Membrane-cytoskeleton interactions during the formation of the immunological synapse and subsequent T-cell activation

Immunological Reviews

Volumn 189, Issue , 2002, Pages 123-135

  Das, Vincent ^a   Nal, Béatrice ^a   Roumier, Anne ^a   Meas Yedid, Vannary ^a   Zimmer, Christophe ^a   Olivo Marin, Jean Christophe ^a   Roux, Pascal ^a   Ferrier, Pierre ^b   Dautry Varsat, Alice ^a   Alcover, Andrés ^a  

^a INSTITUT PASTEUR   (France)

^b CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

Author keywords

[No Author keywords available]

Indexed keywords

EZRIN; T LYMPHOCYTE RECEPTOR; ACTIN; CD3 ANTIGEN; CYTOSKELETON PROTEIN; DRUG DERIVATIVE; GAMMA BUTYROLACTONE; KHELLIN; LYMPHOCYTE ANTIGEN RECEPTOR; PHOSPHOPROTEIN;

ANTIGEN PRESENTATION; CYTOSKELETON; ENZYME LOCALIZATION; HUMAN; MICROFILAMENT; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; ANIMAL; ANTIGEN PRESENTING CELL; BIOLOGICAL MODEL; CELL JUNCTION; CELL POLARITY; CHEMISTRY; IMAGE PROCESSING; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; MOUSE; T LYMPHOCYTE;

4-BUTYROLACTONE; ACTINS; ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS, CD3; CELL POLARITY; CYTOSKELETAL PROTEINS; CYTOSKELETON; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; INTERCELLULAR JUNCTIONS; LYMPHOCYTE ACTIVATION; MICE; MODELS, IMMUNOLOGICAL; PHOSPHOPROTEINS; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES;

EID: 18744390475     PISSN: 01052896     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1600-065X.2002.18911.x     Document Type: Review

References (72)

