Identification of a nonpeptidic and conformationally restricted bradykinin B1 receptor antagonist with anti-inflammatory activity

Journal of Medicinal Chemistry

Volumn 50, Issue 4, 2007, Pages 607-610

  D'Amico, Derin C ^a   Aya, Toshi ^a   Human, Jason ^a   Fotsch, Christopher ^a   Chen, Jian Jeffrey ^a   Biswas, Kaustav ^a   Riahi, Bobby ^a   Norman, Mark H ^a   Willoughby, Christopher A ^a   Hungate, Randall ^a   Reider, Paul J ^a   Biddlecome, Gloria ^a   Lester Zeiner, Dianna ^a   Van Staden, Carlo ^a   Johnson, Eileen ^a   Kamassah, Augustus ^a   Arik, Leyla ^a   Wang, Judy ^a   Viswanadhan, Vellarkad N ^a   Groneberg, Robert D ^b   Zhan, James ^b   Suzuki, Hideo ^b   Toro, Andras ^b   Mareska, David A ^b   Clarke, David E ^b   Harvey, Darren M ^b   Burgess, Laurence E ^b   Laird, Ellen R ^b   Askew, Benny ^c   Ng, Gordon ^a   more..

^a AMGEN INC   (United States)

^b ARRAY BIOPHARMA INC   (United States)

^c Serono Repro Biology Institute   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BRADYKININ B1 RECEPTOR; BRADYKININ B1 RECEPTOR ANTAGONIST; CHROMAN DERIVATIVE;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CALCULATION; CHEMICAL REACTION; DRUG CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; ENTROPY; HUMAN; NONHUMAN; PRIMATE; RABBIT; RAT;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CAPILLARY PERMEABILITY; CERCOPITHECUS AETHIOPS; CHO CELLS; CHROMANS; CRICETINAE; CRICETULUS; CRYSTALLOGRAPHY, X-RAY; ENTROPY; HUMANS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PLEURISY; RABBITS; RATS; RECEPTOR, BRADYKININ B1; SPECIES SPECIFICITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33847414932     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm061224g     Document Type: Article

References (19)

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