The TSC1 gene product hamartin interacts with NADE

Molecular and Cellular Neuroscience

Volumn 35, Issue 1, 2007, Pages 100-108

  Yasui, Sakiko ^a   Tsuzaki, Kokoro ^a   Ninomiya, Haruaki ^a   Floricel, Florin ^a   Asano, Yasuo ^a   Maki, Hirotoshi ^a   Takamura, Ayumi ^b   Nanba, Eiji ^b   Higaki, Katsumi ^b   Ohno, Kousaku ^a  

^a TOTTORI UNIVERSITY   (Japan)

^b TOTTORI UNIVERSITY   (Japan)

Author keywords

Cell death; Hamartin; NADE; p75NTR; Tuberin; Tuberous sclerosis

Indexed keywords

GENE PRODUCT; HAMARTIN; NERVE GROWTH FACTOR RECEPTOR; P75NTR ASSOCIATED CELL DEATH EXECUTOR PROTEIN; SMALL INTERFERING RNA; TUBEROUS SCLEROSIS COMPLEX 1 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN; CELL LYSATE; CONTROLLED STUDY; EMBRYO; GENE REPRESSION; HUMAN; HUMAN CELL; IMMOBILIZED CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; MOUSE; NERVE CELL; NERVE CELL CULTURE; NERVE FUNCTION; NONHUMAN; PATHOLOGY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN INTERACTION;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CERCOPITHECUS AETHIOPS; CEREBELLUM; COS CELLS; HUMANS; KIDNEY; MICE; MICE, INBRED C57BL; NERVE GROWTH FACTOR; PC12 CELLS; PROTEIN STRUCTURE, TERTIARY; RATS; RECOMBINANT FUSION PROTEINS; TUBEROUS SCLEROSIS; TUMOR SUPPRESSOR PROTEINS; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 34247403005     PISSN: 10447431     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mcn.2007.02.007     Document Type: Article

References (55)