1. Dustin ML, Cooper JA. The immunological synapse and the actin cytoskeleton: Molecular hardware for T cell signaling. Nat Immunol 2000;1:23-29.
2. Krummel MF, Davis MM. Dynamics of the immunological synapse: Finding, establishing and solidifying a connection. Curr Opin Immunol 2002;14:66-74.
3. van den Merwe PA. Formation and function of the immunological synapse. Curr Opin Immunol 2002;14:293-298.
4. Kupfer A, Singer SJ. Cell biology of cytotoxic and helper T-cell functions: Immunofluorescence microscopic studies of single cells and cell couples. Annu Rev Immunol 1989;7:309-337.
5. Critchley DR. Focal adhesions - The cytoskeletal connection. Curr Opin Cell Biol 2000:12:133-139.
6. Monks CRF, Freiberg BA, Kupfer H, Sciaky N, Kupfer A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature 1998;395:82-86.
7. Dustin ML, et al. A novel adaptor protein orchestrates receptor patterning and cytoskeletal polarity in T cell contacts. Cell 1998;94:667-677.
8. Allenspach EJ, et al. ERM-dependent movement of CD43 defines a novel protein complex distal to the immunological synapse. Immunity 2001;15:739-750.
9. Delon J, Kaibuchi K, Germain RN. Exclusion of CD43 from the immunological synapse is mediated by phosphorylation-regulated relocation of the cytoskeletal adaptor moesin. Immunity 2001;15:691-701.
10. Roumier A, et al. The membrane-microfilament linker ezrin is involved in the formation of the immunological synapse and in T cell activation. Immunity 2001;15:715-728.
11. Savage NDG, Kimzey SL, Bromley SK, Johnson KG, Dustin ML, Green JM. Polar redistribution of the sialoglycoprotein CD43: Implications for T cell function. J Immunol 2002;168:3740-3746.
12. Itoh K, et al. Negative regulation of immune synapse formation by anchoring lipid raft to cytoskeleton through Cbp-EBP50-ERM assembly. J Immunol 2002;168:541-544.
13. Egerton M, Burgess WH, Chen D, Druker BJ, Bretscher A, Samelson LE. Identification of ezrin as an 81-kDa tyrosine-phosphorylated protein in T cells. J Immunol 1992;149:1847-1852.
14. Thuillier L, Hivroz C, Fagard R, Andreoli C, Mangeat P. Ligation of CD4 surface antigen induces rapid tyrosine phosphorylation of the cytoskeletal protein ezrin. Cell Immunol 1994;156:322-331.
15. Pietromonaco SF, Simons PC, Altman A, Elias L. Protein kinase C-θ phosphorylation of moesin in the actin-binding sequence. J Biol Chem 1998;273:7594-7603.
16. Bretscher A, Chambers D, Nguyen R, Reczek D. ERM-Merlin and EBP50 protein families in plasma membrane organization and function. Ann Rev Cell Dev Biol 2000;16:113-143.
17. Gautreau A, Louvard D, Arpin M. ERM proteins and NF2 tumor suppressor: The yin and yang of cortical actin organization and cell growth signaling. Curr Opin Cell Biol 2002;14:104-109.
18. Algrain M, Turunen O, Vaheri A, Louvard D, Arpin M. Ezrin contains cytoskeleton and membrane binding domains accounting for its proposed role as a membrane-cytoskeletal linker. J Cell Biol 1993:120:129-139.
19. Pearson MA, Recezk D, Bretscher A, Karplus PA. Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain. Cell 2000;101:259-270.
20. Simons PC, Pietromonaco SF, Reczec D, Bretscher A, Elias L. C-terminal threonine phosphorylation activates ERM proteins to link the cell's cortical lipid bilayer to the cytoskeleton. Biochem Biophys Res Commun 1998;253:561-565.
21. Matsui T, et al. Rho-kinase phosphorylates COOH-terminal threonines of ezrin/radixin/moesin (ERM) proteins and regulates their head to tail association. J Cell Biol 1998;3:647-657.
22. Nakamura F, Amieva MR, Furthmayr H. Phosphorylation of threonine 558 in the carboxyl-terminal actin-binding domain of moesin by thrombin activation of human platelets. J Biol Chem 1995;270:31377-31385.
23. Huang L, Wong TYW, Lin RCC, Furthmayr H. Replacement of threonine 558, a critical site of phosphorylation of moesin in vivo, with aspartate activates F-actin binding of moesin. Regulation by conformational change. J Biol Chem 1999;274:12803-12810.
24. Nakamura F, Huang L, Pestonjamasp K, Luna EJ, Furthmayr H. Regulation of F-actin binding to platelet moesin in vitro by both phosphorylation of threonine 558 and phosphatidylinositides. Mol Biol Cell 1999;10:2669-2685.
