Pages 661-669

  Gougat, Jean ^a   Ferrari, Bernard ^a   Sarran, Lionel ^a   Planchenault, Claudine ^a   Poncelet, Martine ^a   Maruani, Jeanne ^a   Alonso, Richard ^a   Cudennec, Annie ^a   Croci, Tiziano ^a   Guagnini, Fabio ^a   Urban Szabo, Katalin ^a   Martinolle, Jean Pierre ^a   Soubrié, Philippe ^a   Finance, Olivier ^a   Le Fur, Gérard ^a  

^a SANOFI   (France)

Author keywords

[No Author keywords available]

Indexed keywords

2 [[3 (1,3 BENZODIOXOL 5 YL) 3 [[(6 METHOXY 2 NAPHTHYL)SULFONYL]AMINO]PROPANOYL]AMINO] 3 [4 [(2,6 DIMETHYLPIPERIDINYL)METHYL]PHENYL] N ISOPROPYL N METHYLPROPANAMIDE; BRADYKININ B1 RECEPTOR; BRADYKININ B1 RECEPTOR ANTAGONIST; BRADYKININ B2 RECEPTOR; BRADYKININ DERIVATIVE; BRADYKININ[LYSINE 9 DEARGININE]; CAPSAICIN; DEXAMETHASONE; FORMALDEHYDE; INOSITOL PHOSPHATE; SSR 240612; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; GUINEA PIG; HUMAN; HUMAN CELL; HYPERALGESIA; IC 50; ILEUM CONTRACTION; MALE; MESENTERIC ARTERY; MESENTERIC ARTERY OCCLUSION; MOUSE; NERVE COMPRESSION; NEUROPATHIC PAIN; NEUTROPHIL; NOCICEPTION; NONHUMAN; PAW EDEMA; PRIORITY JOURNAL; SCIATIC NERVE; TISSUE INJURY; ULTRAVIOLET IRRADIATION;

ADMINISTRATION, ORAL; ANALGESICS; ANIMALS; CHO CELLS; CRICETINAE; DIOXOLES; DISEASE MODELS, ANIMAL; EDEMA; FORMALDEHYDE; HUMANS; ILEUM; MALE; MICE; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, BRADYKININ B1; REPERFUSION INJURY; SULFONAMIDES;

EID: 11144355212     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.059527     Document Type: Article

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