1. Barker P.A. p75NTR is positively promiscuous: novel partners and new insights. Neuron 42 (2004) 529-533
2. Brown A.L., and Kay G.F. Bex1, a gene with increased expression in parthenogenetic embryos, is a member of a novel gene family of the mouse X chromosome. Hum. Mol. Genet. 8 (1999) 611-619
3. Cai S.L., Tee A.R., Short J.D., Bergeron J.M., Kim J., Shen J., Guo R., Johnson C.L., Kiguchi K., and Walker C.L. Activity of TSC2 is inhibited by AKT-mediated phosphorylation and membrane partitioning. J. Cell Biol. 173 (2006) 279-289
4. Canu N., Tufi R., Serafino A.L., Amadoro G., Ciotti M.T., and Calissano P. Role of the autophagic-lysosomal system on low potassium-induced apoptosis in cultured cerebellar granule cells. J. Neurochem. 92 (2005) 1228-1242
5. Catania M.G., Johnson M.W., Liau L.M., Kremen T.J., deVellis J.S., and Vinters H.V. Hamartin expression and interaction with tuberin in tumor cell lines and primary cultures. J. Neurosci. Res. 63 (2001) 276-283
6. Chittka A., and Chao M.V. Identification of a zinc finger protein whose subcellular distribution is regulated by serum and nerve growth factor. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 10705-10710
7. Consortium (The European Chromosome 16 Tuberous Sclerosis Consortium). Tuberous sclerosis gene on chromosome 16. Cell 75 (1993) 1305-1315
8. Crino P.B., Trojanowski J.Q., Dichter M.A., and Eberwine J. Embryonic neuronal markers in tuberous sclerosis: single-cell molecular pathology. Proc. Natl. Acad. Sci. U. S. A. 93 (1996) 14152-14157
9. Ess K.C. The neurobiology of tuberous sclerosis complex. Semin. Pediatr. Neurol. 13 (2006) 37-42
10. Frade J.M., Rodriguez-Tebar A., and Barde Y.A. Induction of cell death by endogenous nerve growth factor through its p75 receptor. Nature 383 (1996) 166-168
11. Gao X., Zhang Y., Arrazola P., Hino O., Kobayashi T., Yeung R.S., Ru B., and Pan D. Tsc tumor suppressor proteins antagonize amino-acid-TOR signaling. Nat. Cell Biol. 4 (2002) 699-704
12. Gomez M.R., Sampson J.R., and Wittemore V.H. Tuberous Sclerosis Complex. 3rd ed. (1999), Oxford University Press, New York
13. Goncharova E., Goncharov D., Noonan D., and Krymskaya V.P. TSC2 modulates actin cytoskelton and focal adhesion through TSC1-binding domain and the Rac1 GTPase. J. Cell Biol. 167 (2004) 1171-1182
14. Haddad L.A., Smith N., Bowser M., Niida Y., Murthy V., Gonzalez-Agosti C., and Ramesh V. The TSC1 tumor suppressor hamartin interacts with neurofilament-L and possibly functions as a novel integrator of the neuronal cytoskelton. J. Biol. Chem. 277 (2002) 44180-44186
15. Heuer J.G., von Bartheld C.S., Kinoshita Y., Evers P.C., and Bothwell M. Alternating phases of FGF receptor and NGF receptor expression in the developing chicken nervous system. Neuron 5 (1990) 283-296
16. Inoki K., Li Y., Zhu T., We J., and Guan K.L. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signaling. Nat. Cell Biol. 4 (2002) 648-657
17. Kenchappa R.S., Zampieri N., Chao M.V., Barker P.A., Teng H.K., Hempstead B.L., and Carter B.D. Ligand-dependent cleavage of the p75 neurotrophin receptor is necessary for NRIF nuclear translocation and apoptosis in sympathetic neurons. Neuron 50 (2006) 219-232
18. Kendall S.E., Ryczko M.C., Mehan M., and Verdi J.M. Characterization of NADE, NRIF and SC-1 gene expression during mouse neurogenesis. Dev. Brain Res. 144 (2003) 151-158
19. Kimura M.T., Irie S., Shoji-Hoshino S., Mukai J., Nadano D., Oshimura M., and Sato T.A. 14-3-3 is involved in p75 neurotrophin receptor-mediated signal transduction. J. Biol. Chem. 276 (2001) 17291-17300
20. Kyin R., Hua Y., Baybis M., Scheithauer B., Kolson D., Uhlmann E., Gutmann D., and Crino P.B. Differential cellular expression of neurotrophin in cortical tubers of the tuberous sclerosis complex. Am. J. Pathol. 159 (2001) 1541-1554
21. Lamb R.F., Roy C., Diefenbach T.J., Vinters H.V., Johnson M.W., Jay D.G., and Hall A. The TSC1 tumor suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho. Nat. Cell Biol. 2 (2000) 281-287
22. Li Y., Inoki K., Yeung R., and Guan K.L. Regulation of TSC2 by 14-3-3 binding. J. Biol. Chem. 277 (2002) 44593-44596
23. Li Y., Inoki K., and Guan K.L. Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity. Mol. Cell Biol. 24 (2004) 7965-7975
24. Ma L., Chen Z., Erdjument-Bromage H., Tempst P., and Pandolfi P.P. Phosphorylation and functional inactivation of TSC2 by Erk implications for tuberous sclerosis and cancer pathogenesis. Cell 121 (2006) 179-193
25. Manning B.D., Tee A.R., Logsdon M.N., Blenis J., and Cantley L.C. Identification of the tuberous sclerosis complex-2 tumor suppressor gene product tuberin as a target of the phosphoinositide-3-kinase/akt pathway. Mol. Cell 10 (2002) 151-162
26. Marmur R., Mabie P.C., Gokhan S., Song Q., Kessler J.A., and Mehler M.F. Isolation and developmental characterization of cerebral cortical multipotent progenitors. Dev. Biol. 204 (1998) 577-591
27. McClintock W.M. Neurologic manifestations of tuberous sclerosis complex. Curr. Neurol. Neurosci. Rep. 2 (2002) 158-163
28. Mizuguchi M., and Takashima S. Neuropathology of tuberous sclerosis. Brain Dev. 23 (2001) 508-515