25. Gautreau A, Louvard D, Arpin M. Morphogenic effects of ezrin require a phosphorylation-induced transition from oligomers to monomers at the plasma membrane. J Cell Biol 2000;150:193-203.
26. Yonemura S, et al. Ezrin/Radixin/Moesin (ERM) proteins bind to a positively charged aminoacid cluster in the juxta-membrane cytoplasmic domain of CD44, CD43 and ICAM-2. J Cell Biol 1998;140:885-895.
27. Heiska L, Alfthan A, Gronholm M, Vilja P, Vaheri A, Carpen O. Association of ezrin with intercellular adhesion molecule-1 and -2 (ICAM-1 and ICAM-2). Regulation by phosphatidylinositol 4,5-bisphosphate. J Biol Chem 1998;273:21893-21900.
28. Serrador JM, et al. Moesin interacts with the cytoplasmic region of intercellular adhesion molecule-3 and is redistributed to the uropod of T lymphocytes during cell polarization. J Cell Biol 1997;138:1409-1423.
29. Serrador JM, et al. CD43 interacts with moesin and ezrin and regulates its distribution to the uropods of T lymphocytes at the cell-cell contacts. Blood 1998;91:4632-4644.
30. Alonso-Lebrero JL, et al. Polarization and interaction of adhesion molecules P-selectin glycoprotein ligand 1 and intercellular adhesion molecule 3 with moesin and ezrin in lymphoid cells. Blood 2000;95:2413-2419.
31. Helander TS, Carpen O, Turunen O, Kovanen P, Vaheri A, Timonen T. ICAM-2 redistributed by ezrin as a target for killer cells. Nature 1996;382:265-268.
32. Sánchez-Madrid F, del Pozo MA. Leukocyte polarization in cell migration and immune interactions. EMBO J 1999;18:501-511.
33. Barret C, Roy C, Montcurrier P, Mangeat P, Niggli V. Mutagenesis of the phosphatidylinositol 4,5-bisphosphate (PIP2) binding site in the NH2-terminal domain of ezrin correlates with its altered cellular distribution. J Cell Biol 2000;151:1067-1079.
34. Hirao M, et al. Regulation mechanisms of ERM (ezrin, radixin, moesin) protein/plasma membrane association: possible involvement of phosphatidylinositol turnover and Rho-dependent signaling pathway. J Cell Biol 1996;135:37-51.
35. Takahashi K, et al. Direct interaction of the Rho dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein. J Biol Chem 1997;272:23371-23375.
36. Gautreau A, Poullet P, Louvard D, Arpin M. Ezrin, a plasma membrane-microfilament linker, signals cell survival through the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci USA 1999;96:7300-7305.
37. Parlato S, et al. CD95 (APO1/Fas) linkage to the actin cytoskeleton through ezrin in human T lymphocytes: A novel regulatory mechanism of the CD95 apoptotic pathway. EMBO J 2000;19:5123-5134.
38. Ng T, et al. Ezrin is a downstream effector of trafficking PKC-integrin complexes involved in the control of cell motility. EMBO J 2001;20:2723-2741.
39. Poullet P, Gantreau A, Kadaré G, Girault JA, Louvard D, Arpin M. Ezrin interacts with focal adhesion kinase and induces its activation independendy of cell-matrix adhesion. J Biol Chem 2001;276:37686-37691.
40. Defacque H, et al. Involvement of ezrin/moesin in de novo actin assembly on phagosomal membranes. EMBO J 2000;19:199-212.
41. Donnadieu E, Bismuth G, Trantman A. Antigen recognition by helper T cells elicits a sequence of distinct changes of their shape and intracellular calcium. Curr Biol 1994;4:584-595.
42. Valitutti S, Dessing M, Aktories K, Gallati H, Lanzavecchia A. Sustained signaling leading to T cell activation results from prolonged T cell receptor occupancy. Role of T cell actin cytoskeleton. J Exp Med 1995;181:577-584.
43. Negulescu PA, Krasieva TB, Khan A, Kerschbaum HH, Cahalan MD. Polarity of T cell shape, motility, and sensitivity to antigen. Immunity 1996;4:421-430.
44. + T cells. Compulsory cytoskeletal alterations for the triggering of an intracellular calcium response. Eur J Immunol 1998;28:716-729.
45. Wülfing C, Davis MM. A receptor/cytoskeletal movement triggered by costimulation during T cell activation. Science 1998;282:2266-2269.
46. Grakoui A, et al. The immunological synapse: A molecular machine controlling T cell activation. Science 1999;285:221-227.
47. Gunzer M, et al. Antigen presentation in extracellular matrix, interactions of T cells with dendritic cells are dynamic, short lived, and sequential. Immunity 2000;13:323-332.
48. Krummel MF, Sjaastad MD, Wülfing C, Davis MM. Differential dustering of CD4 and CD3ζ during T cell recognition. Science 2000;289:1349-1352.
49. Stoll S, Delon J, Brotz TM, Germain RN. Dynamic imaging of T cell-dendritic cell interactions in lymph nodes. Science 2002;296:1873-1875.
50. Miller MJ, Wei SH, Parker I, Cahalan MD. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 2002;296:1869-1873.
51. Bousso P, Bhakta NR, Lewis RS, Robey E. Dynamics of thymocyte stromal cell interactions visualized by two photon microscopy. Science 2002;296:1876-1880.
52. Michaely PA, Mineo C, Ying YS, Anderson RGW. Polarized distribution of endogenous Racl and RhoA at the cell surface. J Biol Chem 1999;274:21430-21436.
53. Tomas EM, Chan TA, Madrenas J. Clustering of a lipid-raft associated pool of ERM proteins at the immunological synapse upon T cell receptor or CD28 ligation. Immunol Lett 2002;83:143-147.
54. Lowin-Kropf B, Smith-Shapiro V, Weiss A. Cytoskeletal polarization of T cells is regulated by an immunoreceptor tyrosine-based mechanism. J Cell Biol 1998;140:861-871.
55. Krause M, Sechi A, Konradt M, Monner D, Gertler FB, Wehland J. Fyn binding protein (Fyb) /SLP-76-associated protein (SLAP), Ena/Vasodilator-stimulated phosphoprotein (VASP) proteins and the ARP2/3 complex link T cell receptor (TCR) signaling to the actin cytoskeleton. J Cell Biol 2000;149:181-194.
56. Sperling AI, Sedy JR, Manjunath N, Kupfer A, Ardam B, Burkhardt JK. TCR signaling induces selective exclusion of CD43 from the T cell-antigen presenting cell contact site. J Immunol 1998;161:6459-6462.
57. Montoya MC, et al. Role of ICAM-3 in the initial interaction of T lymphocytes and APCs. Nat Immunol 2002:3:159-168.
58. Crepaldi T, Gautreau A, Comoglio PM, Louvard D, Arpin M. Ezrin is an effector of hepatocyte growth factor-mediated migration and morphogenesis in epithelial cells. J Cell Biol 1997;138:423-434.
59. Olivo-Marin JC. Extraction of spots in biological images using multiscale products. Pattern Recognition 2002;35:1989-1996.
60. Monks CRF, Kupfer H, Tamir I, Barlow A, Kupfer A. Selective modulation of protein kinase C-θ during T-cell activation. Nature 1997;385:83-86.
61. Simons K, Toomre D. Lipid rafts and signal transduction. Nature Rev Mol Cell Biol 2000;1:31-39.
62. Drevot P, et al. TCR signal initiation machinery is pre-assembled and activated in a subset of membrane rafts. EMBO J 2002;21:1899-1908.
63. Harder T. Raft membrane domains and immunoreceptor functions. Adv Immunol 2001;77:45-92.
64. Bi K, et al. Antigen-induced translocation of PKCθ to membrane rafts is required for T cell activation. Nat Immunol 2001;2:556-563.
65. de Hostos EL. The coronin family of actin-associated proteins. Trends Cell Biol 1999;9:345-350.
66. Smith TF, Gaitatxes C, Saxena K, Neer EJ. The WD repeat: A common architecture for diverse functions. Trends Biochem Sci 1999;24:181-185.
67. Grogan A, et al. Cytosolic phox proteins interact with and regulate the assembly of coronin in neutrophils. J Cell Sci 1997;110:3071-3081.
68. Ferrari G, Langen H, Naito M, Pieters J. A coat protein on phagosomes involved in the intracellular survival of Mycobacteria. Cell 1999;97:435-447.
69. Schüller S, Neefjes J, Ottenhoff T, Thole J, Young D. Coronin is involved in uptake of Mycobacterium bovis BCG in human macrophages but not in phagosome maintenance. Cell Microbiol 2001;3:785-793.
70. David V, et al. Identification of cofilin, coronin, Rac and CapZ in actin tails using a Listeria affinity approach. J Cell Sci 1998;111:2877-2884.
71. Maniak M, Rauchengerger R, Albrecht R, Murphy J, Gerisch G. Coronin involved in phagocytosis. Dynamics of particle-induced relocalization visualized by a green fluorescent protein tag. Cell 1995;15:915-924.
72. Mishima M, Nishida E. Coronin localizes to leading edges and is involved in cell spreading and lamellipodium extension in vertevrate cells. J Cell Sci 1999;112:2833-2842.