29. Mizuguchi M., Ikeda K., and Takashima S. Simultaneous loss of hamartin and tuberin from the cerebrum, kidney and heart with tuberous sclerosis. Acta Neuropathol. 99 (2000) 503-510
30. Mukai J., Hachiya T., Shoji-Hoshino S., Kimura M.T., Nadano D., Suvanto P., Hanaoka T., Li Y., Irie S., Greene L.A., and Sato T.A. NADE, a p75NTR-associated cell death executor, is involved in signal transduction mediated by the common neurotrophin receptor p75NTR. J. Biol. Chem. 275 (2000) 17566-17570
31. Mukai J., Shiji S., Kimura M.T., Okubo S., Sano H., Suvanto P., Li Y., Irie S., and Sato T.A. Structure-function analysis of NADE. J. Biol. Chem. 227 (2002) 13973-13982
32. Nakamura Y., Yamamoto M., Oda E., Yamamoto A., Kanemura Y., Hara M., Suzuki A., Yamasaki M., and Okano H. Expression of tubulin beta II in neural stem/progenitor cells and radial fibers during human fetal brain development. Lab. Invest. 83 (2003) 479-489
33. Nellist M., Goedbloed M.A., de Winter C., Verhaaf B., Jankie A., Reuser A.J., van den Ouweland A.M., van der Sluijs P., and Halley D.J. Identification and characterization of the interaction between tuberin and 14-3-3zeta. J. Biol. Chem. 277 (2002) 39417-39424
34. Ohno K., Yakura N., Zhang H., Ninomiya H., and Nanba E. Molecular epidemiology of tuberous sclerosis. In: Niimura M., Otsuka F., and Hino O. (Eds). Phacomatosis in Japan-epidemiology, Clinical Picture, and Molecular Biology (1999), Japan Scientific Societies Press, Tokyo 53-59
35. Onda H., Crino P.B., Zhang H., Murphey R.D., Rastelli L., Gould-Rothberg B.E., and Kwiatkowski D.J. Tsc2 null murine neuroepithelial cells are a model for human tuber giant cells, and show activation of an mTOR pathway. Mol. Cell Neurosci. 21 (2002) 561-574
36. Park J.A., Lee J.Y., Sato T.A., and Koh J.Y. Co-induction of p75NTR and p75NTR-associated death executor in neurons after zinc exposure in cortical culture or transient ischemia in the rat. J. Neurosci. 20 (2000) 9096-9103
37. Parry L., Maynard J.H., Patel A., Clifford S.C., Morrissey C., Maher E.R., Cheadle J.P., and Sampson J.R. Analysis of the TSC1 and TSC2 gene in sporadic renal cell carcinoma. Br. J. Cancer 85 (2001) 1226-1230
38. Potter C.J., Pedraza L.G., and Xu T. Akt regulates growth by directly phosphorylating Tsc2. Nat. Cell. Biol. 4 (2002) 658-665
39. Rabizadeh S., Oh J., Zhong L.T., Yang J., Bitler C.M., Butcher L.L., and Bredesen D.E. Induction of apoptosis by the low-affinity NGF receptor. Science 261 (1993) 345-348
40. Sampson J.R. TSC1 and TSC2 genes that are mutated in the human genetic disorder tuberous sclerosis. Biochem. Soc. Trans. 31 (2003) 592-596
41. Saucedo L.J., Gao X., Chiarelli D.A., Li L., Pan D., and Edgar B.A. Rheb promotes cell growth as a component of the insulin/TOR signaling network. Nat. Cell Biol. 5 (2003) 566-571
42. Sepp T., Yates J.R., and Green A.J. Loss of heterozygosity in tuberous sclerosis hamartomas. J. Med. Genet. 33 (1996) 962-966
43. Shumway S.D., Li Y., and Xiong Y. 14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin. J. Biol. Chem. 278 (2003) 2089-2092
44. van Slegtenhorst M., dde Hoogt R., Hermans C., Nellist M., Janssen B., Verhoef S., Lindhout D., et al. Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34. Science 277 (1997) 805-808
45. Wiederholt W.C., Gomez M.R., and Kurland L.T. Incidence and prevalence of tuberous sclerosis in Rochester, Minnesota, 1950 through 1982. Neurology 35 (1985) 600-603
46. Wienecke R., Konig A., and DeClue J.E. Identification of tuberin, the tuberous sclerosis-2 product. Tuberin possesses specific Rap1GAP activity. J. Biol. Chem. 270 (1995) 16409-16414
47. Wiznitzer M. Autism and tuberous sclerosis. J. Child Neurol. 19 (2004) 675-679
48. Yamashita T., and Tohyama M. The p75 receptor acts as a displacement factor that releases Rho from Rho-GDI. Nat. Neurosci. 6 (2003) 461-467
49. Yamazaki M., Chiba K., Mohri T., and Hatanaka H. Cyclic GMP-dependent neurite outgrowth by genipin and nerve growth factor in PC12h cells. Eur. J. Pharmacol. 488 (2004) 35-43
50. Yi J.S., Lee S.K., Sato T.A., and Koh J.Y. Co-induction of p75NTR and the associated death executor NADE in degenerating hippocampal neurons after kinate-induced seizures in the rat. Neurosci. Lett. 347 (2003) 126-130
51. Yoon K., Jang H.D., and Lee S.Y. Direct interaction of Smac with NADE promotes TRAIL-induced apoptosis. Biochem. Biophys. Res. Commun. 319 (2004) 649-654
52. Yu J., Astrinidis A., and Henske E.P. Chromosome 16 loss of heterozytosity in tuberous sclerosis and sporadic lymphangiomyomatosis. Am. J. Respir. Crit. Care Med. 164 (2001) 1537-1540
53. Yu Y., Wang J., Yuan H., Qin F., Wang J., Zhang N., Li Y.Y., Liu J., and Lu H. Characterization of human dopamine responsive protein DRG-1 that binds to p75NTR-associated cell death executor NADE. Brain Res. 1100 (2006) 13-20
54. Zaroff C.M., Barr W.B., Carlson C., LaJoie J., Madhavan D., Miles D.K., Nass R., and Devinsky O. Mental retardation and relation to seizure and tuber burden in tuberous sclerosis complex. Seisure 15 (2006) 558-562
55. Zhang Y., Gao X., Saucedo L.J., Ru B., Edgar B.A., and Pan D. Rheb is a direct target of the tuberous sclerosis tumor suppressor proteins. Nat. Cell Biol. 5 (2003) 578-581